A new and improved synthesis of the precursor of the hypoxia marker [ 18F]-FMISO

Synthesis

Volumn , Issue 21, 2010, Pages 3700-3704

  Nieto, Elena ^a   Alajarín, Ramón ^a   Álvarez Builla, Julio ^a   Larrañaga, Ignacio ^b   Gorospe, Elena ^b   Pozo, Miguel A ^c  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b Instituto Tecnologico PET   (Spain)

^c INSTITUTO PLURIDISCIPLINAR   (Spain)

Author keywords

18F FMISO; hypoxia; radiopharmaceutical; regioselective tosylation

Indexed keywords

[18F]-FMISO; HYPOXIA; HYPOXIA MARKER; RADIOPHARMACEUTICAL; REGIO-SELECTIVE; SYNTHETIC APPROACH; TOSYLATION;

REGIOSELECTIVITY;

1 (2,2 DIMETHYL [1,3] DIOXOLAN 4 YLMETHYL) 2 NITRO 1H IMIDAZOLE; 1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; 2 NITROIMIDAZOLE; 3 (2 NITROIMIDAZOL 1 YL)PROPANE 1,2 DIOL; FLUORINE 18; HYDROCHLORIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TOLUENE 4 SULFONIC ACID 2 HYDROXY 3 (2 NITROIMIDAZOL 1 YL)PROPYL ESTER; TOLUENE 4 SULFONIC ACID 3 (2 NITROIMIDAZOL 1 YL) 2 (TETRAHYDROPYRAN 2 YLOXY)PROPYL ESTER; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; NONHUMAN; ONE POT SYNTHESIS; POSITRON EMISSION TOMOGRAPHY;

EID: 78049296505     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1258269     Document Type: Article

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