Validation of the intact rat weanling uterotrophic assay with notes on the formulation and analysis of the positive control chemical in vehicle

Journal of Applied Toxicology

Volumn 30, Issue 7, 2010, Pages 694-698

  Tyl, Rochelle W ^a   Marr, Melissa C ^a   Brown, Sherri S ^a   Dolbow, Emily A ^a   Myers, Christina B ^a  

^a RTI INTERNATIONAL   (United States)

Author keywords

17 ethinyl estradiol; Hyperplasia; Hypertrophy; Imbibition; Intact; Puberty; Uterotrophic; Weanling

Indexed keywords

CARBON DIOXIDE; ETHINYLESTRADIOL;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TESTING ALTERNATIVE; ANIMAL TISSUE; ARTICLE; ASPHYXIA; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; EUTHANASIA; FEMALE; FOOD INTAKE; IN VIVO STUDY; LIVER WEIGHT; NONHUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; RAT; RAT WEANLING UTEROTROPHIC ASSAY; TOXICITY TESTING; UTERUS WEIGHT; VAGINA; VALIDATION STUDY; WEIGHT CHANGE;

ANIMALS; BIOLOGICAL ASSAY; CORN OIL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENDOCRINE SYSTEM; ESTROGENS; ETHINYL ESTRADIOL; FEMALE; INTUBATION, GASTROINTESTINAL; LIVER; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; TOXICITY TESTS; UTERUS; VAGINA;

RATTUS; ZEA MAYS;

EID: 78049291393     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1544     Document Type: Article

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