Cyclone selection influences protein damage during drying in a mini spray-dryer

International Journal of Pharmaceutics

Volumn 401, Issue 1-2, 2010, Pages 68-71

  Bögelein, Jürgen ^a   Lee, Geoffrey ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Cyclone; Inactivation; Protein; Spray drying

Indexed keywords

LYSOZYME;

AIRFLOW; AQUEOUS SOLUTION; ARTICLE; CYCLONE SEPARATOR; DRY POWDER; FLOW RATE; MOISTURE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SPRAY DRYING;

DESICCATION; EQUIPMENT DESIGN; MURAMIDASE; PARTICLE SIZE; POWDERS; PROTEIN STABILITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; THERMODYNAMICS;

EID: 78049272798     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.09.023     Document Type: Article

References (7)

1. Chiou D., Langrish T., Brahom R. Partial crystallization behaviour during spray drying: simulations and experiments. Dry. Technol. 2008, 26:27-38.
2. Hanus M., Langrish T. Re-entrainment of wall deposits from a laboratory-scale spray-dryer. Asia-Pac. J. Chem. Eng. 2007, 2:90-107.
3. Langrish T. Degradation of vitamin C in spray-dryers and temperature and moisture content profiles in these dryers. Food Bioprocess. Technol. 2009, 2(4):400-408.
4. Langrish T., Chiou D. Producing powders of hibiscus extract in a laboratory-scale spray-dryer. Int. J. Food Eng. 2008, 4(3):1-20.
5. Lee G. Spray-drying of proteins. Rational Protein Formulation: Theory and Practice 2002, Plenum Press. J. Carpenter, M. Manning (Eds.).
6. Masters K. The Spray-Drying Handbook 1991, Longman Scientific. 5th ed.
7. Maury M., Murphy K., Kumar S., Shi L., Lee G. Effects of process variables on the powder yield of spray-dried trehalose on a laboratory spray-dryer. Eur. J. Pharm. Biopharm. 2005, 59(3):566-573.