Drosophila melanogaster lipins are tissue-regulated and developmentally regulated and present specific subcellular distributions

FEBS Journal

Volumn 277, Issue 22, 2010, Pages 4775-4788

  Valente, Valeria ^a   Maia, Rafaela Martins ^a   Vianna, Murilo Carlos Bizam ^a   Paçó Larson, Maria Luisa ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Drosophila; Isoforms; Lipin; Pah1p; Subcellular localization

Indexed keywords

DROSOPHILA MELANOGASTER LIPIN A; DROSOPHILA MELANOGASTER LIPIN J; DROSOPHILA MELANOGASTER LIPIN K; PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELLULAR DISTRIBUTION; DROSOPHILA MELANOGASTER; FAT BODY; GANGLION; GENOME; IMMUNOFLUORESCENCE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TESTIS;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; OVARY; PHOSPHORIC MONOESTER HYDROLASES; PHYLOGENY; PROTEIN ISOFORMS; SEQUENCE ALIGNMENT; SUBCELLULAR FRACTIONS; TISSUE DISTRIBUTION; TRIGLYCERIDES;

DROSOPHILA MELANOGASTER; MAMMALIA;

EID: 78049266773     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07883.x     Document Type: Article

References (41)

1. Reue K (2009) The lipin family: mutations and metabolism. Curr Opin Lipidol 20, 165-170.
2. Siniossoglou S (2009) Lipins, lipids and nuclear envelope structure. Traffic 10, 1181-1187.
3. Han GS, Wu WI & Carman GM (2006) The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme. J Biol Chem 281, 9210-9218.
4. Donkor J, Sariahmetoglu M, Dewald J, Brindley DN & Reue K (2007) Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. J Biol Chem 282, 3450-3457.
5. Carman GM & Han GS (2006) Roles of phosphatidate phosphatase enzymes in lipid metabolism. Trends Biochem Sci 31, 694-699.
6. Peterfy M, Phan J, Xu P & Reue K (2001) Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat Genet 27, 121-124.
7. Koh YK, Lee MY, Kim JW, Kim M, Moon JS, Lee YJ, Ahn YH & Kim KS (2008) Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2. J Biol Chem 283, 34896-34906.
8. Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence JC Jr & Kelly DP (2006) Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab 4, 199-210.
9. Donkor J, Zhang P, Wong S, O'Loughlin L, Dewald J, Kok BP, Brindley DN & Reue K (2009) A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2. J Biol Chem 284, 29968-29978.
10. Huffman TA, Mothe-Satney I & Lawrence JC Jr (2002) Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. Proc Natl Acad Sci USA 99, 1047-1052.
11. Harris TE, Huffman TA, Chi A, Shabanowitz J, Hunt DF, Kumar A & Lawrence JC Jr (2007) Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1. J Biol Chem 282, 277-286.
12. Zhang P, O'Loughlin L, Brindley DN & Reue K (2008) Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis. J Lipid Res 49, 1519-1528.
13. Santos-Rosa H, Leung J, Grimsey N, Peak-Chew S & Siniossoglou S (2005) The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth. EMBO J 24, 1931-1941.
14. O'Hara L, Han GS, Peak-Chew S, Grimsey N, Carman GM & Siniossoglou S (2006) Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase. J Biol Chem 281, 34537-34548.
15. Golden A, Liu J & Cohen-Fix O (2009) Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope. J Cell Sci 122, 1970-1978.
16. Gorjanacz M & Mattaj IW (2009) Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans. J Cell Sci 122, 1963-1969.
17. Langner CA, Birkenmeier EH, Ben-Zeev O, Schotz MC, Sweet HO, Davisson MT & Gordon JI (1989) The fatty liver dystrophy (fld) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities. J Biol Chem 264, 7994-8003.
18. Langner CA, Birkenmeier EH, Roth KA, Bronson RT & Gordon JI (1991) Characterization of the peripheral neuropathy in neonatal and adult mice that are homozygous for the fatty liver dystrophy (fld) mutation. J Biol Chem 266, 11955-11964.
19. Rehnmark S, Giometti CS, Slavin BG, Doolittle MH & Reue K (1998) The fatty liver dystrophy mutant mouse: microvesicular steatosis associated with altered expression levels of peroxisome proliferator-regulated proteins. J Lipid Res 39, 2209-2217.
20. Klingenspor M, Xu P, Cohen RD, Welch C & Reue K (1999) Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics. J Biol Chem 274, 23078-23084.
21. Reue K, Xu P, Wang XP & Slavin BG (2000) Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene. J Lipid Res 41, 1067-1076.
22. Verheijen MH, Chrast R, Burrola P & Lemke G (2003) Local regulation of fat metabolism in peripheral nerves. Genes Dev 17, 2450-2464.
23. Nadra K, De Preux Charles AS, Médard JJ, Hendriks WT, Han GS, Grès S, Carman GM, Saulnier-Blache JS, Verheijen MH & Chrast R (2008) Phosphatidic acid mediates demyelination in Lpin1 mutant mice. Genes Dev 22, 1647-1661.
24. Ferguson PJ & El-Shanti HI (2007) Autoinflammatory bone disorders. Curr Opin Rheumatol 19, 492-498.
25. El-Shanti HI & Ferguson PJ (2007) Chronic recurrent multifocal osteomyelitis: a concise review and genetic update. Clin Orthop Relat Res 462, 11-19.
26. Peterfy M, Phan J & Reue K (2005) Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis. J Biol Chem 280, 32883-32889.
27. Grimsey N, Han GS, O'Hara L, Rochford JJ, Carman GM & Siniossoglou S (2008) Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2. J Biol Chem 283, 29166-29174.
28. Maia RM, Valente V, Cunha MA, Sousa JF, Araujo DD, Silva WA Jr, Zago MA, Dias-Neto E, Souza SJ & Simpson AJ (2007) Identification of unannotated exons of low abundance transcripts in Drosophila melanogaster and cloning of a new serine protease gene upregulated upon injury. BMC Genomics 8, 249-258.
29. Han GS, Siniossoglou S & Carman GM (2007) The cellular functions of the yeast lipin homolog PAH1p are dependent on its phosphatidate phosphatase activity. J Biol Chem 282, 37026-37035.
30. Ladd AN & Cooper TA (2002). Finding signals that regulate alternative splicing in the post-genomic era. Genome Biol 3, reviews 0008.1-0008.16.
31. Gropler MC, Harris TE, Hall AM, Wolins NE, Gross RW, Han X, Chen Z & Finck BN (2009) Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice. J Biol Chem 284, 6763-6772.
32. Tange Y, Hirata A & Niwa O (2002) An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin. J Cell Sci 115, 4375-4385.
33. Feingold KR, Moser A, Patsek SM, Shigenaga JK & Grunfeld C (2009). Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm. J Lipid Res 50, 2055-2063.
34. Bodenstein D (1994) The postembryonic development of Drosophila. In Biology of Drosophila (Demerec M ed), pp. 275-364. Cold Spring Harbor Laboratory Press, New York.
35. Klapper R (2000) The longitudinal visceral musculature of Drosophila melanogaster persists through metamorphosis. Mech Dev 95, 47-54.
36. Zhang N, Zhang J, Cheng Y & Howard K (1996) Identification and genetic analysis of wunen, a gene guiding Drosophila melanogaster germ cell migration. Genetics 143, 1231-1241.
37. Kim Y, Gentry MS, Harris TE, Wiley SE, Lawrence JC Jr & Dixon JE (2007) A conserved phosphatase cascade that regulates nuclear membrane biogenesis. Proc Natl Acad Sci USA 104, 6596-6601.
38. Hudson AM & Cooley L (2002) Understanding the function of actin-binding proteins through genetic analysis of Drosophila oogenesis. Annu Rev Genet 36, 455-488.
39. Balla T, Szentpetery Z & Kim YJ (2009) Phosphoinositide signaling: new tools and insights. Physiology (Bethesda) 24, 231-244.
40. Monesi N, Fernandez MA, Fontes AM, Basso LR Jr, Nakanishi Y, Baron B, Buttin G & Paco-Larson ML (1995) Molecular characterization of an 18 kb segment of DNA puff C4 of Bradysia hygida (Diptera, sciaridae). Chromosoma 103, 715-724.
41. Lin MD, Jiao X, Grima D, Newbury SF, Kiledjian M & Chou TB (2008) Drosophila processing bodies in oogenesis. Dev Biol 322, 276-288.