Hepatic α-tocopherol transfer protein: Ligand-induced protection from proteasomal degradation

Biochemistry

Volumn 49, Issue 43, 2010, Pages 9339-9344

  Thakur, Varsha ^a   Morley, Samantha ^a,b   Manor, Danny ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL FRACTIONATION; CELLULAR COMPARTMENTS; CYTOSOLIC; CYTOSOLS; DOSE-DEPENDENT; HEPATOCYTES; IN-VITRO; MEMBRANOUS ORGANELLE; NATURALLY OCCURRING; PROTEASOMAL DEGRADATION; PROTEASOMES; PROTEIN CONFORMATION; PROTEOLYTIC DEGRADATION; STEADY-STATE LEVEL; TRANSFER PROTEIN; UBIQUITINATION; VITAMIN-E;

LIGANDS; PROTEINS;

DEGRADATION;

ALPHA TOCOPHEROL; CARRIER PROTEIN; HEPATIC ALPHA TOCOPHEROL TRANSFER PROTEIN; PROTEASOME; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; CELL FRACTIONATION; CELL ORGANELLE; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGAND BINDING; LIVER CELL CULTURE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STABILITY; STEADY STATE; UBIQUITINATION;

ALPHA-TOCOPHEROL; CARRIER PROTEINS; CELL COMPARTMENTATION; CELL FRACTIONATION; CELLS, CULTURED; HEPATOCYTES; HUMANS; LIGANDS; LIVER; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN TRANSPORT; VITAMIN E;

VERTEBRATA;

EID: 78049262595     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100960b     Document Type: Article

References (33)

1. Burton, G. W., Joyce, A., and Ingold, K. U. (1983) Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes? Arch. Biochem. Biophys. 221, 281-290
2. Traber, M. G. and Kayden, H. J. (1989) Preferential incorporation of α-tocopherol vs γ-tocopherol in human lipoproteins Am. J. Clin. Nutr. 49, 517-526
3. Kaempf-Rotzoll, D. E., Traber, M. G., and Arai, H. (2003) Vitamin E and transfer proteins Curr. Opin. Lipidol. 14, 249-254
4. Traber, M. G. and Arai, H. (1999) Molecular mechanisms of vitamin E transport Annu. Rev. Nutr. 19, 343-355
5. Manor, D. and Morley, S. (2007) The α-tocopherol transfer protein Vitam. Horm. 76, 45-65
6. Cavalier, L., Ouahchi, K., Kayden, H. J., Di Donato, S., Reutenauer, L., Mandel, J. L., and Koenig, M. (1998) Ataxia with isolated vitamin E deficiency: Heterogeneity of mutations and phenotypic variability in a large number of families Am. J. Hum. Genet. 62, 301-310
7. Hentati, A., Deng, H. X., Hung, W. Y., Nayer, M., Ahmed, M. S., He, X., Tim, R., Stumpf, D. A., Siddique, T., and Ahmed (1996) Human alpha-tocopherol transfer protein: Gene structure and mutations in familial vitamin E deficiency Ann. Neurol. 39, 295-300
8. Yokota, T., Igarashi, K., Uchihara, T., Jishage, K., Tomita, H., Inaba, A., Li, Y., Arita, M., Suzuki, H., Mizusawa, H., and Arai, H. (2001) Delayed-onset ataxia in mice lacking α-tocopherol transfer protein: Model for neuronal degeneration caused by chronic oxidative stress Proc. Natl. Acad. Sci. U.S.A. 98, 15185-15190
9. Jishage, K., Arita, M., Igarashi, K., Iwata, T., Watanabe, M., Ogawa, M., Ueda, O., Kamada, N., Inoue, K., Arai, H., and Suzuki, H. (2001) α-Tocopherol transfer protein is important for the normal development of placental labyrinthine trophoblasts in mice J. Biol. Chem. 276, 1669-1672
10. Horiguchi, M., Arita, M., Kaempf-Rotzoll, D. E., Tsujimoto, M., Inoue, K., and Arai, H. (2003) pH-dependent translocation of α-tocopherol transfer protein (α-TTP) between hepatic cytosol and late endosomes Genes Cells 8, 789-800
11. Arita, M., Nomura, K., Arai, H., and Inoue, K. (1997) α-Tocopherol transfer protein stimulates the secretion of α-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway Proc. Natl. Acad. Sci. U.S.A. 94, 12437-12441
12. Qian, J., Morley, S., Wilson, K., Nava, P., Atkinson, J., and Manor, D. (2005) Intracellular trafficking of vitamin E in hepatocytes: Role of tocopherol transfer protein J. Lipid Res. 46, 2072-2082
13. Qian, J., Atkinson, J., and Manor, D. (2006) Biochemical Consequences of Heritable Mutations in the α-Tocopherol Transfer Protein Biochemistry 45, 8236-8242
14. Morley, S., Cacchini, M., Zhang, W., Virgulti, A., Noy, N., Atkinson, J., and Manor, D. (2008) Mechanisms of ligand transfer by the hepatic tocopherol transfer protein J. Biol. Chem. 283, 17797-17804
15. Basu, A., Meyer, K., Ray, R. B., and Ray, R. (2002) Hepatitis C virus core protein is necessary for the maintenance of immortalized human hepatocytes Virology 298, 53-62
16. Morley, S., Panagabko, C., Shineman, D., Mani, B., Stocker, A., Atkinson, J., and Manor, D. (2004) Molecular determinants of heritable vitamin E deficiency Biochemistry 43, 4143-4149
17. Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J., and Schreiber, S. L. (1995) Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin Science 268, 726-731
18. Lee, D. H. and Goldberg, A. L. (1998) Proteasome inhibitors: Valuable new tools for cell biologists Trends Cell Biol. 8, 397-403
19. Min, K. C., Kovall, R. A., and Hendrickson, W. A. (2003) Crystal structure of human α-tocopherol transfer protein bound to its ligand: Implications for ataxia with vitamin E deficiency Proc. Natl. Acad. Sci. U.S.A. 100, 14713-14718
20. Meier, R., Tomizaki, T., Schulze-Briese, C., Baumann, U., and Stocker, A. (2003) The molecular basis of vitamin E retention: Structure of human α-tocopherol transfer protein J. Mol. Biol. 331, 725-734
21. Sato, Y., Hagiwara, K., Arai, H., and Inoue, K. (1991) Purification and characterization of the α-tocopherol transfer protein from rat liver FEBS Lett. 288, 41-45
22. Ouahchi, K., Arita, M., Kayden, H., Hentati, F., Ben Hamida, M., Sokol, R., Arai, H., Inoue, K., Mandel, J. L., and Koenig, M. (1995) Ataxia with isolated vitamin E deficiency is caused by mutations in the α-tocopherol transfer protein Nat. Genet. 9, 141-145
23. Panagabko, C., Morley, S., Hernandez, M., Cassolato, P., Gordon, H., Parsons, R., Manor, D., and Atkinson, J. (2003) Ligand specificity in the CRAL-TRIO protein family Biochemistry 42, 6467-6474
24. Oram, J. F., Vaughan, A. M., and Stocker, R. (2001) ATP-binding cassette transporter A1 mediates cellular secretion of α-tocopherol J. Biol. Chem. 276, 39898-39902
25. Traber, M. G. and Kayden, H. J. (1984) Vitamin E is delivered to cells via the high affinity receptor for low-density lipoprotein Am. J. Clin. Nutr. 40, 747-751
26. Rigotti, A. (2007) Absorption, transport, and tissue delivery of vitamin E Mol. Aspects Med. 28, 423-436
27. Balazs, Z., Panzenboeck, U., Hammer, A., Sovic, A., Quehenberger, O., Malle, E., and Sattler, W. (2004) Uptake and transport of high-density lipoprotein (HDL) and HDL-associated α-tocopherol by an in vitro blood-brain barrier model J. Neurochem. 89, 939-950
28. Kim, H. S., Arai, H., Arita, M., Sato, Y., Ogihara, T., Inoue, K., Mino, M., and Tamai, H. (1998) Effect of α-tocopherol status on α-tocopherol transfer protein expression and its messenger RNA level in rat liver Free Radical Res. 28, 87-92
29. Shaw, H. M. and Huang, C. (1998) Liver α-tocopherol transfer protein and its mRNA are differentially altered by dietary vitamin E deficiency and protein insufficiency in rats J. Nutr. 128, 2348-2354
30. Barella, L., Muller, P. Y., Schlachter, M., Hunziker, W., Stocklin, E., Spitzer, V., Meier, N., de Pascual-Teresa, S., Minihane, A. M., and Rimbach, G. (2004) Identification of hepatic molecular mechanisms of action of α-tocopherol using global gene expression profile analysis in rats Biochim. Biophys. Acta 1689, 66-74
31. Fechner, H., Schlame, M., Guthmann, F., Stevens, P. A., and Rustow, B. (1998) α- and δ-tocopherol induce expression of hepatic α-tocopherol-transfer-protein mRNA Biochem. J. 331, 577-581
32. Copp, R. P., Wisniewski, T., Hentati, F., Larnaout, A., Ben Hamida, M., and Kayden, H. J. (1999) Localization of α-tocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disorders Brain Res. 822, 80-87
33. Bella, D. L., Schock, B. C., Lim, Y., Leonard, S. W., Berry, C., Cross, C. E., and Traber, M. G. (2006) Regulation of the α-tocopherol transfer protein in mice: Lack of response to dietary vitamin E or oxidative stress Lipids 41, 105-112