Enterococcus faecalis endocarditis severity in rabbits is reduced by igg fabs interfering with aggregation substance

PLoS ONE

Volumn 5, Issue 10, 2010, Pages

  Schlievert, Patrick M ^a   Chuang Smith, Olivia N ^a   Peterson, Marnie L ^a   Cook, Laura C C ^a   Dunny, Gary M ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATION SUBSTANCE PROTEIN; BACTERIAL PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COUNT; BACTERIAL ENDOCARDITIS; CONTROLLED STUDY; DISEASE SEVERITY; ENTEROCOCCUS FAECALIS; FEMALE; IMMUNIZATION; IN VITRO STUDY; INFECTION PREVENTION; MALE; MICROBIAL ACTIVITY; NONHUMAN; TREATMENT RESPONSE;

ANIMALS; ENDOCARDITIS; ENTEROCOCCUS FAECALIS; IMMUNOGLOBULIN FAB FRAGMENTS; RABBITS;

ANIMALIA; ENTEROCOCCUS FAECALIS; ORYCTOLAGUS CUNICULUS;

EID: 78049261963     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013194     Document Type: Article

References (20)

1. Murray BE (1990) The life and times of the Enterococcus. Clin Microbiol Rev 3: 46-65.
2. Rice LB, Calderwood SB, Eliopoulos GM, Farber BF, Karchmer AW (1991) Enterococcal endocarditis: a comparison of prosthetic and native valve disease. Rev Infect Dis 13: 1-7.
3. Kaye D (2004) Infective endocarditis. In: Gorbach SL, Bartlett JG, Blacklow NR, eds. Infectious Diseases. 3rd ed. Philadelphia: Lippincott Williams and Wilkins.pp 569-581.
4. Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, et al. (2007) Prevention of Infective Endocarditis. Guidelines From the American Heart Association. A Guideline From the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation.
5. Schlievert PM, Gahr PJ, Assimacopoulos AP, Dinges MM, Stoehr JA, et al. (1998) Aggregation and binding substances enhance pathogenicity in rabbit models of Enterococcus faecalis endocarditis. Infect Immun 66: 218-223.
6. McCormick JK, Hirt H, Waters CM, Tripp TJ, Dunny GM, et al. (2001) Antibodies to a surface-exposed, N-terminal domain of aggregation substance are not protective in the rabbit model of Enterococcus faecalis endocarditis. Infect Immun 69: 3305-3314.
7. Hirt H, Schlievert PM, Dunny GM (2002) In vivo induction of virulence and antibiotic resistance transfer in Enterococcus faecalis mediated by the sex pheromone-sensing system of pCF10. Infect Immun 70: 716-723.
8. Waters CM, Hirt H, McCormick JK, Schlievert PM, Wells CL, et al. (2004) An amino-terminal domain of Enterococcus faecalis aggregation substance is required for aggregation, bacterial internalization by epithelial cells and binding to lipoteichoic acid. Mol Microbiol 52: 1159-1171.
9. Hirt H, Wanner G, Galli D, Wirth R (1993) Biochemical, immunological and ultrastructural characterization of aggregation substances encoded by Enterococcus faecalis sex-pheromone plasmids. Eur J Biochem 211: 711-716.
10. Waters CM, Wells CL, Dunny GM (2003) The aggregation domain of aggregation substance, not the RGD motifs, is critical for efficient internalization by HT-29 enterocytes. Infect Immun 71: 5682-5689.
11. Chuang ON, Schlievert PM, Wells CL, Manias DA, Tripp TJ, et al. (2009) Multiple functional domains of Enterococcus faecalis aggregation substance Asc10 contribute to endocarditis virulence. Infect Immun 77: 539-548.
12. Rakita RM, Vanek NN, Jacques-Palaz K, Mee M, Mariscalco MM, et al. (1999) Enterococcus faecalis bearing aggregation substance is resistant to killing by human neutrophils despite phagocytosis and neutrophil activation. Infect Immun 67: 6067-6075.
13. McCormick JK, Tripp TJ, Dunny GM, Schlievert PM (2002) Formation of vegetations during infective endocarditis excludes binding of bacterial-specific host antibodies to Enterococcus faecalis. J Infect Dis 185: 994-997.
14. Schlievert PM, Dunny GM, Stoehr JA, Assimacopoulos AP (1997) Aggregation and binding substances enhance pathogenicity in a rabbit model of Enterococcus faecalis endocarditis. Adv Exp Med Biol 418: 789-791.
15. Chow JW, Thal LA, Perri MB, Vazquez JA, Donabedian SM, et al. (1993) Plasmid-associated hemolysin and aggregation substance production contribute to virulence in experimental enterococcal endocarditis. Antimicrob Agents Chemother 37: 2474-2477.
16. Patti JM, Allen BL, McGavin MJ, Hook M (1994) MSCRAMM-mediated adherence of microorganisms to host tissues. Annu Rev Microbiol 48: 585-617.
17. Rivas JM, Speziale P, Patti JM, Hook M (2004) MSCRAMM-targeted vaccines and immunotherapy for staphylococcal infection. Curr Opin Drug Discov Devel 7: 223-227.
18. Christie PJ, Kao SM, Adsit JC, Dunny GM (1988) Cloning and expression of genes encoding pheromone-inducible antigens of Enterococcus (Streptococcus) faecalis. J Bacteriol 170: 5161-5168.
19. Blomster-Hautamaa DA, Schlievert PM (1988) Preparation of toxic shock syndrome toxin-1. Methods Enzymol 165: 37-43.
20. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.