Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi region in India

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 11, 2010, Pages 4789-4793

  Khanna, Alka ^a,c   Raj, V Samuel ^a   Tarai, Bansidhar ^d   Sood, Ruchi ^a   Pareek, Pawan Kumar ^a   Upadhyay, Dilip J ^a   Sharma, Pawan ^b   Rattan, Ashok ^d,e   Saini, Kulvinder Singh ^a   Singh, Harpal ^c  

^a RANBAXY RESEARCH LABORATORIES   (India)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^c INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

^d Super Religare Laboratories   (India)

^e Fortis Clinical Research Ltd   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; BACTERIAL PROTEIN; CAPREOMYCIN; CYCLOSERINE; DNA TOPOISOMERASE (ATP HYDROLYSING) A; ETHAMBUTOL; ETHIONAMIDE; ISONIAZID; KANAMYCIN; KATG PROTEIN; LEVOFLOXACIN; MOXIFLOXACIN; OFLOXACIN; PROTEIN RRS; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; RNA 16S; RNA POLYMERASE BETA SUBUNIT; SPARFLOXACIN; STREPTOMYCIN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CODON; DRUG SCREENING; EXTENSIVE DRUG RESISTANCE; FEMALE; GENE AMPLIFICATION; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENOTYPE; HUMAN; INDIA; MALE; MOLECULAR DYNAMICS; MULTIDRUG RESISTANCE; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; PHENOTYPE; PRIORITY JOURNAL; SCREENING; SEROPREVALENCE; TUBERCULOSIS;

AMIKACIN; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CAPREOMYCIN; DNA GYRASE; DNA MUTATIONAL ANALYSIS; EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS; FLUOROQUINOLONES; INDIA; ISONIAZID; KANAMYCIN; MICROBIAL SENSITIVITY TESTS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; POINT MUTATION; POLYMERASE CHAIN REACTION; RIFAMPIN;

EID: 78049251333     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00661-10     Document Type: Article

References (23)

1. Balaji, V., P. Daley, A. A. Anand, T. Sudarsanam, J. S. Michael, R. D. Sahni, P. Chordia, I. A. George, et al. 2010. Risk factors for MDR and XDR-TB in a tertiary referral hospital in India. PLoS One 5:9527.
2. Bottger, E. C. 1994. Resistance to drug targeting protein synthesis in mycobactera. Trends Microbiol. 2:416-421. (Pubitemid 24320456)
3. Cole, S. T., R. Brosch, J. Parkhill, T. Garnier, C. Churcher, D. Harris, et al. 1998. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537-544. (Erratum, 396:190.)
4. Gandhi, N. R., A. Moll, A. W. Sturm, R. Pawinski, T. Govender, U. Lalloo, K. Zeller, J. Andrews, and G. Friedland. 2006. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet 368:1575-1580.
5. Hasnain, S. E., A. Amin, N. Siddiqi, M. Shamim, N. K. Jain, A. Rattan, V. M. Katoch, and S. K. Sharma. 1998. Molecular genetics of multiple drug resistance (MDR) in Mycobacterium tuberculosis, p. 35-40. In R. L. Singhal and O. P. Sood (ed.), Drug resistance: mechanism and management. Proceedings of the Fourth Annual Ranbaxy Science Foundation Symposium. Ranbaxy Science Foundation, New Delhi, India.
6. Jassal, M., and W. R. Bishai. 2009. Extensively drug-resistant tuberculosis. Lancet Infect. Dis. 9:19-30.
7. Kapur, V., L. L. Li, S. Iordanescu, M. C. Hamrick, A. Wanger, B. N. Kreiswirth, and J. M. Musser. 1994. Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymerase beta subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York City and Texas. J. Clin. Microbiol. 32:1095-1098.
8. Miller, L. P., J. T. Crawford, and T. M. Shinnick. 1994. The rpoB gene of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 38:805-811.
9. Mondal, R., and A. Jain. 2007. Extensively drug resistant Mycobacterium tuberculosis, India. Emerg. Infect. Dis. 13:1429-1431.
10. Morris, S., G. Han Bai, P. Suffys, L. P. Gomez, M. Fairchok, and D. Rouse. 1995. Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis. J. Infect. Dis. 171:954-960.
11. Musser, J. M. 1995. Antimicrobial agent resistance in mycobacteria: molecular genetic insights. Clin. Microbiol. Rev. 8:496-514.
12. NCCLS. 2000. Susceptibility testing of mycobacteria, nocardia, and other aerobic actinomycetes: tentative standard M24-T2, vol. 20, no. 26. NCCLS, Wayne, PA.
13. Ramaswamy, S., and J. M. Musser. 1998. Molecular genetic bases of anti-microbial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber. Lung Dis. 79:3-29.
14. Siddiqi, N., M. Shamim, N. K. Jain, A. Rattan, A. Amin, V. M. Katoch, S. K. Sharma, and S. E. Hasnain. 1998. Molecular genetic analysis of multidrug resistance in Indian isolates of Mycobacterium tuberculosis. Mem. Inst. Oswaldo Cruz 93:589-594.
15. Siddiqi, N., M. Shamim, S. Hussain, R. K. Choudhary, N. Ahmed, Prachee, S. Banerjee, G. R. Savithri, M. Alam, N. Pathak, A. Amin, M. Hanief, V. M. Katoch, S. K. Sharma, and S. E. Hasnain. 2002. Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India. Antimicrob. Agents Chemother. 46:443-450.
16. Sood, R., M. Rao, S. Singhal, and A. Rattan. 2005. Activity of RBx 7644 and RBx 8700, new investigational oxazolidinones, against Mycobacterium tuberculosis infected murine macrophages. Int. J. Antimicrob. Agents 25:464-468.
17. Sreevatsan, S., X. Pan, K. E. Stockbauer, N. Connell, B. N. Kreiswirth, T. S. Whittam, and J. M. Musser. 1997. Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionary recent global dissemination. Proc. Natl. Acad. Sci. U. S. A. 94:9869-9874.
18. Sun, Z., Y. Chao, X. Zhang, J. Zhang, Y. Li, Y. Qiu, Y. Liu, L. Nie, A. Guo, and C. Li. 2008. Characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates in China. J. Clin. Microbiol. 46:4075-4077.
19. Taniguchi, H., H. Aramaki, Y. Nikaido, Y. Mizuguchi, M. Nakamura, T. Koga, and S. Yoshida. 1996. Rifampicin resistance and mutations of the rpoB gene in Mycobacterium tuberculosis. FEMS Microbiol. Lett. 144:103-108.
20. Telenti, A., P. Imboden, F. Marchesi, D. Lowrie, S. T. Cole, M. J. Colston, L. Matter, K. Schopfer, and T. Bodmer. 1993. Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis. Lancet 341:647-650.
21. Tortoli, E., M. Benedetti, A. Fontanelli, and M. T. Simonetti. 2002. Evaluation of automated BACTEC MGIT 960 system for testing susceptibility of Mycobacterium tuberculosis to four major antituberculous drugs: comparison with the radiometric BACTEC 460TB method and the agar plate method of proportion. J. Clin. Microbiol. 40:607-610.
22. World Health Organization. 2008. Tuberculosis facts. World Health Organization, Geneva, Switzerland. www.who.int/tb.
23. Xu, C., B. N. Kreiswirth, S. Sreevatsan, J. M. Musser, and K. Drlica. 1996. Fluoroquinolone resistance associated with specific gyrase mutations in clinical isolates of multidrug-resistant Mycobacterium tuberculosis. J. Infect. Dis. 174:1127-1130. (Pubitemid 26357484)