2-(-2-benzofuranyl)-2-imidazoline induces Bcl-2 expression and provides neuroprotection against transient cerebral ischemia in rats

Brain Research

Volumn 1361, Issue , 2010, Pages 86-92

  Han, Zhao ^a   Zhang, Hong Xia ^a   Tian, Ji Sha ^a   Zheng, Rong Yuan ^a   Hou, Sheng T ^b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

2 BFI; Bcl 2; Brain; Cell death; Cerebral ischemia; Rat; Stroke

Indexed keywords

2 (2 BENZOFURANYL) 2 IMIDAZOLINE; IMIDAZOLINE DERIVATIVE; IMIDAZOLINE I2 RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; DRUG MEGADOSE; ELECTRON MICROSCOPE; GENE EXPRESSION; IN VIVO STUDY; LOW DRUG DOSE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRION; NEUROLOGIC DISEASE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; APOPTOSIS; BENZOFURANS; BRAIN; CELL DEATH; CONSCIOUSNESS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIDAZOLES; IMIDAZOLINE RECEPTORS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; MALE; MICROSCOPY, ELECTRON; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME; UP-REGULATION; WALKING;

RATTUS;

EID: 78049245408     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.09.029     Document Type: Article

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