-
1
-
-
33749021387
-
Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART
-
Hogg RS, Bangsberg DR, Lima VD, et al. Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART. PLoS Med. 2006;3:e356.
-
(2006)
PLoS Med
, vol.3
-
-
Hogg, R.S.1
Bangsberg, D.R.2
Lima, V.D.3
-
2
-
-
37349057446
-
The Incidence of HIV drug resistance and its impact on progression of HIV disease among antiretroviral-näve participants started on three different antiretroviral therapy strategies
-
and Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA)
-
Kozal MJ, Hullsiek KH, Macarthur RD, et al, and Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA). The Incidence of HIV drug resistance and its impact on progression of HIV disease among antiretroviral-näve participants started on three different antiretroviral therapy strategies. HIV Clin Trials. 2007;8:357-370.
-
(2007)
HIV Clin Trials
, vol.8
, pp. 357-370
-
-
Kozal, M.J.1
Hullsiek, K.H.2
MacArthur, R.D.3
-
3
-
-
21844462147
-
Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients
-
and Collaborative Group for Clinical Use of HIV Genotype Resistance Test (GRT) at National Institute for Infectious Diseases Lazzaro Spallanzani
-
Zaccarelli M, Tozzi V, Lorenzini P, et al, and Collaborative Group for Clinical Use of HIV Genotype Resistance Test (GRT) at National Institute for Infectious Diseases Lazzaro Spallanzani. Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients. AIDS. 2005;19:1081-1089.
-
(2005)
AIDS
, vol.19
, pp. 1081-1089
-
-
Zaccarelli, M.1
Tozzi, V.2
Lorenzini, P.3
-
4
-
-
34147170524
-
The V118I mutation as a marker of advanced HIV infection and disease progression
-
Zaccarelli M, Tozzi V, Lorenzini P, et al. The V118I mutation as a marker of advanced HIV infection and disease progression. Antivir Ther. 2007;12: 163-168.
-
(2007)
Antivir Ther
, vol.12
, pp. 163-168
-
-
Zaccarelli, M.1
Tozzi, V.2
Lorenzini, P.3
-
5
-
-
3843151487
-
SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir/ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients
-
Gathe JC Jr, Ive P, Wood R, et al. SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir/ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients. AIDS. 2004;18:1529-1537.
-
(2004)
AIDS
, vol.18
, pp. 1529-1537
-
-
Gathe Jr., J.C.1
Ive, P.2
Wood, R.3
-
6
-
-
0037182766
-
Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection
-
and M98-863 Study Team
-
Walmsley S, Bernstein B, King M, et al, and M98-863 Study Team. Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection. N Engl J Med. 2002;346:2039-2046.
-
(2002)
N Engl J Med
, vol.346
, pp. 2039-2046
-
-
Walmsley, S.1
Bernstein, B.2
King, M.3
-
7
-
-
53549114197
-
The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis
-
Gupta SK, Rosenkranz SL, Cramer YS, et al. The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis. AIDS. 2008;22:1919-1927.
-
(2008)
AIDS
, vol.22
, pp. 1919-1927
-
-
Gupta, S.K.1
Rosenkranz, S.L.2
Cramer, Y.S.3
-
8
-
-
70349682997
-
Development of HIV-1 drug resistance through 144 weeks in antire-troviral-näve subjects on emtricitabine, tenofovir disoproxil fumarate, and efavirenz compared with lamivudine/zidovudine and efavirenz in study GS-01-934
-
and Study 934 Team
-
Margot NA, Enejosa J, Cheng AK, et al, and Study 934 Team. Development of HIV-1 drug resistance through 144 weeks in antire-troviral-näve subjects on emtricitabine, tenofovir disoproxil fumarate, and efavirenz compared with lamivudine/zidovudine and efavirenz in study GS-01-934. J Acquir Immune Defic Syndr. 2009;52:209-221.
-
(2009)
J Acquir Immune Defic Syndr
, vol.52
, pp. 209-221
-
-
Margot, N.A.1
Enejosa, J.2
Cheng, A.K.3
-
9
-
-
48949097660
-
Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel; International AIDS Society-USA
-
Hammer SM, Eron JJ Jr, Reiss P, et al. Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel; International AIDS Society-USA. JAMA. 2008;300:555-570.
-
(2008)
JAMA
, vol.300
, pp. 555-570
-
-
Hammer, S.M.1
Eron Jr., J.J.2
Reiss, P.3
-
10
-
-
0027409698
-
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides
-
Schinazi RF, Lloyd RM Jr, Nguyen MH, et al. Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides. Antimicrob Agents Chemother. 1993;37:875-881.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 875-881
-
-
Schinazi, R.F.1
Lloyd Jr., R.M.2
Nguyen, M.H.3
-
11
-
-
0027285372
-
Rapid in-vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
-
Tisdale M, Kemp SD, Parry NR, et al. Rapid in-vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc Natl Acad Sci \USA. 1993;90:5653-5656.
-
(1993)
Proc Natl Acad Sci \USA
, vol.90
, pp. 5653-5656
-
-
Tisdale, M.1
Kemp, S.D.2
Parry, N.R.3
-
12
-
-
77949324191
-
Update of the drug resistance mutations in HIV-1: December 2009
-
Johnson VA, Brun-Vézinet F, Clotet B, et al. Update of the drug resistance mutations in HIV-1: December 2009. Top HIV Med. 2009;17:138-145.
-
(2009)
Top HIV Med
, vol.17
, pp. 138-145
-
-
Johnson, V.A.1
Brun-Vézinet, F.2
Clotet, B.3
-
13
-
-
0028841320
-
Genotypic and phenotypic characterization of HIV-1 isolated from patients receiving (-)-2',3'-dideoxy-3'-thiacytidine
-
Kavlick MF, Shirasaka T, Kojima E, et al. Genotypic and phenotypic characterization of HIV-1 isolated from patients receiving (-)-2',3'-dideoxy-3'- thiacytidine. Antiviral Res. 1995;28:133-146.
-
(1995)
Antiviral Res
, vol.28
, pp. 133-146
-
-
Kavlick, M.F.1
Shirasaka, T.2
Kojima, E.3
-
14
-
-
0029024089
-
Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC)
-
Schuurman R, Nijhuis M, van Leeuwen R, et al. Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC). J Infect Dis. 1995;171:1411-1419.
-
(1995)
J Infect Dis
, vol.171
, pp. 1411-1419
-
-
Schuurman, R.1
Nijhuis, M.2
Van Leeuwen, R.3
-
15
-
-
4143099182
-
Identification of the minimal conserved structure of HIV-1 protease in the presence and absence of drug pressure
-
Ceccherini-Silberstein F, Erba F, Gago F, et al. Identification of the minimal conserved structure of HIV-1 protease in the presence and absence of drug pressure. AIDS. 2004;18:F11-F19.
-
(2004)
AIDS
, vol.18
-
-
Ceccherini-Silberstein, F.1
Erba, F.2
Gago, F.3
-
16
-
-
0031918981
-
Marked inhibitory activity of masked aryloxy aminoacyl phosphoramidate derivatives of dideoxynucleo-side analogues against visna virus infection
-
Balzarini J, Cahard D, Wedgwood O, et al. Marked inhibitory activity of masked aryloxy aminoacyl phosphoramidate derivatives of dideoxynucleo-side analogues against visna virus infection. J AIDS. 1998;17:296-302.
-
(1998)
J AIDS
, vol.17
, pp. 296-302
-
-
Balzarini, J.1
Cahard, D.2
Wedgwood, O.3
-
17
-
-
22144494590
-
Optimization of a genotypic assay applicable to all human immunodeficiency virus type 1 protease and reverse transcriptase subtypes
-
Snoeck J, Riva C, Steegen K, et al. Optimization of a genotypic assay applicable to all human immunodeficiency virus type 1 protease and reverse transcriptase subtypes. J Virol Methods. 2005;128:47-53.
-
(2005)
J Virol Methods
, vol.128
, pp. 47-53
-
-
Snoeck, J.1
Riva, C.2
Steegen, K.3
-
18
-
-
34247110127
-
-
Available at: Accessed June 2009
-
HIV Drug Resistance Database. Available at: http://www.hivdbstanford. edu. Accessed June 2009.
-
HIV Drug Resistance Database.
-
-
-
19
-
-
77950424060
-
-
Available at: Accessed June
-
Protein Data Bank. Available at: http://www.rcsb.org/PDB. Accessed June 2009.
-
(2009)
Protein Data Bank
-
-
-
20
-
-
0032573488
-
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
-
Huang H, Chopra R, Verdine GL, et al. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science. 1998;282:1669-1675.
-
(1998)
Science
, vol.282
, pp. 1669-1675
-
-
Huang, H.1
Chopra, R.2
Verdine, G.L.3
-
21
-
-
0026620007
-
AMBER torsional parameters for the peptide backbone
-
McDonald DQ, Still WC. AMBER torsional parameters for the peptide backbone. Tetrahedron Lett. 1992;33:7743-7746.
-
(1992)
Tetrahedron Lett
, vol.33
, pp. 7743-7746
-
-
McDonald, D.Q.1
Still, W.C.2
-
22
-
-
0344778061
-
Semianalytical treatment of solvation for molecular mechanism and dynamics
-
Still WC, Tempczyk A, Hawley RC, et al. Semianalytical treatment of solvation for molecular mechanism and dynamics. J Am Chem Soc. 1990; 112:6127-6129.
-
(1990)
J Am Chem Soc
, vol.112
, pp. 6127-6129
-
-
Still, W.C.1
Tempczyk, A.2
Hawley, R.C.3
-
23
-
-
84986437005
-
MacroModel: An integrated software system for modeling organic and bioorganic molecules using molecular mechanics
-
Mohamadi F, Richards NGJ, Guida WC. MacroModel: an integrated software system for modeling organic and bioorganic molecules using molecular mechanics. J Comput Chem. 1990;11:440-467.
-
(1990)
J Comput Chem
, vol.11
, pp. 440-467
-
-
Mohamadi, F.1
Ngj, R.2
Guida, W.C.3
-
24
-
-
11644261806
-
Automated docking using a Lamarckian genetic algorithm and an empirical binding free-energy function
-
Morris GM, Goodsell DS, Halliday RS, et al. Automated docking using a Lamarckian genetic algorithm and an empirical binding free-energy function. J Comput Chem. 1998;19:1639-1662.
-
(1998)
J Comput Chem
, vol.19
, pp. 1639-1662
-
-
Morris, G.M.1
Goodsell, D.S.2
Halliday, R.S.3
-
26
-
-
0027534661
-
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: Potent and selective in-vitro and in vivo antiretrovirus activities of (R)-9-(2- phosphonomethoxypropyl)-2,6-diaminopurine
-
Balzarini J, Holy A, Jindrich J, et al. Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in-vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine. Antimicrob Agents Chemother. 1993;37:332-338.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 332-338
-
-
Balzarini, J.1
Holy, A.2
Jindrich, J.3
-
27
-
-
34249321931
-
Dependence of DNA sequence selectivity and cell cytotoxicity on azinomycin A and B epoxyamide stereochemistry
-
Coleman RS, Woodward RL, Hayes AM, et al. Dependence of DNA sequence selectivity and cell cytotoxicity on azinomycin A and B epoxyamide stereochemistry. Org Lett. 2007;9:1891-1894.
-
(2007)
Org Lett
, vol.9
, pp. 1891-1894
-
-
Coleman, R.S.1
Woodward, R.L.2
Hayes, A.M.3
-
28
-
-
78049253688
-
Emerging mutations at failure of HAART containing lamivudine/ tenofovir or emtricitabine/tenofovir: The ARV Resistance Cohort Analysis Database
-
and ARCA Study Group Presented at: February 8-11 Montreal Canada. Abstract 644
-
Maserati R, De Silvestri A, Uglietti A, et al, and ARCA Study Group. Emerging mutations at failure of HAART containing lamivudine/ tenofovir or emtricitabine/tenofovir: The ARV Resistance Cohort Analysis Database. Presented at: 16th Conference on Retroviruses and Opportunistic Infections. February 8-11, 2009; Montreal, Canada. Abstract 644.
-
(2009)
16th Conference on Retroviruses and Opportunistic Infections
-
-
Maserati, R.1
De Silvestri, A.2
Uglietti, A.3
-
29
-
-
29244431976
-
Emtricitabine, a new antiretroviral agent with activity against HIV and hepatitis B virus
-
Saag MS. Emtricitabine, a new antiretroviral agent with activity against HIV and hepatitis B virus. Clin Infect Dis. 2006;42:126-131.
-
(2006)
Clin Infect Dis
, vol.42
, pp. 126-131
-
-
Saag, M.S.1
-
30
-
-
0032829089
-
Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP
-
Feng JY, Shi J, Schinazi RF, et al. Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP. F A S E B J. 1999;13:1511-1517.
-
(1999)
F A S e B J
, vol.13
, pp. 1511-1517
-
-
Feng, J.Y.1
Shi, J.2
Schinazi, R.F.3
-
31
-
-
0026740310
-
Cellular metabolism of (-) enantiomeric 2'-deoxy-3'-thiacytidine
-
Cammack N, Rouse P, Marr CL, et al. Cellular metabolism of (-) enantiomeric 2'-deoxy-3'-thiacytidine. Biochem Pharmacol. 1992;43:2059-2064.
-
(1992)
Biochem Pharmacol
, vol.43
, pp. 2059-2064
-
-
Cammack, N.1
Rouse, P.2
Marr, C.L.3
-
32
-
-
3142717936
-
Pharmacokinetic and pharmacodynamic characteristics of emtricitabine support its once daily dosing for the treatment of HIV infection
-
Wang LH, Begley J, St. Claire RL III, et al. Pharmacokinetic and pharmacodynamic characteristics of emtricitabine support its once daily dosing for the treatment of HIV infection. AIDS Res Hum Retroviruses. 2004;20:1173-1182.
-
(2004)
AIDS Res Hum Retroviruses
, vol.20
, pp. 1173-1182
-
-
Wang, L.H.1
Begley, J.2
Iii Rl S.Claire3
-
33
-
-
54049129967
-
Emtricitabine: Inhibitor and substrate of multidrug resistance associated protein
-
Bousquet L, Pruvost A, Didier N, et al. Emtricitabine: inhibitor and substrate of multidrug resistance associated protein. Eur J Pharm Sci. 2008;35:247-256.
-
(2008)
Eur J Pharm Sci
, vol.35
, pp. 247-256
-
-
Bousquet, L.1
Pruvost, A.2
Didier, N.3
-
34
-
-
1642543083
-
Human immunodeficiency virus type 1 reverse transcriptase mutation selection during in vitro exposure to tenofovir alone or combined with abacavir or lamivudine
-
Stone C, Ait-Khaled M, Craig C, et al. Human immunodeficiency virus type 1 reverse transcriptase mutation selection during in vitro exposure to tenofovir alone or combined with abacavir or lamivudine. Antimicrob Agents Chemother. 2004;48:1413-1415.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 1413-1415
-
-
Stone, C.1
Ait-Khaled, M.2
Craig, C.3
-
35
-
-
0037225839
-
Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine
-
Murry JP, Higgins J, Matthews TB, et al. Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine. J Virol. 2003;77:1120-1130.
-
(2003)
J Virol
, vol.77
, pp. 1120-1130
-
-
Murry, J.P.1
Higgins, J.2
Matthews, T.B.3
-
36
-
-
20644436472
-
In vitro selection and characterization of HIV-1 with reduced susceptibility to PMPA
-
Wainberg MA, Miller MD, Quan Y, et al. In vitro selection and characterization of HIV-1 with reduced susceptibility to PMPA. Antiviral Ther. 1999;4:87-94.
-
(1999)
Antiviral Ther
, vol.4
, pp. 87-94
-
-
Wainberg, M.A.1
Miller, M.D.2
Quan, Y.3
-
37
-
-
33744753057
-
In-vitro evaluation of the anti-HIV activity and metabolic interactions of tenofovir and emtricitabine
-
Borroto-Esoda K, Vela JE, Myrick F, et al. In-vitro evaluation of the anti-HIV activity and metabolic interactions of tenofovir and emtricitabine. Antivir Ther. 2006;11:377-384.
-
(2006)
Antivir Ther
, vol.11
, pp. 377-384
-
-
Borroto-Esoda, K.1
Vela, J.E.2
Myrick, F.3
-
38
-
-
67649553022
-
The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in-vitro: A mechanism of action study
-
Feng JY, Ly JK, Myrick F, et al. The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in-vitro: a mechanism of action study. Retrovirology. 2009;6:44.
-
(2009)
Retrovirology
, vol.6
, pp. 44
-
-
Feng, J.Y.1
Ly, J.K.2
Myrick, F.3
-
39
-
-
0035000024
-
Augmentation of human immunodeficiency virus type 1 subtype e (CRF01-AE) multiple-drug resistance by insertion of a foreign 11-amino-acid fragment into the reverse transcriptase
-
Sato H, Tomita Y, Ebisawa K, et al. Augmentation of human immunodeficiency virus type 1 subtype E (CRF01-AE) multiple-drug resistance by insertion of a foreign 11-amino-acid fragment into the reverse transcriptase. J Virol. 2001;75:5604-5613.
-
(2001)
J Virol
, vol.75
, pp. 5604-5613
-
-
Sato, H.1
Tomita, Y.2
Ebisawa, K.3
-
40
-
-
59649120492
-
Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1
-
Emerging Mutations at Failure of HAART Containing Lamivudine/ Tenofovir or Emtricitabine/Tenofovir: The ARV Resistance Cohort Analysis Database
-
Emerging Mutations at Failure of HAART Containing Lamivudine/ Tenofovir or Emtricitabine/Tenofovir: The ARV Resistance Cohort Analysis Database. Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1. J Virol. 2009;83:2029-2033.
-
(2009)
J Virol
, vol.83
, pp. 2029-2033
-
-
|