메뉴 건너뛰기




Volumn 55, Issue 3, 2010, Pages 336-344

Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens

Author keywords

docking analysis; drug resistance; emtricitabine; HIV 1; in vitro selection experiment; lamivudine; RT; structural analysis; tenofovir

Indexed keywords

EMTRICITABINE; LAMIVUDINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TENOFOVIR; ADENINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DEOXYCYTIDINE; PHOSPHONIC ACID DERIVATIVE; POL PROTEIN; VIRUS RNA;

EID: 78049236987     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181e6763f     Document Type: Article
Times cited : (30)

References (40)
  • 1
    • 33749021387 scopus 로고    scopus 로고
    • Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART
    • Hogg RS, Bangsberg DR, Lima VD, et al. Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART. PLoS Med. 2006;3:e356.
    • (2006) PLoS Med , vol.3
    • Hogg, R.S.1    Bangsberg, D.R.2    Lima, V.D.3
  • 2
    • 37349057446 scopus 로고    scopus 로고
    • The Incidence of HIV drug resistance and its impact on progression of HIV disease among antiretroviral-näve participants started on three different antiretroviral therapy strategies
    • and Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA)
    • Kozal MJ, Hullsiek KH, Macarthur RD, et al, and Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA). The Incidence of HIV drug resistance and its impact on progression of HIV disease among antiretroviral-näve participants started on three different antiretroviral therapy strategies. HIV Clin Trials. 2007;8:357-370.
    • (2007) HIV Clin Trials , vol.8 , pp. 357-370
    • Kozal, M.J.1    Hullsiek, K.H.2    MacArthur, R.D.3
  • 3
    • 21844462147 scopus 로고    scopus 로고
    • Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients
    • and Collaborative Group for Clinical Use of HIV Genotype Resistance Test (GRT) at National Institute for Infectious Diseases Lazzaro Spallanzani
    • Zaccarelli M, Tozzi V, Lorenzini P, et al, and Collaborative Group for Clinical Use of HIV Genotype Resistance Test (GRT) at National Institute for Infectious Diseases Lazzaro Spallanzani. Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients. AIDS. 2005;19:1081-1089.
    • (2005) AIDS , vol.19 , pp. 1081-1089
    • Zaccarelli, M.1    Tozzi, V.2    Lorenzini, P.3
  • 4
    • 34147170524 scopus 로고    scopus 로고
    • The V118I mutation as a marker of advanced HIV infection and disease progression
    • Zaccarelli M, Tozzi V, Lorenzini P, et al. The V118I mutation as a marker of advanced HIV infection and disease progression. Antivir Ther. 2007;12: 163-168.
    • (2007) Antivir Ther , vol.12 , pp. 163-168
    • Zaccarelli, M.1    Tozzi, V.2    Lorenzini, P.3
  • 5
    • 3843151487 scopus 로고    scopus 로고
    • SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir/ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients
    • Gathe JC Jr, Ive P, Wood R, et al. SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir/ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients. AIDS. 2004;18:1529-1537.
    • (2004) AIDS , vol.18 , pp. 1529-1537
    • Gathe Jr., J.C.1    Ive, P.2    Wood, R.3
  • 6
    • 0037182766 scopus 로고    scopus 로고
    • Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection
    • and M98-863 Study Team
    • Walmsley S, Bernstein B, King M, et al, and M98-863 Study Team. Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection. N Engl J Med. 2002;346:2039-2046.
    • (2002) N Engl J Med , vol.346 , pp. 2039-2046
    • Walmsley, S.1    Bernstein, B.2    King, M.3
  • 7
    • 53549114197 scopus 로고    scopus 로고
    • The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis
    • Gupta SK, Rosenkranz SL, Cramer YS, et al. The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis. AIDS. 2008;22:1919-1927.
    • (2008) AIDS , vol.22 , pp. 1919-1927
    • Gupta, S.K.1    Rosenkranz, S.L.2    Cramer, Y.S.3
  • 8
    • 70349682997 scopus 로고    scopus 로고
    • Development of HIV-1 drug resistance through 144 weeks in antire-troviral-näve subjects on emtricitabine, tenofovir disoproxil fumarate, and efavirenz compared with lamivudine/zidovudine and efavirenz in study GS-01-934
    • and Study 934 Team
    • Margot NA, Enejosa J, Cheng AK, et al, and Study 934 Team. Development of HIV-1 drug resistance through 144 weeks in antire-troviral-näve subjects on emtricitabine, tenofovir disoproxil fumarate, and efavirenz compared with lamivudine/zidovudine and efavirenz in study GS-01-934. J Acquir Immune Defic Syndr. 2009;52:209-221.
    • (2009) J Acquir Immune Defic Syndr , vol.52 , pp. 209-221
    • Margot, N.A.1    Enejosa, J.2    Cheng, A.K.3
  • 9
    • 48949097660 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel; International AIDS Society-USA
    • Hammer SM, Eron JJ Jr, Reiss P, et al. Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel; International AIDS Society-USA. JAMA. 2008;300:555-570.
    • (2008) JAMA , vol.300 , pp. 555-570
    • Hammer, S.M.1    Eron Jr., J.J.2    Reiss, P.3
  • 10
    • 0027409698 scopus 로고
    • Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides
    • Schinazi RF, Lloyd RM Jr, Nguyen MH, et al. Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides. Antimicrob Agents Chemother. 1993;37:875-881.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 875-881
    • Schinazi, R.F.1    Lloyd Jr., R.M.2    Nguyen, M.H.3
  • 11
    • 0027285372 scopus 로고
    • Rapid in-vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
    • Tisdale M, Kemp SD, Parry NR, et al. Rapid in-vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc Natl Acad Sci \USA. 1993;90:5653-5656.
    • (1993) Proc Natl Acad Sci \USA , vol.90 , pp. 5653-5656
    • Tisdale, M.1    Kemp, S.D.2    Parry, N.R.3
  • 12
    • 77949324191 scopus 로고    scopus 로고
    • Update of the drug resistance mutations in HIV-1: December 2009
    • Johnson VA, Brun-Vézinet F, Clotet B, et al. Update of the drug resistance mutations in HIV-1: December 2009. Top HIV Med. 2009;17:138-145.
    • (2009) Top HIV Med , vol.17 , pp. 138-145
    • Johnson, V.A.1    Brun-Vézinet, F.2    Clotet, B.3
  • 13
    • 0028841320 scopus 로고
    • Genotypic and phenotypic characterization of HIV-1 isolated from patients receiving (-)-2',3'-dideoxy-3'-thiacytidine
    • Kavlick MF, Shirasaka T, Kojima E, et al. Genotypic and phenotypic characterization of HIV-1 isolated from patients receiving (-)-2',3'-dideoxy-3'- thiacytidine. Antiviral Res. 1995;28:133-146.
    • (1995) Antiviral Res , vol.28 , pp. 133-146
    • Kavlick, M.F.1    Shirasaka, T.2    Kojima, E.3
  • 14
    • 0029024089 scopus 로고
    • Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC)
    • Schuurman R, Nijhuis M, van Leeuwen R, et al. Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC). J Infect Dis. 1995;171:1411-1419.
    • (1995) J Infect Dis , vol.171 , pp. 1411-1419
    • Schuurman, R.1    Nijhuis, M.2    Van Leeuwen, R.3
  • 15
    • 4143099182 scopus 로고    scopus 로고
    • Identification of the minimal conserved structure of HIV-1 protease in the presence and absence of drug pressure
    • Ceccherini-Silberstein F, Erba F, Gago F, et al. Identification of the minimal conserved structure of HIV-1 protease in the presence and absence of drug pressure. AIDS. 2004;18:F11-F19.
    • (2004) AIDS , vol.18
    • Ceccherini-Silberstein, F.1    Erba, F.2    Gago, F.3
  • 16
    • 0031918981 scopus 로고    scopus 로고
    • Marked inhibitory activity of masked aryloxy aminoacyl phosphoramidate derivatives of dideoxynucleo-side analogues against visna virus infection
    • Balzarini J, Cahard D, Wedgwood O, et al. Marked inhibitory activity of masked aryloxy aminoacyl phosphoramidate derivatives of dideoxynucleo-side analogues against visna virus infection. J AIDS. 1998;17:296-302.
    • (1998) J AIDS , vol.17 , pp. 296-302
    • Balzarini, J.1    Cahard, D.2    Wedgwood, O.3
  • 17
    • 22144494590 scopus 로고    scopus 로고
    • Optimization of a genotypic assay applicable to all human immunodeficiency virus type 1 protease and reverse transcriptase subtypes
    • Snoeck J, Riva C, Steegen K, et al. Optimization of a genotypic assay applicable to all human immunodeficiency virus type 1 protease and reverse transcriptase subtypes. J Virol Methods. 2005;128:47-53.
    • (2005) J Virol Methods , vol.128 , pp. 47-53
    • Snoeck, J.1    Riva, C.2    Steegen, K.3
  • 18
    • 34247110127 scopus 로고    scopus 로고
    • Available at: Accessed June 2009
    • HIV Drug Resistance Database. Available at: http://www.hivdbstanford. edu. Accessed June 2009.
    • HIV Drug Resistance Database.
  • 19
    • 77950424060 scopus 로고    scopus 로고
    • Available at: Accessed June
    • Protein Data Bank. Available at: http://www.rcsb.org/PDB. Accessed June 2009.
    • (2009) Protein Data Bank
  • 20
    • 0032573488 scopus 로고    scopus 로고
    • Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
    • Huang H, Chopra R, Verdine GL, et al. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science. 1998;282:1669-1675.
    • (1998) Science , vol.282 , pp. 1669-1675
    • Huang, H.1    Chopra, R.2    Verdine, G.L.3
  • 21
    • 0026620007 scopus 로고
    • AMBER torsional parameters for the peptide backbone
    • McDonald DQ, Still WC. AMBER torsional parameters for the peptide backbone. Tetrahedron Lett. 1992;33:7743-7746.
    • (1992) Tetrahedron Lett , vol.33 , pp. 7743-7746
    • McDonald, D.Q.1    Still, W.C.2
  • 22
    • 0344778061 scopus 로고
    • Semianalytical treatment of solvation for molecular mechanism and dynamics
    • Still WC, Tempczyk A, Hawley RC, et al. Semianalytical treatment of solvation for molecular mechanism and dynamics. J Am Chem Soc. 1990; 112:6127-6129.
    • (1990) J Am Chem Soc , vol.112 , pp. 6127-6129
    • Still, W.C.1    Tempczyk, A.2    Hawley, R.C.3
  • 23
    • 84986437005 scopus 로고
    • MacroModel: An integrated software system for modeling organic and bioorganic molecules using molecular mechanics
    • Mohamadi F, Richards NGJ, Guida WC. MacroModel: an integrated software system for modeling organic and bioorganic molecules using molecular mechanics. J Comput Chem. 1990;11:440-467.
    • (1990) J Comput Chem , vol.11 , pp. 440-467
    • Mohamadi, F.1    Ngj, R.2    Guida, W.C.3
  • 24
    • 11644261806 scopus 로고    scopus 로고
    • Automated docking using a Lamarckian genetic algorithm and an empirical binding free-energy function
    • Morris GM, Goodsell DS, Halliday RS, et al. Automated docking using a Lamarckian genetic algorithm and an empirical binding free-energy function. J Comput Chem. 1998;19:1639-1662.
    • (1998) J Comput Chem , vol.19 , pp. 1639-1662
    • Morris, G.M.1    Goodsell, D.S.2    Halliday, R.S.3
  • 25
  • 26
    • 0027534661 scopus 로고
    • Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: Potent and selective in-vitro and in vivo antiretrovirus activities of (R)-9-(2- phosphonomethoxypropyl)-2,6-diaminopurine
    • Balzarini J, Holy A, Jindrich J, et al. Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in-vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine. Antimicrob Agents Chemother. 1993;37:332-338.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 332-338
    • Balzarini, J.1    Holy, A.2    Jindrich, J.3
  • 27
    • 34249321931 scopus 로고    scopus 로고
    • Dependence of DNA sequence selectivity and cell cytotoxicity on azinomycin A and B epoxyamide stereochemistry
    • Coleman RS, Woodward RL, Hayes AM, et al. Dependence of DNA sequence selectivity and cell cytotoxicity on azinomycin A and B epoxyamide stereochemistry. Org Lett. 2007;9:1891-1894.
    • (2007) Org Lett , vol.9 , pp. 1891-1894
    • Coleman, R.S.1    Woodward, R.L.2    Hayes, A.M.3
  • 28
    • 78049253688 scopus 로고    scopus 로고
    • Emerging mutations at failure of HAART containing lamivudine/ tenofovir or emtricitabine/tenofovir: The ARV Resistance Cohort Analysis Database
    • and ARCA Study Group Presented at: February 8-11 Montreal Canada. Abstract 644
    • Maserati R, De Silvestri A, Uglietti A, et al, and ARCA Study Group. Emerging mutations at failure of HAART containing lamivudine/ tenofovir or emtricitabine/tenofovir: The ARV Resistance Cohort Analysis Database. Presented at: 16th Conference on Retroviruses and Opportunistic Infections. February 8-11, 2009; Montreal, Canada. Abstract 644.
    • (2009) 16th Conference on Retroviruses and Opportunistic Infections
    • Maserati, R.1    De Silvestri, A.2    Uglietti, A.3
  • 29
    • 29244431976 scopus 로고    scopus 로고
    • Emtricitabine, a new antiretroviral agent with activity against HIV and hepatitis B virus
    • Saag MS. Emtricitabine, a new antiretroviral agent with activity against HIV and hepatitis B virus. Clin Infect Dis. 2006;42:126-131.
    • (2006) Clin Infect Dis , vol.42 , pp. 126-131
    • Saag, M.S.1
  • 30
    • 0032829089 scopus 로고    scopus 로고
    • Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP
    • Feng JY, Shi J, Schinazi RF, et al. Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP. F A S E B J. 1999;13:1511-1517.
    • (1999) F A S e B J , vol.13 , pp. 1511-1517
    • Feng, J.Y.1    Shi, J.2    Schinazi, R.F.3
  • 31
    • 0026740310 scopus 로고
    • Cellular metabolism of (-) enantiomeric 2'-deoxy-3'-thiacytidine
    • Cammack N, Rouse P, Marr CL, et al. Cellular metabolism of (-) enantiomeric 2'-deoxy-3'-thiacytidine. Biochem Pharmacol. 1992;43:2059-2064.
    • (1992) Biochem Pharmacol , vol.43 , pp. 2059-2064
    • Cammack, N.1    Rouse, P.2    Marr, C.L.3
  • 32
    • 3142717936 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic characteristics of emtricitabine support its once daily dosing for the treatment of HIV infection
    • Wang LH, Begley J, St. Claire RL III, et al. Pharmacokinetic and pharmacodynamic characteristics of emtricitabine support its once daily dosing for the treatment of HIV infection. AIDS Res Hum Retroviruses. 2004;20:1173-1182.
    • (2004) AIDS Res Hum Retroviruses , vol.20 , pp. 1173-1182
    • Wang, L.H.1    Begley, J.2    Iii Rl S.Claire3
  • 33
    • 54049129967 scopus 로고    scopus 로고
    • Emtricitabine: Inhibitor and substrate of multidrug resistance associated protein
    • Bousquet L, Pruvost A, Didier N, et al. Emtricitabine: inhibitor and substrate of multidrug resistance associated protein. Eur J Pharm Sci. 2008;35:247-256.
    • (2008) Eur J Pharm Sci , vol.35 , pp. 247-256
    • Bousquet, L.1    Pruvost, A.2    Didier, N.3
  • 34
    • 1642543083 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 reverse transcriptase mutation selection during in vitro exposure to tenofovir alone or combined with abacavir or lamivudine
    • Stone C, Ait-Khaled M, Craig C, et al. Human immunodeficiency virus type 1 reverse transcriptase mutation selection during in vitro exposure to tenofovir alone or combined with abacavir or lamivudine. Antimicrob Agents Chemother. 2004;48:1413-1415.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 1413-1415
    • Stone, C.1    Ait-Khaled, M.2    Craig, C.3
  • 35
    • 0037225839 scopus 로고    scopus 로고
    • Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine
    • Murry JP, Higgins J, Matthews TB, et al. Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine. J Virol. 2003;77:1120-1130.
    • (2003) J Virol , vol.77 , pp. 1120-1130
    • Murry, J.P.1    Higgins, J.2    Matthews, T.B.3
  • 36
    • 20644436472 scopus 로고    scopus 로고
    • In vitro selection and characterization of HIV-1 with reduced susceptibility to PMPA
    • Wainberg MA, Miller MD, Quan Y, et al. In vitro selection and characterization of HIV-1 with reduced susceptibility to PMPA. Antiviral Ther. 1999;4:87-94.
    • (1999) Antiviral Ther , vol.4 , pp. 87-94
    • Wainberg, M.A.1    Miller, M.D.2    Quan, Y.3
  • 37
    • 33744753057 scopus 로고    scopus 로고
    • In-vitro evaluation of the anti-HIV activity and metabolic interactions of tenofovir and emtricitabine
    • Borroto-Esoda K, Vela JE, Myrick F, et al. In-vitro evaluation of the anti-HIV activity and metabolic interactions of tenofovir and emtricitabine. Antivir Ther. 2006;11:377-384.
    • (2006) Antivir Ther , vol.11 , pp. 377-384
    • Borroto-Esoda, K.1    Vela, J.E.2    Myrick, F.3
  • 38
    • 67649553022 scopus 로고    scopus 로고
    • The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in-vitro: A mechanism of action study
    • Feng JY, Ly JK, Myrick F, et al. The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in-vitro: a mechanism of action study. Retrovirology. 2009;6:44.
    • (2009) Retrovirology , vol.6 , pp. 44
    • Feng, J.Y.1    Ly, J.K.2    Myrick, F.3
  • 39
    • 0035000024 scopus 로고    scopus 로고
    • Augmentation of human immunodeficiency virus type 1 subtype e (CRF01-AE) multiple-drug resistance by insertion of a foreign 11-amino-acid fragment into the reverse transcriptase
    • Sato H, Tomita Y, Ebisawa K, et al. Augmentation of human immunodeficiency virus type 1 subtype E (CRF01-AE) multiple-drug resistance by insertion of a foreign 11-amino-acid fragment into the reverse transcriptase. J Virol. 2001;75:5604-5613.
    • (2001) J Virol , vol.75 , pp. 5604-5613
    • Sato, H.1    Tomita, Y.2    Ebisawa, K.3
  • 40
    • 59649120492 scopus 로고    scopus 로고
    • Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1
    • Emerging Mutations at Failure of HAART Containing Lamivudine/ Tenofovir or Emtricitabine/Tenofovir: The ARV Resistance Cohort Analysis Database
    • Emerging Mutations at Failure of HAART Containing Lamivudine/ Tenofovir or Emtricitabine/Tenofovir: The ARV Resistance Cohort Analysis Database. Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1. J Virol. 2009;83:2029-2033.
    • (2009) J Virol , vol.83 , pp. 2029-2033


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.