-
1
-
-
0026480950
-
Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
-
Schinazi RF, McMillan A, Cannon D, et al. Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2- (hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine. Antimicrob Agents Chemother 1992; 36:2423-31.
-
(1992)
Antimicrob Agents Chemother
, vol.36
, pp. 2423-2431
-
-
Schinazi, R.F.1
McMillan, A.2
Cannon, D.3
-
2
-
-
0026469165
-
The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1, 3-oxathiolan-5-yl]cytosine
-
Furman PA, Davis M, Liotta DC, et al. The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1, 3-oxathiolan-5-yl]cytosine. Antimicrob Agents Chemother 1992; 36:2686-92.
-
(1992)
Antimicrob Agents Chemother
, vol.36
, pp. 2686-2692
-
-
Furman, P.A.1
Davis, M.2
Liotta, D.C.3
-
3
-
-
0028877076
-
The role of absolute configuration in the anti-HIV and anti-HBV activity of nucleoside analogs
-
Furman PA, Reardon JE, Painter GR. The role of absolute configuration in the anti-HIV and anti-HBV activity of nucleoside analogs. Antivir Chem Chemother 1995; 6:345-55.
-
(1995)
Antivir Chem Chemother
, vol.6
, pp. 345-355
-
-
Furman, P.A.1
Reardon, J.E.2
Painter, G.R.3
-
4
-
-
0028260316
-
Intracellular metabolism of (-) and (+)-cis-5-fluoro-1-[2-(hydroxymethyl) -1,3-oxathiolan-5-yl]cytosine in HepG2 derivative 2.2.15(subclone P5A)cells
-
Paff MT, Averett Dr, Prus KL, Miller WH, Nelson DJ. Intracellular metabolism of (-) and (+)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine in HepG2 derivative 2.2.15(subclone P5A)cells. Antimicrob Agents Chemother 1994; 38:1230-8.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 1230-1238
-
-
Paff, M.T.1
Averett, Dr.2
Prus, K.L.3
Miller, W.H.4
Nelson, D.J.5
-
5
-
-
0027171391
-
The 5′-triphosphates of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl] cytosine equally inhibit human immunodeficiency virus type 1 reverse transcriptase
-
Wilson JE, Martin JL, Borroto-Esoda K, Hopkins S, Painter G, Liotta DC and Furman PA. The 5′-triphosphates of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl] cytosine equally inhibit human immunodeficiency virus type 1 reverse transcriptase. Antimicrobic Agents Chemother 1993; 37:1720-2.
-
(1993)
Antimicrobic Agents Chemother
, vol.37
, pp. 1720-1722
-
-
Wilson, J.E.1
Martin, J.L.2
Borroto-Esoda, K.3
Hopkins, S.4
Painter, G.5
Liotta, D.C.6
Furman, P.A.7
-
6
-
-
0029920290
-
Human immunodeficiency virus type-1 reverse transcriptase contribution of Met-184 to binding of nucleoside 5′-triphosphate
-
Wilson JE, Aulabaugh A, Caligan B, McPherson S, Wakefield JK, Jablonski S, Morrow, CD, Reardon JE, and Furman PA. Human immunodeficiency virus type-1 reverse transcriptase contribution of Met-184 to binding of nucleoside 5′-triphosphate. J Biol Chem 1996; 271: 13656-62.
-
(1996)
J Biol Chem
, vol.271
, pp. 13656-13662
-
-
Wilson, J.E.1
Aulabaugh, A.2
Caligan, B.3
McPherson, S.4
Wakefield, J.K.5
Jablonski, S.6
Morrow, C.D.7
Reardon, J.E.8
Furman, P.A.9
-
7
-
-
0035174783
-
Phosphorylation of nucleoside analog antiretrovirals: A review for clinicians
-
Stein DS, Moore K. Phosphorylation of nucleoside analog antiretrovirals: a review for clinicians. Pharmacotherapy 2001; 21:11-34.
-
(2001)
Pharmacotherapy
, vol.21
, pp. 11-34
-
-
Stein, D.S.1
Moore, K.2
-
8
-
-
0026480950
-
Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl] cytosine
-
Schinazi RF, McMillan A, Cannon D, et al. Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2- (hydroxymethyl)-1,3-oxathiolane-5-yl] cytosine. Antimicrob Agents Chemother 1992; 36:2423-31.
-
(1992)
Antimicrob Agents Chemother
, vol.36
, pp. 2423-2431
-
-
Schinazi, R.F.1
McMillan, A.2
Cannon, D.3
-
9
-
-
0027285372
-
Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′ thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
-
Tisdale M, Kemp SD, Parry NR, Larder BA. Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′ thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc Natl Acad Sci 1993; 90:5653-6.
-
(1993)
Proc Natl Acad Sci
, vol.90
, pp. 5653-5656
-
-
Tisdale, M.1
Kemp, S.D.2
Parry, N.R.3
Larder, B.A.4
-
10
-
-
0027409698
-
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides
-
Schinazi RF, Lloyd RM, Nguyen M-H, et al. Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides. Antimicrob Agents Chemother 1993; 37:875-81.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 875-881
-
-
Schinazi, R.F.1
Lloyd, R.M.2
Nguyen, M.-H.3
-
11
-
-
0027379732
-
Infectious amplification of wild-type human immunodeficiency virus from patients' lymphocytes and modulation by reverse transcriptase inhibitors in vitro
-
Mathez D, Schinazi RF, Liotta DC, Leibowitch J. Infectious amplification of wild-type human immunodeficiency virus from patients' lymphocytes and modulation by reverse transcriptase inhibitors in vitro. Antimicrob Agents Chemother 1993; 37:2206-11.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 2206-2211
-
-
Mathez, D.1
Schinazi, R.F.2
Liotta, D.C.3
Leibowitch, J.4
-
12
-
-
0029965190
-
Favorable interaction of β-L(-) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus
-
Bridges EG, Dutschman GE, Gullen EA, Cheng Y-C. Favorable interaction of β-L(-) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus. Biochem Pharmacol 1996; 51:731-6.
-
(1996)
Biochem Pharmacol
, vol.51
, pp. 731-736
-
-
Bridges, E.G.1
Dutschman, G.E.2
Gullen, E.A.3
Cheng, Y.-C.4
-
13
-
-
0032829089
-
Mechanistic studies show that (-)-emtricitabine-TP is a better inhibitor of HIV-1 reverse transcriptase than 1a-mivudine-TP
-
Feng JY, Anderson KS. Mechanistic studies show that (-)-emtricitabine-TP is a better inhibitor of HIV-1 reverse transcriptase than 1a-mivudine-TP. FASEB Journal 1999; 13:1511-7.
-
(1999)
FASEB Journal
, vol.13
, pp. 1511-1517
-
-
Feng, J.Y.1
Anderson, K.S.2
-
14
-
-
0027514088
-
High-capacity in vitro assessment of antihepatitis B virus compound selectivity by a virion-specific polymerase chain reaction assay
-
Jansen RW, Johnson LC, Averett DR. High-capacity in vitro assessment of antihepatitis B virus compound selectivity by a virion-specific polymerase chain reaction assay. Antimicrob Agents Chemother 1993; 37: 441-7.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 441-447
-
-
Jansen, R.W.1
Johnson, L.C.2
Averett, D.R.3
-
15
-
-
0027981440
-
Pure nucleoside enantiomers of B-2′3′-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro
-
Schinazi RF, Gosselin G, Abdesslem F, et al. Pure nucleoside enantiomers of B-2′3′-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro. Antimicrob Agents Chemother 1994; 38:2172-4.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 2172-2174
-
-
Schinazi, R.F.1
Gosselin, G.2
Abdesslem, F.3
-
17
-
-
0345290976
-
High levels of intracellular emtricitabine-triphosphate correlate with the potent antiviral activity of emtricitabine in vivo
-
Wang LH, Delehanty J, Hulett L, McCreedy B, Sommadossi JP, Rousseau F. High levels of intracellular emtricitabine-triphosphate correlate with the potent antiviral activity of emtricitabine in vivo [abstract LB-2.]. In: Program and abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy (San Diego). 1998.
-
(1998)
Program and Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy (San Diego)
-
-
Wang, L.H.1
Delehanty, J.2
Hulett, L.3
McCreedy, B.4
Sommadossi, J.P.5
Rousseau, F.6
-
18
-
-
0026740310
-
Cellular metabolism (-) enantiomeric 2′-deoxy-3′-thiacytidine
-
Cammack N, Rouse P, Marr CL, et al. Cellular metabolism (-) enantiomeric 2′-deoxy-3′-thiacytidine. Biochem Parmacol 1992; 43:2059.
-
(1992)
Biochem Parmacol
, vol.43
, pp. 2059
-
-
Cammack, N.1
Rouse, P.2
Marr, C.L.3
-
19
-
-
0028077465
-
Pharmacokinetics, oral bioavailability, and metabolism in mice and cynomolgus monkeys of (2′r,5′s)-cis-5-fluoro-1-[2-(hydroxymethyl)-1, 3-oxathiolan-5-yl]cytosine and agent active against human immunodeficiency virus and human hepatitis b virus
-
Frick LW, Lambe CU, St John L, Taylor LC, Nelson DJ. Pharmacokinetics, oral bioavailability, and metabolism in mice and cynomolgus monkeys of (2′r,5′s)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine and agent active against human immunodeficiency virus and human hepatitis b virus. Antimicrob Agents Chemother 1994; 38:2722-9.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 2722-2729
-
-
Frick, L.W.1
Lambe, C.U.2
St. John, L.3
Taylor, L.C.4
Nelson, D.J.5
-
20
-
-
0024381627
-
Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with anti-human immunodeficiency compound 2′, 3′- dideoxycytidine
-
Chen CH, Cheng YC. Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with anti-human immunodeficiency compound 2′, 3′-dideoxycytidine. J Biol Chem 1989; 264:11934-7.
-
(1989)
J Biol Chem
, vol.264
, pp. 11934-11937
-
-
Chen, C.H.1
Cheng, Y.C.2
-
21
-
-
0025274663
-
Mitochondrial myopathy by long-term zidovudine therapy
-
Dalakas MC, Illa I, Pezeshkpour GH, Laukaitis JP, Cohen B, Griffin JL. Mitochondrial myopathy by long-term zidovudine therapy. New Engl J Med 1990; 332:1098-105.
-
(1990)
New Engl J Med
, vol.332
, pp. 1098-1105
-
-
Dalakas, M.C.1
Illa, I.2
Pezeshkpour, G.H.3
Laukaitis, J.P.4
Cohen, B.5
Griffin, J.L.6
-
22
-
-
0034699898
-
Adverse effects of antiretroviral therapy
-
Carr A, Cooper DA. Adverse effects of antiretroviral therapy. Lancet 2000; 356:1423-30.
-
(2000)
Lancet
, vol.356
, pp. 1423-1430
-
-
Carr, A.1
Cooper, D.A.2
-
23
-
-
0028817865
-
Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B
-
McKenzie R, Fried MW, Sallie R, et al. Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B. N Engl J Med 1995; 333:1099-105.
-
(1995)
N Engl J Med
, vol.333
, pp. 1099-1105
-
-
McKenzie, R.1
Fried, M.W.2
Sallie, R.3
-
24
-
-
29244463261
-
Insights into the molecular mechanism of mitochondrial toxicity of antiviral drugs
-
Feng JY, Johnson AA, Johnson KA, Schinazi RF, Anderson KS, Furman PA. Insights into the molecular mechanism of mitochondrial toxicity of antiviral drugs [abstract P17]. In: Program and abstracts of the 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV (Toronto, Canada). 2000.
-
(2000)
Program and Abstracts of the 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV (Toronto, Canada)
-
-
Feng, J.Y.1
Johnson, A.A.2
Johnson, K.A.3
Schinazi, R.F.4
Anderson, K.S.5
Furman, P.A.6
-
25
-
-
0027496517
-
Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis b virus
-
Frick LW, St John L, Taylor LC, et al. Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2- (hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis b virus. antimicrob. Agents Chemother 1993; 37:2285.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 2285
-
-
Frick, L.W.1
St. John, L.2
Taylor, L.C.3
-
26
-
-
0026440603
-
Pharmacokinetics and metabolism of racemic 2′,3′-dideoxy-5- fluoro-3-thiacytidine in rhesus monkeys
-
Schinazi RF, Boudinot FD, Ibrahim SS, Manning C, McClure HM, Liotta DC. Pharmacokinetics and metabolism of racemic 2′,3′-dideoxy-5-fluoro-3- thiacytidine in rhesus monkeys. Antimicrob Agents Chemother 1992; 36:2432-8.
-
(1992)
Antimicrob Agents Chemother
, vol.36
, pp. 2432-2438
-
-
Schinazi, R.F.1
Boudinot, F.D.2
Ibrahim, S.S.3
Manning, C.4
McClure, H.M.5
Liotta, D.C.6
-
30
-
-
0033847883
-
Once-daily combination therapy with emtricitabine, didanosine, and efavirenz in human immunodeficiency virus-infected patients
-
Molina JM, Ferchal F, Rancinan C, et al. Once-daily combination therapy with emtricitabine, didanosine, and efavirenz in human immunodeficiency virus-infected patients. J Infect Dis 2000; 182:599-602.
-
(2000)
J Infect Dis
, vol.182
, pp. 599-602
-
-
Molina, J.M.1
Ferchal, F.2
Rancinan, C.3
-
31
-
-
0003336410
-
Once-daily combination therapy with emtricitabine, didanosine and efavirenz in treatment-naïve HIV-infected adults: 64 Week follow-up of the ANRS091 trial
-
Molina JM, Perusat S, Ferchal F, et al. Once-daily combination therapy with emtricitabine, didanosine and efavirenz in treatment-naïve HIV-infected adults: 64 week follow-up of the ANRS091 trial [abstract 321]. In: Program and abstracts of the 8th Conference on Retroviruses and Opportunistic Infections (Chicago, IL). 2001.
-
(2001)
Program and Abstracts of the 8th Conference on Retroviruses and Opportunistic Infections (Chicago, IL)
-
-
Molina, J.M.1
Perusat, S.2
Ferchal, F.3
-
32
-
-
3142697068
-
Efficacy and safety of emtricitabine vs stavudine in combination therapy in antiretroviral-naïve patients - A randomized trial
-
Saag MS, Cahn P, Raffi F, et al. Efficacy and safety of emtricitabine vs stavudine in combination therapy in antiretroviral-naïve patients - a randomized trial. JAMA 2004;292:180-90.
-
(2004)
JAMA
, vol.292
, pp. 180-190
-
-
Saag, M.S.1
Cahn, P.2
Raffi, F.3
-
33
-
-
33644662842
-
Superior outcome for tenofovir DF, emtricitabine and efavirenz compared to fixed dose zidovudine/lamivudine and EFV in antiretroviral naive patients
-
Pozniak AL, Gallant J, DeJesus E, et al. Superior outcome for tenofovir DF, emtricitabine and efavirenz compared to fixed dose zidovudine/ lamivudine and EFV in antiretroviral naive patients [abstract WeOa0202]. In: Program and abstracts of the 3rd International AIDS Society Conference on Pathogenesis and Treatment (Rio de Janeiro, Brazil). 2005.
-
(2005)
Program and Abstracts of the 3rd International AIDS Society Conference on Pathogenesis and Treatment (Rio de Janeiro, Brazil)
-
-
Pozniak, A.L.1
Gallant, J.2
DeJesus, E.3
-
34
-
-
0005470188
-
Two randomized, controlled, equivalance trials of emtricitabine (emtricitabine) to lamivudine (3TC)
-
Van der Horst C, Sanne I, Wakeford C, Quinn J, Rousseau F. Two randomized, controlled, equivalance trials of emtricitabine (emtricitabine) to lamivudine (3TC) [abstract 18]. In: Program and abstracts of the 8th Conference on Retroviruses and Opportunistic Infections (Chicago, IL). 2001.
-
(2001)
Program and Abstracts of the 8th Conference on Retroviruses and Opportunistic Infections (Chicago, IL)
-
-
Van Der Horst, C.1
Sanne, I.2
Wakeford, C.3
Quinn, J.4
Rousseau, F.5
-
36
-
-
29244474003
-
Antiviral activity, safety, and incidence of resistance in chronically infected hepatitis B patients (CHB) given once daily emtricitabine for 2 years
-
Gish RG, Leung N, Wang C, et al. Antiviral activity, safety, and incidence of resistance in chronically infected hepatitis B patients (CHB) given once daily emtricitabine for 2 years [abstract 838]. In: Program and abstracts of the 53rd Annual Meeting of the American Association for the Study of Liver Diseases (Boston, MA). 2002.
-
(2002)
Program and Abstracts of the 53rd Annual Meeting of the American Association for the Study of Liver Diseases (Boston, MA)
-
-
Gish, R.G.1
Leung, N.2
Wang, C.3
-
37
-
-
0036093269
-
Dose range study of pharmacokientics, safety, and preliminary antiviral activity of emtricitabine in adults with hepatitis B virus infection
-
Gish RG, Leung NWY, Wright TL, et al. Dose range study of pharmacokientics, safety, and preliminary antiviral activity of emtricitabine in adults with hepatitis B virus infection. Antimicrob Agents Chemother 2002; 46:1734-40.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 1734-1740
-
-
Gish, R.G.1
Leung, N.W.Y.2
Wright, T.L.3
-
40
-
-
29244457494
-
A double-blind, placebo-controlled trial of emtricitabine (FTC, Emtriva) administered once-daily for treatment of chronic hepatitis B virus (HBV) infection
-
Shiffman ML, Ng TM, Krastev Z, et al. A double-blind, placebo-controlled trial of emtricitabine (FTC, Emtriva) administered once-daily for treatment of chronic hepatitis B virus (HBV) infection [abstract 22]. In: Program and abstracts of the 55th Annual Meeting of the American Association for the Study of Liver Diseases (Boston, MA). 2004.
-
(2004)
Program and Abstracts of the 55th Annual Meeting of the American Association for the Study of Liver Diseases (Boston, MA)
-
-
Shiffman, M.L.1
Ng, T.M.2
Krastev, Z.3
-
43
-
-
0026693137
-
Crystal structure at 3.5 a resolution of HIV-1 reverse transcriptase complexed with an inhibitor
-
Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 1992; 256:1783-90.
-
(1992)
Science
, vol.256
, pp. 1783-1790
-
-
Kohlstaedt, L.A.1
Wang, J.2
Friedman, J.M.3
Rice, P.A.4
Steitz, T.A.5
-
47
-
-
3042726798
-
Treatment for adult HIV infection: 2004 recommendations of the international AIDS Society-USA Panel
-
Yeni PG, Hammer SM, Hirsch MS, et al. Treatment for adult HIV infection: 2004 recommendations of the international AIDS society-usa Panel. JAMA 2004; 292:251-65.
-
(2004)
JAMA
, vol.292
, pp. 251-265
-
-
Yeni, P.G.1
Hammer, S.M.2
Hirsch, M.S.3
-
49
-
-
29244434771
-
Emtricitabine
-
Dolin, Masur, Saag, eds. Philadelphia: Elsevier Sciences
-
Wellons MF, Bartlett JA. Emtricitabine. In: Dolin, Masur, Saag, eds. AIDS therapy. 2nd ed. Philadelphia: Elsevier Sciences, 2003:106
-
(2003)
AIDS Therapy. 2nd Ed.
, pp. 106
-
-
Wellons, M.F.1
Bartlett, J.A.2
|