Irreversible exocrine pancreatic insufficiency in alcoholic rats without chronic pancreatitis after alcohol withdrawal

Alcoholism: Clinical and Experimental Research

Volumn 34, Issue 11, 2010, Pages 1843-1848

  Li, Jing ^a,b   Zhou, Chao ^a   Wang, Rui ^b   Liu, Rui ^b   Huang, Zhiyin ^b   Tang, Chengwei ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Alcohol Withdrawal; Cholecystokinin; Exocrine Pancreatic Insufficiency; Fatty Infiltration

Indexed keywords

ALCOHOL; ALPHA AMYLASE PANCREAS ISOENZYME; CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR; ENZYME PRECURSOR; FAT DROPLET; FATTY ACID; TRIACYLGLYCEROL LIPASE;

ACINAR CELL; ALCOHOL ABSTINENCE; ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ALCOHOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOANALYZER; CELL GRANULE; CELL INCLUSION; CELL STRUCTURE; CHEMICAL ANALYSIS; CHRONIC PANCREATITIS; CONTROLLED STUDY; CYTOPATHOLOGY; FOOD; INTESTINAL CHYME; INTESTINE SECRETION; MALE; NONHUMAN; PANCREAS EXOCRINE INSUFFICIENCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RADIOIMMUNOASSAY; RAT; ROUGH ENDOPLASMIC RETICULUM; WESTERN BLOTTING; WISTAR RAT;

ALCOHOLISM; AMYLASES; ANIMALS; BLOTTING, WESTERN; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHOLECYSTOKININ; ENERGY INTAKE; ETHANOL; EXOCRINE PANCREATIC INSUFFICIENCY; FATTY ACIDS, NONESTERIFIED; IMMUNOHISTOCHEMISTRY; INTESTINES; LIPASE; MALE; PANCREAS; PANCREATITIS; PANCREATITIS, CHRONIC; RATS; RATS, WISTAR; RECEPTOR, CHOLECYSTOKININ A; SUBSTANCE WITHDRAWAL SYNDROME; TRIGLYCERIDES; WEIGHT GAIN;

RATTUS; RATTUS NORVEGICUS;

EID: 78049232827     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2010.01272.x     Document Type: Article

References (22)

1. Ammann RW, Muellhaupt B (1994) Progression of alcoholic acute to chronic pancreatitis. Gut 35:552-556.
2. Bruno MJ, Haverkort EB, Tytgat GN, Van Leeuwen DJ (1995) Maldigestion associated with exocrine pancreatic insufficiency: implications of gastrointestinal physiology and properties of enzyme preparations for a cause-related and patient-tailored treatment. Am J Gastroenterol 90:1383-1393.
3. Deng X, Wang L, Elm MS, Elm MS, Gabazadeh D, Diorio GJ, Eagon PK, Whitcomb DC (2005) Chronic alcohol consumption accelerates fibrosis in response to cerulein-induced pancreatitis in rats. Am J Pathol 166:93-106.
4. DiMagno MJ, DiMagno EP (2009) Chronic pancreatitis. Curr Opin Gastroenterol 25:454-459.
5. Dufour MC, Adamson MD (2003) The epidemiology of alcohol-induced pancreatitis. Pancreas 27:286-290.
6. Feltrin KL, Little TJ, Meyer JH, Horowitz M, Rades T, Wishart J, Feinle-Bisset C (2008) Comparative effects of intraduodenal infusions of lauric and oleic acids on antropyloroduodenal motility, plasma cholecystokinin and peptide YY, appetite, and energy intake in healthy men. Am J Clin Nutr 87:1181-1187.
7. Grant BF (1997) Prevalence and correlates of alcohol use and DSM-IV alcohol dependence in the United States: results of the National Longitudinal Alcohol Epidemiologic Survey. J Stud Alcohol 58:464-473.
8. Green PH (1983) Alcohol, nutrition and malabsorption. Clin Gastroenterol 12:563-574.
9. Gullo L, Barbara L, Labò G (1988) Effect of cessation of alcohol use on the course of pancreatic dysfunction in alcoholic pancreatitis. Gastroenterology 95:1063-1068.
10. Jurkowska G, Grondin G, Masse S, Morisset J (1992) Soybean trypsin inhibition and cerulein accelerate recovery of cerulein-induced pancreatitis in rats. Gastroenterology 102:550-562.
11. Kanemitsu D, Sakagami J, Motoyoshi T, Nakajima T, Kataoka K (2006) Effects of the cholecystokinin A receptor antagonist loxiglumide on the proliferation and cell cycle time of pancreatic acinar cells in rats. Pancreas 32:190-196.
12. Kuzmuk KN, Swanson KS, Tappenden KA, Schook LB, Fahey GC Jr (2005) Diet and age affect intestinal morphology and large bowel fermentative end-product concentrations in senior and young adult dogs. J Nutr 135:1940-1945.
13. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
14. Lankisch PG, Lohr-Happe A, Otto J, Creutzfeld W (1993) Natural course in chronic pancreatitis. Pain, exocrine and endocrine pancreatic insufficiency and prognosis of the disease. Digestion 54:148-155.
15. Li J, Guo M, Hu B, Liu R, Wang R, Tang C (2008) Does chronic ethanol intake cause chronic pancreatitis? evidence & mechanism. Pancreas 37:189-195.
16. McLaughlin J, Grazia LM, Jones MN, D'Amato M, Dockray GJ, Thompson DG (1999) Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility. Gastroenterology 116:46-53.
17. Nakano S, Kihara Y, Otsuki M (1998) CCK administration after CCK receptor blockade accelerates recovery from cerulean-induced acute pancreatitis in rats. Pancreas 16:169-175.
18. Perides G, Tao X, West N, Sharma A, Steer ML (2005) A mouse model of ethanol dependent pancreatic fibrosis. Gut 54:1461-1467.
19. Povoski SP, Zhou W, Longnecker DS, Jensen RT, Mantey SA, Bell RH Jr (1994) Stimulation of in vivo pancreatic growth in the rat is mediated specifically by way of cholecystokinin-A receptors. Gastroenterology 107:1135-1146.
20. Rivard N, Rydzewska G, Lods JS, Martinez J, Morisset J (1994) Pancreas growth, tyrosine kinase, PtdIns 3-kinase, and PLD involve high-affinity CCK-receptor occupation. Am J Physiol 266:G62-G70.
21. Yamamoto M, Otani M, Jia DM, Fukumitsu KI, Yoshikawa H, Akiyama T, Otsuki M (2003) Different mechanism and site of action of CCK on the pancreatic secretion and growth in rats. Am J Physiol Gastrointest Liver Physiol 285:G681-G687.
22. Zhang J, Wang J, Lu Y, Qiu X, Fang Y (2004) Alcohol abuse in a metropolitan city in China: a study of the prevalence and risk factors. Addiction 99:1103-1110.