QSAR study of some 5-methyl/trifluoromethoxy-1H-indole-2,3-dione-3- thiosemicarbazone derivatives as anti-tubercular agents

Research in Pharmaceutical Sciences

Volumn 4, Issue 2, 2009, Pages 123-131

  Shahlaei, M ^a,b   Fassihi, A ^a,b   Nezami, A ^c  

^a KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c LORESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Anti tuberculosis activity; Principal component analysis; QSAR; Thiosemicarbazone derivaives

Indexed keywords

THIOSEMICARBAZONE DERIVATIVE; TUBERCULOSTATIC AGENT;

ARTICLE; CHEMICAL STRUCTURE; INHIBITION KINETICS; LINEAR SYSTEM; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REGRESSION ANALYSIS;

EID: 77958603847     PISSN: 17355362     EISSN: 17359414     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. World Health Organization. Tuberculosis Fact sheet. Geneva: World Health Organization; 2006.
2. Frieden TR, Sterling TR, Munsiff SS, Watt CJ, Dye C. Tuberculosis. Lancet. 2003;362:887-899.
3. Snider DE, La Montagne JR. The neglected global tuberculosis problem: a report of the 1992 World Congress on Tuberculosis. J Infect Dis. 1994;169:1189.
4. Sriram D, Yogeeswari P, Madhu K. Synthesis and in vitro and in vivo antimycobacterial activity of Isonicotinoyl Hydrazones. Bioorg Med Chem Lett. 2005;15:4502-4505.
5. Zhang Y, Post-Martens K, Denkin S. New drug candidates and therapeutic targets for tuberculosis therapy. Drug Discov Today. 2006;11:21-27. (Pubitemid 43227848)
6. Duncan K, Barry CE. Prospects for new antitubercular drugs. Curr Opin Microbiol. 2004;7:460-465.
7. Young DC. Computational drug design. New Jersey: John Wiley; 2009.
8. Shahlaei M, Fassihi A, Saghaie L. Application of PCANN and PC-LS-SVM in QSAR of CCR1 antagonist compounds: a comparative study. Eur J Med Chem. 2010;45:1572-1582.
9. Arkan E, Shahlaei M, Pourhossein A, Fakhri K, Fassihi A. Validated QSAR analysis of some diaryl substituted pyrazoles as CCR2 inhibitors by various linear and nonlinear multivariate chemometrics methods. Eur J Med Chem. 2010;45:3394-3406.
10. Güzel Ö, Karali N, Salman A. Synthesis and antituberculosis activity of 5-methyl/trifluoromethoxy-1H- indole- 2,3-dione-3-thiosemicarbazone derivatives, Bioorg Med Chem. 2008;16:8976-8987.
11. HyperChem Release 7.0 for Windows, Molecular modeling system: HyperCube. 2002. Available from: URL:http://www. hyperchem.com
12. Todeschini R. Milano chemometrics and QSPR group. 2010. Available from URL:http://michem.disat.unimib.it/
13. Kennard RW, Stone LA. Computer aided design of experiments. Technometrics. 1969;11:137-149.
14. Tropsha A, Gramatica P, Gombar VK. The importance of being earnest: validation is the absolute essential for successful application and interpretation of QSPR models. QSAR Comb Sci. 2003;22:69-77.
15. Roy P, Roy K. On some aspects of variable selection for partial least squares regression models. QSAR Comb Sci. 2008;27:302-313.