A novel high-resolution chipCE assay for rapid detection of EGFR gene mutations and amplifications in lung cancer therapy by a combination of fragment analysis, denaturing CE and MLPA

Electrophoresis

Volumn 31, Issue 21, 2010, Pages 3518-3524

  Minarik, Marek ^a,b   Gassman, Marcus ^c   Belsanova, Barbora ^a,b   Pesek, Milos ^d   Schouten, Jan ^e   Chudoba, Richard ^f   Gas, Bohuslav ^f   Benesova, Lucie ^a,b  

^a Genomac International   (Czech Republic)

^b Center for Applied Genomics of Solid Tumors (CEGES)   (Czech Republic)

^c AGILENT TECHNOLOGIES   (Germany)

^d CHARLES UNIVERSITY   (Czech Republic)

^e MRC HOLLAND   (Netherlands)

^f CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Amplification; Epidermal growth factor receptor gene; Lung cancer; Multiplex ligation dependent probe amplification; Mutation

Indexed keywords

ASSAYS; COST EFFECTIVENESS; DISEASES; DNA SEQUENCES; FLUORESCENCE MICROSCOPY; GENE ENCODING; GENE THERAPY; POLYMERASE CHAIN REACTION; PROBES; TUMORS;

EPIDERMAL GROWTH FACTOR RECEPTOR GENE; EPIDERMAL GROWTH FACTOR RECEPTORS; GENE AMPLIFICATION; GENES MUTATION; HIGH RESOLUTION; LUNG CANCER; MULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION; MUTATION; PROBE AMPLIFICATION; RECEPTOR GENES;

CAPILLARY ELECTROPHORESIS;

EPIDERMAL GROWTH FACTOR RECEPTOR; POLYMER;

ANALYZER; ARTICLE; BIOANALYZER; CANCER THERAPY; CAPILLARY ELECTROPHORESIS; CHIP CAPILLARY ELECTROPHORESIS; DENATURING CAPILLARY ELECTROPHORESIS; FRAGMENT ANALYSIS; GENE AMPLIFICATION; HIGH TEMPERATURE; LUNG CANCER; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; MUTATIONAL ANALYSIS; RECEPTOR GENE; SOMATIC MUTATION; TEMPERATURE DEPENDENCE;

EID: 77958602944     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.201000156     Document Type: Article

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