'Classical' but not 'other' mutations of EGFR kinase domain are associated with clinical outcome in gefitinib-treated patients with non-small cell lung cancer

British Journal of Cancer

Volumn 97, Issue 11, 2007, Pages 1560-1566

  Pallis, A G ^a   Voutsina, A ^b   Kalikaki, Ar ^b   Souglakos, J ^a   Briasoulis, E ^c   Murray, S ^d   Koutsopoulos, A ^a   Tripaki, M ^b   Stathopoulos, E ^a   Mavroudis, D ^a,b   Georgoulias, V ^a,b  

^a UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

^b UNIVERSITY OF CRETE   (Greece)

^c UNIVERSITY HOSPITAL OF IOANNINA   (Greece)

^d METROPOLITAN HOSPITAL   (Greece)

Author keywords

EGFR; EGFR mutations; Gefitinib; NSCLC

Indexed keywords

CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; GEFITINIB; IRINOTECAN; PLATINUM DERIVATIVE; TAXANE DERIVATIVE;

ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER SURVIVAL; DRUG WITHDRAWAL; EXON; FEMALE; GENE AMPLIFICATION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RASH; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; BINDING SITES; CARCINOMA, NON-SMALL-CELL LUNG; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; KAPLAN-MEIERS ESTIMATE; LUNG NEOPLASMS; MALE; MIDDLE AGED; MUTATION; PROGNOSIS; PROTEIN KINASE INHIBITORS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; TIME FACTORS; TREATMENT OUTCOME;

EID: 36448965280     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604068     Document Type: Article

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