Assessing the performance of a computer-based policy model of HIV and AIDS

PLoS ONE

Volumn 5, Issue 9, 2010, Pages 1-13

  Rydzak, Chara E ^a,b   Cotich, Kara L ^b   Sax, Paul E ^c   Hsu, Heather E ^a,d   Wang, Bingxia ^d   Losina, Elena ^c,d,e   Freedberg, Kenneth A ^a,b,d,e   Weinstein, Milton C ^b   Goldie, Sue J ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; EFAVIRENZ PLUS LAMIVUDINE PLUS ZIDOVUDINE; EMTRICITABINE; ENFUVIRTIDE; INDINAVIR; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; STAVUDINE; TENOFOVIR; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CALIBRATION; CLINICAL EFFECTIVENESS; COHORT ANALYSIS; COMPLICATION; COMPUTER MODEL; COMPUTER SIMULATION; CONTROLLED STUDY; FACE VALIDITY; FEMALE; HEALTH CARE POLICY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERNAL CONSISTENCY; MORTALITY; OPPORTUNISTIC INFECTION; PATIENT COMPLIANCE; UNITED STATES; UNSPECIFIED SIDE EFFECT; VIRUS INHIBITION; CD4 LYMPHOCYTE COUNT; HEALTH CARE QUALITY; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOLOGY; MALE; PHYSIOLOGY; POLICY; TREATMENT OUTCOME; VIROLOGY;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; COHORT STUDIES; COMPUTER SIMULATION; FEMALE; HIV; HIV INFECTIONS; HUMANS; MALE; PROGRAM EVALUATION; PUBLIC POLICY; TREATMENT OUTCOME; UNITED STATES;

EID: 77958601289     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012647     Document Type: Article

References (69)

1. Carpenter CC, Cooper DA, Fischl MA, Gatell JM, Gazzard BG, et al. (2000) Antiretroviral therapy in adults: updated recommendations of the International AIDS Society-USA Panel. JAMA 283: 381-390.
2. Detels R, Mun ̃oz A, McFarlane G, Kingsley LA, Margolick JB, et al. (1998) Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. Multicenter AIDS Cohort Study Investigators. JAMA 280: 1497-1503.
3. Detels R, Tarwater P, Phair JP, Margolick J, Riddler SA, et al. (2001) Effectiveness of potent antiretroviral therapies on the incidence of opportunistic infections before and after AIDS diagnosis. AIDS 15: 347-355.
4. Yamashita TE, Phair JP, Mun ̃oz A, Margolick JB, Detels R, et al. (2001) Immunologic and virologic response to highly active antiretroviral therapy in the Multicenter AIDS Cohort Study. AIDS 15: 735-746.
5. Yeni PG, Hammer SM, Carpenter CC, Cooper DA, Fischl MA, et al. (2002) Antiretroviral treatment for adult HIV infection in 2002: updated recommendations of the International AIDS Society-USA Panel. JAMA 288: 222-235.
6. Chene G, Sterne JA, May M, Costagliola D, Ledergerber B, et al. (2003) Prognostic importance of initial response in HIV-1 infected patients starting potent antiretroviral therapy: analysis of prospective studies. Lancet 362: 679-686.
7. Gulick RM, Ribaudo HJ, Shikuma CM, Lalama C, Schackman BR, et al. (2006) Three- vs four-drug antiretroviral regimens for the initial treatment of HIV-1 infection: a randomized controlled trial. JAMA 296: 769-781.
8. Grabar S, Le Moing V, Goujard C, Egger M, Leport C, et al. (2005) Response to highly active antiretroviral therapy at 6 months and long-term disease progression in HIV-1 infection. J Acquir Immune Defic Syndr 39: 284-292.
9. MacArthur RD, Novak RM, Peng G, Chen L, Xiang Y, et al. (2006) A comparison of three highly active antiretroviral treatment strategies consisting of non-nucleoside reverse transcriptase inhibitors, protease inhibitors, or both in the presence of nucleoside reverse transcriptase inhibitors as initial therapy (CPCRA 058 FIRST Study): a long-term randomised trial. Lancet 368: 2125-2135.
10. Mocroft A, Ledergerber B, Viard JP, Staszewski S, Murphy M, et al. (2004) Time to virological failure of 3 classes of antiretrovirals after initiation of highly active antiretroviral therapy: results from the EuroSIDA study group. J Infect Dis 190: 1947-1956.
11. Podlekareva D, Mocroft A, Dragsted UB, Ledergerber B, Beniowski M, et al. (2006) Factors associated with the development of opportunistic infections in HIV-1-infected adults with high CD4+ cell counts: a EuroSIDA study. J Infect Dis 194: 633-641.
12. Robbins GK, De Gruttola V, Shafer RW, Smeaton LM, Snyder SW, et al. (2003) Comparison of sequential three-drug regimens as initial therapy for HIV- 1 infection. N Engl J Med 349: 2293-2303.
13. Shafer RW, Smeaton LM, Robbins GK, De Gruttola V, Snyder SW, et al. (2003) Comparison of four-drug regimens and pairs of sequential three-drug regimens as initial therapy for HIV-1 infection. N Engl J Med 349: 2304-2315.
14. Yeni P, Cooper DA, Aboulker JP, Babiker AG, Carey D, et al. (2006) Virological and immunological outcomes at 3 years after starting antiretroviral therapy with regimens containing non-nucleoside reverse transcriptase inhibitor, protease inhibitor, or both in INITIO: open-label randomised trial. Lancet 368: 287-298.
15. Weinstein MC (2006) Recent developments in decision-analytic modeling for economic evaluation. Pharmacoeconomics 24: 1043-1053.
16. Weinstein MC, O'Brien B, Hornberger J, Jackson J, Johannesson M, et al. (2003) Principles of good practice for decision analytic modeling in health-care evaluation: report of the ISPOR Task Force on Good Research Practices- Modeling Studies. Value Health 6: 9-17.
17. Weinstein MC, Toy EL, Sandberg EA, Neumann PJ, Evans JS, et al. (2001) Modeling for health care and other policy decisions: uses, roles, and validity. Value Health 4: 348-361.
18. Paltiel AD, Freedberg KA, Scott CA, Schackman BR, Losina E, et al. (2009) HIV preexposure prophylaxis in the United States: impact on lifetime infection risk, clinical outcomes, and cost-effectiveness. Clin Infect Dis 48: 806-815.
19. Walensky RP, Freedberg KA, Weinstein MC, Paltiel AD (2007) Costeffectiveness of HIV testing and treatment in the United States. Clin Infect Dis 45(Suppl 4): S248-254.
20. Wolf LL, Ricketts P, Freedberg KA, Williams-Roberts H, Hirschhorn LR, et al. (2007) The cost-effectiveness of antiretroviral therapy for treating HIV disease in the Caribbean. J Acquir Immune Defic Syndr 46: 463-471.
21. Paltiel AD, Walensky RP, Schackman BR, Seage GR, 3rd, Mercincavage LM, et al. (2006) Expanded HIV screening in the United States: effect on clinical outcomes, HIV transmission, and costs. Ann Intern Med 145: 797-806.
22. Goldie SJ, Yazdanpanah Y, Losina E, Weinstein MC, Anglaret X, et al. (2006) Cost-effectiveness of HIV treatment in resource-poor settings-the case of Côte d'Ivoire. N Engl J Med 355: 1141-1153.
23. Yazdanpanah Y, Losina E, Anglaret X, Goldie SJ, Walensky RP, et al. (2005) Clinical impact and cost-effectiveness of co-trimoxazole prophylaxis in patients with HIV/AIDS in Côte d'Ivoire: a trial-based analysis. AIDS 19: 1299-1308.
24. Kimmel AD, Goldie SJ, Walensky RP, Losina E, Weinstein MC, et al. (2005) Optimal frequency of CD4 cell count and HIV RNA monitoring prior to initiation of antiretroviral therapy in HIV-infected patients. Antivir Ther 10: 41-52.
25. Paltiel AD, Weinstein MC, Kimmel AD, Seage GR, 3rd, Losina E, et al. (2005) Expanded screening for HIV in the United States-an analysis of costeffectiveness. N Engl J Med 352: 586-595.
26. Yazdanpanah Y, Goldie SJ, Paltiel AD, Losina E, Coudeville L, et al. (2003) Prevention of human immunodeficiency virus-related opportunistic infections in France: a cost-effectiveness analysis. Clin Infect Dis 36: 86-96.
27. Schackman BR, Goldie SJ, Weinstein MC, Losina E, Zhang H, et al. (2001) Cost-effectiveness of earlier initiation of antiretroviral therapy for uninsured HIV-infected adults. Am J Public Health 91: 1456-1463.
28. Freedberg KA, Losina E, Weinstein MC, Paltiel AD, Cohen CJ, et al. (2001) The cost effectiveness of combination antiretroviral therapy for HIV disease. N Engl J Med 344: 824-831.
29. Paltiel AD, Scharfstein JA, Seage GR, 3rd, Losina E, Goldie SJ, et al. (1998) A Monte Carlo simulation of advanced HIV disease: application to prevention of CMV infection. Med Decis Making 18: S93-105.
30. Weinstein MC, Goldie SJ, Losina E, Cohen CJ, Baxter JD, et al. (2001) Use of genotypic resistance testing to guide hiv therapy: clinical impact and costeffectiveness. Ann Intern Med 134: 440-450.
31. Women's Interagency HIV Study. University of California, San Francisco.
32. Anastos K, Kalish LA, Hessol N, Weiser B, Melnick S, et al. (1999) The relative value of CD4 cell count and quantitative HIV-1 RNA in predicting survival in HIV-1-infected women: results of the women's interagency HIV study. AIDS 13: 1717-1726.
33. Anastos K, Schneider MF, Gange SJ, Minkoff H, Greenblatt RM, et al. (2005) The association of race, sociodemographic, and behavioral characteristics with response to highly active antiretroviral therapy in women. J Acquir Immune Defic Syndr 39: 537-544.
34. Kirstein LM, Greenblatt RM, Anastos K, Levine A, French AL, et al. (2002) Prevalence and correlates of highly active antiretroviral therapy switching in the Women's Interagency HIV Study. J Acquir Immune Defic Syndr 29: 495-503.
35. Multicenter AIDS Cohort Study (MACS) public dataset: release PO4. 1995 ed. Springfield, VA: National Technical Information Service).
36. Losina E, Anglaret X, Yazdanpanah Y, Wang B, Toure S, et al. (2006) Impact of opportunistic diseases on chronic mortality in HIV-infected adults in Côte d'Ivoire. S Afr Med J 96: 526-529.
37. Seage GR, 3rd, Losina E, Goldie SJ, Paltiel AD, Kimmel AD, et al. (2002) The relationship of preventable opportunistic infections, HIV-1 RNA, and CD4 Cell counts to chronic mortality. J Acquir Immune Defic Syndr 30: 421-428.
38. Mellors JW, Muñoz A, Giorgi JV, Margolick JB, Tassoni CJ, et al. (1997) Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med 126: 946-954.
39. Kleeberger CA, Buechner J, Palella F, Detels R, Riddler S, et al. (2004) Changes in adherence to highly active antiretroviral therapy medications in the Multicenter AIDS Cohort Study. AIDS 18: 683-688.
40. Kleeberger CA, Phair JP, Strathdee SA, Detels R, Kingsley L, et al. (2001) Determinants of heterogeneous adherence to HIV-antiretroviral therapies in the Multicenter AIDS Cohort Study. J Acquir Immune Defic Syndr 26: 82-92.
41. (2001) Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents. (Feb 5, 2001). DHHS/Henry J. Kaiser Family Foundation Panel on Clinical Practices for the Treatment of HIV Infection.
42. Staszewski S, Morales-Ramirez J, Tashima KT, Rachlis A, Skiest D, et al. (1999) Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 Team. N Engl J Med 341: 1865-1873.
43. Walensky RP, Paltiel AD, Losina E, Mercincavage LM, Schackman BR, et al. (2006) The survival benefits of AIDS treatment in the United States. J Infect Dis 194: 11-19.
44. Pachl C, Todd JA, Kern DG, Sheridan PJ, Fong SJ, et al. (1995) Rapid and precise quantification of HIV-1 RNA in plasma using a branched DNA signal amplification assay. J Acquir Immune Defic Syndr Hum Retrovirol 8: 446-454.
45. Todd J, Pachl C, White R, Yeghiazarian T, Johnson P, et al. (1995) Performance characteristics for the quantitation of plasma HIV-1 RNA using branched DNA signal amplification technology. J Acquir Immune Defic Syndr Hum Retrovirol 10(Suppl 2): S35-44.
46. Nelson M, Arasteh K, Clotet B, Cooper DA, Henry K, et al. (2005) Durable efficacy of enfuvirtide over 48 weeks in heavily treatment-experienced HIV-1- infected patients in the T-20 versus optimized background regimen only 1 and 2 clinical trials. J Acquir Immune Defic Syndr 40: 404-412.
47. Johnson M, Grinsztejn B, Rodriguez C, Coco J, DeJesus E, et al. (2005) Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures. AIDS 19: 685-694.
48. Johnson M, Grinsztejn B, Rodriguez C, Coco J, DeJesus E, et al. (2006) 96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ ritonavir in patients with multiple virologic failures. AIDS 20: 711-718.
49. Hammer SM, Squires KE, Hughes MD, Grimes JM, Demeter LM, et al. (1997) A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med 337: 725-733.
50. Kousignian I, Abgrall S, Grabar S, Mahamat A, Teicher E, et al. (2008) Maintaining antiretroviral therapy reduces the risk of AIDS-defining events in patients with uncontrolled viral replication and profound immunodeficiency. Clin Infect Dis 46: 296-304.
51. Cole SR, Hernan MA, Robins JM, Anastos K, Chmiel J, et al. (2003) Effect of highly active antiretroviral therapy on time to acquired immunodeficiency syndrome or death using marginal structural models. Am J Epidemiol 158: 687-694.
52. Lalezari J, Goodrich J, DeJesus E, Lampiris H, Gulick R, et al. Efficacy and safety of maraviroc plus optimized background therapy in viremic ARTexperienced patients infected with CCR5-tropic HIV-1: 24-week results of a phase 2b/3 study in the US and Canada [abstract 104bLB]. 2007 February 25- 28; Los Angeles, CA.
53. Gallant JE, DeJesus E, Arribas JR, Pozniak AL, Gazzard B, et al. (2006) Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV. N Engl J Med 354: 251-260.
54. Pozniak AL, Gallant JE, DeJesus E, Arribas JR, Gazzard B, et al. (2006) Tenofovir disoproxil fumarate, emtricitabine, and efavirenz versus fixed-dose zidovudine/lamivudine and efavirenz in antiretroviral-naive patients: virologic, immunologic, and morphologic changes-a 96-week analysis. J Acquir Immune Defic Syndr 43: 535-540.
55. Steigbigel RT, Cooper DA, Kumar PN, Eron JE, Schechter M, et al. (2008) Raltegravir with optimized background therapy for resistant HIV-1 infection. N Engl J Med 359: 339-354.
56. El-Sadr WM, Luskin-Hawk R, Yurik TM, Walker J, Abrams D, et al. (1999) A randomized trial of daily and thrice-weekly trimethoprim-sulfamethoxazole for the prevention of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected persons. Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA). Clin Infect Dis 29: 775-783.
57. Havlir DV, Dube MP, Sattler FR, Forthal DN, Kemper CA, et al. (1996) Prophylaxis against disseminated Mycobacterium avium complex with weekly azithromycin, daily rifabutin, or both. California Collaborative Treatment Group. N Engl J Med 335: 392-398.
58. Nightingale SD, Cameron DW, Gordin FM, Sullam PM, Cohn DL, et al. (1993) Two controlled trials of rifabutin prophylaxis against Mycobacterium avium complex infection in AIDS. N Engl J Med 329: 828-833.
59. Deeks SG, Gange SJ, Kitahata MM, Saag MS, Justice AC, et al. (2009) Trends in Multidrug Treatment Failure and Subsequent Mortality among Antiretroviral Therapy-Experienced Patients with HIV Infection in North America. Clin Infect Dis 49: 1582-1590.
60. Lampe FC, Gatell JM, Staszewski S, Johnson MA, Pradier C, et al. (2006) Changes over time in risk of initial virological failure of combination antiretroviral therapy: a multicohort analysis, 1996 to 2002. Arch Intern Med 166: 521-528.
61. May M, Porter K, Sterne JA, Royston P, Egger M (2005) Prognostic model for HIV-1 disease progression in patients starting antiretroviral therapy was validated using independent data. J Clin Epidemiol 58: 1033-1041.
62. Moore RD, Keruly JC, Gebo KA, Lucas GM (2005) An improvement in virologic response to highly active antiretroviral therapy in clinical practice from 1996 through 2002. J Acquir Immune Defic Syndr 39: 195-198.
63. Porter K, Walker S, Hill T, Anderson J, Leen C, et al. (2008) Changes in outcome of persons initiating highly active antiretroviral therapy at a CD4 count less than 50 Cells/mm3. J Acquir Immune Defic Syndr 47: 202-205.
64. Saag MS, Call S, Westfall A, et al. Patterns of antiretroviral therapy (ART) use from 1988-1998 in a cohort of 120 HIV+ patients [abstract 22355]. Presented at the 12th World AIDS Conference, Geneva, June 28-July 3, 1998.
65. van Roon EN, Verzijl JM, Juttmann JR, Lenderink AW, Blans MJ, et al. (1999) Incidence of discontinuation of highly active antiretroviral combination therapy (HAART) and its determinants. J Acquir Immune Defic Syndr Hum Retrovirol 20: 290-294.
66. d'Arminio Monforte A, Lepri AC, Rezza G, Pezzotti P, Antinori A, et al. (2000) Insights into the reasons for discontinuation of the first highly active antiretroviral therapy (HAART) regimen in a cohort of antiretroviral naïve patients. I.CO.N.A. Study Group. Italian Cohort of Antiretroviral-Naïve Patients. AIDS 14: 499-507.
67. Mocroft A, Youle M, Moore A, Sabin CA, Madge S, et al. (2001) Reasons for modification and discontinuation of antiretrovirals: results from a single treatment centre. AIDS 15: 185-194.
68. Ahdieh Grant L, Silverberg MJ, Palacio H, Minkoff H, Anastos K, et al. (2001) Discontinuation of potent antiretroviral therapy: predictive value of and impact on CD4 cell counts and HIV RNA levels. AIDS 15: 2101-2108.
69. May MT, Sterne JA, Costagliola D, Sabin CA, Phillips AN, et al. (2006) HIV treatment response and prognosis in Europe and North America in the first decade of highly active antiretroviral therapy: a collaborative analysis. Lancet 368: 451-458.