Use of probiotic bacteria as an adjuvant for an influenza vaccine

International Journal of Probiotics and Prebiotics

Volumn 4, Issue 3, 2009, Pages 175-180

  French, Peter W ^a   Penny, Ronald ^b  

^a Fermiscan Ltd   (Australia)

^b Good Health Solutions   (Australia)

Author keywords

Adjuvant; Influenza; Lactobacillus; Probiotic; Vaccine

Indexed keywords

FLUB ANTIGEN; FLUVAX; HEMAGGLUTININ ANTIBODY; IMMUNOGLOBULIN G; INFLUENZA VACCINE; PLACEBO; PROBIOTIC AGENT; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS ANTIGEN; VRI 003;

ADJUVANT THERAPY; ADULT; ANTIBODY BLOOD LEVEL; ANTIBODY TITER; ARTICLE; BACTERIAL STRAIN; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FEVER; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; INFLUENZA A (H1N1); INFLUENZA A (H3N2); INFLUENZA B; INFLUENZA VACCINATION; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; INJECTION SITE PAIN; INJECTION SITE REACTION; LACTOBACILLUS FERMENTUM; MALE; MEASLES VIRUS; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; SEROCONVERSION; VARICELLA ZOSTER VIRUS;

EID: 77958597126     PISSN: 15551431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Ahrne, S., Nobaek, S., Jeppsson, B., Adlerberth, I., Wold, A.E. and Molin, G. (1998) The normal Lactobacillus flora of healthy human rectal and oral mucosa. Journal of Applied Microbiology 85,88-94. (Pubitemid 28363983)
2. Biancone, L., Monteleone, I., Del Vecchio Blanco, G., Vavassori, P. and Pallone. F. (2002) Resident bacterial flora and immune system. Digestive Liver Disease 34 Supplement 2, S37-43.
3. Boersma, W.J.A., Shaw, M. and Claassen, E. (2000) Probiotic bacteria as live oral vaccines: Lactobacillus as the versatile delivery vehicle. In: Fuller, R. and Perdigon, G. (Eds), Probiotics 3: Immunomodulation by the Gut Microflora and Probiotics (Klewar Academic Publishers), pp.234-264.
4. Christensen, H.R., Frokiaer, H. and Pestka, J.J. (2002) Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. Journal of Immunology 168,171-178. (Pubitemid 34014116)
5. de Vrese, M., Rautenberg, P., Laue, C., Koopmans, M., Herremans, T. and Schrezenmeir, J. (2005) Probiotic bacteria stimulate virus-specific neutralizing antibodies following a booster polio vaccination. European Journal of Nutrition 44,406-413.
6. Ellis, J.S. and Zambon, M.C. (1997) Molecular investigation of an outbreak of influenza in the United Kingdom. European Journal of Epidemiology 13,369-372.
7. Erickson, K.L. and Hubbard, N.E. (2000) Probiotic immunomodulation in health and disease. Journal of Nutrition 130, 403S-409S.
8. Grangette, C., Muller-Alouf, H., Goudercourt, D., Geoffroy, M.C., Turneer, M. and Mercenier, A. (2001) Mucosal immune responses and protection against tetanus toxin after intranasal immunization with recombinant Lactobacillus plantarum. Infection and Immunity 69, 1547-1553.
9. Guarner, F. and Schaafsma, G.J. (1998) Probiotics. International Journal of Food Microbiology 39, 237-238.
10. Haghighi, H.R., Gong, J., Gyles, C.L., Hayes, M.A., Sanei, B., Parvizi, P., Gisavi, H., Chambers, J.R. and Sharif, S. (2005) Modulation of antibody-mediated immune response by probiotics in chickens. Clinical and Diagnostic Laboratory Immunology 12, 1387-1392.
11. Kabelitz, D., Wesch, D. and Oberg, H.H. (2006) Regulation of regulatory T cells: role of dendritic cells and toll-like receptors. Critical Reviews in Immunology 26, 291-306. (Pubitemid 44423548)
12. Langley, J.M. and Faughnan, M.E. (2004) Prevention of influenza in the general population. Canadian Medical Association Journal 171, 1213-1222.
13. Mohamadzadeh, M., Mohamadzadeh, H., Brammer, M., Sestak, K. and Luftig, R.B. (2005) Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization. Proceedings of the National Academy of Sciences USA 102, 2880-2885.
14. Olivares, M., Diaz-Ropero, M.P., Sierra, S., Lara-Villoslada, F., Fonolla, J., Navas, M., Rodriguez, J.M. and Xaus, J. (2007) Oral intake of Lactobacillus fermentum CECT5716 enhances the effects of influenza vaccination. Nutrition 23, 254-260.
15. Plant, L.J. and Conway, P.L. (2002) Adjuvant properties and colonization potential of adhering and non-adhering Lactobacillus spp following oral administration to mice. FEMS Immunology and Medical Microbiology 34, 105-111.
16. Prescott, S.L., Dunstan, J.A., Hale, J., Breckler, L., Lehmann, H., Weston, S. and Richmond, P. (2005) Clinical effects of probiotics are associated with increased interferon-gamma responses in very young children with atopic dermatitis. Clinical and Experimental Allergy 35,1557-1564.
17. Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. and Medzhitov, R. (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241.
18. Reid, G., Sanders, M.E., Gaskins, H.R., Gibson, G.R., Mercenier, A., Rastall, R., Roberfroid, M., Rowland, I., Cherbut, C. and Klaenhammer, T.R. (2003) New scientific paradigms for probiotics and prebiotics. Journal of Clinical Gastroenterology 37, 105-118.
19. Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.P. and Ricciardi-Castagnoli, P. (2001) Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nature Immunology 4, 361-367.
20. Stephenson, I., Zambon, M.C., Rudin, A., Colegate, A., Podda, A., Bugarini, R., del Giudice, G., Minutello, A., Bonnington, S., Holmgren, J., Mills, K.H.G. and Nicholson, K.G. (2006) Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers. Journal of Virology 80, 4962-4970.
21. Weston, S., Halbert, A., Richmond, P. and Prescott, S.L. (2005) Effects of probiotics on atopic dermatitis: a randomised controlled trial. Archives of Diseases in Childhood 90,892-897. (Pubitemid 41232336)