HIV and pulmonary arterial hypertension: A systematic review

HIV Medicine

Volumn 11, Issue 10, 2010, Pages 620-634

  Janda, S ^a   Quon, B S ^a   Swiston, J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

HIV; Pulmonary arterial hypertension; Pulmonary hypertension

Indexed keywords

ANTIRETROVIRUS AGENT; BOSENTAN; COCAINE; ILOPROST; PROSTACYCLIN; PROSTAGLANDIN; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR;

CARDIOMEGALY; CARDIOVASCULAR PARAMETERS; CASE CONTROL STUDY; COCAINE DEPENDENCE; COCHRANE LIBRARY; COHORT ANALYSIS; DISEASE ASSOCIATION; EMBASE; HEMODYNAMICS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERSTITIAL PNEUMONIA; KAPOSI SARCOMA; LUNG EMBOLISM; MEDLINE; MORBIDITY; MORTALITY; OBSERVATIONAL STUDY; PNEUMOCYSTIS JIROVECI; PNEUMOCYSTIS PNEUMONIA; PRIORITY JOURNAL; PUBLICATION; PULMONARY HYPERTENSION; PULMONARY VENO-OCCLUSIVE DISEASE; QUALITATIVE ANALYSIS; REVIEW; SURVIVAL; SYSTEMATIC REVIEW; THORAX RADIOGRAPHY;

ADOLESCENT; ADULT; ANTIHYPERTENSIVE AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CARDIOMEGALY; CD4 LYMPHOCYTE COUNT; CHILD; COHORT STUDIES; CONFOUNDING FACTORS (EPIDEMIOLOGY); DATABASES, BIBLIOGRAPHIC; DIAGNOSIS, DIFFERENTIAL; DRUG THERAPY, COMBINATION; DYSPNEA; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; EPOPROSTENOL; FEMALE; HEMODYNAMICS; HIV INFECTIONS; HUMANS; HYPERTENSION, PULMONARY; MALE; PREVALENCE; REVERSE TRANSCRIPTASE INHIBITORS; SULFONAMIDES; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 77958583978     PISSN: 14642662     EISSN: 14681293     Source Type: Journal    
DOI: 10.1111/j.1468-1293.2010.00829.x     Document Type: Review

References (103)

1. Monsuez JJ, Charniot JC, Escaut L et al. HIV-associated vascular diseases: structural and functional changes, clinical implications. Int J Cardiol 2009; 133: 293-306.
2. Chin KM, Rubin LJ. Pulmonary arterial hypertension. J Am Coll Cardiol 2008; 51: 1527-1538.
3. Degano B, Yaici A, Le Pavec J et al. Long-term effects of bosentan in patients with HIV-associated pulmonary arterial hypertension. Eur Respir J 2009; 33: 92-98.
4. Opravil M, Pechere M, Speich R et al. HIV-associated primary pulmonary hypertension. A case control study. Swiss HIV Cohort Study. Am J Respir Crit Care Med 1997; 155: 990-995.
5. Petitpretz P, Brenot F, Azarian R et al. Pulmonary hypertension in patients with human immunodeficiency virus infection. Comparison with primary pulmonary hypertension. Circulation 1994; 89: 2722-2727.
6. Sitbon O, Lascoux-Combe C, Delfraissy JF et al. Prevalence of HIV-related pulmonary arterial hypertension in the current antiretroviral therapy era. Am J Respir Crit Care Med 2008; 177: 108-113.
7. Mehta NJ, Khan IA, Mehta RN et al. HIV-related pulmonary hypertension: analytic review of 131 cases. Chest 2000; 118: 1133-1141.
8. Pellicelli AM, Barbaro G, Palmieri F et al. Primary pulmonary hypertension in HIV patients: a systematic review. Angiology 2001; 52: 31-41.
9. Stroup DF, Berlin JA, Morton SC et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000; 283: 2008-2012.
10. Kim KK, Factor SM. Membranoproliferative glomerulonephritis and plexogenic pulmonary arteriopathy in a homosexual man with acquired immunodeficiency syndrome. Hum Pathol 1987; 18: 1293-1296.
11. Goldsmith GH Jr., Baily RG, Brettler DB et al. Primary pulmonary hypertension in patients with classic hemophilia. Ann Intern Med 1988; 108: 797-799.
12. Schulman S, Johnsson H, Blomqvist S. Pulmonary hypertension in hemophilia. Ann Intern Med 1988; 109: 759-760.
13. Bray GL, Martin GR, Chandra R. Idiopathic pulmonary hypertension, hemophilia A, and infection with human immunodeficiency virus (HIV). Ann Intern Med 1989; 111: 689-690.
14. Himelman RB, Dohrmann M, Goodman P et al. Severe pulmonary hypertension and cor pulmonale in the acquired immunodeficiency syndrome. Am J Cardiol 1989; 64: 1396-1399.
15. Rouveix E, Job C, Delorme G et al. Lethal pulmonary arterial hypertension in a heroin and amphetamine addict. Ann Med Interne (Paris) 1989; 140: 153.
16. Coplan NL, Shimony RY, Ioachim HL et al. Primary pulmonary hypertension associated with human immunodeficiency viral infection. Am J Med 1990; 89: 96-99.
17. Legoux B, Piette AM, Bouchet PF et al. Pulmonary hypertension and HIV infection. Am J Med 1990; 89: 122.
18. Speich R, Jenni R, Opravil M et al. Primary pulmonary hypertension in HIV infection. Chest 1991; 100: 1268-1271.
19. Saadjian A, Gueunoun M, Philip-Joet F et al. Pulmonary hypertension secondary to talc microemboli in a HIV seropositive heroin-addict woman. Arch Mal Coeur Vaiss 1991; 84: 1369-1373.
20. Aarons EJ, Nye FJ. Primary pulmonary hypertension and HIV infection. AIDS 1991; 5: 1276-1277.
21. Hays MD, Wiles HB, Gillette PC. Congenital acquired immunodeficiency syndrome presenting as cor pulmonale in a 10-year-old girl. Am Heart J 1991; 121: 929-931.
22. Jacques C, Richmond G, Tierney L et al. Primary pulmonary hypertension and human immunodeficiency virus infection in a non-hemophiliac man. Hum Pathol 1992; 23: 191-194.
23. Polos PG, Wolfe D, Harley RA et al. Pulmonary hypertension and human immunodeficiency virus infection. Two reports and a review of the literature. Chest 1992; 101: 474-478.
24. Mette SA, Palevsky HI, Pietra GG et al. Primary pulmonary hypertension in association with human immunodeficiency virus infection. A possible viral etiology for some forms of hypertensive pulmonary arteriopathy. Am Rev Respir Dis 1992; 145: 1196-1200.
25. Piette AM, Legoux B, Gepner P et al. "Primary" pulmonary arterial hypertension associated with HIV infection. Two cases. Presse Med 1992; 21: 616-618.
26. Gouello JP, Chennebault JM, Loison J et al. Primary pulmonary arterial hypertension associated with acquired immunodeficiency virus infection. Presse Med 1992; 21: 632-633.
27. Maliakkal R, Friedman SA, Sridhar S. Progressive pulmonary thromboembolism in association with HIV disease. NY State J Med 1992; 92: 403-404.
28. Rhodes J, Schiller MS, Montoya CH et al. Severe pulmonary hypertension without significant pulmonary parenchymal disease in a pediatric patient with acquired immunodeficiency syndrome. Clin Pediatr (Phila) 1992; 31: 629-631.
29. Reiser P, Opravil M, Pfaltz M et al. Primary pulmonary hypertension and mesangioproliferative glomerulonephritis in HIV infection. Dtsch Med Wochenschr 1992; 117: 815-818.
30. Duchesne N, Gagnon JA, Fouquette B et al. Primary pulmonary hypertension associated with HIV infection. Can Assoc Radiol J 1993; 44: 39-41.
31. Diaz PT, Clanton TL. Marked pulmonary function abnormalities in a case of HIV-associated pulmonary hypertension. Chest 1993; 104: 313-315.
32. Arunabh J, Edasery B. Human immunodeficiency virus and primary pulmonary hypertension. West J Med 1993; 159: 708-709.
33. Martos A, Carratala J, Cabellos C et al. AIDS and primary pulmonary hypertension. Am Heart J 1993; 125: 1819.
34. De Chadarevian JP, Lischner HW, Karmazin N et al. Pulmonary hypertension and HIV infection: new observations and review of the syndrome. Mod Pathol 1994; 7: 685-689.
35. Mani S, Smith GJ. HIV and pulmonary hypertension: a review. South Med J 1994; 87: 357-362.
36. Ruchelli ED, Nojadera G, Rutstein RM et al. Pulmonary veno-occlusive disease. Another vascular disorder associated with human immunodeficiency virus infection? Arch Pathol Lab Med 1994; 118: 664-666.
37. Sala-Blanch X, Fabregas N, Martinez JM et al. Primary pulmonary hypertension in an HIV-positive pregnant woman. Med Clin (Barc) 1994; 102: 117-118.
38. Zraik N, Herry I, Setbon O et al. Primary pulmonary hypertension in a HIV positive patient. Rev Pneumol Clin 1994; 50: 68-70.
39. Escamilla R, Hermant C, Berjaud J et al. Pulmonary veno-occlusive disease in a HIV-infected intravenous drug abuser. Eur Respir J 1995; 8: 1982-1984.
40. Weiss JR, Pietra GG, Scharf SM. Primary pulmonary hypertension and the human immunodeficiency virus. Report of two cases and a review of the literature. Arch Intern Med 1995; 155: 2350-2354.
41. Speciale A, Ramundi M, Fabiani F et al. Primary pulmonary hypertension in a HIV+patient. Monaldi Arch Chest Dis 1995; 50: 451-452.
42. Morse JH, Barst RJ, Itescu S et al. Primary pulmonary hypertension in HIV infection: an outcome determined by particular HLA class II alleles. Am J Respir Crit Care Med 1996; 153: 1299-1301.
43. Monsuez JJ, Auperin I, Vittecoq D et al. Pulmonary hypertension associated with thrombotic thrombocytopaenic purpura in AIDS patients. Eur Heart J 1997; 18: 1036-1037.
44. Muthiah M, Mishriki YY. Respiratory distress in a former drug abuser. Hosp Pract (Minneap) 1997; 32: 141-144.
45. Cool CD, Kennedy D, Voelkel NF et al. Pathogenesis and evolution of plexiform lesions in pulmonary hypertension associated with scleroderma and human immunodeficiency virus infection. Hum Pathol 1997; 28: 434-442.
46. Petureau F, Escamilla R, Hermant C et al. Pulmonary artery hypertension in HIV seropositive drug addicts. Apropos of 10 cases. Rev Mal Respir 1998; 15: 97-102.
47. Mesa RA, Edell ES, Dunn WF et al. Human immunodeficiency virus infection and pulmonary hypertension: two new cases and a review of 86 reported cases. Mayo Clin Proc 1998; 73: 37-45.
48. Pellicelli AM, Palmieri F, D'Ambrosio C et al. Role of human immunodeficiency virus in primary pulmonary hypertension - case reports. Angiology 1998; 49: 1005-1011.
49. Conraads VM, Colebunders RL, Boshoff C et al. Primary pulmonary hypertension in a patient with HIV infection. Acta Cardiol 1998; 53: 367-369.
50. Fiorencis R, Zonzin P, Carraro M et al. Pulmonary hypertension associated with human immunodeficiency virus infection. Report of two cases and review of the literature. G Ital Cardiol 1998; 28: 1404-1408.
51. Lambiotte F, Chagnon JL, Fontier C et al. Primary pulmonary hypertension in an HIV-seropositive patient. Presse Med 1999; 28: 582.
52. Heron E, Laaban JP, Capron F et al. Thrombotic primary pulmonary hypertension in an HIV+patient. Eur Heart J 1994; 15: 394-396.
53. Arranz CA, Herrera SI, Cuadrado GLM. Primary pulmonary hypertension in a female patient with HIV infection. Rev Clin Esp 1996; 196: 61-62.
54. Van Montfrans J, Rabie H, Schaaf H. An HIV-infected infant with Bacille Calmette-Guerin disease, recurrent and multidrug-resistant tuberculosis complicated by acute cor pulmonale and hepatitis while on antiretroviral therapy. South Afr J HIV Med 2007; 26: 49-52.
55. Conly J, Hilsden R, Deneer H. Primary pulmonary hypertension and human immunodeficiency virus infection. Can J Infect Dis 1997; 8: 290-293.
56. Montani D, Achouh L, Marcelin AG et al. Reversibility of pulmonary arterial hypertension in HIV/HHV8-associated Castleman's disease. Eur Respir J 2005; 26: 969-972.
57. Zinkernagel AS, Von Overbeck J, Opravil M et al. Long-term survival and interruption of HAART in HIV-related pulmonary hypertension. Eur J Clin Microbiol Infect Dis 2005; 24: 153-155.
58. Pai RK, Kedia A, Hsu PY et al. AIDS associated with severe cor pulmonale and large pericardial effusion with cardiac tamponade. Cardiol Rev 2004; 12: 49-55.
59. Feiterna-Sperling C, Huseman D, Timme J et al. Resolution of human immunodeficiency virus type 1 infection-related severe pulmonary hypertension in a very low-birth-weight infant. Pediatr Infect Dis J 2008; 27: 564-567.
60. Alp S, Schlottmann R, Bauer TT et al. Long-time survival with HIV-related pulmonary arterial hypertension: a case report. AIDS 2003; 17: 1714-1715.
61. Aschmann YZ, Kummer O, Linka A et al. Pharmacokinetics and pharmacodynamics of sildenafil in a patient treated with human immunodeficiency virus protease inhibitors. Ther Drug Monit 2008; 30: 130-134.
62. Cheung WY. Bilateral leg swelling as the initial and predominant presentation of HIV and associated pulmonary arterial hypertension. AIDS Patient Care STDS 2007; 21: 293-296.
63. Gutierrez F, Masia M, Padilla S et al. Occult lymphadenopathic Kaposi's sarcoma associated with severe pulmonary hypertension: a clinical hint about the potential role of HHV-8 in HIV-related pulmonary hypertension? J Clin Virol 2006; 37: 79-82.
64. Schifitto G, Holloway R. Cerebrovascular disease in patients with HIV-1 associated pulmonary hypertension. J NeuroAIDS 1999; 2: 57-64.
65. Wong AR, Rasool AH, Abidin NZ et al. Sildenafil as treatment for human immunodeficiency virus-related pulmonary hypertension in a child. J Paediatr Child Health 2006; 42: 147-148.
66. Chuesakoolvanich K, Boonsawat W, Mootsikapun P et al. HIV-associated primary pulmonary hypertension: a first case report in Thailand and literature review. J Med Assoc Thai 2005; 88: 979-983.
67. Hermans C, Manocha S, McLaughlin JE et al. Ortner syndrome and haemophilia. Haemophilia 2005; 11: 548-551.
68. Carlsen J, Kjeldsen K, Gerstoft J. Sildenafil as a successful treatment of otherwise fatal HIV-related pulmonary hypertension. AIDS 2002; 16: 1568-1569.
69. Bugnone AN, Viamonte M Jr., Garcia H. Imaging findings in human immunodeficiency virus-related pulmonary hypertension: report of five cases and review of the literature. Radiology 2002; 223: 820-827.
70. Speich R, Jenni R, Opravil M et al. Regression of HIV-associated pulmonary arterial hypertension and long-term survival during antiretroviral therapy. Swiss Med Wkly 2001; 131: 663-665.
71. Dawson DG, Johnson MW. Ciliochoroidal effusion and pulmonary hypertension in a patient with human immunodeficiency virus infection. Retina 2001; 21: 672-674.
72. Schumacher YO, Zdebik A, Huonker M et al. Sildenafil in HIV-related pulmonary hypertension. AIDS 2001; 15: 1747-1748.
73. Smith FB, Arias JH, Elmquist TH et al. Microvascular cytomegalovirus endothelialitis of the lung: a possible cause of secondary pulmonary hypertension in a patient with AIDS. Chest 1998; 114: 337-340.
74. Valencia Ortega ME, Ortega MG, Guinea EJ. Pulmonary hypertension in patients with HIV infection: study of 14 cases. Med Clin (Barc) 2000; 115: 181-184.
75. Leautez S, Boutoille D, Renard B et al. Pulmonary hypertension in HIV-infected patients. Rev Mal Respir 2001; 18: 432-435.
76. Le Houssine P, Karmochkine M, Ledru F et al. Primary pulmonary hypertension in human immunodeficiency virus infection. Study of 9 cases and review of the literature. Rev Med Interne 2001; 22: 1196-1203.
77. Cea-Calvo L, Subias PE, Telo De Menesses R et al. Treatment of HIV-associated pulmonary hypertension with treprostinil. Rev Esp Cardiol 2003; 56: 421-425.
78. Aguilar RV, Farber HW. Epoprostenol (prostacyclin) therapy in HIV-associated pulmonary hypertension. Am J Respir Crit Care Med 2000; 162: 1846-1850.
79. Ghofrani HA, Friese G, Discher T et al. Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension. Eur Respir J 2004; 23: 321-326.
80. Nunes H, Humbert M, Sitbon O et al. Prognostic factors for survival in human immunodeficiency virus-associated pulmonary arterial hypertension. Am J Respir Crit Care Med 2003; 167: 1433-1439.
81. Barbaro G, Lucchini A, Pellicelli AM et al. Highly active antiretroviral therapy compared with HAART and bosentan in combination in patients with HIV-associated pulmonary hypertension. Heart 2006; 92: 1164-1166.
82. Sitbon O, Gressin V, Speich R et al. Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension. Am J Respir Crit Care Med 2004; 170: 1212-1217.
83. Pugliese A, Isnardi D, Saini A et al. Impact of highly active antiretroviral therapy in HIV-positive patients with cardiac involvement. J Infect 2000; 40: 282-284.
84. Zuber JP, Calmy A, Evison JM et al. Pulmonary arterial hypertension related to HIV infection: improved hemodynamics and survival associated with antiretroviral therapy. Clin Infect Dis 2004; 38: 1178-1185.
85. Hsue PY, Deeks SG, Farah HH et al. Role of HIV and human herpesvirus-8 infection in pulmonary arterial hypertension. AIDS 2008; 22: 825-833.
86. Humbert M, Sitbon O, Chaouat A et al. Pulmonary arterial hypertension in France: results from a national registry. Am J Respir Crit Care Med 2006; 173: 1023-1030.
87. Recusani F, Di Matteo A, Gambarin F et al. Clinical and therapeutical follow-up of HIV-associated pulmonary hypertension: prospective study of 10 patients. AIDS 2003; 17 (Suppl. 1): S88-S95.
88. Cunha Mdo C, De Siqueira Filho AG, Dos Santos SR et al. AIDS in childhood: cardiac involvement with and without triple combination antiretroviral therapy. Arq Bras Cardiol 2008; 90: 11-17.
89. Mondy K, Gottdiener J, Overton ET et al. Prevalence and risk factors in HIV-infected persons for echocardiographic abnormalities in the era of modern HAART. 15th Conference on Retroviruses and Opportunistic Infections. Boston, USA, February 2008 [Abstract 978].
90. Almeida L, Amado P, Santos I et al. Pulmonary hypertension. Topic review. 2 clinical cases. Rev Port Cardiol 2002; 21: 173-180.
91. Hourseau M, Capron F, Nunes H et al. Pulmonary veno-occlusive disease in a patient with HIV infection. A case report with autopsy findings. Ann Pathol 2002; 22: 472-475.
92. McLaughlin VV, Archer SL, Badesch DB et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society Inc.; and the Pulmonary Hypertension Association. J Am Coll Cardiol 2009; 53: 1573-1619.
93. Pietra GG, Edwards WD, Kay JM et al. Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, primary pulmonary hypertension registry. Circulation 1989; 80: 1198-1206.
94. Rich S. Primary pulmonary hypertension. Prog Cardiovasc Dis 1988; 31: 205-238.
95. Vachiery JL, Brimioulle S, Crasset V et al. False-positive diagnosis of pulmonary hypertension by Doppler echocardiography. Eur Respir J 1998; 12: 1476-1478.
96. Denton CP, Cailes JB, Phillips GD et al. Comparison of Doppler echocardiography and right heart catheterization to assess pulmonary hypertension in systemic sclerosis. Br J Rheumatol 1997; 36: 239-243.
97. Barst RJ, McGoon M, Torbicki A et al. Diagnosis and differential assessment of pulmonary arterial hypertension. J Am Coll Cardiol 2004; 43: 40S-47S.
98. Pantaleo G, Fauci AS. New concepts in the immunopathogenesis of HIV infection. Annu Rev Immunol 1995; 13: 487-512.
99. Ehrenreich H, Rieckmann P, Sinowatz F et al. Potent stimulation of monocytic endothelin-1 production by HIV-1 glycoprotein 120. J Immunol 1993; 150: 4601-4609.
100. Humbert M, Monti G, Fartoukh M et al. Platelet-derived growth factor expression in primary pulmonary hypertension: comparison of HIV seropositive and HIV seronegative patients. Eur Respir J 1998; 11: 554-559.
101. Pellicelli AM, Palmieri F, Cicalini S et al. Pathogenesis of HIV-related pulmonary hypertension. Ann NY Acad Sci 2001; 946: 82-94.
102. Bisset LR, Cone RW, Huber W et al. Highly active antiretroviral therapy during early HIV infection reverses T-cell activation and maturation abnormalities. Swiss HIV Cohort Study. AIDS 1998; 12: 2115-2123.
103. Marecki JC, Cool CD, Parr JE et al. HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques. Am J Respir Crit Care Med 2006; 174: 437-445.