Targeting the PI3K/AKT cell survival pathway to induce cell death of HIV-1 infected macrophages with alkylphospholipid compounds

PLoS ONE

Volumn 5, Issue 9, 2010, Pages 1-8

  Lucas, Amanda ^a   Kim, Yuri ^b   Rivera Pabon, Omayra ^a   Chae, Sunju ^b   Kim, Dong Hyun ^b   Kim, Baek ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b Kyung Hee University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLPHOSPHOLIPID DERIVATIVE; EDELFOSINE; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPID DERIVATIVE; PROTEIN KINASE B; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DRUG DERIVATIVE; ETHER PHOSPHOLIPID; PHOSPHORYLCHOLINE;

ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; PHENOTYPE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; CELL CULTURE; CELL LINE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENTS; CELL DEATH; CELL LINE; CELLS, CULTURED; HIV INFECTIONS; HIV-1; HUMANS; MACROPHAGES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHOLIPID ETHERS; PHOSPHORYLCHOLINE; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 77958569154     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013121     Document Type: Article

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