Increased adipose tissue expression of tumor necrosis factor-alpha and insulin resistance in obese subjects with type II diabetes

World Journal of Medical Sciences

Volumn 5, Issue 2, 2010, Pages 30-35

  Al Dahr, Mohammed Hassan Saiem ^a   Jiffri, Essam H ^a  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Insulin resistance; Obesity; Tumor necrosis factor ; Type II diabetes mellitus

Indexed keywords

ALBUMIN; CHOLESTEROL; CREATININE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UREA;

ADIPOSE TISSUE; ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; DISEASE DURATION; ERYTHROCYTE COUNT; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; LEUKOCYTE COUNT; LIPID ANALYSIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; THROMBOCYTE COUNT; TISSUE DISTRIBUTION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

EID: 77958549058     PISSN: 18173055     EISSN: 19904061     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Arner, P., 2002. Insulin resistance in type 2 diabetes: role of fatty acids. Diabetes Metab. Res. Rev., 18(2): S5-S9.
2. Antuna-Puente, B., B. Feve, S. Fellahi and J. Bastard, 2008. Adipokines: The missing link between insulin resistance and obesity. Diabetes and Metabolism, 34: 2-11.
3. Ohya, M., A. Taniguchi, M. Fukushima, Y. Nakai, Y. Kawasaki, S. Nagasaka, et al., 2005. Three measures of tumor necrosis factor α activity and insulin resistance in nonobese Japanese type 2 diabetic patients. Metabolism, 54: 1297-1301. (Pubitemid 41262585)
4. Cao, Y., C. Hu, X. Meng, D. Wang and J. Zhang, 2008. Expression of TNF-α protein in omental and subcutaneous adipose tissue in obesity. Diabetes Research and Clinical Practice, 79: 214-219.
5. Hotamisligil, S., N. Shargill andM. Spiegelman, 1993. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science, 259: 87-91.
6. Egido, J., M. Gómez-Chiarri, A. Ortíz, C. Bustos, J. Alonso, C. Gómez-Guerrero et al., 1993. Role of tumor necrosis factor-alpha in the pathogenesis of glomerular diseases, Kidney Int. Suppl., 39: S59-S64.
7. Rus, G., F. Niculescu and R. Vlaicu, 1991. Tumor necrosis factor-alpha in human arterial wall with atherosclerosis. Atherosclerosis, 89: 247-254.
8. Rashid, G., S. Benchetrit, D. Fishman and J. Bernheim, 2004. Effect of advanced glycation end-products on gene expression and synthesis of TNF-alpha and endothelial nitric oxide synthase by endothelial cells. Kidney Int., 66: 1099-1106. (Pubitemid 39121015)
9. Ruiz-Ortega, M., M. Ruperez, O. Lorenzo, V. Esteban, J. Blanco, S. Mezzano, et al., 2002. Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney. Kidney Int. Suppl., 82: 12-22.
10. Jovinge, S., P. Ares, B. Kallin and J. Nilsson, 1996. Human monocytes/macrophages release TNF-alpha in response to Ox-LDL. Arterioscler. Thromb. Vasc. Biol, 16: 1573-1579.
11. Chia, S., M. Qadan, R. Newton, C. Ludlam, A. Fox and E. Newby, 2003. Intra-arterial tumor necrosis factor-alpha impairs endothelium-dependent vasodilatation and stimulates local tissue plasminogen activator release in humans. Arterioscler. Thromb. Vasc. Biol., 23: 695-701.
12. Hotamisligil, S. and M. Spiegelman, 1994. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes, 43: 1271-1278.
13. Katsuki, A., Y. Sumida, S. Murashima, K. Murata, Y. Takarada, Y. Ito, et al., 1998. Serum levels of tumor necrosis factor-alpha are increased in obese patients with noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab., 83: 859-862.
14. Moriwaki, Y., T. Yamamoto, Y. Shibutani, E. Aoki, Z. Tsutsumi, S. Takahashi et al., 2003. Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy. Metabolism, 52: 605-608. (Pubitemid 36896287)
15. Mishima, Y., A. Kuyama, A. Tada, K. Takahashi, T. Ishioka and M. Kibata, 2001. Relationship between serum tumor necrosis factor-α and insulin resistance in obese men with Type 2 diabetes mellitus. Diabetes Research and Clinical Practice, 52: 119-123. (Pubitemid 32366481)
16. Zou, C. and J. Shao, 2008. Role of adipocytokines in obesity-associated insulin resistance. The J. Nutritional Biochem., 19: 277-286.
17. American Diabetes Association, 2006. Type 2 diabetes in children and adolescents. Pediatrics, 105(3 Pt1): 671-680.
18. American Diabetes Association, 1996. Diabetes vital statistics. Alexandria, VA: American Diabetes Association, 1995.
19. Beutler, B. and A. Cerami, 1989. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature, 320: 584-588. (Pubitemid 16039134)
20. Caro, J.F., M.K. Sinha, S.M. Raju, O. Ittoop, W.J. Pories, E.G. Flickinger, D. Meelheim and G.L. Dohm, 1987. Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes. J. Clin. Invest., 79: 1330-1337.
21. Gimeno, R.E. and L.D. Klaman, 2005. Adipose tissue as an active endocrine organ:recent advances. Curr. Opin. Pharmacol., 5: 122-128.
22. Groop, L.C., C. Saloranta, M. Shank, R.C. Bonadonna, E. Ferrannini and RA. DeFronzo, 1991. The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin dependent diabetes mellitus. J. Clin. Endocrinol. Metab., 72: 96-107.
23. Hotamisligil, G.S., N.S. Shargill and B.M. Spiegelman, 1993. Adipose expression of tumor rnecrosis factor-alpha: direct role in obesity linked insulin resistance. Science, 259: 87-91.
24. Jovinge, S., A. Hamsten and P. Tornvall, 1998. Evidence for a role of tumor necrosis factor alpha in disturbances of triglyceride and glucose metabolism predisposing to coronary heart disease. Metabolism, 47: 113-8. (Pubitemid 28086243)
25. Libby, P. And PM. Ridker, 1999. Novel inflammatory markers of coronary risk: theory versus practice. Circulation, 100: 1148-50.
26. Valle, H., P. Hamalainen, S. Ilanne-Parikka, J. Keinanen-Kiukaanniemi, M. Tuomilehto and P. Vassalli, 1992. The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol., 10: 411 52.
27. Ruan, H. and H. Lodish, 2003. Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-α. Cytokine and Growth Factor Reviews, 14: 447-455. (Pubitemid 37099456)