Theoretical and experimental evaluation of hydrophobicity of proteins to predict their partitioning behavior in aqueous two phase systems: A review

Separation Science and Technology

Volumn 45, Issue 15, 2010, Pages 2165-2170

  Andrews, Barbara A ^a   Asenjo, Juan A ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Aqueous two phase systems; Hydrophobicity; Proteins

Indexed keywords

3D STRUCTURES; AMMONIUM SULPHATE; AQUEOUS TWO PHASE SYSTEM; AVERAGE SURFACE HYDROPHOBICITY; EXPERIMENTAL EVALUATION; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; REVERSE PHASE CHROMATOGRAPHY; STATE OF THE ART; STATISTICAL DESCRIPTIONS; THEORETICAL EVALUATION;

AMMONIUM COMPOUNDS; HYDROPHOBIC CHROMATOGRAPHY; PROTEINS; THREE DIMENSIONAL;

HYDROPHOBICITY;

EID: 77958544463     PISSN: 01496395     EISSN: 15205754     Source Type: Journal    
DOI: 10.1080/01496395.2010.507436     Document Type: Review

References (28)

1. Diamond, A.D.; Hsu, J.T. (1989) Fundamental studies of biomolecule partitioning in aqueous two-phase systems. Biotechnol. Bioeng., 34: 1000-1014.
2. Baskir, J.N.; Hatton, T.A.; Suter, U.W. (1987) Thermodynamics of separation of biomaterials in two-phase aqueous polymer systems: Effect of the phase-forming polymers. Macromolecules, 20: 1300-1311.
3. Cabezas, H.J.; Kabiri-Badr, M.; Szlag, D.C. (1990) Statistical thermodynamics of phase separation and ion partitioning in aqueous two-phase systems. Bioseparation, 1: 227-233.
4. Eiteman, M.A.; Gainier, J.L. (1991) A model for the prediction of partition coefficients in aqueous two-phase systems. Bioseparation, 2: 31-41.
5. King, R.S.; Blanch, H.W.; Prausnitz, J.M. (1988) Molecular thermodynamics of aqueous two-phase systems for bioseparation. AICHE J., 34: 1585-1594.
6. Schmidt, A.S.; Ventom, A.M.; Asenjo, J.A. (1994) Partitioning and purification of a-amylase in aqueous two-phase systems. Enzyme Microb. Technol., 16: 131.
7. Cascone, O.; Andrews, B.A.; Asenjo, J.A. (1991) Partition and purification of thaumatin in aqueous two-phase systems. Enzyme Microb. Technol., 13: 629.
8. Andrews, B.A.; Nielsen, S.; Asenjo, J.A.; (1996) Partitioning and purification of monoclonal antibodies in aqueous two-phase systems. Bioseparation, 6: 303-313.
9. Asenjo, J.A.; Schmidt, A.S.; Hachem, F.; Andrews, B.A. (1994) Model for predicting the partition behavior of proteins in aqueous two-phase systems. J. Chromatography, 668: 47.
10. Albertson, P.A. (1986) Partition of Cells, Particles and Macromolecules, 3rd Ed.; Wiley.
11. Kula, M.R. (1990) Trends and future prospects of aqueous two-phase extraction. Bioseparation, 1: 181-189.
12. Andrews, B.A.; Schmidt, A.S.; Asenjo, J.A. (2005) Correlation for the partition behavior of proteins in aqueous two phase systems: Effect of surface hydrophobicity and charge. Biotechnol. Bioeng., 90: 380.
13. Hachem, F.; Andrews, B.A.; Asenjo, J.A. (1996) Hydrophobic partitioning of proteins in aqueous two-phase systems. Enz. Microb. Technol., 19: 507.
14. Schmidt, A.S.; Andrews, B.A.; Asenjo, J.A. (1996) Correlations for the partition behaviour of proteins in aqueous two-phase systems: Effect of overall protein concentration. Biotechnol. Bioeng., 50: 617-626.
15. Hachem, F.M. (1992) Hydrophobic behavior of five model proteins in chromatography, precipitation and aqueous two-phase systems. PhD Thesis, University of Reading, UK.
16. Franco, T.T.; Andrews, A.T.; Asenjo, J.A. (1996a) Use of chemically modified proteins to study the effect of a single protein property on partitioning in aqueous two-phase systems: Effect of surface hydrophobicity. Biotechnol. Bioeng., 49: 300-308.
17. Melander, W.; Horvath, C. (1977) Salt effects on hydrophobic interactions in precipitation and chromatography of proteins; an interpretation of the lyotropic series. Arch. Biochem. Biophys., 183: 200.
18. Przybycien, T.M.; Bailey, J.E. (1989) Solubility-activity relationships in the inorganic salt-induced precipitation of a-chymotrypsin. Enzyme Microb. Technol., 11: 264.
19. Johansson, G. (1974) Effects of salts on the partition of proteins in aqueous polymeric biphasic systems. Acta Chem. Scand., B28: 873-882.
20. Franco, T.T.; Andrews, A.T.; Asenjo, J.A. (1996b) Use of chemically modified proteins to study the effect of a single protein property on partitioning in aqueous two-phase systems: effect of surface charge. Biotechnol. Bioeng., 49: 309-315.
21. Hodgson, C.J. (1992) Partitioning and separation of tPA (Tissue Plasminogen Activator) in aqueous two-phase systems. PhD Thesis, University of Reading, UK.
22. Azevedo, A.M.; Rosa, P.A.J.; Ferreira, I.F.; Aires-Barros, M.R. (2008) Integrated process for the purification of antibodies combining aqueous two-phase extraction, hydrophobic interaction chromatography and size-exclusion chromatography. J. Chromat. A, 1213: 154.
23. Azevedo, A.M.; Rosa, P.A.J.; Ferreira, I.F.; Aires-Barros, M.R. (2009) Chromatography-free recovery of biopharmaceuticals through aqueous two-phase processing. Trends in Biotechnol., 27: 240.
24. Yu, D.Q.; Chen, X.N.; Pelton, R.; Ghosh, R. (2008) Paper-PEGbased membranes for hydrophobic interaction chromatography: Purification of monoclonal antibody. Biotech. Bioeng., 99: 1434.
25. Berggren, K.; Wolf, A.; Asenjo, J.A.; Andrews, B.A.; Tjerneld, F. (2002) The surface exposed amino acid residues of monomeric proteins determine the partitioning in aqueous two-phase systems. Biochim. Biophys. Acta, 1596: 253.
26. Salgado, J.C.; Rapaport, I.; Asenjo, J.A. (2006) Predicting the behavior of proteins in hydrophobic interaction chromatography 1: Using the hydrophobic inbalance (HI) to describe their surface amino acid distribution. J. Chromatography A, 1107: 110.
27. Salgado, J.C.; Rapaport, I.; Asenjo, J.A. (2006) Predicting the behavior of proteins in hydrophobic interaction chromatography 2: Using a statistical description of their surface amino acid distribution. J. Chromatography A, 1107: 120.
28. Salgado, J.C.; Andrews, B.A.; Ortuzar, M.F.; Asenjo, J.A. (2008) Prediction of the partitioning behaviour of proteins in aqueous two-phase systems using only their amino acid composition. J. Chromatography A, 1178: 134.