Respiratory alkalosis and metabolic acidosis in a child treated with sulthiame

Pediatric Emergency Care

Volumn 26, Issue 10, 2010, Pages 752-753

  Weissbach, Avichai ^a   Tirosh, Irit ^a   Scheuerman, Oded ^a   Hoffer, Vered ^a   Garty, Ben Zion ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

metabolic acidosis; respiratory alkalosis; sulthiame

Indexed keywords

CARBAMAZEPINE; SULTIAME; VALPROIC ACID;

ANOREXIA; ARTERIAL GAS; ARTICLE; CASE REPORT; CHILD; COMPUTER ASSISTED TOMOGRAPHY; CONFUSION; DIZZINESS; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DYSPNEA; EMERGENCY MEDICINE; HEADACHE; HUMAN; LABORATORY TEST; MALE; METABOLIC ACIDOSIS; PHYSICAL EXAMINATION; RESPIRATORY ALKALOSIS; SCHOOL CHILD; SYMPTOMATIC EPILEPSY; WEAKNESS;

ACID-BASE EQUILIBRIUM; ACIDOSIS; ALKALOSIS; ANTICONVULSANTS; CARBAMAZEPINE; CHILD; CONFUSION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; EPILEPSY, TONIC-CLONIC; HUMANS; HYPERAMMONEMIA; MALE; RECURRENCE; THIAZINES; VALPROIC ACID;

EID: 77958526378     PISSN: 07495161     EISSN: None     Source Type: Journal    
DOI: 10.1097/PEC.0b013e3181f39b4b     Document Type: Article

References (6)

1. Ospolot (Sulthiame) [product information]. Pharmalab Pty Ltd, Lane Cove NSW, Australia. February 19, 2009.
2. Debus OM, Kurlemann G. Study group. Sulthiame in the primary therapy of West syndrome: a randomized double-blind placebo-controlled add-on trial on baseline pyridoxine medication. Epilepsia. 2004;45:103Y108.
3. Troger U, Fritzch C, Darius J, et al. Sulthiame-associated mild compensated metabolic acidosis. Int J Clin Pharmacol Ther. 1996;34:542Y545.
4. Brunton L, Lazo JS, Parker KL, eds. Goodman & Gilman's the Pharmacological Basis of Therapeutics. 11th ed. New York, NY: McGraw-Hill; 2006.
5. Leniger T, Wiemann M, Bingmann D, et al. Carbonic anhydrase inhibitor Sulthiame reduces intracellular pH and epileptiform activity of hippocampal CA3 neurons. Epilepsia. 2002;43:469Y474.
6. Siniatchkin M, Groppa S, Siebner H, et al. A single dose of sulthiame induces a selective increase in resting motor threshold in human motor cortex: a transcranial magnetic stimulation study. Epilepsy Res. 2006;72:18Y24.