Cofilin-1 inactivation leads to proteinuria - Studies in zebrafish, mice and humans

PLoS ONE

Volumn 5, Issue 9, 2010, Pages 1-10

  Ashworth, Sharon ^a,c   Teng, Beina ^b   Kaufeld, Jessica ^b,c   Miller, Emily ^b   Tossidou, Irini ^b   Englert, Christoph ^d   Bollig, Frank ^b   Staggs, Lynne ^b,c   Roberts, Ian S D ^e   Park, Joon Keun ^b   Haller, Hermann ^b,c   Schiffer, Mario ^b,c  

^a UNIVERSITY OF MAINE   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c MOUNT DESERT ISLAND BIOLOGICAL LABORATORY   (United States)

^d FRITZ LIPMANN INSTITUTE   (Germany)

^e JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COFILIN 1; DEXTRAN; F ACTIN; MUTANT PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSFORMING GROWTH FACTOR BETA;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CYCLE REGULATION; CELL MIGRATION; CELL MUTANT; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; DISEASE COURSE; EMBRYO; GENE ACTIVATION; GENE INACTIVATION; GENE SILENCING; GENE TRANSLOCATION; GENETIC TRANSFECTION; GLOMERULAR STRUCTURE; GLOMERULUS FILTRATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CLEARANCE; MINIMAL CHANGE GLOMERULONEPHRITIS; MOUSE; NONHUMAN; PODOCYTE; PROTEIN AGGREGATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEINURIA; SPECIES DIFFERENCE; TRANSMISSION ELECTRON MICROSCOPY; ZEBRA FISH; ANIMAL; CELL CULTURE; DISEASE MODEL; GENETICS; METABOLISM;

DANIO RERIO; MURINAE; MUS;

ACTIN CYTOSKELETON; ANIMALS; CELLS, CULTURED; COFILIN 1; DISEASE MODELS, ANIMAL; GENE SILENCING; HUMANS; MICE; PODOCYTES; PROTEINURIA; ZEBRAFISH;

EID: 77958523803     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012626     Document Type: Article

References (34)

1. Tryggvason K, Patrakka J, Wartiovaara J (2006) Hereditary proteinuria syndromes and mechanisms of proteinuria. N Engl J Med 354: 1387-1401.
2. Faul C, Asanuma K, Yanagida-Asanuma E, Kim K, Mundel P (2007) Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol 17: 428-437.
3. Kriz W, Lemley KV (1999) The role of the podocyte in glomerulosclerosis. Curr Opin Nephrol Hypertens 8: 489-497.
4. Kerjaschki D (2001) Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis. J Clin Invest 108: 1583-1587.
5. Takeda T, McQuistan T, Orlando RA, Farquhar MG (2001) Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton. J Clin Invest 108: 289-301.
6. Kriz W, Mundel P, Elger M (1994) The contractile apparatus of podocytes is arranged to counteract GBM expansion. Contrib Nephrol 107: 1-9.
7. Schiffer M, Haller H (2006) [Focal segmental glomerulosclerosis (FSGS). Molecular defects and clinical relevance]. Dtsch Med Wochenschr 131: 1541-1545.
8. Schiffer M, Bitzer M, Roberts IS, Kopp JB, ten DP, et al. (2001) Apoptosis in podocytes induced by TGF-beta and Smad7. J Clin Invest 108: 807-816.
9. Peters I, Tossidou I, Achenbach J, Woroniecki R, Mengel M, et al. (2006) IGF- binding protein-3 modulates TGF-beta/BMP-signaling in glomerular podocytes. J Am Soc Nephrol 17: 1644-1656.
10. Kaplan JM, Kim SH, North KN, Rennke H, Correia LA, et al. (2000) Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet 24: 251-256.
11. Weins A, Schlondorff JS, Nakamura F, Denker BM, Hartwig JH, et al. (2007) Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci U S A 104: 16080-16085.
12. Weins A, Kenlan P, Herbert S, Le TC, Villegas I, et al. (2005) Mutational and Biological Analysis of alpha-actinin-4 in focal segmental glomerulosclerosis. J Am Soc Nephrol 16: 3694-3701.
13. Bamburg JR (1999) Proteins of the ADF/cofilin family: essential regulators of actin dynamics. Annu Rev Cell Dev Biol 15: 185-230.
14. Van TM, Huyck L, Leyman S, Dhaese S, Vandekerkhove J, et al. (2008) Ins and outs of ADF/cofilin activity and regulation. Eur J Cell Biol 87: 649-667.
15. Scott RW, Olson MF (2007) LIM kinases: function, regulation and association with human disease. J Mol Med 85: 555-568.
16. Huang TY, DerMardirossian C, Bokoch GM (2006) Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol 18: 26-31.
17. Wiggan O, Bernstein BW, Bamburg JR (2005) A phosphatase for cofilin to be HAD. Nat Cell Biol 7: 8-9.
18. Hentschel DM, Mengel M, Boehme L, Liebsch F, Albertin C, et al. (2007) Rapid screening of glomerular slit diaphragm integrity in larval zebrafish. Am J Physiol Renal Physiol 293: F1746-F1750.
19. Bollig F, Mehringer R, B, Hartung C, Schafer M, et al. (2006) Identification and comparative expression analysis of a second wt1 gene in zebrafish. Dev Dyn 235: 554-561.
20. Amsterdam A, Nissen RM, Sun Z, Swindell EC, Farrington S, et al. (2004) Identification of 315 genes essential for early zebrafish development. Proc Natl Acad Sci U S A 101: 12792-12797.
21. Mundel P, Kriz W (1996) Cell culture of podocytes. Exp Nephrol 4: 263-266.
22. Saleem MA, O'Hare MJ, Reiser J, Coward RJ, Inward CD, et al. (2002) A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol 13: 630-638.
23. Perner B, Englert C, Bollig F (2007) The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros. Dev Biol 309: 87-96.
24. Djafarzadeh S, Niggli V (1997) Signaling pathways involved in dephosphorylation and localization of the actin-binding protein cofilin in stimulated human neutrophils. Exp Cell Res 236: 427-435.
25. Kriz W, Kretzler M, Provoost AP, Shirato I (1996) Stability and leakiness: opposing challenges to the glomerulus. Kidney Int 49: 1570-1574.
26. Schiffer M, Mundel P, Shaw AS, Bottinger EP (2004) A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis. J Biol Chem 279: 37004-37012.
27. Schiffer M, Schiffer LE, Gupta A, Shaw AS, Roberts IS, et al. (2002) Inhibitory smads and tgf-Beta signaling in glomerular cells. J Am Soc Nephrol 13: 2657-2666.
28. Vartiainen MK, Mustonen T, Mattila PK, Ojala PJ, Thesleff I, et al. (2002) The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requiremnets for actin dynamics. Mol Biol Cell 13: 183-194.
29. Hotulainen P, Paunola E, Vartiainen MK, Lappalainen P (2005) Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells. Mol Biol Cell 16: 649-664.
30. Gurniak CB, Perlas E, Wittke W (2005) The actin-depolymerizing factor n- cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev Biol Cell 278: 231-241.
31. Kiuchi T, Ohashi K, Kurita S, Mizuno K (2007) Cofilin promotes stimulus- induced lamellipodium formation by generating an abundant supply of actin monomers. J Cell Biol 177: 465-476.
32. Yamaguchi H, Lorenz M, Kempiak S, Sarmiento C, Coniglio S, et al. (2005) Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J Cell Biol 168: 441-452.
33. Kriz W (2004) Podocytes as a target for treatment with ACE inhibitors and/or angiotensin-receptor blockers. Kidney Int 65: 333-334.
34. Garg P, Verma R, Cook L, Soofi A, Venkatareddy M, et al. (2010) Actin-depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture: J Biol Chem 285(29): 22676-22688.