High-performance liquid chromatographic enantioseparation of (R,S)-fluoxetine using Marfey's reagent and (S)-N-(4-nitrophenoxycarbonyl) phenylalanine methoxyethyl ester as chiral derivatizing reagents along with direct thin-layer chromatographic resolution and isolation of enantiomers using l-tartaric acid as mobile phase additive

Biomedical Chromatography

Volumn 24, Issue 11, 2010, Pages 1152-1158

  Bhushan, Ravi ^a   Agarwal, Charu ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

Author keywords

(R, S) fluoxetine; (S) NIFE; Chiral resolution; l tartaric acid; Liquid chromatography; Marfey's reagent; Mobile phase additive

Indexed keywords

AMINO ACIDS; CHIRALITY; ESTERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEREOCHEMISTRY; THIN LAYER CHROMATOGRAPHY;

(R, S)-FLUOXETINE; (S)-NIFE; CHIRAL RESOLUTIONS; DIASTEREOMERS; ENANTIOSEPARATIONS; FLUOXETINE; L-TARTARIC ACIDS; MARFEY REAGENT; MOBILE PHASE ADDITIVES; PERFORMANCE;

ENANTIOMERS;

1 FLUORO 2,4 DINITROPHENYLMETHIONINAMIDE; 2,4 DINITROPHENOL; FLUOXETINE; MARFEY REAGENT; N (4 NITROPHENOXYCARBONYL)PHENYLALANINE METHYL ESTER; PRODEP; REAGENT; TARTARIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DERIVATIZATION; DIASTEREOISOMER; DRUG ISOLATION; DRUG STRUCTURE; ENANTIOMER; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; THIN LAYER CHROMATOGRAPHY;

EID: 77958506569     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1421     Document Type: Article

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