Differential expression of genes in the calcium-signaling pathway underlies lesion development in the LDb mouse model of atherosclerosis

Atherosclerosis

Volumn 213, Issue 1, 2010, Pages 40-51

  Mak, Solida ^a,b,c   Sun, Hua ^a,b   Acevedo, Frances ^b   Shimmin, Lawrence C ^c   Zhao, Lei ^b   Teng, Ba Bie ^a,b   Hixson, James E ^a,c  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Aorta; Atherosclerosis; Calcium signaling pathway; CDNA microarray; Risk factors

Indexed keywords

APOLIPOPROTEIN B; COMPLEMENTARY DNA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; ATHEROSCLEROSIS; CALCIUM SIGNALING; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENDOTHELIUM CELL; GENE EXPRESSION; GENOTYPE; HYPERLIPIDEMIA; LIPID DIET; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; TRIACYLGLYCEROL BLOOD LEVEL; VALIDATION STUDY; WESTERN BLOTTING;

ANIMAL FEED; ANIMALS; AORTA; ATHEROSCLEROSIS; CALCIUM; CALCIUM SIGNALING; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENOTYPE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RISK FACTORS; SIGNAL TRANSDUCTION;

EID: 77958499975     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2010.06.038     Document Type: Article

References (37)

1. Cheng C., Tempel D., van Haperen R., et al. Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation 2006, 113:2744-2753.
2. Stone P.H., Coskun A.U., Kinlay S., et al. Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: in vivo 6-month follow-up study. Circulation 2003, 108:438-444.
3. Schwenke D.C, St Clair R.W. Accumulation of 125I-tyramine cellobiose-labeled low density lipoprotein is greater in the atherosclerosis-susceptible region of White Carneau pigeon aorta and further enhanced once atherosclerotic lesions develop. Arterioscler Thromb 1992, 12:446-460.
4. Stehbens W.E. Chronic changes in the walls of experimentally produced aneurysms in sheep. Surg Gynecol Obstet 1979, 149:43-48.
5. Wagner J.D., St Clair R.W., Schwenke D.C., et al. Regional differences in arterial low density lipoprotein metabolism in surgically postmenopausal cynomolgus monkeys. Effects of estrogen and progesterone replacement therapy. Arterioscler Thromb 1992, 12:717-726.
6. Himburg H.A., Dowd S.E., Friedman M.H. Frequency-dependent response of the vascular endothelium to pulsatile shear stress. Am J Physiol Heart Circ Physiol 2007, 293:H645-653.
7. Tabibiazar R., Wagner R.A., Spin J.M., et al. Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular disease. Arterioscler Thromb Vasc Biol 2005, 25:302-308.
8. Wang X., Gargalovic P., Wong J., et al. Hyplip2, a new gene for combined hyperlipidemia and increased atherosclerosis. Arterioscler Thromb Vasc Biol 2004, 24:1928-1934.
9. Dutta R, Singh U., Li T.B., Fornage M., Teng B.B. Hepatic gene expression profiling reveals perturbed calcium signaling in a mouse model lacking both LDL receptor and Apobec1 genes. Atherosclerosis 2003, 169:51-62.
10. Singh U., Zhong S., Xiong M., et al. Increased plasma non-esterified fatty acids and platelet-activating factor acetylhydrolase are associated with susceptibility to atherosclerosis in mice. Clin Sci (Lond) 2004, 106:421-432.
11. Powell-Braxton L., Veniant M., Latvala R.D., et al. A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet. Nat Med 1998, 4:934-938.
12. Li C., Wong W.H. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci USA 2001, 98:31-36.
13. Brown M.P., Grundy W.N., Lin D., et al. Knowledge-based analysis of microarray gene expression data by using support vector machines. Proc Natl Acad Sci USA 2000, 97:262-267.
14. Irizarry R.A., Warren D., Spencer F., et al. Multiple-laboratory comparison of microarray platforms. Nat Methods 2005, 2:345-350.
15. Cheng C., Pounds S. False discovery rate paradigms for statistical analyses of microarray gene expression data. Bioinformation 2007, 1:436-446.
16. Tusher V.G., Tibshirani R., Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001, 98:5116-5121.
17. Khatri P., Desai V., Tarca A.L., et al. New Onto-Tools: Promoter-Express, nsSNPCounter and Onto-Translate. Nucleic Acids Res 2006, 34:W626-631.
18. Khatri P, Sellamuthu S., Malhotra P., et al. Recent additions and improvements to the Onto-Tools. Nucleic Acids Res 2005, 33:W762-765.
19. Draghici S., Khatri P., Tarca A.L., et al. A systems biology approach for pathway level analysis. Genome Res 2007, 17:1537-1545.
20. Khatri P., Voichita C., Kattan K., et al. Onto-Tools: new additions and improvements in 2006. Nucleic Acids Res 2007, 35:W206-211.
21. Rajeevan M.S., Ranamukhaarachchi D.G., Vernon S.D., Unger E.R. Use of real-time quantitative PCR to validate the results of cDNA array and differential display PCR technologies. Methods 2001, 25:443-451.
22. Rajeevan M.S., Vernon S.D., Taysavang N., Unger E.R. Validation of array-based gene expression profiles by real-time (kinetic) RT-PCR. J Mol Diagn 2001, 3:26-31.
23. Shi W., Haberland M.E., Jien M.L., Shih D.M., Lusis A.J. Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice. Circulation 2000, 102:75-81.
24. Berridge M.J., Bootman M.D., Lipp P. Calcium - a life and death signal. Nature 1998, 395:645-648.
25. Bootman M.D., Collins T.J., Peppiatt C.M., et al. Calcium signalling - an overview. Semin Cell Dev Biol 2001, 12:3-10.
26. Trump B.F., Berezesky I.K. Calcium-mediated cell injury and cell death. FASEB J 1995, 9:219-228.
27. Chen J.H., Riazy M., Smith E.M., et al. Oxidized LDL-mediated macrophage survival involves elongation factor-2 kinase. Arterioscler Thromb Vasc Biol 2009, 29:92-98.
28. Sanson M., Ingueneau C., Vindis C., et al. Oxygen-regulated protein-150 prevents calcium homeostasis deregulation and apoptosis induced by oxidized LDL in vascular cells. Cell Death Differ 2008, 15:1255-1265.
29. Yuan Z., Miyoshi T., Bao Y., et al. Microarray analysis of gene expression in mouse aorta reveals role of the calcium signaling pathway in control of atherosclerosis susceptibility. Am J Physiol Heart Circ Physiol 2009, 296:H1336-1343.
30. 2+ handling of smooth muscle cells in aorta of apolipoprotein E-deficient mice before development of atherosclerotic lesions. Cell Calcium 2007, 41:295-302.
31. Hill B.J., Price E.M., Dixon J.L., Sturek M. Increased calcium buffering in coronary smooth muscle cells from diabetic dyslipidemic pigs. Atherosclerosis 2003, 167:15-23.
32. Massaeli H., Austria J.A., Pierce G.N. Overexpression of SERCA2 Atpase in vascular smooth muscle cells treated with oxidized low density lipoprotein. Mol Cell Biochem 2000, 207:137-141.
33. Wang L., Hauser E.R., Shah S.H., et al. Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease. Am J Hum Genet 2007, 80:650-663.
34. Horne B.D., Hauser E.R., Wang L., et al. Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking. Ann Hum Genet 2009, 73:551-558.
35. Wysolmerski R.B., Lagunoff D. Involvement of myosin light-chain kinase in endothelial cell retraction. Proc Natl Acad Sci USA 1990, 87:16-20.
36. Recinos A., Carr B.K., Bartos D.B., et al. Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway. Physiol Genomics 2004, 19:131-142.
37. Collins A.R., Lyon C.J., Xia X., et al. Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes. Circ Res 2009, 104:e42-54.