Rectal dose-volume histogram parameters are associated with long-term patient-reported gastrointestinal quality of life after conventional and high-dose radiation for prostate cancer: A subgroup analysis of a randomized trial

International Journal of Radiation Oncology Biology Physics

Volumn 78, Issue 4, 2010, Pages 1081-1085

  Nguyen, Paul L ^a,c   Chen, Ronald C ^a,c   Hoffman, Karen E ^a,c   Trofimov, Alexei ^b,c   Efstathiou, Jason A ^b,c   Coen, John J ^b,c   Shipley, William U ^b,c   Zietman, Anthony L ^b,c   Talcott, James A ^b,c  

^a HARVARD RADIATION ONCOLOGY PROGRAM   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

DVH; Prostate cancer; Quality of life; Radiation; Randomized trial

Indexed keywords

AFTER-TREATMENT; DOSE ESCALATION; DOSE-VOLUME; DOSE-VOLUME HISTOGRAMS; DVH; EXTERNAL BEAM RADIATION; HIGH DOSE; LOCALIZED PROSTATE CANCER; MASSACHUSETTS; PEARSON CORRELATION; PROSTATE CANCERS; QUALITY OF LIFE; RANDOMIZED TRIAL; RECTAL WALL; T-TESTS;

CORRELATION METHODS; DISEASES; GRAPHIC METHODS; RADIATION;

RADIOTHERAPY;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXTERNAL BEAM RADIOTHERAPY; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE CANCER; QUALITY OF LIFE; QUESTIONNAIRE; RADIATION DOSE; ABDOMINAL PAIN; COLIC; COMPLICATION; DEFECATION; DIARRHEA; GASTROINTESTINAL HEMORRHAGE; PATHOLOGY; PROSTATIC NEOPLASMS; RADIATION INJURY; RADIATION RESPONSE; RANDOMIZED CONTROLLED TRIAL; RECTUM;

ABDOMINAL PAIN; COLIC; DEFECATION; DIARRHEA; FOLLOW-UP STUDIES; GASTROINTESTINAL HEMORRHAGE; HUMANS; MALE; PROSTATIC NEOPLASMS; QUALITY OF LIFE; QUESTIONNAIRES; RADIATION INJURIES; RADIOTHERAPY DOSAGE; RECTUM;

EID: 77958481499     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.09.015     Document Type: Article

References (24)

1. J.M. Michalski, K. Winter, and J.A. Purdy Toxicity after three-dimensional radiotherapy for prostate cancer on RTOG 9406 dose level V Int J Radiat Oncol Biol Phys 62 2005 706 713
2. J.M. Michalski, K. Winter, and J.A. Purdy Toxicity after three-dimensional radiotherapy for prostate cancer with RTOG 9406 dose level IV Int J Radiat Oncol Biol Phys 58 2004 735 742
3. C. Cozzarini, C. Fiorino, and G.L. Ceresoli Significant correlation between rectal DVH and late bleeding in patients treated after radical prostatectomy with conformal or conventional radiotherapy (66.6-70.2 Gy) Int J Radiat Oncol Biol Phys 55 2003 688 694
4. J.D. Fenwick, V.S. Khoo, and A.E. Nahum Correlations between dose-surface histograms and the incidence of long-term rectal bleeding following conformal or conventional radiotherapy treatment of prostate cancer Int J Radiat Oncol Biol Phys 49 2001 473 480
5. C. Fiorino, C. Cozzarini, and V. Vavassori Relationships between DVHs and late rectal bleeding after radiotherapy for prostate cancer: Analysis of a large group of patients pooled from three institutions Radiother Oncol 64 2002 1 12
6. C. Greco, C. Mazzetta, and F. Cattani Finding dose-volume constraints to reduce late rectal toxicity following 3D-conformal radiotherapy (3D-CRT) of prostate cancer Radiother Oncol 69 2003 215 222
7. E.H. Huang, A. Pollack, and L. Levy Late rectal toxicity: Dose-volume effects of conformal radiotherapy for prostate cancer Int J Radiat Oncol Biol Phys 54 2002 1314 1321
8. A. Jackson, M.W. Skwarchuk, and M.J. Zelefsky Late rectal bleeding after conformal radiotherapy of prostate cancer. II. Volume effects and dose-volume histograms Int J Radiat Oncol Biol Phys 49 2001 685 698
9. C. Vargas, A. Martinez, and L.L. Kestin Dose-volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy Int J Radiat Oncol Biol Phys 62 2005 1297 1308
10. S. Wachter, N. Gerstner, and G. Goldner Rectal sequelae after conformal radiotherapy of prostate cancer: Dose-volume histograms as predictive factors Radiother Oncol 59 2001 65 70
11. V.A. Benk, J.A. Adams, and W.U. Shipley Late rectal bleeding following combined x-ray and proton high dose irradiation for patients with stages T3-T4 prostate carcinoma Int J Radiat Oncol Biol Phys 26 1993 551 557
12. A.C. Hartford, A. Niemierko, and J.A. Adams Conformal irradiation of the prostate: Estimating long-term rectal bleeding risk using dose-volume histograms Int J Radiat Oncol Biol Phys 36 1996 721 730
13. W.U. Shipley, J.E. Tepper, and G.R. Prout Jr. Proton radiation as boost therapy for localized prostatic carcinoma J Am Med Assoc 241 1979 1912 1915
14. M.R. Storey, A. Pollack, and G. Zagars Complications from radiotherapy dose escalation in prostate cancer: Preliminary results of a randomized trial Int J Radiat Oncol Biol Phys 48 2000 635 642
15. M.G. Sanda, R.L. Dunn, and J. Michalski Quality of life and satisfaction with outcome among prostate-cancer survivors N Engl J Med 358 2008 1250 1261
16. A.L. Zietman Correction: Inaccurate analysis and results in a study of radiation therapy in adenocarcinoma of the prostate J Am Med Assoc 299 2008 898 899
17. A.L. Zietman, M.L. DeSilvio, and J.D. Slater Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: A randomized controlled trial J Am Med Assoc 294 2005 1233 1239
18. J.A. Clark, and J.A. Talcott Symptom indexes to assess outcomes of treatment for early prostate cancer Med Care 39 2001 1118 1130
19. J.A. Talcott, J.D. Slater, and A. Zietman Long-term quality of life after conventional-dose versus high-dose radiation for prostate cancer: Results from a randomized trial (PROG 95-09) [Abstract] J Clin Oncol 2008 26 5058 (Supplement)
20. D. Kuban, A. Pollack, and E. Huang Hazards of dose escalation in prostate cancer radiotherapy Int J Radiat Oncol Biol Phys 57 2003 1260 1268
21. W.D. Heemsbergen, M.S. Hoogeman, and G.A. Hart Gastrointestinal toxicity and its relation to dose distributions in the anorectal region of prostate cancer patients treated with radiotherapy Int J Radiat Oncol Biol Phys 61 2005 1011 1018
22. P.C. Koper, W.D. Heemsbergen, and M.S. Hoogeman Impact of volume and location of irradiated rectum wall on rectal blood loss after radiotherapy of prostate cancer Int J Radiat Oncol Biol Phys 58 2004 1072 1082
23. D. Vordermark, M. Schwab, and R. Ness-Dourdoumas Association of anorectal dose-volume histograms and impaired fecal continence after 3D conformal radiotherapy for carcinoma of the prostate Radiother Oncol 69 2003 209 214
24. E. Dale, D.R. Olsen, and S.D. Fossa Normal tissue complication probabilities correlated with late effects in the rectum after prostate conformal radiotherapy Int J Radiat Oncol Biol Phys 43 1999 385 391