Androgenetic complete mole with trisomy 13: Report of a case with microsatellite genotyping and review of the literature

Pathology Research and Practice

Volumn 206, Issue 11, 2010, Pages 776-781

  Dube V ^a   Chun, K ^b   Osborne, R ^a   Sherman, C ^a   Nofech Mozes, S ^a   Ismiil, N ^a   Saad, R S ^a   Khalifa, M A ^a  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b NORTH YORK GENERAL HOSPITAL   (Canada)

Author keywords

Hydatidiform mole; Microsatellite; Review; Trisomy 13

Indexed keywords

ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; CHORIONIC GONADOTROPIN; CYCLIN DEPENDENT KINASE INHIBITOR 1C; DACTINOMYCIN;

ADULT; ALLELE; ANDROGENESIS; ARTICLE; CASE REPORT; CHORION VILLUS SAMPLING; CHROMOSOME 13; CHROMOSOME 16; CHROMOSOME 18; CHROMOSOME 21; CHROMOSOME ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CURETTAGE; DYSPNEA; ECHOGRAPHY; FEMALE; FERTILIZATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENOTYPE; GONADOTROPIN BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYDATIDIFORM MOLE; HYPEREMESIS GRAVIDARUM; IMMUNOHISTOCHEMISTRY; LUNG METASTASIS; MICROSATELLITE MARKER; MULTIPLE CYCLE TREATMENT; PRENATAL DISORDER; SECOND TRIMESTER PREGNANCY; TRISOMY 13; UNIPARENTAL DISOMY; VAGINA BLEEDING; X CHROMOSOME; Y CHROMOSOME;

CHORIONIC VILLI; CHROMOSOME DISORDERS; CHROMOSOMES, HUMAN, PAIR 13; COMBINED MODALITY THERAPY; FATHERS; FEMALE; GENOTYPE; HUMANS; HYDATIDIFORM MOLE; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PREGNANCY; TRISOMY; TROPHOBLASTS; TUMOR MARKERS, BIOLOGICAL; UTERINE NEOPLASMS;

EID: 77958476035     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2010.02.013     Document Type: Article

References (15)

1. Brajenović-Milić B., Petrović O., Krasević M., Ristic S., Kapovic M. Chromosomal anomalies in abnormal human pregnancies. Fetal Diagn. Ther. 1998, 13:187-191.
2. Curtin W.M., Marcotte M.P., Myers L.L., Brost B.C. Trisomy 13 appearing as a mimic of a triploid partial mole. J. Ultrasound Med. 2001, 20:1137-1139.
3. Fisher R.A., Nucci M.R., Thaker H.M., Weremowicz S., Genest D.R., Castrillon D.H. Complete hydatidiform mole retaining a chromosome 11 of maternal origin: molecular genetic analysis of a case. Mod. Pathol. 2004, 17:1155-1160.
4. Helwani M.N., Seoud M., Zahed L., Zaatari G., Khalil A., Slim R. A familial case of recurrent hydatidiform molar pregnancies with biparental genomic contribution. Hum. Genet. 1999, 105:112-115.
5. Hoffner L., Dunn J., Esposito N., Macpherson T., Surti U. P57KIP2 immunostaining and molecular cytogenetics: combined approach aids in diagnosis of morphologically challenging cases with molar phenotype and in detecting androgenetic cell lines in mosaic/chimeric conceptions. Hum. Pathol. 2008, 39:63-72.
6. Jacobs P.A., Wilson C.M., Sprenkle J.A., Rosenshein N.B., Migeon B.R. Mechanism of origin of complete hydatidiform moles. Nature 1980, 286:714-716.
7. Kajii T., Ohama K. Androgenetic origin of hydatidiform mole. Nature 1977, 268:633-634.
8. Kovacs B.W., Shahbahrami B., Tast D.E., Curtin J.P. Molecular genetic analysis of complete hydatidiform moles. Cancer Genet. Cytogenet. 1991, 54:143-152.
9. Lawler S.D., Fisher R.A., Dent J. A prospective genetic study of complete and partial hydatidiform moles. Am. J. Obstet. Gynecol. 1991, 164:1270-1277.
10. Lawler S.D., Povey S., Fisher R.A., Pickthall V.J. Genetic studies on hydatidiform moles II. The origin of complete moles. Ann. Hum. Genet. 1982, 46:209-222.
11. McConnell T.G., Murphy K.M., Hafez M., Vang R., Ronnett B.M. Diagnosis and subclassification of hydatidiform moles using p57 immunohistochemistry and molecular genotyping: validation and prospective analysis in routine and consultation practice settings with development of an algorithmic approach. Am. J. Surg. Pathol. 2009, 33:805-817.
12. Mutter G.L., Pomponio R.J., Berkowitz R.S., Genest D.R. Sex chromosome composition of complete hydatidiform moles: relationship to metastasis. Am. J. Obstet. Gynecol. 1993, 168:1547-1551.
13. Surti U., Hoffner L., Kolthoff M., Dunn J., Hunt J., Sniezek L., Macpherson T. Persistent gestational trophoblastic disease after an androgenetic/biparental fetal chimera: a case report and review. Int. J. Gynecol. Pathol. 2006, 25:366-372.
14. Surti U., Szulman A.E., O'Brien S. Complete (classic) hydatidiform mole with 46 XY karyotype of paternal origin. Hum. Genet. 1979, 51:153-155.
15. Wake N., Takagi N., Sasaki M. Androgenesis as a cause of hydatidiform mole. J. Natl. Cancer Inst. 1978, 60:51-57.