MxA: A biomarker for predicting multiple sclerosis disease activity

Neurology

Volumn 75, Issue 14, 2010, Pages 1222-1223

  Reder, Anthony T ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CASPASE; GADOLINIUM; GLATIRAMER; HEMOGLOBIN A1C; INTERFERON REGULATORY FACTOR; MESSENGER RNA; MYXOVIRUS RESISTANCE PROTEIN A; STAT1 PROTEIN; BIOLOGICAL MARKER; GUANINE NUCLEOTIDE BINDING PROTEIN; MYXOVIRUS RESISTANCE PROTEINS;

CELL PROLIFERATION; COGNITION; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE COURSE; DISEASE EXACERBATION; DISEASE RESISTANCE; DNA TRANSCRIPTION; EDITORIAL; GLUCOSE BLOOD LEVEL; HAZARD RATIO; HOST RESISTANCE; HUMAN; INFLUENZA; MULTIPLE SCLEROSIS; MYELOOPTIC NEUROPATHY; NEUROPROTECTION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN INDUCTION; REMISSION; SINGLE NUCLEOTIDE POLYMORPHISM; SJOEGREN SYNDROME; TH1 CELL; TH2 CELL; GENETICS; METABOLISM; NOTE;

BIOLOGICAL MARKERS; GTP-BINDING PROTEINS; HUMANS; MULTIPLE SCLEROSIS;

EID: 77958195780     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3181f6466f     Document Type: Editorial

References (9)

1. Yamaguchi KD, Ruderman DL, Croze E, et al. IFN-regulated genes are abnormally expressedin therapy-naive MS mononuclear cells: unbiased gene expression analysis parallels literature on signaling pathways. J Neuroimmunol 2008;195:116-120.
2. Van der Voort LF, Vennegoor A, Visser A, et al. Spontaneous MxA mRNA level predicts relapses in patients with recently diagnosed MS. Neurology 2010;75:1228-1233.
3. Dettke M, Scheidt P, Prange H, Kirchner H. Correlation between interferon production and clinical disease activity in patients with multiple sclerosis. J Clin Immunol 1997; 17:293-299.
4. Baranzini SE, Mousavi P, Rio J, et al. Transcription-based prediction of response to IFN-using supervised computational methods. PLoS Biol 2005;3:0166-0176.
5. Axtell RC, de Jong BA, Boniface K, et al. T helper type 1 and 17 cells determine efficacy of interferon-in multiple sclerosis and experimental encephalomyelitis. Nat Med 2010;16:406-413.
6. Feng X, Petraglia AL, Chen M, Byskosh PV, Boos MD, Reder AT. Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1. J Neuroimmunol 2002;129:105- 115.
7. Reder AT, Velichko S, Yamaguchi KD, et al. Interferon-1b induces transient and variable gene expression in relapsing-remitting multiple sclerosis patients, independent of neutralizing antibodies or changes in IFN receptor RNA expression. J Interferon Cytokine Res 2008;28:317-331.
8. Hesse D, Sellebjerg F, Sorensen PS. Absence of MxA induction by interferon beta in patients with MS reflects complete loss of bioactivity. Neurology 2009;73:372-377.
9. Comabella M, Lunemann JD, Rio J, et al. A type I interferon signature in monocytes is associated with poor response to interferon-beta in multiple sclerosis. Brain 2009; 132:3353-3365.