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Volumn 46, Issue 7, 2010, Pages 451-461

Ofatumumab in the treatment of chronic lymphocytic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; BENDAMUSTINE; CD20 ANTIGEN; CETIRIZINE; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; FLUDARABINE; GLUCOCORTICOID; LENALIDOMIDE; OFATUMUMAB; PARACETAMOL; PENTOSTATIN; PREDNISOLONE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RITUXIMAB;

EID: 77958193889     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2010.46.71497416     Document Type: Review
Times cited : (4)

References (47)
  • 3
    • 36048931110 scopus 로고    scopus 로고
    • Recent progress in the management of chronic lymphocytic leukemia
    • DOI 10.1016/j.ctrv.2007.08.003, PII S0305737207001181
    • Robak, T. Recent progress in the management of chronic lymphocytic leukemia. Canc Treat Rev 2007, 33(8): 710-28. (Pubitemid 350089291)
    • (2007) Cancer Treatment Reviews , vol.33 , Issue.8 , pp. 710-728
    • Robak, T.1
  • 4
    • 77953677610 scopus 로고    scopus 로고
    • Ofatumumab
    • Zhang, B. Ofatumumab. MABs 2009, 1(4): 326-31.
    • (2009) MABs , vol.1 , Issue.4 , pp. 326-331
    • Zhang, B.1
  • 6
    • 73649125004 scopus 로고    scopus 로고
    • Ofatumumab approved for advanced CLL
    • Traynor, K. Ofatumumab approved for advanced CLL. Am J Health Syst Pharm 2009, 66(23): 2062.
    • (2009) Am J Health Syst Pharm , vol.66 , Issue.23 , pp. 2062
    • Traynor, K.1
  • 8
    • 67649272030 scopus 로고    scopus 로고
    • Ofatumumab (HuMax-CD20), a novel CD20 monoclonal antibody, is an active treatment for patients with CLL refractory to both fludarabine and alemtuzumab or bulky fludarabine-refractory disease: Results from the planned interim analysis of an international pivotal trial
    • Abst 328 [50th Annu Meet Am Soc Hematol (Dec 6-9, San Francisco) 2008
    • Osterborg, A., Kipps, T., Mayer, J. et al. Ofatumumab (HuMax-CD20), a novel CD20 monoclonal antibody, is an active treatment for patients with CLL refractory to both fludarabine and alemtuzumab or bulky fludarabine-refractory disease: Results from the planned interim analysis of an international pivotal trial. Blood 2008, 112(11): Abst 328 [50th Annu Meet Am Soc Hematol (Dec 6-9, San Francisco) 2008).
    • (2008) Blood , vol.112 , Issue.11
    • Osterborg, A.1    Kipps, T.2    Mayer, J.3
  • 9
    • 0021203714 scopus 로고
    • B cell origin of non-T cell acute lymphoblastic leukemia. A model for discrete stages of neoplastic and normal pre-B cell differentiation
    • Nadler, L.M., Korsmeyer, S.J., Anderson, K.C. et al. B cell origin of non-T cell acute lymphoblastic leukemia. A model for discrete stages of neoplastic and normal pre-B cell differentiation. J Clin Invest 1984, 74(2): 332-40.
    • (1984) J Clin Invest , vol.74 , Issue.2 , pp. 332-340
    • Nadler, L.M.1    Korsmeyer, S.J.2    Anderson, K.C.3
  • 10
    • 0018949401 scopus 로고
    • Characterization of a human B lymphocyte-specific antigen
    • Stashenko, P., Nadler, L.M., Hardy, R., Schlossman, S.F. Characterization of a human B lymphocyte-specific antigen. J Immunol 1980, 125(4): 1678-85.
    • (1980) J Immunol , vol.125 , Issue.4 , pp. 1678-1685
    • Stashenko, P.1    Nadler, L.M.2    Hardy, R.3    Schlossman, S.F.4
  • 12
    • 77950326933 scopus 로고    scopus 로고
    • CD20-targeted therapy: The next generation of antibodies
    • van Meerten, T., Hagenbeek, A. CD20-targeted therapy: The next generation of antibodies. Semin Hematol 2010, 47(2): 199-210.
    • (2010) Semin Hematol , vol.47 , Issue.2 , pp. 199-210
    • Van Meerten, T.1    Hagenbeek, A.2
  • 13
    • 0034857069 scopus 로고    scopus 로고
    • Higher levels of surface CD20 expression on circulating lymphocytes compared with bone marrow and lymph nodes in B-cell chronic lymphocytic leukemia
    • DOI 10.1309/438N-E0FH-A5PR-XCAC
    • Huh, Y.O., Keating, M.J., Saffer, H.L., Jilani, I., Lerner, S., Albitar, M. Higher levels of surface CD20 expression on circulating lymphocytes compared with bone marrow and lymph nodes in B-cell chronic lymphocytic leukemia. Am J Clin Pathol 2001, 116(3): 437-43. (Pubitemid 32851978)
    • (2001) American Journal of Clinical Pathology , vol.116 , Issue.3 , pp. 437-443
    • Huh, Y.O.1    Keating, M.J.2    Saffer, H.L.3    Jilani, I.4    Lerner, S.5    Albitar, M.6
  • 15
    • 40349114506 scopus 로고    scopus 로고
    • FDA drug approval summary: Alemtuzumab as single-agent treatment for B-cell chronic lymphocytic leukemia
    • DOI 10.1634/theoncologist.2007-0218
    • Demko, S., Summers, J., Keegan, P., Pazdur, R. FDA drug approval summary: Alemtuzumab as single-agent treatment for B-cell chronic lymphocytic leukemia. Oncologist 2008, 13(2):167-174. (Pubitemid 351342581)
    • (2008) Oncologist , vol.13 , Issue.2 , pp. 167-174
    • Demko, S.1    Summers, J.2    Keegan, P.3    Pazdur, R.4
  • 17
    • 76949091824 scopus 로고    scopus 로고
    • First-line treatment with fludarabine, cyclophosphamide, and rituximab improves overall survival in previously untreated patients with advanced chronic lymphocytic leukemia: Results of a randomized phase III trial on behalf of an international group of investigators and the German CLL study group
    • Abst 535 [51st Annu Meet Am Soc Hematol (Dec 5-8, New Orleans) 2009]
    • Hallek, M., Fingerle-Rowson, G., Fink, A. et al. First-line treatment with fludarabine, cyclophosphamide, and rituximab improves overall survival in previously untreated patients with advanced chronic lymphocytic leukemia: Results of a randomized phase III trial on behalf of an international group of investigators and the German CLL study group. Blood 2009, 114(22): Abst 535 [51st Annu Meet Am Soc Hematol (Dec 5-8, New Orleans) 2009].
    • (2009) Blood , vol.114 , Issue.22
    • Hallek, M.1    Fingerle-Rowson, G.2    Fink, A.3
  • 18
    • 4444343395 scopus 로고    scopus 로고
    • Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas
    • Teeling, J.L., French, R.R., Cragg, M.S. et al. Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas. Blood 2004, 104(6): 1793-1800.
    • (2004) Blood , vol.104 , Issue.6 , pp. 1793-1800
    • Teeling, J.L.1    French, R.R.2    Cragg, M.S.3
  • 19
    • 44849134493 scopus 로고    scopus 로고
    • Ofatumumab, a human monoclonal antibody for lymphoid malignancies and autoimmune disorders
    • Robak, T. Ofatumumab, a human monoclonal antibody for lymphoid malignancies and autoimmune disorders. Curr Opin Mol Ther 2008, 10(3): 294-309.
    • (2008) Curr Opin Mol Ther , vol.10 , Issue.3 , pp. 294-309
    • Robak, T.1
  • 21
    • 77958192391 scopus 로고    scopus 로고
    • WO-2004035607: Medarex Inc; Genmab A/S WORLD PATENT April 29
    • WO-2004035607: Human monoclonal antibodies against CD20. Medarex Inc; Genmab A/S WORLD PATENT 2004 April 29.
    • (2004) Human Monoclonal Antibodies Against CD20
  • 22
    • 47049124865 scopus 로고    scopus 로고
    • First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: Results of a phase 1/2 trial
    • Hagenbeek, A., Gadeberg, O., Johnson, P. et al. First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: results of a phase 1/2 trial. Blood 2008, 111(12): 5486-95.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5486-5495
    • Hagenbeek, A.1    Gadeberg, O.2    Johnson, P.3
  • 23
    • 77958158159 scopus 로고    scopus 로고
    • Research Triangle Park, NC: GlaxoSmithKline
    • ARZERRA (ofatumumab) [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2009.
    • (2009) ARZERRA (Ofatumumab) [Package Insert]
  • 24
    • 34547799828 scopus 로고    scopus 로고
    • Novel fully human CD20 antibodies with different mechanisms of action
    • Abst 349
    • Dechant, M., Teeling, J., Beyer, T. et al. Novel fully human CD20 antibodies with different mechanisms of action. Blood 2003, 102(11, Part 1): Abst 349.
    • (2003) Blood , vol.102 , Issue.11 PART 1
    • Dechant, M.1    Teeling, J.2    Beyer, T.3
  • 25
    • 84878708370 scopus 로고
    • In vivo characterization of HuMax-CD20, a novel fully human antibody targeting CD20
    • Abst G.10 [Jt Annu Meet German Dutch Soc Immunol (October 20-23, Maastricht) 2004]
    • Mackus, W.J.M., Teeling, J., Brakel, J. et al. In vivo characterization of HuMax-CD20, a novel fully human antibody targeting CD20. Immunobiology (1979) 2004, 209(4-6): Abst G.10 [Jt Annu Meet German Dutch Soc Immunol (October 20-23, Maastricht) 2004].
    • (1979) Immunobiology , vol.209 , Issue.4-6
    • Mackus, W.J.M.1    Teeling, J.2    Brakel, J.3
  • 26
    • 33745324686 scopus 로고    scopus 로고
    • The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20
    • Teeling, J.L., Mackus, W.J., Wiegman, L.J. et al. The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. J Immunol 2006, 177(1): 362-71.
    • (2006) J Immunol , vol.177 , Issue.1 , pp. 362-371
    • Teeling, J.L.1    Mackus, W.J.2    Wiegman, L.J.3
  • 27
    • 51349099954 scopus 로고    scopus 로고
    • Adequate synapse formation between leukemic B cells and effector T cells following stimulation with artificial TCR ligands
    • Mous, R., Savage, P., Eldering, E., Teeling, P., van Oers, M.H., van Lier, R.A. Adequate synapse formation between leukemic B cells and effector T cells following stimulation with artificial TCR ligands. Leuk Lymphoma 2008, 49(8): 1592-602.
    • (2008) Leuk Lymphoma , vol.49 , Issue.8 , pp. 1592-1602
    • Mous, R.1    Savage, P.2    Eldering, E.3    Teeling, P.4    Van Oers, M.H.5    Van Lier, R.A.6
  • 28
    • 38349138517 scopus 로고    scopus 로고
    • Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody
    • Bleeker, W.K., Munk, M.E., Mackus, W.J. et al. Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody. Brit J Haemat 2008, 140(3): 303-12.
    • (2008) Brit J Haemat , vol.140 , Issue.3 , pp. 303-312
    • Bleeker, W.K.1    Munk, M.E.2    Mackus, W.J.3
  • 29
    • 0029981025 scopus 로고    scopus 로고
    • National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment
    • Cheson, B.D., Bennett, J.M., Grever, M., Kay, N., Keating, M.J., O'Brien, S., Rai, K.R. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment. Blood 1996, 87(12): 4990-7. (Pubitemid 26189840)
    • (1996) Blood , vol.87 , Issue.12 , pp. 4990-4997
    • Cheson, B.D.1    Bennett, J.M.2    Grever, M.3    Kay, N.4    Keating, M.J.5    O'Brien, S.6    Rai, K.R.7
  • 31
    • 33745879850 scopus 로고    scopus 로고
    • HuMax CD20 fully human monoclonal antibody in chronic lymphocytic leukemia. Early results from an ongoing phase I/II clinical trial
    • Abst 448 [47th Annu Meet Am Soc Hematol (December 10-13, Atlanta) 2005]
    • Coiffier, B., Tilly, H., Pedersen, L. et al. HuMax CD20 fully human monoclonal antibody in chronic lymphocytic leukemia. Early results from an ongoing phase I/II clinical trial. Blood 2005, 106(11): Abst 448 [47th Annu Meet Am Soc Hematol (December 10-13, Atlanta) 2005].
    • (2005) Blood , vol.106 , Issue.11
    • Coiffier, B.1    Tilly, H.2    Pedersen, L.3
  • 32
    • 34547753160 scopus 로고    scopus 로고
    • Significant correlation between survival endpoints and exposure to ofatumumab (HuMax-CD20) in chronic lymphocytic leukemia
    • Abst 2842 [48th Annu Meet Am Soc Hematol (December 9-12, Orlando) 2006]
    • Coiffier, B., Tilly, H., Pedersen, L. et al. Significant correlation between survival endpoints and exposure to ofatumumab (HuMax-CD20) in chronic lymphocytic leukemia. Blood 2006, 108(11): Abst 2842 [48th Annu Meet Am Soc Hematol (December 9-12, Orlando) 2006].
    • (2006) Blood , vol.108 , Issue.11
    • Coiffier, B.1    Tilly, H.2    Pedersen, L.3
  • 33
    • 77950502126 scopus 로고    scopus 로고
    • Ofatumumab as single-agent CD20 immunotherapy in fludarablne-refractory chronic lymphocytic leukemia
    • Wierda, W.G., Kipps, T.J., Mayer, J. et al. Ofatumumab as single-agent CD20 immunotherapy in fludarablne-refractory chronic lymphocytic leukemia. J Clin Oncol 2010, 28(10): 1749-55.
    • (2010) J Clin Oncol , vol.28 , Issue.10 , pp. 1749-1755
    • Wierda, W.G.1    Kipps, T.J.2    Mayer, J.3
  • 34
    • 76149128849 scopus 로고    scopus 로고
    • Ofatumumab combined with fludarabine and cyclophosphamide shows high activity in patients with previously untreated chronic lymphocytic leukemia: Results from a randomized, multicenter, international, two-dose, parallel group, phase II trial
    • Abst 207 51st Annu Meet Am Soc Hematol (Nov New Orteans)
    • Wierda, W.G., Kipps, T.J., Durig, J. et al. Ofatumumab combined with fludarabine and cyclophosphamide shows high activity in patients with previously untreated chronic lymphocytic leukemia: Results from a randomized, multicenter, international, two-dose, parallel group, phase II trial. Blood 2009, 114: Abst 207 [51st Annu Meet Am Soc Hematol (Nov New Orteans).
    • (2009) Blood , vol.114
    • Wierda, W.G.1    Kipps, T.J.2    Durig, J.3
  • 45
    • 53649101010 scopus 로고    scopus 로고
    • Emerging therapeutics for rheumatoid arthritis
    • Bingham, C.O. 3rd. Emerging therapeutics for rheumatoid arthritis. Bull NYU Hosp Jt Dis 2008, 66(3): 210-5.
    • (2008) Bull NYU Hosp Jt Dis , vol.66 , Issue.3 , pp. 210-215
    • Bingham III, C.O.1
  • 46
    • 53649104652 scopus 로고    scopus 로고
    • Ofatumumab, a human CD20 monoclonal antibody, in the treatment of rheumatoid arthritis: Early results from an ongoing, double-blind, randomized, placebo controlled clinical trial
    • Abst 2086 [71st Annu Sci Meet Am Coll Rheumatol (November 6-11, Boston) 2007]
    • Ostergaard, M., Baslund, B., Rigby, W. et al. Ofatumumab, a human CD20 monoclonal antibody, in the treatment of rheumatoid arthritis: Early results from an ongoing, double-blind, randomized, placebo controlled clinical trial. Arthritis Rheum 2007, 56(9, Suppl.): Abst 2086 [71st Annu Sci Meet Am Coll Rheumatol (November 6-11, Boston) 2007].
    • (2007) Arthritis Rheum , vol.56 , Issue.9 SUPPL.
    • Ostergaard, M.1    Baslund, B.2    Rigby, W.3
  • 47
    • 67649368710 scopus 로고    scopus 로고
    • Ofatumumab, a second-generation anti-CD20 monoclonal antibody, for the treatment of lymphoproliferative and autoimmune disorders
    • Castillo, J., Milani, C., Mendez-Allwood, D. Ofatumumab, a second-generation anti-CD20 monoclonal antibody, for the treatment of lymphoproliferative and autoimmune disorders. Expert Opin Investig Drugs 2009, 18(4): 491-500.
    • (2009) Expert Opin Investig Drugs , vol.18 , Issue.4 , pp. 491-500
    • Castillo, J.1    Milani, C.2    Mendez-Allwood, D.3


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