Beta-adrenergic blockade and traumatic brain injury: Protective?

Journal of Trauma - Injury, Infection and Critical Care

Volumn 69, Issue 4, 2010, Pages 776-780

  Schroeppel, Thomas J ^a   Fischer, Peter E ^a   Zarzaur, Ben L ^a   Magnotti, Louis J ^a   Clement, L Paige ^a   Fabian, Timothy C ^a   Croce, Martin A ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Beta blocker; Traumatic brain injury

Indexed keywords

ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; ESMOLOL; LABETALOL; METOPROLOL; NADOLOL; PROPRANOLOL; SOTALOL;

ADULT; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BLOOD TRANSFUSION; BLUNT TRAUMA; CATECHOLAMINE RELEASE; DISEASE SEVERITY; FEMALE; GLASGOW COMA SCALE; HEAD INJURY; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; TRAUMATIC BRAIN INJURY;

ADRENERGIC BETA-ANTAGONISTS; ADULT; AGED; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; EMERGENCY MEDICAL SERVICES; FEMALE; GLASGOW COMA SCALE; HEAD INJURIES, CLOSED; HOSPITAL MORTALITY; HUMANS; INFUSIONS, INTRAVENOUS; INJURY SEVERITY SCORE; MALE; MIDDLE AGED; NEUROPROTECTIVE AGENTS; PROPORTIONAL HAZARDS MODELS; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; TENNESSEE; YOUNG ADULT;

EID: 77958176545     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e3181e981b8     Document Type: Article

References (41)

1. Langlois J, Rutland-Brown W, Wald M. The epidemiology and impactof traumatic brain injury: a brief overview. J Head Trauma Rehabil.2006;21: 375-378.
2. Shackford SR, Mackersie RC, HolBrook TL, et al. The epidemiology oftraumatic death: a population-based analysis. Arch Surg. 1993;128: 571-575.
3. Thurman D, Guerro J. Trends in hospitalization associated with traumaticbrain injury. JAMA. 1999;282: 954-957.
4. Acosta JA, Yang JC, Winchell RJ, et al. Lethal injuries and time to deathin a level I trauma center. J Am Coll Surg. 1998;186: 528-533.
5. Rossitch E Jr, Bullard DE. The autonomic dysfunction syndrome: aetiology and treatment. Br J Neurosurg. 1988;2: 471-478.
6. Hamill RW, Woolf PD, McDonald JV, Lee LA, Kelly M. Catecholaminespredict outcome in traumatic brain injury. Ann Neurol.1987;21: 438-443.
7. Woiciechowsky C, Asadullah K, Nestler D, et al. Sympathetic activationtriggers systemic interleukin-10 release in immunodepression inducedby brain injury. Nat Med. 1998;4: 808-813.
8. Clifton GL, Ziegler MG, Grossman RG. Circulating catecholamines andsympathetic activity after head injury. Neurosurgery. 1981;8: 10-14.
9. Freibel JH, Baldwin CA, Joynt RJ. Catecholamine-associated refractoryhypertension following acute intracranial hemorrhage: control with propranolol.Ann Neurol. 1981;9: 340-343.
10. Naredi S, Lambert G, Eden E, et al. Increased sympathetic nervousactivity in patients with nontraumatic subarachnoid hemorrhage. Stroke.2000;31: 901-906.
11. Inaba K, Teizeira P, David J, et al. Beta-blockers in isolated blunt headinjury. J Am Coll Surg. 2008;206: 432-438.
12. Cotton BA, Snodgrass KB, Fleming SB, et al. Beta-blocker exposure isassociated with improved survival after severe traumatic brain injury.J Trauma. 2007;62: 26-35.
13. Riordan WP Jr, Cotton BA, Norris PR, Waitman LR, Jenkins JM, MorrisJA Jr. Beta-blocker exposure in patients with severe traumatic braininjury (TBI) and cardiac uncoupling. J Trauma. 2007;63: 503-511.
14. Arbabi S, Campion EM, Hemmila MR, et al. Beta-blocker use isassociated with improved outcomes in adult trauma patients. J Trauma.2007;62: 56-62.
15. Woolf PD, Hamill RW, Lee LA, Cox C, McDonald JV. The predictivevalue of catecholamines in assessing outcome in traumatic brain injury.J Neurosurg. 1987;66: 875-882.
16. Hortnagl H, Hammerle AF, Hackl JM, Brücke T, Rumpl E, Hörtnagl H.The activity of sympathetic nervous system following severe headinjury. Intensive Care Med. 1980;6: 169-177.
17. Grunsfeld A, Fletcher JJ, Nathan BR. Cardiopulmonary complications ofbrain injury. Curr Neurol Neurosci Rep. 2005;5: 488-493.
18. Pollick C, Cujec B, Parker S, Tator C. Left ventricular wall motionabnormalities in subarachnoid hemorrhage: an echocardiographic study.J Am Coll Cardiol. 1988;12: 600-605.
19. Kono T, Morita H, Kuroiwa T, Onaka H, Takatsuka H, Fujiwara A. Leftventricular wall motion abnormalities in patients with subarachnoidhemorrhage: neurogenic stunned myocardium. J Am Coll Cardiol. 1994;24: 636-640.
20. Greenhoot JH, Reighenbach DD. Cardiac injury and subarachnoid hemorrhage: a clinical, pathological, and physiological correlation. J Neurosurg.1969;30: 521-531.
21. Connor RC. Myocardial damage secondary to brain lesions. Am Heart J.1969;78: 145-148.
22. McLeod AA, Neil-Dwyer G, Meyer CH, Richardson PL, Cruickshank J,Bartlett J. Cardiac sequelae of acute head injury. Br Heart J. 1982;47: 221-226.
23. Solenski NJ, Haley EC Jr, Kassell NF, et al. Medical complications ofaneurismal subarachnoid hemorrhage: a report of the multicenter, cooperativeaneurysm study. Participants of the Multicenter CooperativeAneurysm Study. Crit Care Med. 1995;23: 1007-1016.
24. Neil-Dwyer G, Walter P, Cruickshank JM, Doshi B, O'Gorman P. Effectof propranolol and phentolamine on myocardial necrosis after subarachnoidhaemorrhage. Br Med J. 1978;2: 990-992.
25. Elenkov IJ, Hasko G, Kovacs KJ, Vizi ES. Modulation of liposaccharide-induced tumor necrosis factor-alpha production by selective alphaand beta-adrenergic drugs in mice. J Neuroimmunol. 1995;61: 123-131.
26. Randell T, Tanskanen P, Scheinin M, Kyttä J, Ohman J, Lindgren L. QTdispersion after subarachnoid hemorrhage. J Neurosurg Anesthesiol.1999;11: 163-166.
27. Weir BK. Pulmonary edema following fatal aneursym rupture. J Neurosurg.1978;48: 502-507.
28. Mangano DT, Layug EL, Wallace A, Tateo I. Effect of atenolol onmortality and cardiovascular morbidity after noncardiac surgery. MulticenterStudy of Perioperative Ischemia Research Group. N Engl J Med.1996;335: 1713-1720.
29. Wallace A, Layug B, Tateo I, et al. Prophylactic atenolol reducespostoperative myocardial ischemia. McSPI Research Group. Anesthesiology.1998;88: 7-17.
30. Amory DW, Grigore A, Amory JK et al. Neuroprotection is associated withbeta-adrenergic receptor antagonists during cardiac surgery: evidence with2,575 patients. J Cardiothorac Vasc Anesth. 2002;16: 270-277.
31. Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR. Reversal ofcatabolism by beta-blockade after severe burns. N Engl J Med. 2001;345: 1223-1229.
32. Arbabi S, Ahrns KS, Wahl WL, et al. Beta-blocker use is associated withimproved outcomes in adult burn patients. J Trauma. 2004;56: 265-271.
33. Neil-Dwyer G, Bartlett J, McAinsh J, Cruickshank JM. Beta- adrenoceptorblockers and the blood-brain barrier. Br J Clin Pharmacol. 1981;11: 549-553.
34. Woolf PD, McDonald JV, Feliciano D, Kelly MM, Nichols D, Cox C.The catecholamine response to multisystem trauma. Arch Surg. 1992;127: 899-903.
35. Jaatela A, Alho A, Avikainen V, et al. Plasma catecholamines inseverely injured patients: a prospective study on 45 patients withmultiple injuries. Br J Surg. 1975;62: 177-181.
36. Fukuzawa M, Satoh J, Ohta S, et al. Modulation of tumor necrosisfactor-alpha production with anti-hypertensive drugs. Immunopharmacology.2000;48: 65-74.
37. Deng J, Muthu K, Gamelli R, Shankar R, Jones SB. Adrenergic modulationof splenic macrophage cytokine release in polymicrobial sepsis.Am J Physiol Cell Physiol. 2004;287: C730-CC.
38. Kalinchenko VV, Mokyr MB, Graf LH Jr, Cohen RL, Chambers DA.Norepinephrine-mediated inhibition of antitumor cytotoxic T lymphocytegeneration involves a beta-adrenergic receptor mechanism anddecreased TNF-alpha gene expression. J Immunol. 1999;163: 2492-2499.
39. Prass K, Meisel C, Hoflich C, et al. Stroke-induced immunodeficiencypromotes spontaneous bacterial infections and is mediated by sympatheticactivation reversal by post stroke T helper cell type 1-likeimmunostimulation. J Exp Med. 2003;298: 725-736.
40. Hawkings WE, Clower WH. Myocardial damage after head trauma andsimulated intracranial haemorrhage in mice: the role of the autonomicnervous system. Cardiovasc Res. 1971;5: 524-529.
41. Neil-Dwyer G, Walter P, Cruickshank JM. Beta-blockade benefits patientsfollowing a subarachnoid haemorrhage. Eur J Clin Pharmacol.1985;28: 25-29.