Role of metabolism in 1-bromopropane-induced hepatotoxicity in mice

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 73, Issue 21-22, 2010, Pages 1431-1440

  Lee, Sang Kyu ^a   Kang, Mi Jeong ^a   Jeon, Tae Won ^a   Ha, Hyun Woo ^a   Yoo, Jin Woo ^a   Ko, Gyu Sub ^a   Kang, Wonku ^a   Jeong, Hye Gwang ^b   Lyoo, Won Seok ^a   Jeong, Tae Cheon ^a  

^a Yeungnam University   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1 BROMOPROPANE; 2 HYDROXYPROPYLGLUTATHIONE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450; GLUTATHIONE; GLUTATHIONE DERIVATIVE; ORGANOBROMINE DERIVATIVE; PHENOBARBITAL; PROADIFEN; S PROPYLGLUTATHIONE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; 1-BROMOPROPANE; BROMINATED HYDROCARBON; CYTOCHROME P450 INHIBITOR; ENZYME INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; IN VIVO STUDY; LIVER METABOLISM; LIVER TOXICITY; MALE; METABOLIC ACTIVATION; METABOLITE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTON TRANSPORT; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INDUCTION; GERMFREE ANIMAL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER; METABOLISM; TOXICITY;

MUS;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME INHIBITORS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG-INDUCED LIVER INJURY; ENZYME INDUCTION; ENZYME INHIBITORS; GLUTATHIONE; HYDROCARBONS, BROMINATED; LIVER; MALE; MICE; MICE, INBRED ICR; PHENOBARBITAL; PROADIFEN; SPECIFIC PATHOGEN-FREE ORGANISMS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 77958174981     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287394.2010.511546     Document Type: Article

References (25)

1. Aniya, Y., Shimoji, M., and Naito, A. 1993. Increase in liver microsomal glutathione-S-transferase activity by phenobarbital treatment of rats. Possible involvement of oxidative activation via cytochrome P450. Biochem. Pharmacol. 46:1741-1747.
2. B'Hymer, C., and Cheever, K. L. 2004. Development of a gas chromatographic test for the quantification of the biomarker 3-bromopropionic acid in human urine. J. Chromatogr. B 802:361-366.
3. Barnsley, E. A, Grenby, T. H., and Young, L. 1966. Biochemical studies of toxic agents: the metabolism of 1-and 2-bromopropane in rats. Biochem. J. 100:282-288.
4. Boekelheide, K., Darney, S. P., Daston, G. P., David, R. M., Luderer, U., Olshan, A. F., Sanderson, W. T., Willhite, C. C., and Woskie S. 2004. NTP-CERHR expert panel report on the reproductive and developmental toxicity of 1-bromopropane. Reprod. Toxicol. 18:157-188.
5. Ellman, G. L. 1959. Tissue sulfhydryl group. Arch. Biochem. Biophys. 82:70-77.
6. Fromowicz, P., Brondeau, M. T., Bonnet, P., and de Ceaurriz, J. 1987. Effect of SKF525-A on the glutathione-conjugating enzyme system and on liver toxicity. Toxicol. Lett. 36:275-280.
7. Ghanayem, B. I., and Hoffler, U. 2007. Investigation of xenobiotics metabolism, genotoxicity, and carcinogenicity using Cyp2e1 (-/-) mice. Curr. Drug Metab. 8:728-749.
8. Han, E. H., Hwang, Y. P., Lee, K. J., Jeong, T. C., and Jeong, H. G. 2008. 1-Bromopropane induces macrophage activation via extracellular signal-regulated kinase 1/2 MAPK and NF-κB pathways. Cancer Lett. 262:28-36.
9. Hinchman, C. A., and Ballatori, N. 1994. Glutathione conjugation and conversion to mercapturic acids can occur as an intrahepatic process. J. Toxicol. Environ. Health 41:387-409.
10. Ichihara, G., Kitoh, J., Yu, X., Asaeda, N., Iwai, H., and Kumazawa, T. 2000. 1-Bromopropane, an alternative to ozone layerdepleting solvents, is dose-dependently neurotoxic to rats in long-term inhalation exposure. Toxicol. Sci. 55:116-123.
11. Jeong, T. C., Chang, H. W., Lee, E. S., Jeon, T. W., Jeong, H. G., and Holsapple, M. P. 2004. SKF 525-A induces cocaine N-demethylase, ethoxyresorufin O-deethylase, and pentoxyresorufin O-dealkylase activities by induction of cytochrome P-450 2B in female BALB/c mice. J. Toxicol. Environ. Health A 67:1955-1970.
12. Jones, A. R., and Walsh, D. A. 1979. The oxidative metabolism of 1-bromopropane in the rat. Xenobiotica 9:763-772.
13. Kim, D. O., Lee, S. K., Jeon, T. W., Jin, C. H., Hyun, S. H., Kim, E. J., Moon, G. I., Kim, J. A., Lee, E. S., Lee, B. M., Jeong, H. G., and Jeong, T. C. 2005. Role of metabolism in parathion-induced hepatotoxicty and immunotoxicity. J. Toxicol. Environ. Health A 68:2187-2205.
14. Låg, M., Søderlund, E. J., Omichinski, J. G., Brunborg, G., Holme, J. A., Dahl, J. E., Nelson, S. D., and Dybing, E. 1991. Effect of bromine and chlorine positioning in the induction of renal and testicular toxicity by halogenated propanes. Chem. Res. Toxicol. 4:528-534.
15. Lee, S. K., Jeon, T. W., Kim, Y. B., Lee, E. S., Jeong, H. G., and Jeong, T. C. 2007a. Role of glutathione conjugates in the hepatotoxicity and immunotoxicity induced by 1-bromopropane in female BALB/c mice. J. Appl. Toxicol. 27:358-367.
16. Lee, S. K., Jin, C. H., Hyun, S. H., Lee, D. W., Kim, G. H., Jeon, T. W., Lee, J., Kim, D. H., Jeong, H. G., Lee, E. S., and Jeong, T. C. 2005a. Identification of glutathione conjugates of 1, 2-dibromopropane in female BALB/c mice by liquid chromatographyelectrospray ionization tandem mass spectrometry. Xenobiotica 35:97-105.
17. Lee, S. K., Jo, S. W., Jeon, T. W., Jun, I. H., Jin, C. H., Kim, G. H., Lee, D. J. Kim, T. O., Lee, E. S., and Jeong, T. C. 2005b. Hepatotoxic effect of 1-bromopropane and its conjugation with glutathione in male ICR mice. Arch. Pharm. Res. 28:1177-1182.
18. Lee, S. K., Lee, D. J., Jeong, H., Bista, S. R., Kang, M. J., Lee, E. S., Son, J. K., Nam, D. H., Chang, H. W., Lee, S. H., Jahng, Y., and Jeong, T. C. 2007b. Hepatotoxic and immunotoxic effects produced by 1, 3-dibromopropane and its conjugation with glutathione in female BALB/c mice. J. Toxicol. Environ. Health A 70:1381-1390.
19. Lowry, O. H., Rosenbrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
20. Lubet, R. A., Yao, R., Grubbs, C. J., You, M., and Wang, Y. 2009. Induced expression of drug metabolizing enzymes by preventive agents: Role of the antioxidant response element. Chem. Biol. Interact. 182:22-28.
21. Ogata, A., Yoneyama, M., Sasaki, M., Suzuki, K., and Imamichi, T. 1987. Effects of pretreatment with SKF-525A or sodium phenobarbital on thiabendazole-induced teratogenicity in ICR mice. Food Chem. Toxicol. 25:119-124.
22. Tachizawa, H., MacDonald, T. L., and Neal, R. A. 1982. Rat liver microsomal metabolism of propyl halides. Mol. Pharmacol. 22:745-751.
23. Wang, H., Ichihara, G., Ito, H., Kato, K., Kitoh, J., Yamada, T., Yu, X., Tsuboi, S., Moriyama, Y., Sakatani, R., Shibata, E., Kamijima, M., Itohara, S., and Takeuchi, Y. 2002. Biochemical changes in the central nervous system of rats exposed to 1-bromopropane for seven days. Toxicol. Sci. 67:114-120.
24. Wang, H., Ichihara, G., Ito, H., Kato, K., Kitoh, J., Yamada, T., Yu, X., Tsuboi, S., Moriyama, Y., and Takeuchi, Y. 2003. Dose-dependent biochemical changes in rat central nervous system after 12-week exposure to 1-bromopropane. Neurotoxicology 24:199-206.
25. Yu, X., Ichihara, G., Kitoh, J., Xie, Z., Shibata, E., and Kamijima, M. 1998. Preliminary report on the neurotoxicity of 1-bromopropane, an alternative solvent for chlorofluorocarbons. J. Occup. Health 40:234-235.