Dose-dependent biochemical changes in rat central nervous system after 12-week exposure to 1-bromopropane

NeuroToxicology

Volumn 24, Issue 2, 2003, Pages 199-206

  Wang, Hailan ^a   Ichihara, Gaku ^a   Ito, Hidenori ^b   Kato, Kanefusa ^a   Kitoh, Junzoh ^a   Yamada, Tetsuya ^a   Yu, Xiaozhong ^a   Tsuboi, Seiji ^c   Moriyama, Yoshinori ^c   Takeuchi, Yasuhiro ^a,d  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b INSTITUTE FOR DEVELOPMENTAL RESEARCH   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Enolase; 1 Bromopropane; Creatine kinase; Glutathione; Sulfhydryl

Indexed keywords

1 BROMOPROPANE; ADHESIVE AGENT; CREATINE KINASE ISOENZYME; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEAT SHOCK PROTEIN 27; NEURON SPECIFIC ENOLASE; PROPANE; PROTEIN S100B; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BRAIN; BRAIN REGION; BRAIN STEM; BRAIN WEIGHT; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CLEANING; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; LONG TERM EXPOSURE; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; WORKPLACE;

ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; BRAIN; CENTRAL NERVOUS SYSTEM; CREATINE KINASE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HYDROCARBONS, BROMINATED; IMMUNOASSAY; MALE; NERVE TISSUE PROTEINS; ORGAN SIZE; OXIDATION-REDUCTION; PROTEIN BINDING; RATS; RATS, WISTAR; SOLVENTS; SPINAL CORD; SULFHYDRYL COMPOUNDS;

RATTUS NORVEGICUS;

EID: 0037334985     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-813X(02)00195-X     Document Type: Article

References (28)

1. Antti-Poika M. Toluene. In: Snyder S, editor. Ethel Browning's toxicitytpandtp metabolism of industrial solvents. Amsterdam: Elsevier; 1987. p. 38-63.
2. Barnsley EA, Grenby TH, Young L. Biochemical studies of toxic agents. The metabolism of 1- and 2-bromopropane in rats. Biochem J 1966;100:282-8.
3. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
4. Bruckner JV, Peterson RG. Evaluation of toluene and acetone inhalant abuse. II. Model development and toxicology. Toxicol Appl Pharmacol 1981;61:302-12.
5. Habeeb FSA. Reaction of protein sulfhydryl groups with Ellman's reagent. Methods Enzymol 1972;25:457-64.
6. Huang J, Asaeda N, Takeuchi Y, Shibata E, Hisanaga N, Ono Y, et al. Dose-dependent effects of chronic exposure to toluene on neuronal and glial cell marker proteins in the central nervous system of rats. Br J Ind Med 1992;49:282-6.
7. Huang J, Kato K, Shibata E, Hisanaga N, Ono Y, Takeuchi Y. Effects of subacute toluene exposure on neuronal and glial marker proteins in rat brain. Toxicology 1990;61:109-17.
8. Ichihara G, Asaeda N, Kumazawa T, Tagawa Y, Kamijima M, Yu X, et al. Testicular and hematopoietic toxicity of 2-bromopropane, a substitute for ozone layer-depleting chorofluorocarbons. J Occup Health 1997;39:57-63.
9. Ichihara G, Kitoh J, Yu X, Asaeda N, Iwai H, Kumazawa T, et al. 1-Bromopropane, an alternative to ozone layer-depleting solvents, is dose-dependently neurotoxic to rats in long-term inhalation exposure. Toxicol Sci 2000;55:116-23.
10. Ichihara G, Miller KJ, Ziolkowska A, Itohara S, Tateuthi Y. Neurological disorders in three workers exposed to 1-bromopropane. J Occup Health 2002;44:1-7.
11. Ito H, Okamoto K, Kato K. Enhancement of expression of stress proteins by agents that lower the levels of glutathione in cells. Biochim Biophys Acta 1998;1397:223-30.
12. Jones AR, Walsh DA. The oxidative metabolism of 1-bromopropane in the rat. Xenobiotica 1979;9:763-72.
13. Kato K, Katoh-Semba R, Takeuchi IK, Ito H, Kamei K. Responses of heat shock proteins Hsp27, alphaB-crystallin, and Hsp70 in rat brain after kainic acid-induced seizure activity. J Neurochem 1999;73:229-36.
14. Kato K, Nakajima T, Ishiguro Y, Matsutani T. Sensitive enzyme immunoassay for S-100 protein: determination in human cerebrospinal fluid. Biomed Res 1982;3:24-8.
15. Kato K, Suzuki F, Shimizu A, Shinohara H, Semba R. Highly sensitive immunoassay for rat brain-type creatine kinase: determination in isolated Purkinje cells. J Neurochem 1986;46:1783-8.
16. Kato K, Suzuki F, Umeda Y. Highly sensitive immunoassays for three forms of rat brain enolase. J Neurochem 1981;36:793-7.
17. Ladefoged O, Strange P, Moller A, Lam HR, Ostergaard G, Larsen JJ, et al. Irreversible effects in rats of toluene (inhalation) exposure for 6 months. Pharmacol Toxicol 1991;68:384-90.
18. Matsumoto S, Tashigawara M, Tsuboi S, Ohmori S. Determination of glutathione and glutathione disulfide in biological samples using acrylonitrile as a thiol-blocking reagent. Anal Sci 1996;12:91-5.
19. Ron MA. Volatile substance abuse: a review of possible long-term neurological, intellectual and psychiatric sequelae. Br J Psychiatry 1986;148:235-46.
20. Sclar G. Encephalomyeloradiculoneuropathy following exposure to an industrial solvent. Clin Neurol Neurosurg 1999;101:199-202.
21. Shukla GS, Srivastava RS, Chandra SV. Glutathione status and cadmium neurotoxicity: studies in discrete brain regions of growing rats. Fundam Appl Toxicol 1988;11:229-35.
22. Sohn YK, Suh JS, Kim JW, Seo HH, Kim JY, Kim HY, et al. A histopathologic study of the nervous system after inhalation exposure of 1-bromopropane in rat. Toxicol Lett 2002;131:195-201.
23. Takeuchi Y, Huang J, Shibata E, Hisanaka N, Ono Y. A trail to automate an organic solvent exposure system for small animals. Jpn J Ind Health 1989;31:722(Japanese).
24. Trenge CA, Kunkel DD, Eaton DL, Costa LG. Effect of stryrene oxide on rat brain glutathione. Neurotoxicology 1991;12:165-78.
25. Wang H, Ichihara G, Ito H, Kato K, Kitoh J, Yamada T, et al. Biochemical changes in the central nervous system of rats exposed to 1-bromopropane for 7 days. Toxicol Sci 2002;67:114-20.
26. Wyss M, Smeitink J, Wevers RA, Wallimann T. Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism. Biochim Biophys Acta 1992;102:119-66.
27. Yu X, Ichihara G, Kitoh J, Xie Z, Shibata E, Kamijima M, et al. Preliminary report on the neurotoxicity of 1-bromopropane, an alternative solvent for chlorofluorocarbons. J Occup Health 1998;40:234-5.
28. Zhou HM, Tsou CL. The presence of reactive SH groups in the enzymatically active dicyano derivative of creatine kinase. Biochim Biophys Acta 1987;911:136-43.