Challenges and prospects of adoptive immunotherapy in prevention and treatment of opportunistic mycoses in hematologic transplant recipients

Current Infectious Disease Reports

Volumn 12, Issue 6, 2010, Pages 444-449

  Tramsen, Lars ^a   Schmidt, Stanislaw ^a   Roeger, Frauke ^a   Koehl, Ulrike ^a   Lehrnbecher, Thomas ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Adoptive immunotherapy; Allogeneic hematopoietic stem cell transplantation; Aspergillus; Candida; Invasive fungal infection; Natural killer cell; Prevention; T lymphocyte; T H1 cell; Therapy; Zygomycetes

Indexed keywords

GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ADAPTIVE IMMUNITY; ADOPTIVE IMMUNOTHERAPY; ADOPTIVE TRANSFER; ASPERGILLUS; CANDIDA; CELLULAR IMMUNITY; CLINICAL TRIAL; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; MYCOSIS; NATURAL KILLER CELL; OPPORTUNISTIC INFECTION; REVIEW; SYSTEMIC MYCOSIS; TH1 CELL;

EID: 77958170661     PISSN: 15233847     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11908-010-0130-3     Document Type: Review

References (35)

1. D Neofytos D Horn E Anaissie, et al. 2009 Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry Clin Infect Dis 48 265 273 1:CAS:528:DC%2BD1MXivVSlsLY%3D 10.1086/595846 19115967 This article reports one of the few larger studies on epidemiology and outcome of invasive fungal infections in transplant recipients
2. B De Pauw TJ Walsh JP Donnelly, et al. 2008 Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group Clin Infect Dis 46 1813 1821 10.1086/588660 18462102 This article presents the revised definitions of invasive fungal infections used in all major clinical trials
3. L Pagano M Caira A Nosari, et al. 2007 Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study-Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne Clin Infect Dis 45 1161 1170 1:STN:280:DC%2BD2srpsFylsQ%3D%3D 10.1086/522189 17918077 (Pubitemid 47580314)
4. D Caillot A Thiebaut R Herbrecht, et al. 2007 Liposomal amphotericin B in combination with caspofungin for invasive aspergillosis in patients with hematologic malignancies: a randomized pilot study (Combistrat trial) Cancer 110 2740 2746 1:CAS:528:DC%2BD1cXitVOgsw%3D%3D 10.1002/cncr.23109 17941026 (Pubitemid 350250344)
5. OA Cornely J Maertens M Bresnik, et al. 2007 Liposomal amphotericin B as initial therapy for invasive mold infection: a randomized trial comparing a high-loading dose regimen with standard dosing (AmBiLoad trial) Clin Infect Dis 44 1289 1297 1:CAS:528:DC%2BD2sXmtFegtro%3D 10.1086/514341 17443465 This randomized study evaluates the benefit of high-dose liposomal amphotericin B (Pubitemid 46717290)
6. E Roilides CA Lyman P Panagopoulou S Chanock 2003 Immunomodulation of invasive fungal infections Infect Dis Clin North Am 17 193 219 10.1016/S0891-5520(02)00070-3 12751266 (Pubitemid 36514576)
7. A Safdar GH Rodriguez B Lichtiger, et al. 2006 Recombinant interferon gamma1b immune enhancement in 20 patients with hematologic malignancies and systemic opportunistic infections treated with donor granulocyte transfusions Cancer 106 2664 2671 1:CAS:528:DC%2BD28Xms1Sit7w%3D 10.1002/cncr.21929 16691620
8. DW Denning 1998 Invasive aspergillosis Clin Infect Dis 26 781 803 1:STN:280:DyaK1c3isFKnsA%3D%3D 10.1086/513943 9564455 quiz 804-785
9. A Wald W Leisenring JA van Burik RA Bowden 1997 Epidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantation J Infect Dis 175 1459 1466 1:STN:280:DyaK2szitl2qsw%3D%3D 10.1086/516480 9180187
10. O Beck U Koehl L Tramsen, et al. 2008 Enumeration of functionally active anti-Aspergillus T-cells in human peripheral blood J Immunol Methods 335 41 45 1:CAS:528:DC%2BD1cXlvFyitr0%3D 10.1016/j.jim.2008.02.014 18395221
11. E Cenci A Mencacci A Bacci, et al. 2000 T cell vaccination in mice with invasive pulmonary aspergillosis J Immunol 165 381 388 1:CAS:528: DC%2BD3cXksVKltrk%3D 10861075
12. H Hebart C Bollinger P Fisch, et al. 2002 Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematologic malignancies Blood 100 4521 4528 1:CAS:528:DC%2BD38XpsFCqsbY%3D 10.1182/blood-2002-01-0265 12393638 (Pubitemid 35429693)
13. H Einsele E Roosnek N Rufer, et al. 2002 Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy Blood 99 3916 3922 1:CAS:528:DC%2BD38XktFyrsrk%3D 10.1182/blood.V99.11.3916 12010789 (Pubitemid 35332029)
14. T Feuchtinger S Matthes-Martin C Richard, et al. 2006 Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation Br J Haematol 134 64 76 10.1111/j.1365-2141.2006.06108.x 16803570 (Pubitemid 43830030)
15. HJ Wagner YC Cheng MH Huls, et al. 2004 Prompt versus preemptive intervention for EBV lymphoproliferative disease Blood 103 3979 3981 1:CAS:528:DC%2BD2cXjvF2hs7w%3D 10.1182/blood-2003-12-4287 14751931 (Pubitemid 38596322)
16. O Beck MS Topp U Koehl, et al. 2006 Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus Blood 107 2562 2569 1:CAS:528:DC%2BD28XisFOisr8%3D 10.1182/blood-2005-04-1660 16322466 (Pubitemid 43345583)
17. L Tramsen O Beck FR Schuster, et al. 2007 Generation and characterization of anti-Candida T cells as potential immunotherapy in patients with Candida infection after allogeneic hematopoietic stem-cell transplant J Infect Dis 196 485 492 1:CAS:528:DC%2BD2sXpt1Glu7w%3D 10.1086/519389 17597464 (Pubitemid 47093900)
18. V Appay JJ Zaunders L Papagno, et al. 2002 Characterization of CD4(+) CTLs ex vivo J Immunol 168 5954 5958 1:CAS:528:DC%2BD38XktFCrtbs%3D 12023402
19. G Ramadan S Konings VP Kurup CA Keever-Taylor 2004 Generation of Aspergillus- and CMV- specific T-cell responses using autologous fast DC Cytotherapy 6 223 234 1:STN:280:DC%2BD2czjtFymsA%3D%3D 10.1080/14653240410006040 15203979 (Pubitemid 38868095)
20. L Tramsen U Koehl T Tonn, et al. 2009 Clinical-scale generation of human anti-Aspergillus T cells for adoptive immunotherapy Bone Marrow Transplant 43 13 19 1:CAS:528:DC%2BD1MXlvFOitA%3D%3D 10.1038/bmt.2008.271 18762764 This paper describes for the first time a method for the clinical-scale generation of antifungal T cells
21. JP Latge 1999 Aspergillus fumigatus and aspergillosis Clin Microbiol Rev 12 310 350 1:STN:280:DyaK1M3ht1Smsw%3D%3D 10194462
22. S Bozza C Clavaud G Giovannini, et al. 2009 Immune sensing of Aspergillus fumigatus proteins, glycolipids, and polysaccharides and the impact on Th immunity and vaccination J Immunol 183 2407 2014 1:CAS:528:DC%2BD1MXpsVKgt7s%3D 10.4049/jimmunol.0900961 19625642 This study analyzes the cellular host response to various recombinant Aspergillus antigens
23. PJ Hanley CR Cruz B Savoldo, et al. 2009 Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes Blood 114 1958 1967 1:CAS:528:DC%2BD1MXhtFWgtr7K 10.1182/blood-2009-03- 213256 19443656
24. Y Sun I Tawara T Toubai P Reddy 2007 Pathophysiology of acute graft-versus-host disease: recent advances Transl Res 150 197 214 1:CAS:528:DC%2BD2sXhtFWhtr%2FE 10.1016/j.trsl.2007.06.003 17900507 (Pubitemid 47444613)
25. G Rauser H Einsele C Sinzger, et al. 2004 Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants Blood 103 3565 3572 1:CAS:528: DC%2BD2cXjslKgtLc%3D 10.1182/blood-2003-09-3056 14670917 (Pubitemid 38525695)
26. K Perruccio A Tosti E Burchielli, et al. 2005 Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation Blood 106 4397 4406 1:CAS:528:DC%2BD2MXhtlaltrjE 10.1182/blood-2005-05-1775 16123217 (Pubitemid 41775954)
27. AM Leen A Christin GD Myers, et al. 2009 Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation Blood 114 4283 4292 1:CAS:528:DC%2BD1MXhsVGku7nN 10.1182/blood-2009-07-232454 19700662
28. + Hodgkin's disease J Exp Med 200 1623 1633 1:CAS:528:DC%2BD2cXhtFGmurbI 10.1084/jem.20040890 15611290 (Pubitemid 40094186)
29. P Tiberghien C Ferrand B Lioure, et al. 2001 Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft Blood 97 63 72 1:CAS:528:DC%2BD3MXis1eqtw%3D%3D 10.1182/blood.V97.1.63 11133743 (Pubitemid 32061243)
30. JR Passweg U Koehl L Uharek, et al. 2006 Natural-killer-cell-based treatment in haematopoietic stem-cell transplantation Best Pract Res Clin Haematol 19 811 824 1:CAS:528:DC%2BD28XpvFegs74%3D 10.1016/j.beha.2006.06.004 16997185 (Pubitemid 44424290)
31. S Gill JA Olson RS Negrin 2009 Natural killer cells in allogeneic transplantation: effect on engraftment, graft- versus-tumor, and graft-versus-host responses Biol Blood Marrow Transplant 15 765 776 1:CAS:528:DC%2BD1MXos1Ojt7c%3D 10.1016/j.bbmt.2009.01.019 19539207
32. L Ruggeri A Mancusi M Capanni, et al. 2007 Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value Blood 110 433 440 1:CAS:528:DC%2BD2sXnsVait7c%3D 10.1182/blood-2006-07-038687 17371948 (Pubitemid 47026866)
33. KC Newman EM Riley 2007 Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens Nat Rev Immunol 7 279 291 1:CAS:528:DC%2BD2sXjtlyhuro%3D 10.1038/nri2057 17380157 (Pubitemid 46480956)
34. BE Morrison SJ Park JM Mooney B Mehrad 2003 Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis J Clin Invest 112 1862 1870 1:CAS:528:DC%2BD3sXhtVSmtLvE 14679181
35. SJ Park MA Hughes M Burdick, et al. 2009 Early NK cell-derived IFN-{gamma} is essential to host defense in neutropenic invasive aspergillosis J Immunol 182 4306 4312 1:CAS:528:DC%2BD1MXjsVSjurs%3D 10.4049/jimmunol.0803462 19299730