Differential responses to sympathetic stimulation in the cerebral and brachial circulations during rhythmic handgrip exercise in humans

Experimental Physiology

Volumn 95, Issue 11, 2010, Pages 1089-1097

  Hartwich, Doreen ^a   Fowler, Katherine L ^a   Wynn, Laura J ^a   Fisher, James P ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC STIMULATION; ADULT; ARTERY BLOOD FLOW; ARTICLE; BLOOD FLOW VELOCITY; BLOOD VESSEL REACTIVITY; BRACHIAL ARTERY; BRAIN BLOOD FLOW; BRAIN CIRCULATION; BREATH ANALYSIS; CARBON DIOXIDE TENSION; COLD PRESSOR TEST; DOPPLER ECHOGRAPHY; EXERCISE; EXERCISE INTENSITY; FEMALE; FOREARM BLOOD FLOW; HAND GRIP; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY; NORMAL HUMAN;

EID: 77958157076     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2010.054387     Document Type: Article

References (61)

1. 2 and sympathetic stimulation in the cerebral and femoral circulations in humans. J Physiol 566, 613-624.
2. Ainslie PN & Tzeng YC (2010). On the regulation of the blood supply to the brain: old age concepts and new age ideas. J Appl Physiol 108, 1447-1449.
3. Auer LM, Edvinsson L & Johansson BB (1983). Effect of sympathetic nerve stimulation and adrenoceptor blockade on pial arterial and venous calibre and on intracranial pressure in the cat. Acta Physiol Scand 119, 213-217.
4. Bogert LW & Van Lieshout JJ (2005). Non-invasive pulsatile arterial pressure and stroke volume changes from the human finger. Exp Physiol 90, 437-446.
5. Borg GA (1998). Borg's Perceived Exertion and Pain Scales. Human Kinetics, Champaign, IL
6. Brassard P, Seifert T & Secher NH (2009). Is cerebral oxygenation negatively affected by infusion of norepinephrine in healthy subjects? Br J Anaesth 102, 800-805.
7. Brassard P, Seifert T, Wissenberg M, Jensen PM, Hansen CK & Secher NH (2010). Phenylephrine decreases frontal lobe oxygenation at rest but not during moderately intense exercise. J Appl Physiol 108, 1472-1478.
8. Davis SL, Fadel PJ, Cui J, Thomas GD & Crandall CG (2006). Skin blood flow influences near-infrared spectroscopy-derived measurements of tissue oxygenation during heat stress. J Appl Physiol 100, 221-224.
9. Dinenno FA & Joyner MJ (2003). Blunted sympathetic vasoconstriction in contracting skeletal muscle of healthy humans: is nitric oxide obligatory? J Physiol 553, 281-292.
10. Edvinsson L, Lacombe P, Owman C, Reynier-Rebuffel AM & Seylaz J (1979). Quantitative changes in regional cerebral blood flow of rats induced by α- and Β-adrenergic stimulants. Acta Physiol Scand 107, 289-296.
11. Edvinsson L, Owman C & Siesjö B (1976). Physiological role of cerebrovascular sympathetic nerves in the autoregulation of cerebral blood flow. Brain Res 117, 519-523.
12. Fisher JP, Ogoh S, Young CN, Raven PB & Fadel PJ (2008). Regulation of middle cerebral artery blood velocity during dynamic exercise in humans: influence of aging. J Appl Physiol 105, 266-273.
13. Gross PM, Marcus ML & Heistad DD (1980). Regional distribution of cerebral blood-flow during exercise in dogs. J Appl Physiol 48, 213-217.
14. Halter JB, Stratton JR & Pfeifer MA (1984). Plasma catecholamines and hemodynamic responses to stress states in man. Acta Physiol Scand Suppl 527, 31-38.
15. Hamel E (2006). Perivascular nerves and the regulation of cerebrovascular tone. J Appl Physiol 100, 1059-1064.
16. Hamner JW, Tan CO, Lee K, Cohen MA & Taylor JA (2010). Sympathetic control of the cerebral vasculature in humans. Stroke 41, 102-109.
17. Hansen J, Sander M & Thomas GD (2000). Metabolic modulation of sympathetic vasoconstriction in exercising skeletal muscle. Acta Physiol Scand 168, 489-503.
18. Hansen J, Thomas GD, Harris SA, Parsons WJ & Victor RG (1996). Differential sympathetic neural control of oxygenation in resting and exercising human skeletal muscle. J Clin Invest 98, 584-596.
19. Hellström G, Fischer-Colbrie W, Wahlgren NG & Jogestrand T (1996). Carotid artery blood flow and middle cerebral artery blood flow velocity during physical exercise. J Appl Physiol 81, 413-418.
20. Hines EA & Brown G (1933). A standard test measuring the variability of blood pressure. Its significance as an index of the prehypertensive state. Ann Int Med 7, 209-217.
21. Ide K, Boushel R, Sorensen HM, Fernandes A, Cai Y, Pott F & Secher NH (2000). Middle cerebral artery blood velocity during exercise with Β-1 adrenergic and unilateral stellate ganglion blockade in humans. Acta Physiol Scand 170, 33-38.
22. Ide K, Pott F, Van Lieshout JJ & Secher NH (1998). Middle cerebral artery blood velocity depends on cardiac output during exercise with a large muscle mass. Acta Physiol Scand 162, 13-20.
23. Imholz BP (1996). Automated blood pressure measurement during ergometric stress testing: possibilities of Finapres. Z Kardiol 85(Suppl 3), 76-80.
24. Jansen JR, Schreuder JJ, Mulier JP, Smith NT, Settels JJ & Wesseling KH (2001). A comparison of cardiac output derived from the arterial pressure wave against thermodilution in cardiac surgery patients. Br J Anaesth 87, 212-222.
25. Jones PR & Pearson J (1969). Anthropometric determination of leg fat and muscle plus bone volumes in young male and female adults. J Physiol 204, 63P-66P.
26. Jørgensen LG, Perko G & Secher NH (1992). Regional cerebral artery mean flow velocity and blood flow during dynamic exercise in humans. J Appl Physiol 73, 1825-1830.
27. ATP channel activity augments baroreflex-mediated vasoconstriction in exercising human skeletal muscle. J Physiol 561, 273-282.
28. Keller DM, Wasmund WL, Wray DW, Ogoh S, Fadel PJ, Smith ML & Raven PB (2003). Carotid baroreflex control of leg vascular conductance at rest and during exercise. J Appl Physiol 94, 542-548.
29. Kirkham FJ, Padayachee TS, Parsons S, Seargeant LS, House FR & Gosling RG (1986). Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: velocity as an index of flow. Ultrasound Med Biol 12, 15-21.
30. Levine BD & Zhang R (2008). Comments on Point:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Autonomic control of the cerebral circulation is most important for dynamic cerebral autoregulation. J Appl Physiol 105, 1369-1373.
31. Linkis P, Jørgensen LG, Olesen HL, Madsen PL, Lassen NA & Secher NH (1995). Dynamic exercise enhances regional cerebral artery mean flow velocity. J Appl Physiol 78, 12-16.
32. Low DA, Wingo JE, Keller DM, Davis SL, Cui J, Zhang R & Crandall CG (2009). Dynamic cerebral autoregulation during passive heat stress in humans. Am J Physiol Regul Integr Comp Physiol 296, R1598-R1605.
33. Lowe RF & Gilboe DD (1971). Demonstration of alpha and beta adrenergic receptors in canine cerebral vasculature. Stroke 2, 193-200.
34. Lucas SJ, Tzeng YC, Galvin SD, Thomas KN, Ogoh S & Ainslie PN (2010). Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension 55, 698-705.
35. Micieli G, Tassorelli C, Bosone D, Cavallini A, Viotti E & Nappi G (1994). Intracerebral vascular changes induced by cold pressor test: a model of sympathetic activation. Neurol Res 16, 163-167.
36. Mitchell DA, Lambert G, Secher NH, Raven PB, Van Lieshout J & Esler MD (2009). Jugular venous overflow of noradrenaline from the brain: a neurochemical indicator of cerebrovascular sympathetic nerve activity in humans. J Physiol 587, 2589-2597.
37. Nielsen KC & Owman C (1967). Adrenergic innervation of pial arteries related to the circle of Willis in the cat. Brain Res 6, 773-776.
38. Ogoh S & Ainslie PN (2009). Cerebral blood flow during exercise: mechanisms of regulation. J Appl Physiol 107, 1370-1380.
39. Ogoh S, Brothers RM, Barnes Q, Eubank WL, Hawkins MN, Purkayastha S, O-Yurvati A & Raven PB (2005). The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise. J Physiol 569, 697-704.
40. Ogoh S, Brothers RM, Eubank WL & Raven PB (2008). Autonomic neural control of the cerebral vasculature: acute hypotension. Stroke 39, 1979-1987.
41. Olesen J (1972). The effect of intracarotid epinephrine, norepinephrine, and angiotensin on the regional cerebral blood flow in man. Neurol 22, 978-987.
42. Pott F, Ray CA, Olesen HL, Ide K & Secher NH (1997). Middle cerebral artery blood velocity, arterial diameter and muscle sympathetic nerve activity during post-exercise muscle ischaemia. Acta Physiol Scand 160, 43-47.
43. Rasmussen P & Lundby C (2010). Influence of changes in blood pressure on cerebral oxygenation: role of skin blood flow? Hypertension 56, e1.
44. Remensnyder JP, Mitchell JH & Sarnoff SJ (1962). Functional sympatholysis during muscular activity - observations on influence of carotid sinus on oxygen uptake. Circ Res 11, 370-380.
45. Roatta S, Micieli G, Bosone D, Losano G, Bini R, Cavallini A & Passatore M (1998). Effect of generalised sympathetic activation by cold pressor test on cerebral haemodynamics in healthy humans. J Auton Nerv Syst 71, 159-166.
46. Rowell LB (1993). Control of regional blood flow during dynamic exercise. In Human Cardiovascular Control, pp. 204-254. Oxford University Press, New York
47. Sander M, Macefield VG & Henderson LA (2010). Cortical and brain stem changes in neural activity during static handgrip and postexercise ischemia in humans. J Appl Physiol 108, 1691-1700.
48. Schrage WG, Wilkins BW, Dean VL, Scott JP, Henry NK, Wylam ME & Joyner MJ (2005). Exercise hyperemia and vasoconstrictor responses in humans with cystic fibrosis. J Appl Physiol 99, 1866-1871.
49. Secher NH, Seifert T & Van Lieshout JJ (2008). Cerebral blood flow and metabolism during exercise: implications for fatigue. J Appl Physiol 104, 306-314.
50. Seifert T, Fisher JP, Young CN, Hartwich D, Ogoh S, Raven PB, Fadel PJ & Secher NH (2010). Glycopyrrolate abolishes the exercise-induced increase in cerebral perfusion in humans. Exp Physiol 95, 1016-1025.
51. Strandgaard S & Sigurdsson ST (2008). Point:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Counterpoint: Sympathetic nerve activity does not influence cerebral blood flow. J Appl Physiol 105, 1366-1367; discussion 1367-1368.
52. Thomas GD & Segal SS (2004). Neural control of muscle blood flow during exercise. J Appl Physiol 97, 731-738.
53. Tschakovsky ME, Shoemaker JK & Hughson RL (1995). Beat-by-beat forearm blood flow with Doppler ultrasound and strain-gauge plethysmography. J Appl Physiol 79, 713-719.
54. Tschakovsky ME, Sujirattanawimol K, Ruble SB, Valic Z & Joyner MJ (2002). Is sympathetic neural vasoconstriction blunted in the vascular bed of exercising human muscle? J Physiol 541, 623-635.
55. Vianna LC, Araujo CGS & Fisher JP (2009). Influence of central command and muscle afferent activation on anterior cerebral artery blood velocity responses to calf exercise in humans. J Appl Physiol 107, 1113-1120.
56. Victor RG, Leimbach WN Jr, Seals DR, Wallin BG & Mark AL (1987). Effects of the cold pressor test on muscle sympathetic nerve activity in humans. Hypertension 9, 429-436.
57. Victor RG & Seals DR (1989). Reflex stimulation of sympathetic outflow during rhythmic exercise in humans. Am J Physiol Heart Circ Physiol 257, H2017-H2024.
58. Wagerle LC, Heffernan TM, Sacks LM & Delivoria-Papadopoulos M (1983). Sympathetic effect on cerebral blood flow regulation in hypoxic newborn lambs. Am J Physiol Heart Circ Physiol 245, H487-H494.
59. Watanabe H, Watanabe K, Wadazumi T & Yoneyama F (2007). Effect of exercise intensity on mild rhythmic-handgrip-exercise-induced functional sympatholysis. J Physiol Anthropol 26, 593-597.
60. Wilson TD, Shoemaker JK, Kozak R, Lee TY & Gelb AW (2005). Reflex-mediated reduction in human cerebral blood volume. J Cereb Blood Flow Metab 25, 136-143.
61. Zhang R, Zuckerman JH, Iwasaki K, Wilson TE, Crandall CG & Levine BD (2002). Autonomic neural control of dynamic cerebral autoregulation in humans. Circulation 106, 1814-1820.