Characterization of tumor cells and stem cells by differential nuclear methylation imaging

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 6859, Issue , 2008, Pages

  Tajbakhsh, Jian ^a   Wawrowsky, Kolja A ^a   Gertych, Arkadiusz ^a   Bar Nur, Ori ^b   Vishnevsky, Eugene ^a   Lindsley, Erik H ^a   Farkas, Daniel L ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

3D image analysis; 5 azacytidine; cancer; cellular differentiation; confocal microscopy; CpG island; Global DNA methylation imaging; human embryonic stem cell; immunofluorescence; pituitary tumor

Indexed keywords

3D IMAGE ANALYSIS; 5-AZACYTIDINE; CANCER; CELLULAR DIFFERENTIATION; CPG ISLANDS; GLOBAL DNA METHYLATION IMAGING; HUMAN EMBRYONIC STEM CELLS; IMMUNOFLUORESCENCE; PITUITARY TUMOR;

ALKYLATION; BIOMOLECULES; CELL GROWTH; CONFOCAL MICROSCOPY; DNA; FLUORESCENCE; GENES; HISTOLOGY; IMAGE ANALYSIS; ONCOGENIC VIRUSES; PLANTS (BOTANY); STEM CELLS; THREE DIMENSIONAL; TOPOLOGY; TUMORS;

METHYLATION;

EID: 77958152634     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.769289     Document Type: Conference Paper

References (47)

1. W. Doerfler. DNA methylation and gene activity. Annu Rev Biochem. 1983;52:93-124.
2. T. Bestor et al. Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J Mol Biol. 1988 Oct 20;203(4):971-83.
3. M. Okano et al. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999 Oct 29;99(3):247-57.
4. A. Riggs, P.A. Jones. 5-methylcytosine, gene regulation, and cancer. Adv Cancer Res. 1983;40:1-30.
5. M. Gardiner-Garden, Frommer M. CpG islands in vertebrate genomes. J Mol Biol. 1987 Jul 20;196(2):261-82.
6. A.P. Bird. CpG-rich islands and the function of DNA methylation. Nature 1986 May 15-21;321(6067):209-13.
7. F. Antequera, A. Bird. Number of CpG islands and genes in human and mouse. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11995-9.
8. A. Bird. The essentials of DNA methylation. Cell 1992 Jul 10;70(1):5-8.
9. A.J. Silva, R. White. Inheritance of allelic blueprints for methylation patterns. Cell 1988 Jul 15;54(2):145-52.
10. G.L. Xu et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature 1999 Nov 11;402(6758):187-91.
11. R.S. Hansen et. al. The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14412-7.
12. R.E. Amir et al. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet. 1999 Oct;23(2):185-8.
13. W. Reik et al. Imprinting mutations in the Beckwith-Wiedemann syndrome suggested by altered imprinting pattern in the IGF2-H19 domain. Hum Mol Genet. 1995 Dec;4(12):2379-85.
14. M. Zeschnigk et al. Imprinted segments in the human genome: different DNA methylation patterns in the Prader- Willi/Angelman syndrome region as determined by the genomic sequencing method. Hum Mol Genet. 1997 Mar;6(3):387-95.
15. A. Petronis et al. Psychiatric epigenetics: a new focus for the new century. Mol Psychiatry 2000 Jul;5(4):342-6.
16. J.A. Thomson et al. Embryonic stem cell lines derived from humanblastocysts. Science 1998; 282: 1145-47.
17. B.E. Reubinoff et al. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat. Biotechnol. 18: 399-404.
18. N Rougier et al. Chromosome methylation patterns during mammalian preimplantation development. Genes Dev. 1998 Jul 15;12(14):2108-13.
19. S.C. Barton et al. Genome-wide methylation patterns in normal and uniparental early mouse embryos. Hum Mol Genet. 2001 Dec 15;10(26):2983-7.
20. K.L. Arney et al. Histone methylation defines epigenetic asymmetry in the mouse zygote. Int J Dev Biol. 2002 May;46(3):317-20.
21. F. Santos et al. Dynamic reprogramming of DNA methylation in the early mouse embryo. Dev Biol. 2002 Jan 1;241(1):172-82.
22. W. Reik et al. Epigenetic asymmetry in the mammalian zygote and early embryo: relationship to lineage commitment? Philos Trans R Soc Lond B Biol Sci. 2003 Aug 29;358(1436):1403-9.
23. M. Ehrlich DNA methylation: normal development, inherited diseases, and cancer. J Clin Ligand Assay 2000, 23:144-6.
24. S.B. Baylin et al. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res. 1998;72:141-96.
25. P.A. Jones. The DNA methylation paradox. Trends Genet. 1999 Jan;15(1):34-7.
26. B. Tycko. Epigenetic gene silencing in cancer. J Clin Invest. 2000 Feb;105(4):401-7.
27. B. Galusca et al. Global DNA methylation evaluation: potential complementary marker in differential diagnosis of thyroid neoplasia. Virchows Arch. 2005 Jul;447(1):18-23.
28. K.L. Arney, A.G. Fisher. Epigenetic aspects of differentiation. J Cell Sci. 2004 Sep 1;117(Pt 19):4355-63.
29. A.G. Fisher, M. Merkenschlager. Gene silencing, cell fate and nuclear organisation. Curr Opin Genet Dev. 2002 Apr;12(2):193-7.
30. G. Narayan, R. Raman. Cytological evaluation of global DNA methylation in mouse testicular genome. Hereditas. 1995;123(3):275-83.
31. S. Kobayakawa et al. Dynamic changes in the epigenomic state and nuclear organization of differentiating mouse embryonic stem cells. Genes Cells. 2007 Apr;12(4):447-60.
32. N. Gilbert et al. DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction. J Cell Biol. 2007 May 7;177(3):401-11.
33. I. Ginis et al. Differences between human and mouse embryonic stem cells. Dev Biol. 2004 May 15;269(2):360-80.
34. A. Ben-Shlomo et al. Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion. J Biol Chem. 2005 Jun 24;280(25):24011-21.
35. J. Itskovitz-Eldor et al. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Mol Med. 2000 Feb;6(2):88-9595.
36. M. Schuldiner et al. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A. 2000; 97: 11307-12.
37. J. Tajbakhsh et al. Spatial distribution of GC- and AT-rich DNA sequences within human chromosome territories. Exp Cell Res. 2000 Mar 15;255(2):229-37.
38. M.O. Scheuermann, J. Tajbakhsh et al. Topology of genes and nontranscribed sequences in human interphase nuclei. Exp Cell Res. 2004 Dec 10;301(2):266-79.
39. JK Christman. 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002 Aug 12;21(35):5483-95.
40. S.A. Grigoryev et al. The end adjust the means: Heterochromatin remodeling during terminal cell differentiation. Chromosome Res. 2006;14(1):53-69.
41. J.D. Lewis et al. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 1992 Jun 12;69(6):905-14.
42. K. Furuta et al. Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis. Chromosoma 1997 Jun;106(1):11-9.
43. A. Bird, A.P. Wolffe. Methylation-induced repression - belts, braces, and chromatin. Cell. 1999 Nov 24;99(5):451-4.
44. M. Lachner et al. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature. 2001 Mar 1;410(6824):116-20.
45. A.J. Bannister et al. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature. 2001 Mar 1;410(6824):120-4.
46. S.A. Jacobs, S. Khorasanizadeh. Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail. Science. 2002 Mar 15;295(5562):2080-3.
47. A. Brero et al. Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation. J Cell Biol. 2005 Jun 6;169(5):733-43.