Estrogens: A new player in spermatogenesis

Folia Histochemica et Cytobiologica

Volumn 45, Issue SUPPL. 1, 2007, Pages 5-10

  Carreau, Serge ^a   Silandre, Dorothée ^a   Bois, Camille ^a   Bouraima, Hélene ^a   Galeraud Denis, Isabelle ^a   Delalande, Christelle ^a  

^a UNIVERSITÉ DE CAEN   (France)

Author keywords

Aromatase; Estrogen receptors; Estrogens; Fertility; Man; Spermatogenesis

Indexed keywords

ANDROGEN; AROMATASE; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA;

ACROSOME; ANIMAL CELL; CCYP19 GENE; CELL STRUCTURE; CONFERENCE PAPER; ENZYME ACTIVITY; ESTROGEN ACTIVITY; EXON; GENE EXPRESSION; HUMAN; LEYDIG CELL; MICROCEPHALY; NONHUMAN; PACHYTENE; RAT; REGULATORY MECHANISM; RNA TRANSLATION; SPERMATID; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; STEROIDOGENESIS;

ANIMALIA; CLETHRIONOMYS GLAREOLUS; MAMMALIA; MUS; RATTUS;

EID: 44949131714     PISSN: 02398508     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (54)

1. Aquila S, Sisci D, Gentile M, Middea E, Siciliano L, Ando S. Human ejaculated spermatozoa contain active P450 aromatase. J Clin Endocrinol Metab. 2002;87:3385-3390.
2. Aquila S, Sisci D, Gentile M, Middea E, Catalano S, Carpino A, et al. Estrogen receptor ERα and ERβ are both expressed in human ejaculated spermatozoa: evidence for their direct interaction with phosphatidylinositol-3-OH Kinase/Akt pathway. J Clin Endocrinol Metab. 2004;89:1443-1451.
3. Aschim EL, Saether T, Wiger R, Grotmol T, Haugen TB. Differential distribution of splice variants of estrogen receptor beta in human testicular cells suggests specific functions in spermatogenesis. J Steroid Biochem Mol Biol. 2004;92:97-106.
4. Bilinska B, Schmalz-Fraczek B, Kotula M, Carreau S. Photoperiod-dependent capability of androgen aromatization and the role of estrogens in bank vole testis visualized by means of immunohistichemistry. Mol Cell Endocrinol. 2001;178:189-198.
5. Bourguiba S, Chater S, Delalande C, Benhamed M, Carreau S. Regulation of aromatase gene expression in purified germ cells of adult male rats : effects of TGFβ, TNFα and cyclic AMP. Biol Reprod. 2003;69:592-601.
6. Bulun SE, Rosenthal IM, Brodie AM, Inkster S, Zeller WP, DiGeorege AM, et al. Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors as well as in mormal fetal and adut gonads. J Clin Endocrinol Metab. 1993;77:1616-1621.
7. Carpino F, Romeo F, Rago FV. Aromatase immunolocalization in human ductuli efferentes and proximal ductus epididymis. J Anat. 2004; 204:217-220.
8. Carreau S. Paracrine control of human Leydig cell and Sertoli cell functions. Folia Histochem Cytobiol. 1996;3:111-119.
9. Carreau S, Genissel C, Bilinska B, Levallet J. The oestrogen sources in the testis and the reproductive tract of the male. Inter J Androl. 1999;22:211-223.
10. Carreau S, Bourguiba S, Lambard S, Galeraud-Denis I, Genissel C, Levallet J. Reproductive System: aromatase and estrogens. Mol Cell Endocrinol. 2002;193:137-143.
11. Carreau S, Lambard S, Delalande C, Denis-Galeraud I, Bilinska B, Bourguiba S Aromatase expression and role of estrogens in male gonad: a review. Reprod Biol Endocrinol. 2003;1:35-43.
12. Carreau S, Bourguiba S, Lambard S, Silandre D, Delalande C. The promoter(s) of the aromatase gene in male testicular cells. Reprod Biol. 2004;4:23-34.
13. Carreau S, Delalande C, Silandre D, Bourguiba S, Lambard S. Aromatase and estrogen receptors in male reproduction. Mol Cell Endocrinol. 2006;246:65-68.
14. Carreau S, Said L, Lmabard S, Saad A, Galeraud-Denids I. RNA dynamics of fertile and infertile spermatozoa. Biochem Soc Trans. 2007;35:634-636.
15. Carreau S, Silandre D, Hamden K, Bourguiba S, Said L, Lambard S et al. Estrogens and male reproduction. Braz J Med Biol Res. 2007;40:761-768.
16. Carreau S. Leydig cell aromatase: from gene to physiology. AH Payne & MP Hardy (Eds), The Leydig cell in health and disease. Humana Press, Totowa (NJ), 2007, pp. 189-195.
17. Durkee TJ, Mueller M, Zinaman M. Identification of estrogen receptor protein and messenger ribonucleic acid in human spermatozoa. Amer J Obst Gyn. 1998;178:1288-1295.
18. Golovine K, Schwerin M, Vanselow J. Three different promoters control expression of the aromatase cytochrome p450 gene (cyp 19) in mouse gonads and brain. Biol Reprod. 2003;68:978-984.
19. Gunasegaram R, Chew PCT, Loganath A, Peh KL, Ratman SS. A delta 4-3 keto pathway for testosterone synthesis in the human spermatozoa. Arch Androl. 1995;40:49-57.
20. Hamden K, Silandre D, Delalande C, El Feki A, Carreau S. Age-related decrease in aromatase and ER (ERα and ERβ) in rat testes: protective effect of low caloric diets. Asian J Androl. 2008;2: (in press).
21. Hess RA, Carnes K. The role of estrogen in the testis and the male reproductive tract: a review. Anim Reprod. 2004;1:5-30.
22. Kuiper GGJM., Carlsson B, Grandien K, Enmark E, Häggbland J, Nilsson S et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology. 1997;138: 863-870.
23. Lambard S, Galeraud-Denis I, Bouraima H, Bourguiba S, Chocat A, Carreau S. Expression of aromatase in human ejaculated spermatozoa: a putative marker of motility. Molec Human Reprod. 2003;9:117-124.
24. Lambard S, Galeraud-Denis I, Saunders PTK, Carreau S. Human immature germ cells and ejaculated spermatozoa contain aromatase and oestrogen receptors. J Molec Endocrinol. 2004;32:279-289.
25. Lambard S, Galeraud-Denis I, Martin G, Levy R, Chocat A, Carreau S.Analysis and significance of messenger RNAs in human ejaculated spermatozoa from normospermic donors : relation to sperm motility and capacitation. Mol Human Reprod. 2004;10:535-541.
26. Lanzino M, Catalano S, Genissel C, Ando S, Carreau S, Hamra K et al. Aromatase messenger RNA is derived from the proximal promoter of the aromatase gene in Leydig, Sertoli, and germ cells of the rat testis. Biol Reprod. 2001;64:1439-1443.
27. Levallet J, Delarue B, Mittre H, Carreau S. Alternative splicing events in the coding region of cytochrome P450 aromatase in adult male rat germ cells. J Mol Endocrinol. 1998;20:305-312.
28. Levallet J, Bilinska B, Mittre H, Genissel C, Fresnel J, Carreau S. Expression and immunolocalization of functional cytochrome P450 aromatase in mature rat testicular cells. Biol Reprod. 1998;58:919-926.
29. Makinen S, Makela S, Zhang WH, Warner M, Rosenlund B, Sami S et al. Localization of oestrogen receptors alpha and beta in human testis. Mol Human Reprod. 2001;7:497-503.
30. Nitta H, Bunick D, Hess RA, Janulis L, Newton SC, Milette C et al. Germ cells of the mouse testis express P450 aromatase. Endocrinology. 1993;132:1396-1401.
31. O'Donnell L, Robertson KM, Jones ME, Simpson ER. Estrogen and spermatogenesis. Endocr Rev. 2001;22:289-318.
32. Payne AH, Kelch RP, Musich SS, Halpern ME. Intratesticular site of aromatization in the human. J Clin Endocrinol Metab. 1976;42:1081-1087.
33. Pelletier G, El-Alfy M. Immunocytochemical localization of estrogen receptors α and β in the human reproductive organs. J Clin Endocrinol. Metab. 2000;85:4835-4840.
34. Pentikad'nen V, Erkkilä K, Suomalainen L, Otala M, Pentikainen MO, Parvinen M. et al. Estradiol acts as a germ cell survival factor in the human testis in vitro. J Clin Endocrinol Metab. 2000;85:2057-2067.
35. Pereyra-Martinez AC, Roselli CE, Stadelman HL, Resko JA. Cytochrome P450 aromatase in testis and epididymis of male Rhesus monkeys. Endocrine. 2001;16:15-19.
36. Pezzi V, Sirianni R, Chimento A, Maggiolini M, Bourguiba S, Delalande C et al. Differential expression of steroidogenic factor-1/adrenal 4 binding protein and liver receptor homolog-1 (LRH-1)/fetoprotein transcription factor in the rat testis: LRH-1 as a potential regulator of testicular aromatase expression. Endocrinology. 2004;145:2186-2196.
37. Rago V, Bilinska B, Palma A, Ando S, Carpino A. Evidence of aromatase localization in cytoplasmic droplet of human immature ejaculated spermatozoa. Folia Histochem Cytobiol. 2003;41:23-28.
38. Rochira V, Granata ARM, Madeo B, Zirilli L, Rossi G, Carani C. Estrogens in males: what we have learned in last 10 years? Asian J Androl. 2005;7:3-20.
39. Saunders PTK, Fisher JS, Sharpe RM, Millar MR. Expression of oestrogen receptor beta (ERβ) occurs in multiple cell types, including some germ cells, in the rat testis. J Endocrinol. 1998;156:R13-R17.
40. Saunders PTK, Sharpe RM, Williams K, Macpherson S, Urquart H, Irvine DS. Differential expression of oestrogen receptor α and β proteins in the testes and male reproductive system of human and non-human primates. Molec Human Reprod. 2001;7:227-336.
41. Saunders PTK, Millar MR, MacPherson S, Irvin DS, Groome NG, Evans LR. et al. ERβ1 and ERβ2 splice variant (ERβcx/β2) are expressed in distinct cell populations in the adult human testis. J Clin Endocrin Metab. 2002;87:2706-2715.
42. Sebastian S, Bulun SE. A highly complex organization of the regulatory region of the human cyp19 (aromatase) gene revealed by the Human genome project. J Clin Endocrinol Metab. 2001;86:4600-4602.
43. Silandre D, Delalande C, Durand P, Carreau S. Three promoters PII, PI.f and 1.6 direct the expression of aromatase (cyp19) gene in male rat germ cells. J Molec Endocrinol. 2007;39:169-181.
44. Simpson ER, Mahendroo MS, Means GD, Kilgore MW, Hinshelwood MM, Graham-Lorence S et al. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr Rev. 1994;15:342-355.
45. Simpson ER, Clyne C, Rubin G, Boon WC, Robertson K, Britt K, et al. Aromatase-a brief overview. Ann Rev Physiol. 2002;64:93-127.
46. Skakkebaek NE. Testicular disgenesis syndrome: new epidemioloical evidence. Int J Androl. 2004;27:189-201.
47. Solakidi S, Psarra AMG, Nikolaropoulos S, Sekeris CE. Estrogen receptors alpha and beta (ERalpha and ERbeta) and androgen receptor (AR) in human sperm: localization of ERbeta and AR in mitochondria of the midpiece. Human Reprod. 2005;20:3481-3485.
48. Swider-Al-Amawi M, Marchlewicz M, Kolasa A, Wenda-Rozewicka, Wiszniewska B. Rat epididymal epithelial cells and 17β-estradiol synthesis under hCG stimulation in vitro. Folia Histochem Cytobiol. 2007;45:255-263.
49. Teixeira CV, Silandre D, de Souza Santos AM, Delalande C, Sampaio FJB, Carreau S et al. Effects of maternal undernutrition during lactation on aromatase, estrogen, and androgen receptors expression in rat testis at weaning. J Endocrinol. 2007;192:301-311.
50. Toppari J, Larsen JC, Christiansen P, Giwercman, A, Grandjean P, Guillette LJ, et al. Male reproductive health and environmental xenoestrogens. Environm Health Perspect. 1996;104:741-803.
51. Tsubota T, Howell-Skalla L, Nitta H, Osawa Y, Mason JI, Meiers PG, et al. Seasonal changes in spermatogenesis and testicular steroidogenesis in the male black bear Ursus americanus. J Reprod Pert. 1997;109:21-27.
52. Turner KJ, MacPherson S, Millar MR, McNeilly AS, Williams K, Cranfield M, et al. Development and validation of a new monoclonal antibody to mammalian aromatase. J Endocrinol. 2002;172: 21-30.
53. Wiszniewska B. Primary culture of rat epididymal epithelial cells as a source of estrogen. Andrologia. 2002;34:1-8.
54. Zondek B. Mass excretion of oestrogenic hormone in the urine of the stallion. Nature (London). 1934;193:209-210.