In vivo assessment of retinal vascularwall dimensions

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 10, 2010, Pages 5254-5259

  Dominik Fischer, M ^a   Huber, Gesine ^a   Feng, Yuxi ^b   Tanimoto, Naoyuki ^a   Mühlfriedel, Regine ^a   Beck, Susanne C ^a   Tröger, Eric ^c   Kernstock, Christoph ^c   Preising, Markus N ^d   Lorenz, Birgit ^d   Hammes, Hans Peter ^b   Seeligerü, Mathias W ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^d UNIVERSITY HOSPITAL GIESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ACTIN; ALPHA SMOOTH MUSCLE ACTIN, MOUSE; ALPHA-SMOOTH MUSCLE ACTIN, MOUSE; COLORING AGENT; DIAGNOSTIC AGENT; GREEN FLUORESCENT PROTEIN; INDOCYANINE GREEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIOLE; ARTERIOVENOUS RATIO; ARTICLE; BLOOD VESSEL LUMEN; BLOOD VESSEL PARAMETERS; BLOOD VESSEL WALL WIDTH; CONTROLLED STUDY; ELECTRORETINOGRAM; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETINA ANGIOGRAPHY; RETINA BLOOD VESSEL; SCANNING LASER OPHTHALMOSCOPY; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; VENULE; ANIMAL; C57BL MOUSE; ELECTRORETINOGRAPHY; FLUORESCENCE ANGIOGRAPHY; HISTOLOGY; LASER; METABOLISM; MORPHOMETRICS; OPHTHALMOSCOPY; OPTICAL COHERENCE TOMOGRAPHY; RETINA ARTERY; RETINA VEIN;

ACTINS; ANIMALS; BODY WEIGHTS AND MEASURES; COLORING AGENTS; ELECTRORETINOGRAPHY; FLUORESCEIN ANGIOGRAPHY; GREEN FLUORESCENT PROTEINS; HUMANS; INDOCYANINE GREEN; LASERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OPHTHALMOSCOPY; RETINAL ARTERY; RETINAL VEIN; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 77958131188     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-5139     Document Type: Article

References (29)

1. Wong TY, Mitchell P. Hypertensive retinopathy. N Engl J Med. 2004;351:2310-2317.
2. Kwa VI, van der Sande JJ, Stam J, Tijmes N, Vrooland JL. Retinal arterial changes correlate with cerebral small-vessel disease. Neurology. 2002;59:1536-1540.
3. Goto I, Katsuki S, Ikui H, Kimoto K, Mimatsu T. Pathological studies on the intracerebral and retinal arteries in cerebrovascular and noncerebrovascular diseases. Stroke. 1975;6:263-269.
4. Brinchmann-Hansen O, Sandvik L. The intensity of the light reflex on retinal arteries and veins. Acta Ophthalmol (Copenh). 1986; 64:547-552.
5. Brinchmann-Hansen O, Sandvik L. The width of the light reflex on retinal arteries and veins. Acta Ophthalmol (Copenh). 1986;64: 433-438.
6. Preece SJ, Claridge E. Monte Carlo modelling of the spectral reflectance of the human eye. Phys Med Biol. 2002;47:2863-2877.
7. Cioffi GA, Granstam E, Alm A. Ocular circulation. In: Kaufman PL, Alm A, eds. Adler's Physiology of the Eye. St. Louis: Mosby. 2003:747-784.
8. Nehls V, Drenckhahn D. Heterogeneity of microvascular pericytes for smooth muscle type alpha-actin. J Cell Biol. 1991;113:147-154.
9. Siemering KR, Golbik R, Sever R, Haseloff J. Mutations that suppress the thermosensitivity of green fluorescent protein. Curr Biol. 1996;6:1653-1663.
10. Seeliger MW, Beck SC, Pereyra-Munoz N, et al. In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy. Vision Res. 2005;45:3512-3519.
11. Beck SC, Schaeferhoff K, Michalakis S, et al. In vivo analysis of cone survival in mice. Invest Ophthalmol Vis Sci. 2010;51:493-497.
12. Wang J, Niu W, Nikiforov Y, et al. Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice. J Clin Invest. 1997;100:1425-1439.
13. Yokota T, Kawakami Y, Nagai Y, et al. Bone marrow lacks a transplantable progenitor for smooth muscle type alpha-actin-expressing cells. Stem Cells. 2006;24:13-22.
14. Fischer MD, Huber G, Beck SC, et al. Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography. PLoS One. 2009;4:e7507.
15. Huber G, Beck SC, Grimm C, et al. Spectral domain optical coherence tomography in mouse models of retinal degeneration. Invest Ophthalmol Vis Sci. 2009;50:5888-5895.
16. Helb HM, Issa PC, Fleckenstein M, et al. Clinical evaluation of simultaneous confocal scanning laser ophthalmoscopy imaging combined with high-resolution, spectral-domain optical coherence tomography. Acta Ophthalmol. 2009:August 25 [Epub ahead of print].
17. Wolf-Schnurrbusch UE, Enzmann V, Brinkmann CK, Wolf S. Morphological changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination. Invest Ophthalmol Vis Sci. 2008;49:3095-3099.
18. Davis MD, Bressler SB, Aiello LP, et al. Comparison of time-domain OCT and fundus photographic assessments of retinal thickening in eyes with diabetic macular edema. Invest Ophthalmol Vis Sci. 2008;49:1745-1752.
19. Seeliger MW, Grimm C, Stahlberg F, et al. New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis. Nat Genet. 2001;29:70-74.
20. Tanimoto N, Muehlfriedel RL, Fischer MD, et al. Vision tests in the mouse: functional phenotyping with electroretinography. Front Biosci. 2009;14:2730-2737.
21. Kuwabara T, Cogan DG. Studies of retinal vascular patterns, I: normal architecture. Arch Ophthalmol. 1960;64:904-911.
22. Kimura T. Light and electron microscopic studies on the sclerotic changes in human central retinal arteries, II: observation comparing ophthalmoscopic and histologic findings. Nippon Ganka Gakkai Zasshi. 1970;74:1494-1508.
23. Iwasaki M, Ishibashi T, Inomata H, Taniguchi Y. Ultrastructure of sheathed vessels in the retina from patients with various diseases. Graefes Arch Clin Exp Ophthalmol. 1987;225:177-184.
24. Ikui H, Tominaga Y, Inomata H. Ultra structure of the retinal blood vessels-the characteristics of their structures and objectives of the future research. Ganka. 1966;8:77-92.
25. Kimura T. Light and electron microscopic studies on the sclerotic changes in human central retinal arteries, I: the "crossing phenomenon." Nippon Ganka Gakkai Zasshi. 1970;74:987-998.
26. Izumi Y, Hammerman SB, Benz AM, Labruyere J, Zorumski CF, Olney JW. Comparison of rat retinal fixation techniques: chemical fixation and microwave irradiation. Exp Eye Res. 2000;70:191-198.
27. Puro DG. Physiology and pathobiology of the pericyte-containing retinal microvasculature: new developments. Microcirculation. 2007;14:1-10.
28. Motiejunaite R, Kazlauskas A. Pericytes and ocular diseases. Exp Eye Res. 2008;86:171-177.
29. Kobayashi T, Puro DG. Loss of insulin-mediated vasoprotection: early effect of diabetes on pericyte-containing microvessels of the retina. Invest Ophthalmol Vis Sci. 2007;48:2350-2355.