Lewis Y promotes growth and adhesion of ovarian carcinoma-derived RMG-I cells by upregulating growth factors

International Journal of Molecular Sciences

Volumn 11, Issue 10, 2010, Pages 3748-3759

  Li, Feifei ^a,b   Lin, Bei ^a   Hao, Yingying ^a   Li, Yan ^c   Liu, Juanjuan ^a   Cong, Jianping ^a   Zhu, Liancheng ^a   Liu, Qing ^a   Zhang, Shulan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^c Department of Obstetrics and Gynecology   (China)

Author keywords

Adhesion; Inhibition; Lewis y; Ovarian cancer; Proliferation; Tumorigenecity

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; LEWIS Y ANTIGEN; MONOCLONAL ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1; TUMOR ANTIGEN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN FUNCTION; ARTICLE; CANCER GROWTH; CANCER INVASION; CARCINOGENESIS; CARCINOMA CELL; CELL ADHESION; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; IN VITRO STUDY; MOUSE; NONHUMAN; OVARY CARCINOMA; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UPREGULATION;

ADHESION; INHIBITION; LEWIS Y; OVARIAN CANCER; PROLIFERATION; TUMORIGENECITY;

ANIMALS; CARCINOGENESIS; CARCINOMA; CELL ADHESION; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; FIBROBLAST GROWTH FACTORS; HUMANS; LEWIS BLOOD-GROUP SYSTEM; MICE; MICE, NUDE; OVARIAN NEOPLASMS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MUS MUSCULUS;

EID: 77958121205     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms11103748     Document Type: Article

References (31)

1. Phillips, M.L.; Nudelman, E.; Gaeta, F.C.; Perez, M.; Singhal, A.K.; Hakomori, S.; Paulson, J.C. ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. Science 1990, 250, 1130-1132.
2. Christie, D.R.; Shaikh, F.M.; Lucas, J.A., IV.; Lucas, J.A., Bellis, S.L. ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and function. J. Ovarian Res. 2008, 1, 3.
3. Kim, Y.S.; Hwang, S.Y.; Kang, H.Y.; Sohn, H.; Oh, S.; Kim, J.Y.; Yoo, J.S.; Kim, Y.H.; Kim, C.H.; Jeon, J.H.; et al. Functional proteomics study reveals that N-Acetylglucosaminyltransferase V reinforces the invasive/metastatic potential of colon cancer through aberrant glycosylation on tissue inhibitor of metalloproteinase-1. Mol. Cell Proteomics 2008, 7, 1-14.
4. Dettke, M.; Palfi, G.; Loibner, H. Activation-dependent expression of the blood group-related Lewis Y antigen on peripheral blood granulocytes. J. Leukoc. Biol. 2000, 68, 511-514.
5. Kim, Y.S.; Yuan, M.; Itzkowitz, S.H.; Sun, Q.B.; Kaizu, T.; Palekar, A.; Trump, B.F.; Hakomori, S. Expression of LeY and extended LeY blood group related antigens in human malignant, premalignant, and non-malignant colonic tissues. Cancer Res. 1986, 46, 5985-5992.
6. López-Ferrer, A.; de Bolós, C.; Barranco, C.; Garrido, M.; Isern, J.; Carlstedt, I.; Reis, C.A.; Torrado, J.; Real, F.X. Role of fucosyltransferases in the association between apomucin and Lewis antigen expression in normal and malignant gastric epithelium. Gut 2000, 47, 349-356.
7. Chhieng, D.C.; Rodriguez-Burford, C.; Talley, L.I.; Sviglin, H.; Stockard, C.R.; Kleinberg, M.J.; Barnes, M.N.; Partridge, E.E.; Khazaeli, M.B.; Grizzle, W.E. Expression of CEA, Tag-72, and Lewis-Y antigen in primary and metastatic lesions of ovarian carcinoma. Hum. Pathol. 2003, 34, 1016-1021.
8. Madjd, Z.; Parsons, T.; Watson, N.F.; Spendlove, I.; Ellis, I.; Durrant, L.G. High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas. Breast Cancer Res. 2005, 7, R780-787.
9. Kuemmel, A.; Single, K.; Bittinger, F.; Faldum, A.; Schmidt, L.H.; Sebastian, M.; Taube, C.; Buhl, R.; Wiewrodt, R. The prognostic impact of blood group-related antigen Lewis Y and the ABH blood groups in resected non-small cell lung cancer. Tumour Biol. 2007, 28, 340-349.
10. Iwamori, M.; Tanaka, K.; Kubushiro, K.; Lin, B.; Kiguchi, K.; Ishiwata, I.; Tsukazaki, K.; Nozawa, S. Alterations in the glycolipid composition and cellular properties of ovarian carcinoma-derived RMG-1 cells on transfection of the _1,2-fucosyltransferase gene. Cancer Sci. 2005, 96, 26-30.
11. Lin, B.; Hao, Y.Y.; Wang, D.D.; Zhu, L.C.; Zhang, S.L.; Saito, M.; Iwamori, M. Transfection of _1,2-Fucosyltransferase Gene Increases the Antigenic Expression of Lewis y in Ovarian Cancer Cell Line RMG-I. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2008, 30, 284-289.
12. Hao, Y.Y.; Lin, B.; Zhao, Y.; Zhang, Y.H.; Li, F.F.; Diao, B.; Ou, Y.L.; Zhang, S.L. alpha1,2-fucosyltransferase gene transfection influences on biological behavior of ovarian carcinoma-derived RMG-I cells. Fen Zi Xi Bao Sheng Wu Xue Bao 2008, 41, 435-442.
13. Kelly, M.P.; Lee, S.T.; Lee, F.T.; Smyth, F.E.; Davis, I.D.; Brechbiel, M.W.; Scott, A.M. Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy. Prostate 2009, 69, 92-104.
14. Kelly, M.P.; Lee, F.T.; Smyth, F.E.; Brechbiel, M.W.; Scott, A.M. Enhanced efficacy of 90Yradiolabeled anti-Lewis Y humanized monoclonal antibody hu3S193 and paclitaxel combinedmodality radioimmunotherapy in a breast cancer model. J. Nucl. Med. 2006, 47, 716-725.
15. Kelly, M.P.; Lee, F.T.; Tahtis, K.; Smyth, F.E.; Brechbiel, M.W.; Scott, A.M.Radioimmunotherapy with alpha-particle emitting 213Bi-C-functionalized trans-cyclohexyldiethylenetriaminepentaacetic acid-humanized 3S193 is enhanced by combination with paclitaxel chemotherapy. Clin. Cancer Res. 2007, 13, 5604s-5612s.
16. Krug, L.M.; Milton, D.T.; Jungbluth, A.A.; Chen, L.C.; Quaia, E.; Pandit-Taskar, N.; Nagel, A.; Jones, J.; Kris, M.G.; Finn, R.; Smith-Jones, P.; Scott, A.M.; Old, L.; Divgi, C. Targeting Lewis Y (LeY) in small cell lung cancer with a humanized monoclonal antibody, hu3S193: a pilot trial testing two dose levels. J. Thorac. Oncol. 2007, 2, 947-952.
17. Makrilia, N.; Lappa, T.; Xyla, V.; Nikolaidis, I.; Syrigos, K. The role of angiogenesis in solid tumours: An overview. Eur. J. Intern. Med. 2009, 20, 663-671.
18. Korc, M.; Friesel, R.E. The role of fibroblast growth factors in tumor growth. Curr. Cancer Drug Targets 2009, 9, 639-651.
19. Halper, J. Growth factors as active participants in carcinogenesis: a perspective. Vet Pathol. 2010, 47, 77-97.
20. Basu, A.; Murthy, U.; Rodeck, U.; Herlyn, M.; Mattes, L.; Das, M. Presence of tumor-associated antigens in epidermal growth factor receptors from different human carcinomas. Cancer Res. 1987, 47, 2531-2536.
21. Klinger, M.; Farhan, H.; Just, H.; Drobny, H.; Himmler, G.; Loibner, H.; Mudde, G.C.; Freissmuth, M.; Sexl, V. Antibodies directed against Lewis-Y antigen inhibit signaling of Lewis-Y modified erbB receptors. Cancer Res. 2004, 64, 1087-1093.
22. Farhan, H.; Schuster, C.; Klinger, M.; Weisz, E.; Waxenecker, G.; Schuster, M.; Sexl, V.; Mudde, G.C.; Freissmuth, M.; Kircheis, R. Inhibition of xenograft tumor growth and downregulation of ErbB receptors by an antibody directed against Lewis-Y antigen. J. Pharmacol. Exp. Ther. 2006, 319, 1459-1466.
23. Zhu, K.; Amin, M.A.; Zha, Y.; Harlow, L.A.; Koch, A.E. Mechanism by which H-2g, a glucose analog of blood group H antigen, mediates angiogenesis. Blood 2005, 105, 2343-2349.
24. Zhu, L.C.; Lin, B.; Hao, Y.Y.; Li, F.F.; Diao, B.; Zhang, S.L. Impact of alpha1,2-fucosyl transferase gene transfection on cancer-related gene expression profile of human ovarian cancer cell line RMG-1. Ai Zheng 2008, 27, 934-941.
25. Li, F.F. Shengjing Hospital of China Medical University, Shenyang, China. Unpublished work, 2010.
26. Zhang, Y.; Zhang, X.Y.; Liu, F.; Qi, H.L.; Chen, H.L. Relationship between terminal sialyl and fucosyl residues of glycans on cell surface and cell biological behaviors. Acta Biol. Exp. Sin. 2002, 35, 271-277.
27. Labarrière, N.; Piau, J.P.; Otry, C.; Denis, M.; Lustenberger, P.; Meflah, K.; Le Pendu, J. H blood group antigen carried by CD44V modulates tumorigenicity of rat colon carcinoma cells. Cancer Res. 1994, 54, 6275-6281.
28. García-Vallejo, J.J.; van Liempt, E.; da Costa Martins, P.; Beckers, C.; van het Hof, B.; Gringhuis, S.I.; Zwaginga, J.J.; van Dijk, W.; Geijtenbeek, T.B.; van Kooyk, Y.; van Die, I. DC-SIGN mediates adhesion and rolling of dendritic cells on primary human umbilical vein endothelial cells through LewisY antigen expressed on ICAM-2. Mol. Immunol. 2008, 45, 2359-2369.
29. Yan, L.M.; Lin, B.; Zhu, L.C.; Hao, Y.Y.; Qi, Y.; Wang, C.Z.; Gao, S.; Liu, S.C.; Zhang, S.L.; Iwamori, M. Enhancement of the adhesive and spreading potentials of ovarian carcioma RMG-1 cells due to increased expression of integrin alpha5beta1 with the Lewis Y-structure on transfection of the alpha1,2-fucosyltransferase gene. Biochimie 2010, 92, 852-857.
30. Cao, Y.; Merling, A.; Karsten, U.; Schwartz-Albiez, R. The fucosylated histo-blood group antigens H type 2 (blood group O, CD173) and Lewis Y (CD174) are expressed on CD34(+) hematopoietic progenitors but absent on mature lymphocytes. Glycobiology 2001, 11, 677-683.
31. Inaba, Y.; Ohyama, C.; Kato, T.; Satoh, M.; Saito, H.; Hagisawa, S.; Takahashi, T.; Endoh, M.; Fukuda, M.N.; Arai, Y.; Fukuda, M. Gene transfer of alpha1,3-fucosyltransferase increases tumor growth of the PC-3 human prostate cancer cell line through enhanced adhesion to prostatic stromal cells. Int. J. Cancer 2003, 107, 949-957.