Ectopic mitf in the embryonic chick retina by co-transfection of β-catenin and Otx2

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 10, 2010, Pages 5328-5335

  Westenskow, Peter D ^a   McKean, Jon B ^a   Kubo, Fumi ^b   Nakagawa, Shinichi ^b   Fuhrmann, Sabine ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; LYMPHOID ENHANCER FACTOR 1; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR OTX2; WNT PROTEIN; TRANSCRIPTION FACTOR OTX;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOREGULATION; CELL DIFFERENTIATION; CELL VACUOLE; CHICK; CONTROLLED STUDY; CULTURE MEDIUM; DOWN REGULATION; ELECTROPORATION; EMBRYO; ENHANCER REGION; EXPLANT; EYE DEVELOPMENT; GENE EXPRESSION; NONHUMAN; OPTIC NERVE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINA; SIGNAL TRANSDUCTION; ANIMAL; CELL COUNT; CELL CULTURE; CHICK EMBRYO; CONFOCAL MICROSCOPY; CYTOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHYSIOLOGY; PLASMID; PRENATAL DEVELOPMENT; RETINA NERVE CELL; TRANSCRIPTION INITIATION;

ANIMALS; BETA CATENIN; CELL COUNT; CELL DIFFERENTIATION; CELLS, CULTURED; CHICK EMBRYO; ELECTROPORATION; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MICROSCOPY, CONFOCAL; OTX TRANSCRIPTION FACTORS; PLASMIDS; RETINA; RETINAL NEURONS; RETINAL PIGMENT EPITHELIUM; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; WNT PROTEINS;

EID: 77958120919     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-5015     Document Type: Article

References (69)

1. Idelson M, Alper R, Obolensky A, et al. Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells. Cell Stem Cell. 2009;5:396-408.
2. Klimanskaya I, Hipp J, Rezai K, West M, Atala A, Lanza R. Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics. Cloning Stem Cells. 2004;6:217-245.
3. Lund R, Wang S, Klimanskaya I, et al. Human embryonic stem cell-derived stem cells rescue visual function in dystrophic RCS rats. Cloning Stem Cells. 2006;8:189-199.
4. Vugler A, Carr A, Lawrence J, et al. Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation. Exp Neurol. 2008;214:347-361.
5. Alge CS, Suppmann S, Priglinger SG, et al. Comparative proteome analysis of native differentiated and cultured dedifferentiated human RPE cells. Invest Ophthalmol Vis Sci. 2003;44:3629-3641.
6. Davis AA, Bernstein PS, Bok D, Turner J, Nachtigal M, Hunt RC. A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture. Invest Ophthalmol Vis Sci.1995;36:955-964.
7. Rizzolo LJ. The distribution of Na+,K+-ATPase in the retinal pigmented epithelium from chicken embryo is polarized in vivo but not in primary cell culture. Exp Eye Res. 1990;51:435-446.
8. Baumer N, Marquardt T, Stoykova A, et al. Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development. 2003;130:2903-2915.
9. Fuhrmann S, Levine EM, Reh TA. Extraocular mesenchyme patterns the optic vesicle during early eye development in the embryonic chick. Development. 2000;127:4599-4609.
10. Fujimura N, Taketo MM, Mori M, Korinek V, Kozmik Z. Spatial and temporal regulation of Wnt/β-catenin signaling is essential for development of the retinal pigment epithelium. Dev Biol. 2009;334:31-45.
11. Gage PJ, Suh H, Camper SA. Dosage requirement of Pitx2 for development of multiple organs. Development. 1999;126:4643-4651.
12. Ishii Y, Weinberg K, Oda-Ishii I, Coughlin L, Mikawa T. Morphogenesis and cytodifferentiation of the avian retinal pigmented epithelium require downregulation of group B1 sox genes. Development.2009;136:2579-2589.
13. Liu ZZ, Zhu LQ, Eide FF. Critical role of TrkB and brain-derived neurotrophic factor in the differentiation and survival of retinal pigment epithelium. J Neurosci. 1997;17:8749-8755.
14. Muller F, Rohrer H, Vogel-Hopker A. Bone morphogenetic proteins specify the retinal pigment epithelium in the chick embryo. Development.2007;134:3483-3493.
15. Perron M, Boy S, Amato MA, et al. A novel function for Hedgehog signalling in retinal pigment epithelium differentiation. Development.2003;130:1565-1577.
16. West-Mays JA, Zhang J, Nottoli T, et al. AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle. Dev Biol. 1999;206:46-62.
17. Westenskow P, Piccolo S, Fuhrmann S.β-Catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression. Development. 2009;136:2505-2510.
18. Zhang X, Yang X. Temporal and spatial effects of sonic Hedgehog signaling in chick eye morphogenesis. Dev Biol. 2001;233:271.
19. Bharti K, Liu W, Csermely T, Bertuzzi S, Arnheiter H. Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development. 2008;135:1169-1178.
20. Bumsted KM, Barnstable CJ. Dorsal retinal pigment epithelium differentiates as neural retina in the microphthalmia (mi/mi) mouse. Invest Ophthalmol Vis Sci. 2000;41:903-908.
21. Martinez-Morales JR, Signore M, Acampora D, Simeone A, Bovolenta P. Otx genes are required for tissue specification in the developing eye. Development. 2001;128:2019-2030.
22. Mochii M, Mazaki Y, Mizuno N, Hayashi H, Eguchi G. Role of Mitf in differentiation and transdifferentiation of chicken pigmented epithelial cell. Dev Biol. 1998;193:47-62.
23. Nguyen M, Arnheiter H. Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF. Development. 2000;127:3581-3591.
24. Scholtz CL, Chan KK. Complicated colobomatous microphthalmia in the microphthalmic (mi/mi) mouse. Development. 1987;99:501-508.
25. Nusse R. The Wnt Homepage http://www.stanford.edu/rnusse/wntwindow.html/2009. Accessed December 18, 2009.
26. Cho SH, Cepko CL. Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye. Development.2006;133:3167-3177.
27. Kubo F, Takeichi M, Nakagawa S. Wnt2b controls retinal cell differentiation at the ciliary marginal zone. Development. 2003; 130:587-598.
28. Kubo F, Takeichi M, Nakagawa S. Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes. Development. 2005; 132:2759-2770.
29. Kubo F, Nakagawa S. Hairy1 acts as a node downstream of Wnt signaling to maintain retinal stem cell-like progenitor cells in the chick ciliary marginal zone. Development. 2009;136:1823-1833.
30. Liu H, Xu S, Wang Y, et al. Ciliary margin transdifferentiation from neural retina is controlled by canonical Wnt signaling. Dev Biol.2007;308:54-67.
31. Hamburger V, Hamilton J. A series of normal stages in the development of the chick embryo. J Morphol. 1951;88:49-62.
32. Katahira T, Sato T, Sugiyama S, et al. Interaction between Otx2 and Gbx2 defines the organizing center for the optic tectum. Mech Devel. 2000;91:43-52.
33. Kengaku M, Capdevila J, Rodriguez-Esteban C, et al. Distinct WNT Pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science. 1998;280:1274-1277.
34. Yost C, Torres M, Miller JR, Huang E, Kimelman D, Moon RT. The axis-inducing activity, stability, and subcellular distribution of betacatenin is regulated in Xenopus by glycogen synthase kinase 3. Genes Dev. 1996;10:1443-1454.
35. Krylov D, Kasai K, Echlin D, Taparowsky E, Arnheiter H, Vinson C. A general method to design dominant negatives to B-HLHZip proteins that abolish DNA binding. Proc Natl Acad Sci U S A.1997;94:12274-12279.
36. Martinez-Morales JR, Dolez V, Rodrigo I, et al. OTX2 activates the molecular network underlying retina pigment epithelium differentiation. J Biol Chem. 2003;278:21721-21731.
37. Wingender E, Chen X, Fricke E, et al. The TRANSFAC system on gene expression regulation. Nucleic Acids Res. 2001;29:281-283.
38. Czar MJ, Anderson JC, Bader JS, Peccoud J. Gene synthesis demystified. Trends Biotechnol. 2009;27:63-72.
39. Richardson SM, Wheelan SJ, Yarrington RM, Boeke JD. GeneDesign: rapid, automated design of multikilobase synthetic genes. Genome Res. 2006;16:550-556.
40. Sauka-Spengler T, Barembaum M, Bronner-Fraser M. Gain-and lossof- function approaches in the chick embryo. Methods in Cell Biology. San Diego: Academic Press; 2008:237-256.
41. Matsuda T, Cepko CL. Electroporation and RNA interference in the rodent retina in vivo and in vitro. Proc Natl Acad Sci U S A.2004;101:16-22.
42. Fuhrmann S, Riesenberg AN, Mathiesen AM, Brown EC, Vetter ML, Brown NL. Characterization of a transient TCF/LEF-responsive progenitor population in the embryonic mouse retina. Invest Ophthalmol Vis Sci. 2009;50:432-440.
43. Klein PS, Melton DA. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci U S A. 1996;93:8455-8459.
44. Mochii M, Ono T, Matsubara Y, Eguchi G. Spontaneous Transdifferentiation of quail pigmented epithelial cell is accompanied by a mutation in theMitf Gene. Dev Biol. 1998;196:145-159.
45. Fauroux CM, Freeman S. Inhibitors of inositol monophosphatase. J Enzyme Inhib. 1999;14:97-108.
46. Fu X, Sun H, Klein WH, Mu X. β-catenin is essential for lamination but not neurogenesis in mouse retinal development. Dev Biol.2006;299:424-437.
47. Koike C, Nishida A, Ueno S, et al. Functional roles of Otx2 transcription factor in postnatal mouse retinal development. Mol Cell Biol. 2007;27:8318-8329.
48. Nishida A, Furukawa A, Koike C, et al. Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. Nat Neurosci. 2003;6:1255-1263.
49. Viczian AS, Vignali R, Zuber ME, Barsacchi G, Harris WA. XOtx5b and XOtx2 regulate photoreceptor and bipolar fates in the Xenopus retina. Development. 2003;130:1281-1294.
50. Hanes S, Brent R. DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9. Cell.1989;57:1275-1283.
51. Pannese M, Polo C, Andreazzoli M, et al. The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions. Development. 1995;121:707-720.
52. Agathocleous M, Iordanova I, Willardsen M, et al. A directional Wnt/β-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina. Development.2009;136:3289-3299.
53. Taranova OV, Magness ST, Fagan BM, et al. SOX2 is a dosedependent regulator of retinal neural progenitor competence. Genes Dev. 2006;20:1187-1202.
54. Van Raay TJ, Moore KB, Iordanova I, et al. Frizzled 5 signaling governs the neural potential of progenitors in the developing Xenopus retina. Neuron. 2005;46:23-36.
55. Saito H, Yasumoto K, Takeda K, et al. Melanocyte-specific MITF isoform activates its own gene promoter through physical interaction with LEF-1. J Biol Chem. 2002;277:28787-28794.
56. Ephrussi A, Church GM, Tonegawa S, Gilbert W. B lineagespecific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science. 1985;227:134-140.
57. Araki M, Okada TS. Differentiation of lens and pigment cells in cultures of neural retinal cells of early chick embryos. Dev Biol.1977;60:278-286.
58. Clayton R, Pomerai D, Pritchard D. Experimental manipulation of alternative pathways of differentiation in cultures of embryonic chick neural retina. Dev Growth Diff. 1977;19:319-328.
59. Itoh Y, Okada T, Ide H, Eguchi G. The differentiation of pigment cells in cultures of chick embryonic neural retinae. Dev Growth Diff. 1975;17:39-50.
60. Baas D, Bumsted KM, Martinez JA, Vaccarino FM, Wikler KC, Barnstable CJ. The subcellular localization of OTX2 is cell-type specific and developmentally regulated in the mouse retina. Mol Brain Res. 2000;78:26-37.
61. Bovolenta P, Mallamaci A, Briata P, Corte G, Boncinelli E. Implication of OTX2 in pigment epithelium determination and neural retina differentiation. J Neurosci. 1997;17:4243-4252.
62. Acampora D, Di Giovannantonio L, Di Salvio M, Mancuso P, Simeone A. Selective inactivation of Otx2 mRNA isoforms reveals isoform- specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech Dev. 2009;126:882-897.
63. Courtois V, Chatelain G, Han ZY, Le Novere N, Brun G, Lamonerie T. New Otx2 mRNA isoforms expressed in the mouse brain. J Neurochem. 2003;84:840-853.
64. Fossat N, Courtois V, Chatelain G, Brun G, Lamonerie T. Alternative usage of Otx2 promoters during mouse development. Dev Dyn. 2005;233:154-160.
65. Galy A, Neron B, Planque N, Saule S, Eychene A. Activated MAPK/ ERK kinase (MEK-1) induces transdifferentiation of pigmented epithelium into neural retina. Dev Biol. 2002;248:251-264.
66. Sakami S, Etter P, Reh TA. Activin signaling limits the competence for retinal regeneration from the pigmented epithelium. Mech Dev. 2008;125:106-116.
67. Belecky-Adams T, Scheurer D, Adler R. Activin family members in the developing chick retina: expression patterns, protein distribution, and in vitro effects. Dev Biol. 1999;210:107-123.
68. Buchholz B, Hikita S, Rowland T, et al. Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells. Stem Cells. 2009;27:2427-2434.
69. Hirami Y, Osakada F, Takahashi K, et al. Generation of retinal cells from mouse and human induced pluripotent stem cells. Neurosci Lett. 2009;458:126-131.