Regulatory actions of neuropeptides and peptide hormones on the reproduction of molluscs

Canadian Journal of Zoology

Volumn 88, Issue 9, 2010, Pages 825-845

  Morishita, Fumihiro ^a   Furukawa, Yasuo ^b   Matsushima, Osamu ^c   Minakata, Hiroyuki ^d  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c HIROSHIMA INSTITUTE OF TECHNOLOGY   (Japan)

^d SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; BEHAVIORAL ECOLOGY; BIVALVE; EVOLUTIONARY BIOLOGY; HORMONE; PEPTIDE; PHYSIOLOGICAL RESPONSE; REPRODUCTIVE SUCCESS; SURVIVAL;

ANIMALIA; MOLLUSCA;

EID: 77958093570     PISSN: 00084301     EISSN: 14803283     Source Type: Journal    
DOI: 10.1139/Z10-041     Document Type: Review

References (231)

1. Adamo, S.A. 2002. Modulating the modulators: parasites, neuro modulators and host behavioral change. Brain Behav.Evol. 60(6): 370-377. doi:10.1159/000067790. PMID:12563169
2. Akalal, D.B., Cummins, S.F., Painter, S.D., and Nagle, G.T. 2003. Peptide products of the atrial gland are not water-borne reproductive pheromones during egg laying in Aplysia. Peptides, 24(8): 1117-1122. doi:10.1016/j.peptides.2003.06.001. PMID:14612181.
3. Alevizos, A., Weiss, K.R., and Koester, J. 1991. Synaptic actions of identified peptidergic neuron R15 in Aplysia. III. Activation of the large hermaphroditic duct. J. Neurosci. 11(5): 1282-1290. PMID:2027047.
4. Audesirk, T.E. 1977. Chemoreception in Alphysia californica. III. Evidence for pheromones influencing reproductive behavior. Behav.Biol. 20(2): 235-243. doi:10.1016/S0091-6773(77)90799-4. PMID:901355.
5. Bernay, B., Gagnon, J., and Henry, J. 2004. Egg capsule secretion in invertebrates: a new ovarian regulatory peptide identified by mass spectrometry comparative screening in Sepia officinalis. Biochem.Biophys.Res.Commun. 314(1): 215-222. doi:10.1016/j.bbrc.2003.12.085. PMID:14715268.
6. Bernay, B., Baudy-Floc'h, M., Zanuttini, B., Gagnon, J., and Henry, J. 2005. Identification of SepCRP analogues in the cut tlefish Sepia officinalis: a novel family of ovarian regulatory peptides. Biochem.Biophys.Res.Commun. 338(2): 1037-1047. doi:10.1016/j.bbrc.2005.10.034. PMID:16256953.
7. Bernay, B., Baudy-Floc'h, M., Gagnon, J., and Henry, J. 2006a. Ovarian jellypeptides (OJPs), a new family of regulatory peptides identified in the cephalopod Sepia officinalis. Peptides, 27(6): 1259-1268. doi:10.1016/j.peptides.2005.11.025. PMID:16434122.
8. Bernay, B., Baudy-Floc'h, M., Zanuttini, B., Zatylny, C., Pouvreau, S., and Henry, J. 2006b. Ovarian and sperm regulatory peptides regulate ovulation in the oyster Crassostrea gigas. Mol.Reprod.Dev. 73(5): 607-616. doi:10.1002/mrd.20472. PMID:16493672
9. Bernheim, S.M., and Mayeri, E. 1995. Complex behavior induced by egg-laying hormone in Aplysia. J.Comp.Physiol.A Neuroethol.Sens.Neural Behav.Physiol. 176(1): 131-136.PMID:7823307.
10. Blankenship, J.E., and Haskins, J.T. 1979. Electrotonic coupling among neuroendocrine cells in Aplysia. J. Neurophysiol. 42(2): 347-355.PMID:217972.
11. Bouton, D., Escriva, H., de Mendonça, R.L., Glineur, C., Bertin, B., Noël, C., Robinson-Rechavi, M., de Groot, A., Cornette, J., Laudet, V., and Pierce, R.J. 2005. A conserved retinoid X receptor (RXR) from the mollusk Biomphalaria glabrata transactivates transcription in the presence of retinoids. J. Mol. Endocrinol. 34(2): 567-582. doi:10.1677/jme.1.01766. PMID:15821117.
12. Brown, R.O., and Mayeri, E. 1989. Positive feedback by autoexcitatory neuropeptides in neuroendocrine bag cells of Aplysia. J. Neurosci. 9(4): 1443-1451PMID:2703887.
13. Brown, R.O., Pulst, S.M., and Mayeri, E. 1989. Neuroendocrine bag cells of Aplysia are activated by bag cell peptidecontaining neurons in the pleural ganglion. J. Neurophysiol. 61(6): 1142-1152PMID:2746315.
14. Buresch, K.C., Boal, J.G., Nagle, G.T., Knowles, J., Nobuhara, R., Sweeney, K., and Hanlon, R.T. 2004. Experimental evidence that ovary and oviducal gland extracts influence male agonistic behavior in squids. Biol.Bull.tWoods Hole), 206(1): 1-3. doi:10.2307/1543192. PMID:14977724.
15. Castro, L.F., Lima, D., Machado, A., Melo, C., Hiromori, Y., Nishikawa, J., Nakanishi, T., Reis-Henriques, M.A., and Santos, M.M. 2007. Imposex induction is mediated through the retinoid X receptor signalling pathway in the neogastropod Nucellalapil lus. Aquat. Toxicol. 85(1): 57-66. doi:10.1016/j.aquatox.2007.07.016. PMID:17875330.
16. Chase, R. 2002. Behavior and its neural control in gastropod molluscs. Oxford University Press, New York.
17. Chase, R., and Blanchard, K.C. 2006. The snail's love-dart delivers mucus to increase paternity. Proc. R. Soc. B Biol. Sci. 273(1593): 1471-1475. doi:doi:10.1098/rspb.2006.3474
18. Chen, P.S., Stumm-Zollinger, E., Aigaki, T., Balmer, J., Bienz, M., and Bohlen, P. 1988. A male accessory gland peptide that regulates reproductive behavior of female D. melanogaster. Cell, 54(3): 291-298. doi:10.1016/0092-8674(88)90192-4. PMID:3135120.
19. Chiu, A.Y., and Strumwasser, F. 1981. An immunohistochemical study of the neuropeptidergic bag cells of Aplysia. J. Neurosci. 1(8): 812-826PMID:7050309.
20. Chiu, A.Y., and Strumwasser, F. 1984. Two neuronal populations in the head ganglia of Aplysia californica with egg-laying hormone-like immunoreactivity. Brain Res. 294(1): 83-93. doi:10. 1016/0006-8993(84)91312-X. PMID:6697245.
21. Chiu, A.Y., Hunkapiller, M.W., Heller, E., Stuart, D.K., Hood, L.E., and Strumwasser, F. 1979. Purification and primary structure of the neuropeptide egg-laying hormone of Aplysia califor nica. Proc. Natl. Acad. Sci. U.S.A. 76(12): 6656-6660. doi:10. 1073/pnas.76.12.6656. PMID:293751.
22. Cho, S., Chung, J., Han, J., Ju Lee, B., Han Kim, D., Rhee, K., and Kim, K. 2001. 9-cis-Retinoic acid represses transcription of the gonadotropin-releasing hormone (GnRH) gene via proximal promoter region that is distinct from all-trans-retinoic acid response element. Brain Res.Mol.Brain Res. 87(2): 214-222. doi:10. 1016/S0169-328X(01)00020-1. PMID:11245924.
23. Coe, W.R. 1938. Influence of association on the sezual phases of gastropods having protandric consecutive sexuality. Biol. Bull. (Woods Hole), 75(2): 274-285. doi:10.2307/1537735
24. Conn, P.J., and Kaczmarek, L.K. 1989. The bag cell neurons of Aplysia: a model for the study of the molecular mechanisms involved in the control of prolonged animal behaviors. Mol.Neurobiol. 3(4): 237-273. doi:10.1007/BF02740607. PMID:2698177.
25. Cottrell, G.A. 1997. The first peptidegated ion channel. J. Exp. Biol. 200(18): 2377-2386PMID:9343851.
26. Cox, K.J., Tensen, C.P., van der Schors, R.C., Li, K.W., van Heerikhuizen, H., Vreugdenhil, E., Geraerts, W.P., and Burke, J.F. 1997. Cloning, characterization, and expression of a G-protein coupled receptor from Lymnaea stagnalis and identification of a leucokinin-like peptide, PSFHSWSamide, as its endogenous ligand. J. Neurosci. 17(4): 1197-1205. PMID:9006965
27. Croll, R.P., and van Minnen, J. 1992. Distribution of the peptide Ala-Pro-Gly-Trp-NH2 (APGWamide) in the nervous system and periphery of the snail Lymnaea stagnalis as revealed by immunocytochemistry and in situ hybridization. J. Comp. Neurol. 324(4): 567-574. doi:10.1002/cne.903240409. PMID:1430338
28. Cummins, S.F., and Nagle, G.T. 2005. Aplysia capsulin is localized to egg capsules and egg cordon sheaths and shares sequence homology with Drosophila dec1 gene products. Peptides,26(4): 589-596. doi:10.1016/j.peptides.2004.11.006. PMID:15752572.
29. Cummins, S.F., Nichols, A.E., Amare, A., Hummon, A.B., Sweedler, J.V., and Nagle, G.T. 2004. Characterization of Aplysia enticin and temptin, two novel water-borne protein pheromones that act in concert with attractin to stimulate mate attraction. J. Biol. Chem. 279(24): 25614-25622. doi:10.1074/jbc.M313585200. PMID:15054104.
30. Cummins, S.F., Nichols, A.E., Warso, C.J., and Nagle, G.T. 2005. Aplysia seductin is a water-borne protein pheromone that acts in concert with attractin to stimulate mate attraction. Peptides, 26(3): 351-359. doi:10.1016/j.peptides.2004.10.024. PMID:15652640.
31. Cummins, S.F., Nichols, A.E., Schein, C.H., and Nagle, G.T. 2006. Newly identified water-borne protein pheromones interact with attractin to stimulate mate attraction in Aplysia. Peptides, 27(3): 597-606. doi:10.1016/j.peptides.2005.08.026. PMID:16309784
32. Cummins, S.F., De Vries, M.R., Hill, K.S., Boehning, D., and Nagle, G.T. 2007. Gene identification and evidence for expression of G protein a subunits, phospholipase C, and an inositol 1,4,5-trisphosphate receptor in Aplysia californica rhinophore. Genomics, 90(1): 110-120. doi:10.1016/j.ygeno.2007.03.020.PMID:17498918.
33. Cummins, S.F., Erpenbeck, D., Zou, Z., Claudianos, C., Moroz, L.L., Nagle, G.T., and Degnan, B.M. 2009. Candidate chemoreceptor subfamilies differentially expressed in the chemosensory organs of the mollusc Aplysia. BMC Biol. 7(1): 28-47. doi:10. 1186/1741-7007-7-28. PMID:19493360.
34. D'Aniello, A., Di Cosmo, A., Di Cristo, C., Assisi, L., Botte, V., and Di Fiore, M.M. 1996. Occurrence of sex steroid hormones and their binding proteins in Octopus vulgaris lam. Biochem.Biophys.Res.Commun. 227(3): 782-788. doi:10.1006/bbrc.1996.1585. PMID:8886010.
35. De Boer, P.A.C.M., ter Maat, A., Pieneman, A.W., Croll, R.P., Kurokawa, M., and Jansen, R.F. 1997. Functional role of peptidergic anterior lobe neurons in male sexual behavior of the snail Lymnaea stagnalis. J. Neurophysiol. 78(6): 2823-2833PMID: 9405503.
36. de Lange, R.P.J., and van Minnen, J. 1998. Localization of the neuropeptide APGWamide in gastropod molluscs by in situ hybridization and immunocytochemistry. Gen.Comp.Endocrinol. 109(2): 166-174. doi:10.1006/gcen.1997.7001. PMID:9473361
37. de Lange, R.P.J., van Golen, F.A., and van Minnen, J. 1997. Diversity in cell specific co-expression of four neuropeptide genes involved in control of male copulation behaviour in Lymnaea stagnalis. Neuroscience, 78(1): 289-299. doi:10.1016/S0306-4522(96)00576-3. PMID:9135108.
38. de Longcamp, D., Lubet, P., and Drosdowsky, M. 1974. The in vitro biosynthesis of steroids by the gonad of the mussel (Mytilus edulis). Gen.Comp.Endocrinol. 22(1): 116-127. doi:10.1016/ 0016-6480(74)90093-8. PMID:4273599.
39. DesGroseillers, L. 1990. Molecular aspects of egg-laying behavior in Aplysia californica. Behav. Genet. 20(2): 251-264. doi:10. 1007/BF01067793. PMID:2191647.
40. Di Cosmo, A., and Di Cristo, C. 1998. Neuropeptidergic control of the optic gland of Octopus vulgaris: FMRF-amide and GnRH immunoreactivity. J. Comp. Neurol. 398(1): 1-12. doi:10.1002/ (SICI)1096-9861(19980817)398:1<1::AID-CNE1>3.0.CO;2-5. PMID:9703024.
41. Di Cosmo, A., Paolucci, M., Di Cristo, C., Botte, V., and Ciarcia, G. 1998. Progesterone receptor in the reproductive system of the female of Octopus vulgaris: characterization and immunolocalization. Mol. Reprod. Dev. 50(4): 451-460. doi:10.1002/(SICI) 1098-2795(199808)50:4<451::AID-MRD9>3.0.CO;2-H. PMID: 9669529.
42. Di Cosmo, A., Di Cristo, C., and Paolucci, M. 2001. Sex steroid hormone fluctuations and morphological changes of the reproductive system of the female of Octopus vulgaris throughout the annual cycle. J. Exp. Zool. 289(1): 33-47. doi:10.1002/1097-010X(20010101/31)289:1<33::AID-JEZ4>3.0.CO;2-A. PMID:11169491.
43. Di Cosmo, A., Di Cristo, C., and Paolucci, M. 2002. A estradiol-17β receptor in the reproductive system of the female of Octopus vulgaris: characterization and immunolocalization. Mol.Reprod. Dev. 61(3): 367-375. doi:10.1002/mrd.10014. PMID:11835582.
44. Di Cristo, C., and Di Cosmo, A. 2007. Neuropeptidergic control of Octopus oviducal gland. Peptides, 28(1): 163-168. doi:10.1016/ j.peptides.2006.09.016. PMID:17157961.
45. Di Cristo, C., Paolucci, M., Iglesias, J., Sanchez, J., and Di Cosmo, A. 2002. Presence of two neuropeptides in the fusiform ganglion and reproductive ducts of Octopus vulgaris: FMRFamide and gonadotropin-releasing hormone (GnRH). J. Exp. Zool. 292(3): 267-276. doi:10.1002/jez.90000. PMID:11857460.
46. Di Cristo, C., Delli Bovi, P., and Di Cosmo, A. 2003. Role of FMRFamide in the reproduction of Octopus vulgaris: molecular analysis and effect on visual input. Peptides, 24(10): 1525-1532. doi:10.1016/j.peptides.2003.07.018. PMID:14706531
47. Di Cristo, C., van Minnen, J., and Di Cosmo, A. 2005. The presence of APGWamide in Octopus vulgaris: a possible role in the reproductive behavior. Peptides, 26(1): 53-62. doi:10.1016/ j.peptides.2004.07.019. PMID:15626504.
48. Di Cristo, C., De Lisa, E., and Di Cosmo, A. 2009a. Control of GnRH expression in the olfactory lobe of Octopus vulgaris. Peptides, 30(3): 538-544. doi:10.1016/j.peptides.2008.07.007.PMID:18703100.
49. Di Cristo, C., De Lisa, E., and Di Cosmo, A. 2009b. GnRH in the brain and ovary of Sepia officinalis. Peptides, 30(3): 531-537. doi:10.1016/j.peptides.2008.07.008. PMID:18692104
50. Dictus, W.J., de Jong-Brink, M., and Boer, H.H. 1987. A neuropeptide (Calfluxin) is involved in the influx of calcium into mitochondria of the albumen gland of the freshwater snail Lymnaea stagnalis. Gen.Comp.Endocrinol. 65(3): 439-450. doi:10.1016/ 0016-6480(87)90130-4. PMID:3557101.
51. Dmetrichuk, J.M., Carlone, R.L., and Spencer, G.E. 2006. Retinoic acid induces neurite outgrowth and growth cone turning in in vertebrate neurons. Dev.Biol. 294(1): 39-49. doi:10.1016/j.ydbio.2006.02.018. PMID:16626686.
52. Dmetrichuk, J.M., Carlone, R.L., Jones, T.R., Vesprini, N.D., and Spencer, G.E. 2008. Detection of endogenous retinoids in the molluscan CNS and characterization of the trophic and tropic actions of 9-cis retinoic acid on isolated neurons. J. Neurosci. 28(48): 13014-13024. doi:10.1523/JNEUROSCI.3192-08.2008.PMID:19036995.
53. Dogterom, G.E., Bohlken, S., and Geraerts, W.P. 1983a. A rapid in vivo bioassay of the ovulation hormone of Lymnaea stagnalis. Gen Comp.Endocrinol. 50(3): 476-482. doi:10.1016/0016-6480(83)90269-1. PMID:6684070.
54. Dogterom, G.E., Bohlken, S., and Joosse, J. 1983b. Effect of the photoperiod on the time schedule of egg mass production in Lymnaea stagnalis, as induced by ovulation hormone injections. Gen.Comp.Endocrinol. 49(2): 255-260. doi:10.1016/0016-6480(83)90142-9. PMID:6840519.
55. Dogterom, G.E., Hofs, H.P., Wapenaar, P., Roubos, E.W., and Geraerts, W.P. 1984. The effect of temperature on spontaneous, and ovulation hormone-induced female reproduction in Lymnaea stagnalis. Gen.Comp.Endocrinol. 56(2): 204-209. doi:10.1016/ 0016-6480(84)90032-7. PMID:6510683.
56. Dudek, F.E., and Tobe, S.S. 1978. Bag cell peptide acts directly on ovotestis of Aplysia californica: basis for an in vitro bioassay. Gen.Comp.Endocrinol. 36(4): 618-627. doi:10.1016/0016-6480(78)90103-X. PMID:571383.
57. Dudek, F.E., Cobbs, J.S., and Pinsker, H.M. 1979. Bag cell electrical activity underlying spontaneous egg laying in freely behaving Aplysia brasiliana. J. Neurophysiol. 42(3): 804-817PMID: 571008.
58. Dudek, F.E., Weir, G., Acosta-Urquidi, J., and Tobe, S.S. 1980. A secretion from neuroendocrine bag cells evokes egg release in vitro from ovotestis of Aplysia californica.Gen. Comp. Endocrinol. 40(2): 241-244. doi:10.1016/0016-6480(80)90129-X. PMID:6892702.
59. Duvail, L., Lopez, E., and Fouchereau-Peron, M. 1997. Characterization of a calcitonin gene related peptide-like molecule in the abalone, Haliotis tuberculata. Comp.Biochem.Physiol.C Pharmacol.Toxicol.Endocrinol. 116(2): 155-159. doi:10.1016/ S0742-8413(96)00193-4. PMID:9134700.
60. El Filali, Z., van Minnen, J., Liu, W.K., Smit, A.B., and Li, K.W. 2006. Peptidomics analysis of neuropeptides involved in copulatory behavior of the mollusk Lymnaea stagnalis. J. Proteome Res. 5(7): 1611-1617. doi:10.1021/pr060014p. PMID:16823968
61. Fan, X., Spijker, S., Akalal, D.B., and Nagle, G.T. 2000. Neuropeptide amidation: cloning of a bifunctional aamidating enzyme from Aplysia. Brain Res. Mol. Brain Res. 82(1-2): 25-34. doi:10.1016/S0169-328X(00)00173-X. PMID:11042355
62. Favrel, P., and Mathieu, M. 1996. Molecular cloning of a cDNA encoding the precursor of Ala-Pro-Gly-Trp amide-related neuro peptides from the bivalve mollusc Mytilus edulis. Neurosci.Lett. 205(3): 210-214. doi:10.1016/0304-3940(96)12390-9. PMID:8852595.
63. Feral, C., and LeGall, S. 1983. The influence of a pollutant factor (tributyltin) on the neuroendocrine mechanism responsible for the occurrence of a penis in the female of Ocenebraerinacea. In Molluscan neuro-endocrinology. Edited by J. Lever and H. Boer. North Holland Publishing Company, Amsterdam, the Netherlands. pp. 173-175.
64. Fisher, J.M., Sossin, W., Newcomb, R., and Scheller, R.H. 1988. Multiple neuropeptides derived from a common precursor are differentially packaged and transported. Cell, 54(6): 813-822. doi:10.1016/S0092-8674(88)91131-2. PMID:3409320
65. Fisher, T., Lin, C.H., and Kaczmarek, L.K. 1993. The peptide FMRFa terminates a discharge in Aplysia bag cell neurons by modulating calcium, potassium, and chloride conductances.J. Neurophysiol. 69(6): 2164-2173. PMID:7688803.
66. Florey, E., and Stefano, G.B. 1991. Comparative aspects of neuro peptide function. Manchester University Press, Manchester, UK
67. Franchini, A., Rebecchi, B., and Fantin, A.M. 1994. Immunocyto chemical detection of endocrine cells in the gut of Viviparus ater (Mollusca, Gastropoda). Eur. J. Histochem. 38(3): 237-244PMID:7530517.
68. Froesch, D. 1974. The subpedunculate lobe of the octopus brain: evidence for dual function. Brain Res. 75(2): 277-285. doi:10. 1016/0006-8993(74)90747-1. PMID:4842840.
69. Froesch, D., and Mangold, K. 1976. Uptake of ferritin by the cephalopod optic gland. Cell Tissue Res. 170(4): 549-551. doi:10. 1007/BF00361712. PMID:963730.
70. Fujisawa, Y., Furukawa, Y., Ohta, S., Ellis, T.A., Dembrow, N.C., Li, L., Floyd, P.D., Sweedler, J.V., Minakata, H., Nakamaru, K., Morishita, F., Matsushima, O., Weiss, K.R., and Vilim, F.S. 1999. The Aplysia mytilus inhibitory peptide-related peptides: identification, cloning, processing, distribution, and action. J. Neurosci. 19(21): 9618-9634. PMID:10531464.
71. Furukawa, Y., Nakamaru, K., Sasaki, K., Fujisawa, Y., Minakata, H., Ohta, S., Morishita, F., Matsushima, O., Li, L., Alexeeva, V., Ellis, T.A., Dembrow, N.C., Jing, J., Sweedler, J.V., Weiss, K.R., and Vilim, F.S. 2003. PRQFVamide, a novel pentapeptide identified from the CNS and gut of Aplysia. J. Neurophysiol. 89(6): 3114-3127. doi:10.1152/jn.00014.2003. PMID:12612009
72. Galtsoff, P.S. 1938. Physiology of reproduction of Ostera virginica II.Stimulation of spawning in the female oyster. Biol.Bull. (Woods Hole), 75(2): 286-307. doi:10.2307/1537736.
73. Gauthier-Clerc, S., Pellerin, J., Fournier, M., and Amiard, J.-C. 2006. Immunological and biochemical responses in Mya are naria (Mollusca Bivalvia) exposed in vivo to estradiol-17β.Comp. Biochem. Physiol. C Toxicol. Pharmacol. 144(3): 228-234.
74. Geraerts, W.P., and Joosse, J. 1975. Control of vitellogenesis and of growth of female accessory sex organs by the dorsal body hormone (DBH) in the hermaphroditic freshwater snail Lymnaea stagnalis. Gen.Comp.Endocrinol. 27(4): 450-464. doi:10.1016/ 0016-6480(75)90065-9. PMID:1218695.
75. Geraerts, W.P., Tensen, C.P., and Hogenes, T.M. 1983. Multiple release of peptides by electrically active neurosecretory caudodorsal cells of Lymnaea stagnalis. Neurosci.Lett. 41(1-2): 151-155. doi:10.1016/0304-3940(83)90238-0. PMID:6646514
76. Gore, A.C. 2001. Gonadotropin-releasing hormone neuronsNMDA receptors, and their regulation by steroid hormones across the reproductive life cycle. Brain Res.Brain Res.Rev.37(1-3): 235-248. doi:10.1016/S0165-0173(01)00121-7. PMID:11744089.
77. Hanlon, R.T. 1996. Evolutionary games that squids play: fighting, courting, sneaking, and mating behaviors used for sexual selection in Loligo pealei. Biol. Bull. (Woods Hole), 191: 309-310
78. Haskins, J.T., and Blankenship, J.E. 1979. Interactions between ilateral clusters of neuroendocrine cells in Aplysia. J. Neurophysiol. 42(2): 356-367PMID:217973.
79. Hatcher, N.G., and Sweedler, J.V. 2008. Aplysia bag cells function as a distributed neurosecretory network. J. Neurophysiol. 99(1): 333-343. doi:10.1152/jn.00968.2007. PMID:18003877
80. Heidrich, D.D., Steckelbroeck, S., and Klingmuller, D. 2001. Inhibition of human cytochrome P450 aromatase activity by butyltins. Steroids, 66(10): 763-769. doi:10.1016/S0039-128X(01)00108-8. PMID:11522339.
81. Heller, E., Kaczmarek, L.K., Hunkapiller, M.W., Hood, L.E., and Strumwasser, F. 1980. Purification and primary structure of two neuroactive peptides that cause bag cell afterdischarge and egg laying in Aplysia. Proc.Natl.Acad.Sci.U.S.A. 77(4): 2328-2332. doi:10.1073/pnas.77.4.2328. PMID:6929554
82. Henry, J., and Zatylny, C. 2002. Identification and tissue mapping of APGWamide-related peptides in Sepia officinalis using LC-ESI-MS/MS. Peptides, 23(6): 1031-1037. doi:10.1016/S0196-9781(02)00033-5. PMID:12126729.
83. Henry, M., Benlinmame, N., Belhsen, O.K., Jule, Y., and Mathieu, M. 1995. Immunohistochemical localization of FMRFamide-containing neurons and nerve fibers in the ganglia and the gonad wall of the scallop, Pecten maximus (L). Neuropeptides, 28(2): 79-84. doi:10.1016/0143-4179(95)90079-9. PMID:7746358
84. Henry, J., Favrel, P., and Boucaud-Camou, E. 1997. Isolation and identification of a novel Ala-Pro-Gly-Trp-amide-related peptide inhibiting the motility of the mature oviduct in the cuttlefish, Sepia officinalis. Peptides, 18(10): 1469-1474. doi:10.1016/S0196-9781(97)00241-6. PMID:9437704.
85. Henry, J., Zatylny, C., and Boucaud-Camou, E. 1999. Peptidergic control of egg-laying in the cephalopod Sepia officinalis: involvement of FMRFamide and FMRFamide-related peptides. Peptides, 20(9): 1061-1070. doi:10.1016/S0196-9781(99)00102-3. PMID:10499423.
86. Henry, J., Zatylny, C., and Favrel, P. 2000. HPLC and electrospray ionization mass spectrometry as tools for the identification of APGWamide-related peptides in gastropod and bivalve mollusks: comparative activities on Mytilus muscles. Brain Res. 862(1-2): 162-170. doi:10.1016/S0006-8993(00)02108-9. PMID:10799681
87. Hermann, P., Maat, A., and Jansen, R. 1994. The neural control of egg-laying behaviour in the pond snail Lymnaea stagnalis: motor control of shell turning. J. Exp. Biol. 197(1): 79-99. PMID: 9317378.
88. Hoek, R.M., van Kesteren, R.E., Smit, A.B., de Jong-Brink, M., and Geraerts, W.P. 1997. Altered gene expression in the host brain caused by a trematode parasite: neuropeptide genes are preferentially affected during parasitosis. Proc. Natl. Acad. Sci. U.S.A. 94(25): 14072-14076. doi:10.1073/pnas.94.25.14072.PMID:9391154.
89. Hoek, R.M., Li, K.W., van Minnen, J., Lodder, J.C., de Jong-Brink, M., Smit, A.B., and van Kesteren, R.E. 2005. LFRFamides: a novel family of parasitation-induced RFamide neuropeptides that inhibit the activity of neuroendocrine cells in Lymnaea stagnalis. J. Neurochem. 92(5): 1073-1080. doi:10.1111/j.1471-4159.2004.02927.x. PMID:15715658.
90. Hordijk, P.L., Schallig, H.D., Ebberink, R.H., de Jong-Brink, M., and Joosse, J. 1991. Primary structure and origin of schistosomin, an anti-gonadotropic neuropeptide of the pond snail Lymnaea stagnalis. Biochem. J. 279(3): 837-842. PMID:1953679
91. Hordijk, P.L., de Jong-Brink, M., ter Maat, A., Pieneman, A.W., Lodder, J.C., and Kits, K.S. 1992. The neuropeptide schistosomin and haemolymph from parasitized snails induce similar changes in excitability in neuroendocrine cells controlling reproduction and growth in a freshwater snail. Neurosci.Lett. 136(2): 193-197. doi:10.1016/0304-3940(92)90047-B. PMID:1641190
92. Horiguchi, T. 2006. Masculinization of female gastropod mollusks induced by organotin compounds, focusing on mechanism of actions of tributyltin and triphenyltin for development of imposex. Environ.Sci. 13(2): 77-87PMID:16788559.
93. Horiguchi, T., Nishikawa, T., Ohta, Y., Shiraishi, H., and Morita, M. 2007. Retinoid X receptor gene expression and protein content in tissues of the rock shell Thais clavigera. Aquat. Toxicol. 84(3): 379-388. doi:10.1016/j.aquatox.2007.06.019. PMID:17689673.
94. Horiguchi, T., Ohta, Y., Nishikawa, T., Shiraishi, F., Shiraishi, H., and Morita, M. 2008. Exposure to 9-cis retinoic acid induces penis and vas deferens development in the female rock shell, Thais clavigera. Cell Biol.Toxicol. 24(6): 553-562. doi:10.1007/s10565-007-9051-9. PMID:18085413.
95. Iwakoshi, E., Takuwa-Kuroda, K., Fujisawa, Y., Hisada, M., Ukena, K., Tsutsui, K., and Minakata, H. 2002. Isolation and characterization of a GnRH-like peptide from Octopus vulgaris. Biochem. Biophys. Res. Commun. 291(5): 1187-1193. doi:10. 1006/bbrc.2002.6594. PMID:11883942.
96. Iwakoshi-Ukena, E., Ukena, K., Takuwa-Kuroda, K., Kanda, A., Tsutsui, K., and Minakata, H. 2004. Expression and distribution of octopus gonadotropin-releasing hormone in the central nervous system and peripheral organs of the octopus (Octopus vulgaris) by in situ hybridization and immunohistochemistry. J. Comp. Neurol. 477(3): 310-323. doi:10.1002/cne.20260. PMID: 15305367.
97. Janer, G., Lavado, R., Thibaut, R., and Porte, C. 2005a. Effects of 17β-estradiol exposure in the mussel Mytilus galloprovincialis: a possible regulating role for steroid acyltransferases. Aquat.Toxicol. 75(1): 32-42. doi:10.1016/j.aquatox.2005.01.012.PMID:16083976.
98. Janer, G., LeBlanc, G.A., and Porte, C. 2005b. A comparative study on androgen metabolism in three invertebrate species. Gen. Comp. Endocrinol. 143(3): 211-221
99. Janse, C., van der Roest, M., Jansen, R.F., Montagne-Wajer, C., and Boer, H.H. 1996. Atrophy and degeneration of peptidergic neurons and cessation of egg laying in the aging pond snail Lymnaea stagnalis. J. Neurobiol. 29(2): 202-212. doi:10.1002/ (SICI)1097-4695(199602)29:2<202::AID-NEU6>3.0.CO;2-E. PMID:8821177.
100. Jiménez, C.R., ter Maat, A., Pieneman, A., Burlingame, A.L., Smit, A.B., and Li, K.W. 2004. Spatio-temporal dynamics of the egg-laying-inducing peptides during an egg-laying cycle: a semi quantitative matrix-assisted laser desorption/ionization mass spectrometry approach. J. Neurochem. 89(4): 865-875. doi:10. 1111/j.1471-4159.2004.02353.x. PMID:15140186.
101. Jiménez, C.R., Li, K.W., Smit, A.B., and Janse, C. 2006. Autoinhibitory control of peptidergic molluscan neurons and reproductive senescence. Neurobiol.Aging, 27(5): 763-769. doi:10. 1016/j.neurobiolaging.2005.03.020. PMID:15951060
102. Kanda, T., Kuroki, Y., Kubota, I., Muneoka, Y., and Kobayashi, M. 1990. Neuropeptides isolated from the ganglia of a prosobranch mollusc, Fusinus ferrugineus. Peptide Chemistry, 1989: 39-44. Protein Research Foundation, Osaka, Japan.
103. Kanda, A., Takahashi, T., Satake, H., and Minakata, H. 2006. Molecular and functional characterization of a novel gonadotropin releasing-hormone receptor isolated from the common octopus (Octopus vulgaris). Biochem. J. 395(1): 125-135. doi:10.1042/ BJ20051615. PMID:16367741.
104. Kauer, J.A., Fisher, T.E., and Kaczmarek, L.K. 1987. Alpha bag cell peptide directly modulates the excitability of the neurons that release it. J. Neurosci. 7(11): 3623-3632.PMID:2824716
105. Keay, J., Bridgham, J.T., and Thornton, J.W. 2006. The Octopus vulgaris estrogen receptor is a constitutive transcriptional activator: evolutionary and functional implications. Endocrinology, 147(8): 3861-3869. doi:10.1210/en.2006-0363. PMID:16690796
106. Ketata, I., Denier, X., Hamza-Chaffai, A., and Minier, C. 2008. Endocrine-related reproductive effects in molluscs. Comp. Bio-chem. Physiol. C Toxicol. Pharmacol. 147(3): 261-270
107. Koene, J.M., and Chase, R. 1998. Changes in the reproductive system of the snail Helix aspersa caused by mucus from the love dart. J. Exp. Biol. 201(15): 2313-2319PMID:9662502.
108. Koene, J.M., Jansen, R.F., ter Maat, A., and Chase, R. 2000. A conserved location for the central nervous system control of mating behaviour in gastropod molluscs: evidence from a terrestrial snail. J. Exp. Biol. 203(6): 1071-1080. PMID:10683166
109. Koueta, N., Robbins, I., and Boucaud-Camou, E. 1992. Partial characterization of a gonadotropic, mitogenic factor from the optic gland and hemolymph of the cuttlefish Sepia officinalis. Comp.Biochem.Physiol.A Physiol. 102(2): 229-234. doi:10.1016/0300-9629(92)90126-B.
110. Kriegsfeld, L.J. 2006. Driving reproduction: RFamide peptides behind the wheel. Horm.Behav. 50(5): 655-666. doi:10.1016/j. yhbeh.2006.06.004. PMID:16876801.
111. Kunigelis, S.C., and Saleuddin, A.S.M. 1986. Reproduction in the freshwater gastropod Helisoma: involvement of prostaglandins in egg production. Int. J. Invertebr. Reprod. Dev. 10: 159-167
112. Kupfermann, I., and Kandel, E.R. 1969. Neuronal controls of a behavioral response mediated by the abdominal ganglion of Aplysia. Science (Washington,D.C.), 164(3881): 847-850. doi:10.1126/science.164.3881.847. PMID:5767790.
113. Kupfermann, I., and Kandel, E.R. 1970. Electrophysiological properties and functional interconnections of two symmetrical neuro secretory clusters (bag cells) in abdominal ganglion of Aplysia. J. Neurophysiol. 33(6): 865-876PMID:5485408.
114. Kuroki, Y., Kanda, T., Kubota, I., Fujisawa, Y., Ikeda, T., Miura, A., Minamitake, Y., and Muneoka, Y. 1990. A molluscan neuropeptide related to the crustacean hormone, RPCH. Biochem.Biophys.Res.Commun. 167(1): 273-279. doi:10.1016/0006-291X(90)91761-G. PMID:2310394.
115. Kuroki, Y., Kanda, T., Kubota, I., Ikeda, T., Fujisawa, Y., Minakata, H., and Muneoka, Y. 1993. FMRFamide-related peptides solated from the prosobranch mollusc Fusinus ferrugineus. Acta Biol. Hung. 44(1): 41-44PMID:8493850.
116. Kurosky, A., Gorham, E.L., van Heumen, W.R.A., Garcia, A.T., Smith, J.S., and Mifflin, R.C. 1997. Expression and genetic variation of the Aplysia egg-laying hormone gene family in the atrial gland. Invert. Neurosci. 2(4): 261-271. doi:10.1007/BF02211939. PMID:9460236.
117. Lafont, R., and Mathieu, M. 2007. Steroids in aquatic invertebrates. Ecotoxicology, 16(1): 109-130. doi:10.1007/s10646-006-0113-1. PMID:17238002.
118. Lehman, H.K., and Greenberg, M.J. 1987. The actions of FMRFamide-like peptides on visceral and somatic muscles of the snail Helix aspersa. J. Exp. Biol. 131: 55-68PMID:3694118.
119. Levy, M., Blumberg, S., and Susswein, A.J. 1997. The rhinophores sense pheromones regulating multiple behaviors in Aplysia fasciata. Neurosci.Lett. 225(2): 113-116. doi:10.1016/S0304-3940(97)00200-0. PMID:9147387.
120. Li, K.W., Jiménez, C.R., van Veelen, P.A., and Geraerts, W.P. 1994. Processing and targeting of a molluscan egg-laying peptide prohormone as revealed by mass spectrometric peptide fin erprinting and peptide sequencing. Endocrinology, 134(4):1812-1819. doi:10.1210/en.134.4.1812. PMID:8137747
121. Li, L., Garden, R.W., Floyd, P.D., Moroz, T.P., Gleeson, J.M., Sweedler, J.V., Pasa-Tolic, L., and Smith, R.D. 1999. Egg-laying hormone peptides in the aplysiidae family. J. Exp. Biol. 202(21): 2961-2973PMID:10518477.
122. Lofts, B.D., and Bern, M.A. 1972. The functional morphology of steroidogenic tissues. In Steroids in non-mammalian vertebrates. Edited by O.R. Idler. Academic Press, New York. pp. 37-125
123. Ludwig, A.N., and Walsh, P.J. 2008. Multiple mating, sperm storage, and mating preference in Aplysia californica. Biol. Bull. (Woods Hole), 215(3): 265-271. doi:10.2307/25470710. PMID: 19098147.
124. Mackie, G.L. 1984. Bivalves. In Reproduction. Edited by A.S.Tompa, N.H. Verdonk, and J.A.M. van den Biggerlaar. Academic Press, Orlando, Fla. pp. 351-418.
125. Magoski, N.S. 2004. Regulation of an Aplysia bag-cell neuron cation channel by closely associated protein kinase A and a protein phosphatase. J. Neurosci. 24(30): 6833-6841. doi:10.1523/ JNEUROSCI.1694-04.2004. PMID:15282289.
126. Martínez, G., Mettifogo, L., Lenoir, R., and Olivares, A. 2000. Prostaglandins and reproduction of the scallop Argopecten purpuratus: II. Relationship with gamete release. J. Exp. Zool. 287(1): 86-91. doi:10.1002/1097-010X(20000615)287:1<86::AID-JEZ11>3.0. CO;2-W. PMID:10861554.
127. Matsutani, T., and Nomura, T. 1987. In vitro effects of serotonin and prostaglandins on release of eggs from the ovary of the scallop, Patinopecten yessoensis. Gen.Comp.Endocrinol. 67(1):111-118. doi:10.1016/0016-6480(87)90210-3. PMID:3476349
128. Matthiessen, P., and Gibbs, P.E. 1998. Critical appraisal of the evidence for tributylotin-mediated endocrine disruption in mollusks. Environ. Toxicol. Chem. 17(1): 37-43. doi:10.1002/etc. 5620170106.
129. Mayeri, E. 1979. Local hormonal modulation of neural activity in Aplysia. Fed. Proc. 38(7): 2103-2108PMID:582166
130. Mayeri, E., Rothman, B.S., Brownell, P.H., Branton, W.D., and Padgett, L. 1985. Nonsynaptic characteristics of neurotransmission mediated by egg-laying hormone in the abdominal ganglion of Aplysia. J.Neurosci. 5(8): 2060-2077. PMID:2991481
131. McAllister, L.B., Scheller, R.H., Kandel, E.R., and Axel, R. 1983. In situ hybridization to study the origin and fate of identified neurons. Science (Washington, D.C.), 222(4625): 800-808
132. McClelland, G., and Bourns, T.K. 1969. Effects of Trichobilharziacellata on growth, reproduction, and survival of Lymnaea stagnalis. Exp.Parasitol. 24(2): 137-146. doi:10.1016/0014-4894(69)90150-7. PMID:5813415.
133. McPherson, D.R., and Blankenship, J.E. 1991. Retrograde labelling of serotonergic projections onto the neuroendocrine bag cells of Aplysia. Neurosci.Lett. 123(2): 148-151. doi:10.1016/0304-3940(91)90917-I. PMID:1851265.
134. Miksys, S., and Saleuddin, A.S. 1985. The effect of the brain and dorsal bodies of Helisoma duryi (Mollusca: Pulmonata) on albumen gland synthetic activity in vitro. Gen.Comp.Endocrinol. 60(3): 419-426. doi:10.1016/0016-6480(85)90076-0. PMID:4076761.
135. Minakata, H., Kuroki, Y., Ikeda, T., Fujisawa, Y., Nomoto, K., Kubota, I., and Muneoka, Y. 1991. Effects of the neuropeptide APGW-amide and related compounds on molluscan muscles-GW-amide shows potent modulatory effects. Comp.Biochem.Physiol.C Comp.Pharmacol. 100(3): 565-571doi:10.1016/0742-8413(91)90041-Q. PMID:1687556
136. Minakata, H., Fujita, T., Kawano, T., Nagahama, T., Oumi, T., Ukena, K., Matsushima, O., Muneoka, Y., and Nomoto, K. 1997. The leech excitatory peptide, a member of the GGNG peptide family: isolation and comparison with the earthworm GGNG peptides. FEBS Lett. 410(2-3): 437-442. doi:10.1016/ S0014-5793(97)00567-X. PMID:9237678.
137. Minakata, H., Shigeno, S., Kano, N., Haraguchi, S., Osugi, T., and Tsutsui, K. 2009. Octopus gonadotrophin-releasing hormone: a multifunctional peptide in the endocrine and nervous systems of the cephalopod. J. Neuroendocrinol. 21(4): 322-326. doi:10.1111/j.1365-2826.2009.01852.x. PMID:19210294.
138. Morishita, F., and Furukawa, Y. 2006. Neuropeptides in Aplysia: key players for the neural regulation of physiological functions and behavior. In Invertebrate neuropeptides and hormones: basic knowledge and recent advances. Edited by H. Satake. Transworld Research Network, Kerala, India. pp. 37-73
139. Morishita, F., Minakata, H., Takeshige, K., Furukawa, Y., Matsushima, O., and Horiguchi, T. 2006a. Purifications, physiological functions and localizations of neuropeptides in a prosobranch gastropod, Thais clavigera. Peptide Science, 2005: 43-46
140. Morishita, F., Minakata, H., Takeshige, K., Furukawa, Y., Takata, T., Matsushima, O., Mukai, S.T., Saleuddin, A.S., and Horiguchi, T. 2006b. Novel excitatory neuropeptides isolated from a prosobranch gastropod, Thais clavigera: the molluscan counterpart of the annelidan GGNG peptides. Peptides, 27(3): 483-492. doi:10.1016/j.peptides.2005.06.026. PMID:16309789
141. Moroz, L.L. 2006. Localization of putative nitrergic neurons in peripheral chemosensory areas and the central nervous system of Aplysia californica. J. Comp. Neurol. 495(1): 10-20. doi:10.1002/cne.20842. PMID:16432897.
142. Mukai, S.T., Kiehn, L., and Saleuddin, A.S. 2004. Dopamine stimulates snail albumen gland glycoprotein secretion through the activation of a D1like receptor. J.Exp.Biol. 207(14): 2507-2518. doi:10.1242/jeb.01052. PMID:15184522.
143. Muneoka, Y., Morishita, F., Furukawa, Y., Matsushima, O., Kobayashi, M., Ohtani, M., Takahashi, T., Iwakoshi, E., Fujisawa, Y., and Minakata, H. 2000. Comparative aspects of invertebrate neuropeptides. Acta Biol. Hung. 51(2-4): 111-132PMID:11034137.
144. Nagle, G.T., Painter, S.D., Kelner, K.L., and Blankenship, J.E. 1985. Atrial gland cells synthesize a family of peptides that can induce egg laying in Aplysia. J.Comp.Physiol.B Biochem.Syst.Environ.Physiol. 156(1): 43-55PMID:3836231.
145. Nagle, G.T., Painter, S.D., Blankenship, J.E., Dixon, J.D., and Kurosky, A. 1986. Evidence for the expression of three genes encoding homologous atrial gland peptides that cause egg laying in Aplysia. J. Biol. Chem. 261(17): 7853-7859. PMID:3711112.
146. Nagle, G.T., Painter, S.D., Blankenship, J.E., and Kurosky, A. 1988. Proteolytic processing of egg-laying hormone-related precursors in Aplysia: identification of peptide regions critical for biological activity. J. Biol. Chem. 263(19): 9223-9237. PMID: 3379066.
147. Nagle, G.T., Painter, S.D., and Blankenship, J.E. 1989. Posttranslational processing in model neuroendocrine systems: precursors and products that coordinate reproductive activity n Aplysia and Lymnaea. J. Neurosci. Res. 23(4): 359-370. doi:10.1002/jnr.490230402. PMID:2671398.
148. Nagle, G.T., de Jong-Brink, M., Painter, S.D., Bergamin-Sassen, M.M., Blankenship, J.E., and Kurosky, A. 1990. d-Bag cell peptide from the egg-laying hormone precursor of Aplysia: processing, primary structure, and biological activity. J.Biol.Chem. 265(36): 22329-22335. PMID:2266129.
149. Nagle, G.T., Garcia, A.T., Gorham, E.L., Knock, S.L., van Heumen, W.R., Spijker, S., Smit, A.B., Geraerts, W.P., and Kurosky, A. 1995a. Molecular cloning and cellular localization of a furin-like prohormone convertase from the atrial gland of Aplysia. DNA Cell Biol. 14(5): 431-443. doi:10.1089/dna.1995.14. 431. PMID:7748493.
150. Nagle, G.T., Garcia, A.T., Knock, S.L., Gorham, E.L., van Heumen, W.R., and Kurosky, A. 1995b. Molecular cloning, cDNA sequence, and localization of a prohormone convertase (PC2) from the Aplysia atrial gland. DNA Cell Biol. 14(2): 145-154. doi:10.1089/dna.1995.14.145. PMID:7865132.
151. Nakamura, S., Osada, M., and Kijima, A. 2007. Involvement of GnRH neuron in the spermatogonial proliferation of the scallop, Patinopecten yessoensiss. Mol.Reprod.Dev. 74(1): 108-115. doi:10.1002/mrd.20544. PMID:16941661.
152. Nishikawa, J., Mamiya, S., Kanayama, T., Nishikawa, T., Shiraishi, F., and Horiguchi, T. 2004. Involvement of the retinoid X receptor in the development of imposex caused by organotins in gastropods. Environ.Sci.Technol. 38(23): 6271-6276. doi:10.1021/ es049593u. PMID:15597881.
153. Oberdorster, E., and McClellan-Green, P. 2000. The neuropeptide APGWamide induces imposex in the mud snail, Ilyanassa obsoleta. Peptides, 21(9): 1323-1330. doi:10.1016/S0196-9781(00)00274-6. PMID:11072118.
154. Oehlmann, J., Di Benedetto, P., Tillmann, M., Duft, M., Oetken, M., and Schulte-Oehlmann, U. 2007. Endocrine disruption in prosobranch molluscs: evidence and ecological relevance. Ecotoxicology, 16(1): 29-43. doi:10.1007/s10646-006-0109-x.PMID:17219087.
155. Ohtani, M., Muneoka, Y., Takahashi, T., and Teranishi, H. 1995. Bioactive peptides isolated from the clam Meretrix lusoria. Acta Biol. Hung. 46(2-4): 449-452.PMID:8853717
156. Onitsuka, C., Yamaguchi, A., Kanamaru, H., Oikawa, S., Takeda, T., and Matsuyama, M. 2009. Molecular cloning and expression analysis of a GnRH-Like dodecapeptide in the swordtip squid, Loligo edulis. Zool.Sci.(Tokyo), 26(3): 203-208.
157. Osada, M., Tawarayama, H., and Mori, K. 2004. Estrogen synthesis in relation to gonadal development ofJapanese scallop, Patinopecten yessoensis: gonadal profile and immunolocalization of P450 aromatase and estrogen. Comp.Biochem.Physiol.Biochem.Mol.Biol. 139(1): 123-128. doi:10.1016/j.cbpc.2004. 07.002. PMID:15364295.
158. Owens, D.F., Menon, J.G., and Rothman, B.S. 1992. Structure-activity relationship of the neurotransmitter alpha-bag cell peptide on Aplysia LUQ neurons: implications regarding its inactivation in the extracellular space. J. Neurobiol. 23(6):656-670. doi:10.1002/neu.480230605. PMID:1359004.
159. Painter, S.D., Kalman, V.K., Nagle, G.T., Zuckerman, R.A., and Blankenship, J.E. 1985. The anatomy and functional morphology of the large hermaphroditic duct of three species of Aplysia, with special reference to the atrial gland. J. Morphol. 186(2): 167-194. doi:10.1002/jmor.1051860204. PMID:4078902
160. Painter, S.D., Rock, M.K., Nagle, G.T., and Blankenship, J.E. 1988. Peptide B induction of bag-cell activity in Aplysia: localization of sites of action to the cerebral and pleural ganglia. J. Neurobiol. 19(8): 695-706. doi:10.1002/neu.480190804. PMID: 3235999.
161. Painter, S.D., Gustavson, A.R., Kalman, V.K., Nagle, G.T., and Blankenship, J.E. 1989a. Induction of copulatory behavior in Aplysia: atrial gland factors mimic the excitatory effects of freshly deposited egg cordons. Behav. Neural Biol. 51(2): 222-236. doi:10.1016/S0163-1047(89)90857-1. PMID:2930434
162. Painter, S.D., Kalman, V.K., Nagle, G.T., and Blankenship, J.E. 1989b. Localization of immunoreactive alpha-bag-cell peptide in the central nervous system of Aplysia. J. Comp. Neurol. 287(4): 515-530. doi:10.1002/cne.902870409. PMID:2794131
163. Painter, S.D., Clough, B., Garden, R.W., Sweedler, J.V., and Nagle, G.T. 1998. Characterization of Aplysia attractin, the first waterborne peptide pheromone in invertebrates. Biol. Bull. (Woods Hole), 194(2): 120-131. doi:10.2307/1543042. PMID:9604313
164. Pazos, A.J., and Mathieu, M. 1999. Effects of five natural gonadotropin-releasing hormones on cell suspensions of marine bivalve gonad: stimulation of gonial DNA synthesis. Gen.Comp.Endocrinol. 113(1): 112-120. doi:10.1006/gcen.1998. 186. PMID:9882550.
165. Pinsker, H.M., and Dudek, F.E. 1977. Bag cell control of egg laying in freely behaving Aplysia. Science (Washington, D.C.), 197(4302): 490-493. doi:10.1126/science.197.4302.490
166. Price, D.A., and Greenberg, M.J. 1977. Structure of a molluscan ardioexcitatory neuropeptide. Science (Washington, D.C.),197(4304): 670-671. doi:10.1126/science.877582.
167. Pulst, S.M., Gusman, D., Rothman, B.S., and Mayeri, E. 1986. Coexistence of egg-laying hormone and a-bag cell peptide in bag cell neurons of Aplysia indicates that they are a peptidergic multitransmitter system. Neurosci.Lett. 70(1): 40-45. doi:10.1016/0304-3940(86)90434-9. PMID:2877421.
168. Pulst, S.-M., Gusman, D., and Mayeri, E. 1988. Immunostaining for peptides of the egg-laying hormone/bag cell peptide precursor protein in the head ganglia of Aplysia. Neuroscience, 27(1): 363-371. doi:10.1016/0306-4522(88)90244-8. PMID:3200446
169. Ram, J.L. 1977. Hormonal control of reproduction in Busycon: laying of egg capsules caused by nervous system extracts. Biol. Bull. (Woods Hole), 152(2): 221-232. doi:10.2307/1540561.PMID:856296.
170. Ram, J.L., Ram, M.L., and Davis, J.P. 1982. Hormonal control of reproduction in Busycon: II. Laying of egg-containing capsules caused by nervous system extracts and further characterization of the substance causing egg capsule laying. Biol. Bull. (Woods Hole), 162(3): 360-370. doi:10.2307/1540989.
171. Ram, J.L., Gallardo, C.S., Ram, M.L., and Croll, R.P. 1998. Reproduction-associated immunoreactive peptides in the nervous systems of prosobranch gastropods. Biol. Bull. (WoodsHole), 195(3): 308-318. doi:10.2307/1543142. PMID:9924774.
172. Richard, A. 1971. Contribution à l'étude expérimentale de la croissance et de la maturation sexuelle de Sepia officinalis L.(Mollusque, Céphalopode). Thèse de 3ème cycle, Université de Lille, Lille, France.
173. Rodet, F., Lelong, C., Dubos, M.P., Costil, K., and Favrel, P. 2005. Molecular cloning of a molluscan gonadotropin-releasing hormone receptor orthologue specifically expressed in the gonad.Biochim.Biophys.Acta, 1730(3): 187-195.doi:10.1016/j.bbaexp.2005.05.012.
174. Ronis, M.J.J., and Mason, A.Z. 1996. The metabolism of testosterone by the periwinkle (Littorina littorea) in vitro and in vivo: effects of tributyl tin. Mar. Environ. Res. 42(1-4): 161-166.doi:10.1016/0141-1136(95)00069-0.
175. Roovers, E., Vincent, M.E., van Kesteren, E., Geraerts, W.P., Planta, R.J., Vreugdenhil, E., and van Heerikhuizen, H. 1995. Characterization of a putative molluscan insulin-related peptide receptor. Gene, 162(2): 181-188. doi:10.1016/0378-1119(95)00323-X. PMID:7557427.
176. Rothman, B.S., Mayeri, E., Brown, R.O., Yuan, P.M., and Shively, J.E. 1983a. Primary structure and neuronal effects of a-bag cell peptide, a second candidate neurotransmitter encoded by a single gene in bag cell neurons of Aplysia. Proc. Natl. Acad. Sci. U.S.A. 80(18): 5753-5757. doi:10.1073/pnas.80.18.5753. PMID: 16593372.
177. Rothman, B.S., Weir, G., and Dudek, F.E. 1983b. Egg-laying hormone: direct action on the ovotestis of Aplysia. Gen. Comp. Endocrinol. 52(1): 134-141. doi:10.1016/0016-6480(83)90166-1. PMID:6685081.
178. Rothman, B.S., Hawke, D.H., Brown, R.O., Lee, T.D., Dehghan, A.A., Shively, J.E., and Mayeri, E. 1986. Isolation and primary structure of the califins, three biologically active egg-laying hormone-like peptides from the atrial gland of Aplysia californica. J. Biol. Chem. 261(4): 1616-1623PMID:3753705
179. Rothman, B.S., Dekruyff, S., Talebian, M., Menon, J.G., Squire, C.R., Yeh, C.H., and Lee, T.D. 1992. Aplysia peptide neurotransmitters b-ag cell peptide, Phe-Met-Arg-Phe-amide, and small cardioexcitatory peptide B are rapidly degraded by a leucine aminopeptidase-like activity in hemolymph. J. Biol. Chem. 267(35): 25135-25140PMID:1460014.
180. Saitongdee, P., Apisawetakan, S., Anunruang, N., Poomthong, T., Hanna, P., and Sobhon, P. 2005. Egg-laying-hormone immunoreactivity in the neural ganglia and ovary of Haliotis asinina Linnaeus. Invert. Neurosci. 5(3-4): 165-172. doi:10.1007/s10158-005-0032-5. PMID:15803317.
181. Saleuddin, A.S., Wilson, L.E., Khan, H.R., and Jones, G.M. 1980. Effects of brain extracts on oocyte maturation in Helisoma (Pulmonata: Mollusca). Can. J. Zool. 58(6): 1109-1124. doi:10.1139/z80-155. PMID:7427805.
182. Salzet, M., Verger-Bocquet, M., Vandenbulcke, F., and van Minnen, J. 1997. Leech egg-laying-like hormone: structure, neuronal distribution and phylogeny. Brain Res. Mol. Brain Res. 49(1-2): 211-221. doi:10.1016/S0169-328X(97)00145-9. PMID:9387880
183. Santos, M.M., Reis-Henriques, M.A., Vieira, M.N., and Solé, M. 2006. Triphenyltin and tributyltin, single and in combination, promote imposex in the gastropod Bolinus brandaris. Ecotoxicol. Environ. Saf. 64(2): 155-162. doi:10.1016/j.ecoenv. 2005.02.003. PMID:16406593.
184. Scheller, R.H., Jackson, J.F., McAllister, L.B., Rothman, B.S., Mayeri, E., and Axel, R. 1983. A single gene encodes multiple neuropeptides mediating a stereotyped behavior. Cell, 32(1): 7-22. doi:10.1016/0092-8674(83)90492-0. PMID:6687446
185. Shen, X., Li, Q.L., Brent, G.A., and Friedman, T.C. 2005. Regulation of regional expression in rat brain PC2 by thyroid hormone/ characterization of novel negative thyroid hormone response elements in the PC2 promoter. Am. J. Physiol. Endocrinol. Metab. 288(1): E236-E245. doi:10.1152/ajpendo.00144.2004. PMID: 15585599.
186. Shope, S.B., McPherson, D., Rock, M.K., and Blankenship, J.E. 1991. Functional and morphological evidence for the existence of neurites from abdominal ganglion bag cell neurons in the head-ring ganglia of Aplysia. J. Comp. Physiol. A Neuroethol.Sens. Neural Behav. Physiol. 168(5): 539-552. doi:10.1007/BF00215076. PMID:1920155.
187. Sigvardt, K.A., Rothman, B.S., Brown, R.O., and Mayeri, E. 1986. The bag cells of Aplysia as a multitransmitter system: identification of alpha bag cell peptide as a second neurotransmitter. J. Neurosci. 6(3): 803-813PMID:2870142.
188. Smit, A.B., Spijker, S., and Geraerts, W.P. 1992. Molluscan putative prohormone convertases: structural diversity in the central nervous system of Lymnaea stagnalis. FEBS Lett. 312(2-3):213-218. doi:10.1016/0014-5793(92)80938-D. PMID:1426255
189. Smit, A.B., Spijker, S., Nagle, G.T., Knock, S.L., Kurosky, A., and Geraerts, W.P. 1994. Structural characterization of a Lymnaea putative endoprotease related to human furin. FEBS Lett. 343(1): 27-31. doi:10.1016/0014-5793(94)80600-4. PMID:8163012.
190. Smit, A.B., van Kesteren, R.E., Spijker, S., van Minnen, J., van Golen, F.A., Jiménez, C.R., and Li, K.W. 2003. Peptidergic modulation of male sexual behavior in Lymnaea stagnalis: structural and functional characterization of -FVamideneuropeptides. J. Neurochem. 87(5): 1245-1254. doi:10.1046/j.1471-4159.2003.02086.x. PMID:14622104.
191. Smith, S.A., Nason, J., and Croll, R.P. 1997. Detection of APGWamide-like immunoreactivity in the sea scallop, Placopecten magellanicus. Neuropeptides, 31(2): 155-165. doi:10.1016/S0143-4179(97)90085-8. PMID:9179869.
192. Snyder, M.J. 1998. Cytochrome P450 enzymes belonging to the CYP4 family from marine invertebrates. Biochem. Biophys. Res. Commun. 249(1): 187-190. doi:10.1006/bbrc.1998.9104.PMID:9705854.
193. Sossin, W.S., Sweet-Cordero, A., and Scheller, R.H. 1990. Dale's hypothesis revisited: different neuropeptides derived from a common prohormone are targeted to different processes. Proc. Natl. Acad. Sci. U.S.A. 87(12): 4845-4848. doi:10.1073/pnas. 87.12.4845. PMID:2352952.
194. Spijker, S., Smit, A.B., Eipper, B.A., Malik, A., Mains, R.E., and Geraerts, W.P. 1999. A molluscan peptide a-amidating enzyme precursor that generates five distinct enzymes. FASEB J. 13(6): 735-748PMID:10094934.
195. Spijker, S., Sharp-Baker, H.E., Geraerts, W.P., van Minnen, J., and Smit, A.B. 2004. Stimulus-dependent regulation and cellular expression of genes encoding neuropeptides, prohormone convertases, a-amidating enzyme and 7B2 in identified Lymnaeaneurons. J. Neurochem. 90(2): 287-296. doi:10.1111/j.1471-4159.2004.02484.x. PMID:15228585.
196. Squire, C.R., Talebian, M., Menon, J.G., Dekruyff, S., Lee, T.D., Shively, J.E., and Rothman, B.S. 1991. Leucine aminopeptidase-like activity in Aplysia hemolymph rapidly degrades biologically active a-bag cell peptide fragments. J. Biol.Chem. 266(33): 22355-22363PMID:1939259.
197. Stanley, D.W. 2000. Eicosanoids in invertebrate signal transduction systems. Princeton University Press, Princeton, N.J.
198. Sternberg, R.M., Hotchkiss, A.K., and Leblanc, G.A. 2008. The contribution of steroidal androgens and estrogens to reproductive maturation of the eastern mud snail Ilyanassa obsoleta. Gen.Comp.Endocrinol. 156(1): 15-26. doi:10.1016/j.ygcen.2007.12. 002. PMID:18226815.
199. Susswein, A.J., and Nagle, G.T. 2004. Peptide and protein pheromones in molluscs. Peptides, 25(9): 1523-1530. doi:10.1016/j. peptides.2003.11.027. PMID:15374653.
200. Susswein, A.J., Gev, S., Achituv, Y., and Markovich, S. 1984. Behavioral patterns of Aplysia fasciata along the Mediterranean coast of Israel. Behav.Neural Biol. 41(1): 7-22. doi:10.1016/ S0163-1047(84)90667-8. PMID:6547833.
201. Suzuki, H., Yamamoto, T., Nakagawa, M., and Uemura, H. 2002. Neuropeptide Y-immunoreactive neuronal system and colocalization with FMRFamide in the optic lobe and pedunclecomplex of the octopus (Octopus vulgaris). Cell Tissue Res. 307(2): 255-264. doi:10.1007/s00441-001-0492-9. PMID:11845332
202. Tensen, C.P., Cox, K.J.A., Burke, J.F., Leurs, R., van der Schors, R.C., Geraerts, W.P.M., Vreugdenhil, E., and van Heerikhuizen, H. 1998a. Molecular cloning and characterization of an invertebrate homologue of a neuropeptide Y receptor. Eur. J. Neurosci. 10(11): 3409-3416. doi:10.1046/j.1460-9568.1998.00350.x. PMID:9824454.
203. Tensen, C.P., Cox, K.J., Smit, A.B., van der Schors, R.C., Meyerhof, W., Richter, D., Planta, R.J., Hermann, P.M., van Minnen, J., Geraerts, W.P., Knol, J.C., Burke, J.F., Vreugdenhil, E., and van Heerikhuizen, H. 1998b. The Lymnaea cardioexcitatory peptide (LyCEP) receptor: a G-protein-coupled receptor for a novel member of the RFamide neuropeptide family. J. Neurosci. 18(23): 9812-9821PMID:9822740.
204. ter Maat, A., Lodder, J.C., Veenstra, J., and Goldschmeding, J.T. 1982. Suppression of egg-laying during starvation in the snail Lymnaea stagnalis by inhibition of the ovulation hormone producing caudo-dorsal cells. Brain Res. 239(2): 535-542. doi:10. 1016/0006-8993(82)90528-5. PMID:7093700.
205. ter Maat, A., Lodder, J.C., and Wilbrink, M. 1983. Induction of egg-laying in the pond snail Lymnaea stagnalis by environmental stimulation of the release of ovulation hormone from the caudo-dorsal cells. Int. J. Invertebr. Reprod. 6: 239-247
206. Thorndyke, M.C., and Goldsworthy, G.J. 1988. Neurohormones in invertebrates. Cambridge University Press, Cambridge, UK.
207. Thornton, J.W., Need, E., and Crews, D. 2003. Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling. Science (Washington, D.C.), 301(5640): 1714-1717. doi:10.1126/science.1086185.
208. Tompa, A.S., Verdonk, N.H., and van den Biggelaar, J.A.M. 1982. Reproduction. The Mollusca, No. 7. Academic Press, Orlando, Fla.
209. Too, C.K., and Croll, R.P. 1995. Detection of FMRFamide-like immunoreactivities in the sea scallop Placopecten magellanicus by immunohistochemistry and western blot analysis. Cell Tissue Res. 281(2): 295-304. doi:10.1007/BF00583398. PMID:7648623
210. Tsai, P.S., and Zhang, L. 2008. The emergence and loss of gonadotropin-releasing hormone in protostomes: orthology, phylogeny, structure, and function. Biol. Reprod. 79(5): 798-805. doi:10. 1095/biolreprod.108.070185. PMID:18614699.
211. van Golen, F.A., Li, K.W., de Lange, R.P.J, van Kesteren, R.E., van der Schors, R.C., and Geraerts, W.P. 1995. Co-localized neuropeptides conopressin and ALA-PRO-GLY-TRP-NH2 have antagonistic effects on the vas deferens of Lymnaea. Neuroscience, 69(4): 1275-1287. doi:10.1016/0306-4522(95)00311-6. PMID:8848113.
212. van Kesteren, R.E., Smit, A.B., de With, N.D., van Minnen, J., Dirks, R.W., van der Schors, R.C., and Joosse, J. 1992. A vasopressin-related peptide in the mollusc Lymnaea stagnalis: peptide structure, prohormone organization, evolutionary and functional aspects of Lymnaea conopressin. Prog. Brain Res. 92: 47-57. doi:10.1016/S0079-6123(08)61164-4. PMID:1302887.
213. van Kesteren, R.E., Smit, A.B., de Lange, R.P.J., Kits, K.S., van Golen, F.A., van der Schors, R.C., De With, N.D., Burke, J.F., and Geraerts, W.P. 1995a. Structural and functional evolution of the vasopressin/oxytocin superfamily: vasopressin-related conopressin is the only member present in Lymnaea, and is involved in the control of sexual behavior. J. Neurosci. 15(9):5989-5998PMID:7666183.
214. van Kesteren, R.E., Tensen, C.P., Smit, A.B., van Minnen, J., van Soest, P.F., Kits, K.S., Meyerhof, W., Richter, D., van Heerikhuizen, H., Vreugdenhil, E., and Geraerts, W.P.M. 1995b.A novel G protein-coupled receptor mediating both asopressinand oxytocin-like functions of Lys-conopressin in Lymnaea stagnalis. Neuron, 15(4): 897-908. doi:10.1016/0896-6273(95)90180-9. PMID:7576638.
215. van Kesteren, R.E., Tensen, C.P., Smit, A.B., van Minnen, J., Kolakowski, L.F., Meyerhof, W., Richter, D., van Heerikhuizen, H., Vreugdenhil, E., and Geraerts, W.P.M. 1996. Co-evolution of ligand-receptor pairs in the vasopressin/oxytocin superfamily of bioactive peptides. J. Biol. Chem. 271(7): 3619-3626. doi:10. 1074/jbc.271.7.3619. PMID:8631971.
216. van Minnen, J., Schallig, H.D., and Ramkema, M.D. 1992. Identification of putative egg-laying hormone containing neuronal systems in gastropod molluscs. Gen.Comp.Endocrinol. 86(1):96-102. doi:10.1016/0016-6480(92)90130-C. PMID:1505734
217. Vilim, F.S., Cropper, E.C., Price, D.A., Kupfermann, I., and Weiss, K.R. 1996. Release of peptide cotransmitters in Aplysia: regulation and functional implications. J. Neurosci. 16(24): 8105-8114PMID:8987835.
218. Vreugdenhil, E., Jackson, J.F., Bouwmeester, T., Smit, A.B., van Minnen, J., van Heerikhuizen, H., Klootwijk, J., and Joosse, J. 1988. Isolation, characterization, and evolutionary aspects of a cDNA clone encoding multiple neuropeptides involved in the stereotyped egg-laying behavior of the freshwater snail Lymnaea stagnalis. J. Neurosci. 8(11): 4184-4191. PMID:3183719
219. Wayne, N.L., and Frumovitz, M. 1995. Calcium influx following onset of electrical afterdischarge is not required for hormone secretion from neuroendocrine cells of Aplysia. Endocrinology, 136(1): 369-372. doi:10.1210/en.136.1.369. PMID:7828555
220. Wayne, N.L., Lee, W., Michel, S., Dyer, J., and Sossin, W.S. 2004. Activity-dependent regulation of neurohormone synthesis and its impact on reproductive behavior in Aplysia.Biol. Reprod. 70(2): 277-281. doi:10.1095/biolreprod.103.022491. PMID:14522824
221. Weaver, R.J., and Audsley, N. 2009. Neuropeptide regulators of juvenile hormone synthesis: structures, functions, distribution, and unanswered questions. Ann. N.Y. Acad. Sci. 1163(1): 316-329. doi:10.1111/j.1749-6632.2009.04459.x. PMID:19456353
222. Wells, M.J., and Wells, M. 1977. Optic glands and the endocrinology of reproduction. Symp. Zool. Soc. Lond. 38: 525-540.
223. Wertz, A., Rossler, W., Obermayer, M., and Bickmeyer, U. 2006. Functional neuroanatomy of the rhinophore of Aplysia punctata. Front. Zool. 3(1): 6. doi:10.1186/1742-9994-3-6. PMID:16597345.
224. Wijdenes, J., van Elk, R., and Joosse, J. 1983. Effects of two gonadotropic hormones on polysaccharide synthesis in the albumen gland of Lymnaea stagnalis, studied with the organ culture technique. Gen.Comp.Endocrinol. 51(2): 263-271. doi:10.1016/0016-6480(83)90080-1. PMID:6618157.
225. Wodinsky, J. 1977. Hormonal inhibition of feeding and death in octopus: control by optic gland secretion. Science (Washington, D.C.), 198(4320): 948-951. doi:10.1126/science.198.4320.948
226. Yamanaka, N., Zitnan, D., Kim, Y.J., Adams, M.E., Hua, Y.J., Suzuki, Y., Suzuki, M., Suzuki, A., Satake, H., Mizoguchi, A., Asaoka, K., Tanaka, Y., and Kataoka, H. 2006. Regulation of insect steroid hormone biosynthesis by innervating peptidergic neurons. Proc.Natl.Acad.Sci.U.S.A. 103(23): 8622-8627doi:10.1073/pnas.0511196103. PMID:16707581.
227. Young, K.G., Chang, J.P., and Goldberg, J.I. 1999. Gonadotropin-releasing hormone neuronal system of the freshwater snails Helisoma trivolvis and Lymnaea stagnalis: possible involvement in reproduction. J. Comp. Neurol. 404(4): 427-437. doi:10.1002/ (SICI)1096-9861(19990222)404:4<427::AID-CNE1>3.0.CO;2-R. PMID:9987988.
228. Zatylny, C., Gagnon, J., Boucaud-Camou, E., and Henry, J. 2000a. ILME: a waterborne pheromonal peptide released by the eggs of Sepia officinalis. Biochem.Biophys.Res.Commun. 275(1):217-222. doi:10.1006/bbrc.2000.3286. PMID:10944467
229. Zatylny, C., Gagnon, J., Boucaud-Camou, E., and Henry, J. 2000b. The SepOvotropin: a new ovarian peptide regulating oocyte transport in Sepia officinalis. Biochem.Biophys.Res.Commun. 276(3): 1013-1018. doi:10.1006/bbrc.2000.3595. PMID:11027583
230. Zatylny, C., Marvin, L., Gagnon, J., and Henry, J. 2002. Fertilization in Sepia officinalis: the first mollusk sperm-attracting peptide. Biochem. Biophys. Res. Commun. 296(5): 1186-1193doi.1016/S0006-291X(02)02036-3. PMID:12207899
231. Zhang, L., Tello, J.A., Zhang, W., and Tsai, P.S. 2008. Molecular cloning, expression pattern, and immunocytochemical localization of a gonadotropin-releasing hormone-like molecule in the gastropod mollusk, Aplysia californica. Gen. Comp. Endocrinol. 156(2): 201-209. doi:10.1016/j.ygcen.2007.11.015. PMID:18178211.