메뉴 건너뛰기




Volumn 13, Issue 4, 2010, Pages 288-293

Low-dose and high-dose methotrexate are two different drugs in practical terms

Author keywords

High dose methotrexate; Low dose methotrexate; Methotrexate; Oncology; Rheumatology

Indexed keywords

ACETYLSALICYLIC ACID; DISEASE MODIFYING ANTIRHEUMATIC DRUG; FOLINIC ACID; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; LEUKOTRIENE B4; LIPOXYGENASE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; METHOTREXATE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; RHEUMATOID FACTOR; THROMBOXANE B2;

EID: 77958088656     PISSN: 17561841     EISSN: 1756185X     Source Type: Journal    
DOI: 10.1111/j.1756-185X.2010.01564.x     Document Type: Article
Times cited : (43)

References (47)
  • 1
    • 78651010566 scopus 로고
    • Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroylglutamic acid (aminopterin)
    • Farber S, Diamond LK, Mercer RD, Sylvester RF, Wolf JA (1948) Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroylglutamic acid (aminopterin). N Engl J Med 238, 787-93.
    • (1948) N Engl J Med , vol.238 , pp. 787-793
    • Farber, S.1    Diamond, L.K.2    Mercer, R.D.3    Sylvester, R.F.4    Wolf, J.A.5
  • 2
    • 77958086362 scopus 로고    scopus 로고
    • Pharmacology of cancer chemotherapy: antimetabolite - methotrexate
    • DeVita VT Jr, Hellman S, Rosenberg SA, 8th edn, Lippincott Williams & Wilkins, Philadeplhia.
    • Devita VT, Lawrence TS, Rosenberg SA, DePinto RA, Weinberg RA (2008) Pharmacology of cancer chemotherapy: antimetabolite - methotrexate. In: DeVita VT Jr, Hellman S, Rosenberg SA (eds) Principles and Practice of Oncology, 8th edn, pp 427-28. Lippincott Williams & Wilkins, Philadeplhia.
    • (2008) Principles and Practice of Oncology , pp. 427-428
    • Devita, V.T.1    Lawrence, T.S.2    Rosenberg, S.A.3    DePinto, R.A.4    Weinberg, R.A.5
  • 3
    • 0023503165 scopus 로고
    • High- dose methotrexate: a critical reappraisal
    • Ackland SP, Schilsky RL (1987) High- dose methotrexate: a critical reappraisal. J Clin Oncol 5, 2017-31.
    • (1987) J Clin Oncol , vol.5 , pp. 2017-2031
    • Ackland, S.P.1    Schilsky, R.L.2
  • 4
    • 0029788523 scopus 로고    scopus 로고
    • Concepts in use of high-dose methotrexate therapy
    • Treon SP, Chabner BA (1996) Concepts in use of high-dose methotrexate therapy. Clin Chem 42, 1322-9.
    • (1996) Clin Chem , vol.42 , pp. 1322-1329
    • Treon, S.P.1    Chabner, B.A.2
  • 5
    • 76549239323 scopus 로고
    • Therapeutic suppression of tissue reactivity. Effect of aminopterin in Rheumatoid Arthritis and psoriasis
    • Gubner R, August S, Ginsberg V (1951) Therapeutic suppression of tissue reactivity. Effect of aminopterin in Rheumatoid Arthritis and psoriasis. Am J Med Sci 221, 176-82.
    • (1951) Am J Med Sci , vol.221 , pp. 176-182
    • Gubner, R.1    August, S.2    Ginsberg, V.3
  • 6
    • 0014436555 scopus 로고
    • Treatment of dermatomyositis with methotrexate
    • Malaviya AN, Many A, Schwartz RS (1968) Treatment of dermatomyositis with methotrexate. Lancet 2, 485-8.
    • (1968) Lancet , vol.2 , pp. 485-488
    • Malaviya, A.N.1    Many, A.2    Schwartz, R.S.3
  • 7
    • 0021080093 scopus 로고
    • Methotrexate in rheumatoid arthritis: 15 years experience
    • Hoffmeister RT (1983) Methotrexate in rheumatoid arthritis: 15 years experience. Am J Med 75(6A), 69-73.
    • (1983) Am J Med , vol.75 A , Issue.6 , pp. 69-73
    • Hoffmeister, R.T.1
  • 8
    • 0000685404 scopus 로고
    • Methotrexate in rheumatoid arthritis
    • Hoffmeister RT (1972) Methotrexate in rheumatoid arthritis. Arthritis Rheum 15, 114.
    • (1972) Arthritis Rheum , vol.15 , pp. 114
    • Hoffmeister, R.T.1
  • 9
    • 0021923633 scopus 로고
    • Efficacy of low-dose methotrexate in rheumatoid arthritis
    • Weinblatt ME, Coblyn JS, Fox DA, et al. (1985) Efficacy of low-dose methotrexate in rheumatoid arthritis. N Engl J Med 312, 818-22.
    • (1985) N Engl J Med , vol.312 , pp. 818-822
    • Weinblatt, M.E.1    Coblyn, J.S.2    Fox, D.A.3
  • 10
    • 0022137053 scopus 로고
    • Weekly pulse methotrexate in rheumatoid arthritis. Clinical and immunologic effects in a randomized, double-blind study
    • Andersen PA, West SG, O'Dell JR, Via CS, Claypool RG, Kotzin BL (1985) Weekly pulse methotrexate in rheumatoid arthritis. Clinical and immunologic effects in a randomized, double-blind study. Ann Intern Med 103, 489-96.
    • (1985) Ann Intern Med , vol.103 , pp. 489-496
    • Andersen, P.A.1    West, S.G.2    O'Dell, J.R.3    Via, C.S.4    Claypool, R.G.5    Kotzin, B.L.6
  • 11
    • 0024589484 scopus 로고
    • Increasing methotrexate effect with increasing dose in the treatment of resistant rheumatoid arthritis
    • Furst DE, Koehnke R, Burmeister LF, Kohler J, Cargill I (1989) Increasing methotrexate effect with increasing dose in the treatment of resistant rheumatoid arthritis. J Rheumatol 16, 313-20.
    • (1989) J Rheumatol , vol.16 , pp. 313-320
    • Furst, D.E.1    Koehnke, R.2    Burmeister, L.F.3    Kohler, J.4    Cargill, I.5
  • 12
    • 0028306446 scopus 로고
    • Tolerability of methotrexate starting with 15 or 25 mg/week for rheumatoid arthritis
    • Schnabel A, Reinhold-Keller E, Willmann V, Gross WL (1994) Tolerability of methotrexate starting with 15 or 25 mg/week for rheumatoid arthritis. Rheumatol Int 14, 33-8.
    • (1994) Rheumatol Int , vol.14 , pp. 33-38
    • Schnabel, A.1    Reinhold-Keller, E.2    Willmann, V.3    Gross, W.L.4
  • 13
    • 35648991026 scopus 로고    scopus 로고
    • Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)
    • Verstappen SM, Jacobs JW, Van Der Veen MJ, et al. (2007) Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial). Ann Rheum Dis 66, 1443-9.
    • (2007) Ann Rheum Dis , vol.66 , pp. 1443-1449
    • Verstappen, S.M.1    Jacobs, J.W.2    Van Der Veen, M.J.3
  • 14
    • 67549096874 scopus 로고    scopus 로고
    • Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative
    • Visser K, Katchamart W, Loza E, Martinez-Lopez JA, Salliot C, Trudeau J (2009) Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative. Ann Rheum Dis 68, 1086-93.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1086-1093
    • Visser, K.1    Katchamart, W.2    Loza, E.3    Martinez-Lopez, J.A.4    Salliot, C.5    Trudeau, J.6
  • 15
    • 67650156848 scopus 로고    scopus 로고
    • An update on methotrexate
    • Braun J, Rau R (2009) An update on methotrexate. Curr Opin Rheumatol 21, 216-23.
    • (2009) Curr Opin Rheumatol , vol.21 , pp. 216-223
    • Braun, J.1    Rau, R.2
  • 16
    • 0142124934 scopus 로고    scopus 로고
    • Methotrexate as the 'anchor drug' for the treatment of early rheumatoid arthritis
    • Pincus T, Yazici Y, Sokka T, Aletaha D, Smolen JS (2003) Methotrexate as the 'anchor drug' for the treatment of early rheumatoid arthritis. Clin Exp Rheumatol 21, S179-85.
    • (2003) Clin Exp Rheumatol , vol.21
    • Pincus, T.1    Yazici, Y.2    Sokka, T.3    Aletaha, D.4    Smolen, J.S.5
  • 17
    • 67549101312 scopus 로고    scopus 로고
    • Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature
    • Visser K, Van Der HD (2009) Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature. Ann Rheum Dis 68, 1094-9.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1094-1099
    • Visser, K.1    Van Der, H.D.2
  • 18
    • 0029788523 scopus 로고    scopus 로고
    • Concepts in use of high-dose methotrexate therapy
    • Treon SP, Chabner BA (1996) Concepts in use of high-dose methotrexate therapy. Clin Chem 42 8 (B), 1322-9.
    • (1996) Clin Chem , vol.42 B , Issue.8 , pp. 1322-1329
    • Treon, S.P.1    Chabner, B.A.2
  • 19
    • 0017713675 scopus 로고
    • Incidence of drug-related deaths secondary to high-dose methotrexate and citrovorum factor administration
    • Von Hoff DD, Penta IS, Helman U, Slavik M (1977) Incidence of drug-related deaths secondary to high-dose methotrexate and citrovorum factor administration. Cancer Treat Rep 61, 745-8.
    • (1977) Cancer Treat Rep , vol.61 , pp. 745-748
    • Von Hoff, D.D.1    Penta, I.S.2    Helman, U.3    Slavik, M.4
  • 20
    • 65949115490 scopus 로고    scopus 로고
    • High-dose methotrexate for elderly patients with primary CNS lymphoma
    • Zhu J-J, Gerstner ER, Engler DA, et al. (2009) High-dose methotrexate for elderly patients with primary CNS lymphoma. Neuro Oncol 11, 211-5.
    • (2009) Neuro Oncol , vol.11 , pp. 211-215
    • Zhu, J.-J.1    Gerstner, E.R.2    Engler, D.A.3
  • 21
    • 0019472047 scopus 로고
    • Methotrexate treatment of squamous-cell head and neck cancers: dose-response evaluation
    • Woods RL, Fox RM, Tattersall MHN (1981) Methotrexate treatment of squamous-cell head and neck cancers: dose-response evaluation. Br Med J 282, 600-2.
    • (1981) Br Med J , vol.282 , pp. 600-602
    • Woods, R.L.1    Fox, R.M.2    Tattersall, M.H.N.3
  • 22
    • 0017255763 scopus 로고    scopus 로고
    • Acute and chronic effects of methotrexate on hepatic, pulmonary, and skeletal systems
    • Nesbit M, Krivit W, Heyn R, Sharp H (2006) Acute and chronic effects of methotrexate on hepatic, pulmonary, and skeletal systems. Cancer 37(Suppl 2), 1048-54.
    • (2006) Cancer , vol.37 , Issue.SUPPL 2 , pp. 1048-1054
    • Nesbit, M.1    Krivit, W.2    Heyn, R.3    Sharp, H.4
  • 24
    • 0011328548 scopus 로고    scopus 로고
    • Cancer chemotherapy and the liver
    • Macdonald J (1998) Cancer chemotherapy and the liver. Clin Liver Dis 2, 631-42.
    • (1998) Clin Liver Dis , vol.2 , pp. 631-642
    • Macdonald, J.1
  • 25
    • 0015442331 scopus 로고    scopus 로고
    • Recent advances in the chemotherapy of metastatic osteogenic sarcoma
    • Jaffe N (2006) Recent advances in the chemotherapy of metastatic osteogenic sarcoma. Cancer 30, 1627-31.
    • (2006) Cancer , vol.30 , pp. 1627-1631
    • Jaffe, N.1
  • 26
    • 77958106296 scopus 로고    scopus 로고
    • Drug-induced pulmonary toxicity eMedicine specialties > Pulmonology > iatrogenic pulmonary disorders, updated September 24, (accessed 12 May 2010).
    • Ali A, Schmidt MF (2008) Drug-induced pulmonary toxicity eMedicine specialties > Pulmonology > iatrogenic pulmonary disorders updated September 24, (accessed 12 May 2010).
    • (2008)
    • Ali, A.1    Schmidt, M.F.2
  • 27
    • 67549107120 scopus 로고    scopus 로고
    • Long term safety of methotrexate monotherapy in rheumatoid arthritis patients: a systematic literature research
    • Salliot C, Van Der Heijde D (2009) Long term safety of methotrexate monotherapy in rheumatoid arthritis patients: a systematic literature research. Ann Rheum Dis 68, 1100-4.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1100-1104
    • Salliot, C.1    Van Der Heijde, D.2
  • 28
    • 0037029418 scopus 로고    scopus 로고
    • Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study
    • Choi HK, Hernan MA, Seeger JD, Robins JM, Wolfe F (2002) Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study. Lancet 359, 1173-7.
    • (2002) Lancet , vol.359 , pp. 1173-1177
    • Choi, H.K.1    Hernan, M.A.2    Seeger, J.D.3    Robins, J.M.4    Wolfe, F.5
  • 29
    • 34247564814 scopus 로고    scopus 로고
    • Disease modifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis: a case control study
    • Van HalmVP, Nurmohamed MT, Twisk JW, Dijkmans BA, Voskuyl AE (2006) Disease modifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis: a case control study. Arthritis Res Ther 8, R151.
    • (2006) Arthritis Res Ther , vol.8
    • Van Halm, V.P.1    Nurmohamed, M.T.2    Twisk, J.W.3    Dijkmans, B.A.4    Voskuyl, A.E.5
  • 30
    • 0033830527 scopus 로고    scopus 로고
    • Meta-analysis of treatment termination rates among rheumatoid arthritis patients receiving disease modifying anti-rheumatic drugs
    • Maetzel A, Wong A, Strand V, Tugwell P, Wells G, Bombardier C (2000) Meta-analysis of treatment termination rates among rheumatoid arthritis patients receiving disease modifying anti-rheumatic drugs. Rheumatology (Oxford) 39, 975-81.
    • (2000) Rheumatology (Oxford) , vol.39 , pp. 975-981
    • Maetzel, A.1    Wong, A.2    Strand, V.3    Tugwell, P.4    Wells, G.5    Bombardier, C.6
  • 31
    • 76649094231 scopus 로고    scopus 로고
    • Risk and management of liver toxicity during methotrexate treatment in rheumatoid and psoriatic arthritis: a systematic review of the literature
    • Visser K, Van Der Heijde DM (2009) Risk and management of liver toxicity during methotrexate treatment in rheumatoid and psoriatic arthritis: a systematic review of the literature. Clin Exp Rheumatol 27, 1017-25.
    • (2009) Clin Exp Rheumatol , vol.27 , pp. 1017-1025
    • Visser, K.1    Van Der Heijde, D.M.2
  • 33
    • 33750210943 scopus 로고    scopus 로고
    • Rates and predictors of herpes zoster in patients with rheumatoid arthritis and non-inflammatory musculoskeletal disorders
    • Wolfe F, Michaud K, Chakravarty EF (2006) Rates and predictors of herpes zoster in patients with rheumatoid arthritis and non-inflammatory musculoskeletal disorders. Rheumatology (Oxford) 45, 1370-5.
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 1370-1375
    • Wolfe, F.1    Michaud, K.2    Chakravarty, E.F.3
  • 35
    • 2642554059 scopus 로고    scopus 로고
    • Lymphoma in rheumatoid arthritis: the effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients
    • Wolfe F, Michaud K (2004) Lymphoma in rheumatoid arthritis: the effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients. Arthritis Rheum 50, 1740-51.
    • (2004) Arthritis Rheum , vol.50 , pp. 1740-1751
    • Wolfe, F.1    Michaud, K.2
  • 36
    • 0036624739 scopus 로고    scopus 로고
    • Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France
    • Mariette X, Cazals-Hatem D, Warszawki J, Liote F, Balandraud N, Sibilia J (2002) Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France. Blood 99, 3909-15.
    • (2002) Blood , vol.99 , pp. 3909-3915
    • Mariette, X.1    Cazals-Hatem, D.2    Warszawki, J.3    Liote, F.4    Balandraud, N.5    Sibilia, J.6
  • 37
    • 68049089955 scopus 로고    scopus 로고
    • Determinants of red blood cell methotrexate polyglutamate concentrations in rheumatoid arthritis patients receiving long-term methotrexate treatment
    • Stamp LK, O'Donnell JL, Chapman PT, et al. (2009) Determinants of red blood cell methotrexate polyglutamate concentrations in rheumatoid arthritis patients receiving long-term methotrexate treatment. Arthritis Rheum 60, 2248-56.
    • (2009) Arthritis Rheum , vol.60 , pp. 2248-2256
    • Stamp, L.K.1    O'Donnell, J.L.2    Chapman, P.T.3
  • 38
    • 0017873070 scopus 로고
    • The clinical pharmacology of methotrexate: new applications of an old drug
    • Bleyer WA (1978) The clinical pharmacology of methotrexate: new applications of an old drug. Cancer 41, 36-51.
    • (1978) Cancer , vol.41 , pp. 36-51
    • Bleyer, W.A.1
  • 39
    • 22944470530 scopus 로고    scopus 로고
    • Low-Dose Methotrexate: a mainstay in the treatment of rheumatoid arthritis
    • Cronstein BN (2005) Low-Dose Methotrexate: a mainstay in the treatment of rheumatoid arthritis. Pharmacol Rev 57, 163-72.
    • (2005) Pharmacol Rev , vol.57 , pp. 163-172
    • Cronstein, B.N.1
  • 40
    • 0029898079 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of low-dose pulse methotrexate in rheumatoid arthritis
    • Bannwarth B, Pehourcq F, Schaeverbeke T, Dehais J (1996) Clinical pharmacokinetics of low-dose pulse methotrexate in rheumatoid arthritis. Clin Pharmacokinet 30, 194-210.
    • (1996) Clin Pharmacokinet , vol.30 , pp. 194-210
    • Bannwarth, B.1    Pehourcq, F.2    Schaeverbeke, T.3    Dehais, J.4
  • 41
    • 11444251484 scopus 로고    scopus 로고
    • The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules
    • Johnston A, Gudjonsson JE, Sigmundsdottir H, Ludviksson BR, Valdimarsson H (2005) The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules. Clin Immunol 114, 154-63.
    • (2005) Clin Immunol , vol.114 , pp. 154-163
    • Johnston, A.1    Gudjonsson, J.E.2    Sigmundsdottir, H.3    Ludviksson, B.R.4    Valdimarsson, H.5
  • 42
    • 57349141486 scopus 로고    scopus 로고
    • Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages
    • Reiss AB, Carsons SE, Anwar K, et al. (2008) Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages. Arthritis Rheum 58, 3675-83.
    • (2008) Arthritis Rheum , vol.58 , pp. 3675-3683
    • Reiss, A.B.1    Carsons, S.E.2    Anwar, K.3
  • 44
    • 20044362604 scopus 로고    scopus 로고
    • Lp (a) lipoprotein and lipids in patients with rheumatoid arthritis: serum levels and relationship to inflammation
    • Dursunoglu D, Evrengul H, Polat B, Tanriverdi H, Cobankara V, Kilic AKM (2005) Lp (a) lipoprotein and lipids in patients with rheumatoid arthritis: serum levels and relationship to inflammation. Rheumatol Int 25, 241-5.
    • (2005) Rheumatol Int , vol.25 , pp. 241-245
    • Dursunoglu, D.1    Evrengul, H.2    Polat, B.3    Tanriverdi, H.4    Cobankara, V.5    Kilic, A.K.M.6
  • 45
    • 84960582159 scopus 로고
    • Efficacy of methotrexate in rheumatoid arthritis
    • Weinblatt ME (1995) Efficacy of methotrexate in rheumatoid arthritis. Brit J Rheumatol 34(Suppl 2), 43-8.
    • (1995) Brit J Rheumatol , vol.34 , Issue.SUPPL 2 , pp. 43-48
    • Weinblatt, M.E.1
  • 46
    • 0035124920 scopus 로고    scopus 로고
    • Platelet-Active drugs the relationship among dose, effectiveness and side effects
    • Patrono C, Coller B, Dalen JE, et al. (2001) Platelet-Active drugs the relationship among dose, effectiveness and side effects. Chest 119, 39S-63S.
    • (2001) Chest , vol.119
    • Patrono, C.1    Coller, B.2    Dalen, J.E.3
  • 47
    • 0020537396 scopus 로고
    • Differential inhibition by aspirin of vascular and platelet prostaglandin synthesis in atherosclerotic patients
    • Weksler BB, Pett SB, Alonso D, Richter RC (1983) Differential inhibition by aspirin of vascular and platelet prostaglandin synthesis in atherosclerotic patients. N Engl J Med 308, 800-5.
    • (1983) N Engl J Med , vol.308 , pp. 800-805
    • Weksler, B.B.1    Pett, S.B.2    Alonso, D.3    Richter, R.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.