Induction of pulmonary fibrosis by methotrexate treatment in mice lung in vivo and in vitro

Journal of Toxicological Sciences

Volumn 35, Issue 5, 2010, Pages 653-661

  Ohbayashi, Masayuki ^a   Suzuki, Masanori ^a   Yashiro, Yoshiki ^a   Fukuwaka, Sayaka ^a   Yasuda, Masako ^a   Kohyama, Noriko ^a   Kobayashi, Yasuna ^a   Yamamoto, Toshinori ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

Alveolar epithelial cell; Apoptosis; Cytotoxicity; Lung fibroblast; Methotrexate; Pulmonary toxicity

Indexed keywords

EOSIN; HEMATOXYLIN; HYDROXYPROLINE; METHOTREXATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW SUPPRESSION; CELL DAMAGE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG MEGADOSE; FIBROBLAST; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; LUNG PARENCHYMA; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; SINGLE DRUG DOSE; THERAPY EFFECT; TREATMENT DURATION;

MUS;

EID: 77958068680     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.35.653     Document Type: Article

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