Identification of novel genetic markers and improved treatment options for diabetic kidney disease

Biomarkers in Medicine

Volumn 4, Issue 5, 2010, Pages 739-741

  Distefano, Johanna K ^a  

^a TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

Author keywords

diabetes; end stage renal disease; exome sequencing; genetics; genome wide association studies; microvascular complications; nephropathy; personalized medicine; pharmacogenetics; RNA sequencing

Indexed keywords

DIABETES MELLITUS; DIABETIC NEPHROPATHY; DISEASE COURSE; EDITORIAL; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC MARKER; GENETIC RISK; HEREDITY; HUMAN; KIDNEY FAILURE; PHARMACOGENETICS; RENAL REPLACEMENT THERAPY; RISK ASSESSMENT; RISK FACTOR;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALBUMINURIA; DIABETIC NEPHROPATHIES; DIPEPTIDASES; GENETIC MARKERS; HUMANS; KIDNEY FAILURE, CHRONIC; SEQUENCE ANALYSIS, RNA;

EID: 77958060961     PISSN: 17520363     EISSN: None     Source Type: Journal    
DOI: 10.2217/bmm.10.83     Document Type: Editorial

References (22)

1. Jones CA, Krolewski AS, Rogus J, Xue JL, Collins A, Warram JH: Epidemic of end-stage renal disease in people with diabetes in the United States population: do we know the cause? Kidney Int. 67, 1684-1691 (2005).
2. Hayden PS, Iyengar SK, Schelling JR, Sedor JR: Kidney disease, genotype and the pathogenesis of vasculopathy. Curr. Opin. Nephrol. Hypertens. 12(1), 71-78 (2003).
3. Nelson RG, Kunzelman CL, Pettitt DJ, Saad MF, Bennett PH, Knowler WC: Albuminuria in Type 2 (non-insulin-dependent) diabetes mellitus and impaired glucose tolerance in Pima Indians. Diabetologia 32(12), 870-876 (1989).
4. Pugh JA, Medina R, Ramirez M: Comparison of the course to end-stage renal disease of Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic nephropathy. Diabetologia 36(10), 1094-1098 (1993).
5. Gall MA, Rossing P, Skott P et al.: Prevalence of micro- and macro-albuminuria, arterial hypertension, retinopathy and large vessel disease in European Type 2 (non-insulin-dependent) diabetic patients. Diabetologia 34(9), 655-661 (1991).
6. No authors listed. Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications Trial. Diabetes Control and Complications Trial Research Group. N. Engl. J. Med. 329(14), 977-986 (1993).
7. Gaede P, Vedel P, Parving HH, Pedersen O: Intensified multifactorial intervention in patients with Type 2 diabetes mellitus and microalbuminuria: the steno Type 2 randomised study. Lancet 353(9153), 617-622 (1999).
8. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD: The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N. Engl. J. Med. 329(20), 1456-1462 (1993).
9. Nelson RG, Knowler WC, Pettitt DJ, Hanson RL, Bennett PH: Incidence and determinants of elevated urinary albumin excretion in Pima Indians with NIDDM. Diabetes Care 18(2), 182-187 (1995).
10. Ravid M, Brosh D, Ravid-Safran D, Levy Z, Rachmani R: Main risk factors for nephropathy in Type 2 diabetes mellitus are plasma cholesterol levels, mean blood pressure, and hyperglycemia. Arch. Intern. Med. 158(9), 998-1004 (1998).
11. Nelson RG, Knowler WC, Pettitt DJ, Saad MF, Charles MA, Bennett PH: Assessment of risk of overt nephropathy in diabetic patients from albumin excretion in untimed urine specimens. Arch. Intern. Med. 151(9), 1761-1765 (1991).
12. Schelling JR, Zarif L, Sehgal A, Iyengar S, Sedor JR: Genetic susceptibility to end-stage renal disease. Curr. Opin. Nephrol. Hypertens. 8(4), 465-472 (1999).
13. Pettitt DJ, Saad MF, Bennett PH, Nelson RG, Knowler WC: Familial predisposition to renal disease in two generations of Pima Indians with Type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 33(7), 438-443 (1990).
14. Quinn M, Angelico MC, Warram JH, Krolewski AS: Familial factors determine the development of diabetic nephropathy in patients with IDDM. Diabetologia 39(8), 940-945 (1996).
15. Seaquist ER, Goetz FC, Rich S, Barbosa J: Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy. N. Engl. J. Med. 320(18), 1161-1165 (1989).
16. Craig DW, Millis MP, Distefano JK: Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes. Diabet. Med. 26(11), 1090-1098 (2009).
17. Hanson RL, Craig DW, Millis MP et al.: Identification of PVT1 as a candidate gene for end-stage renal disease in Type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study. Diabetes 56(4), 975-983 (2007).
18. Pezzolesi MG, Poznik GD, Mychaleckyj JC et al.: Genome-wide association scan for diabetic nephropathy susceptibility genes in Type 1 diabetes. Diabetes 58(6), 1403-1410 (2009).
19. Shimazaki A, Kawamura Y, Kanazawa A et al.: Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy. Diabetes 54(4), 1171-1178 (2005). (Pubitemid 40446333)
20. Metzker ML: Sequencing technologies - the next generation. Nat. Rev. Genet. 11(1), 31-46 (2010).
21. Li B, Leal SM: Discovery of rare variants via sequencing: implications for the design of complex trait association studies. PLoS Genet. 5(5), e1000481 (2009).
22. Susztak K, Bottinger EP: Diabetic nephropathy: a frontier for personalized medicine. J. Am. Soc. Nephrol. 17, 361-367 (2006).