Artesunate-mefloquine combination therapy in acute Plasmodium falciparum malaria in young children: A field study regarding neurological and neuropsychiatric safety

Malaria Journal

Volumn 9, Issue 1, 2010, Pages

  Frey, Sarabel G ^a   Chelo, David ^b   Kinkela, Mina N ^b   Djoukoue, Florence ^b   Tietche, Felix ^b   Hatz, Christoph ^c   Weber, Peter ^a  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^b Mother and Child Centre of The Chantal Biya Foundation Yaounde   (Cameroon)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARTESUNATE PLUS MEFLOQUINE; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; ARTESUNATE; MEFLOQUINE;

AFRICA; AGGRESSION; ANEMIA; ANXIETY DISORDER; ARTICLE; ASTHENIA; ATAXIA; AUDITORY HALLUCINATION; CHILD; CLONUS; CONFUSION; CONVULSION; DIARRHEA; DIPLOPIA; DIZZINESS; DRUG INDUCED HEADACHE; DRUG SAFETY; DYSARTHRIA; DYSDIADOCHOKINESIS; DYSESTHESIA; DYSPHAGIA; EATING DISORDER; FEMALE; FIELD STUDY; FORGETFULNESS; HEARING LOSS; HUMAN; HYPERACTIVITY; HYPERREFLEXIA; HYPOREFLEXIA; INSOMNIA; LONELINESS; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MOOD CHANGE; MUSCLE HYPOTONIA; NIGHTMARE; NYSTAGMUS; PANIC; PARESTHESIA; PRESCHOOL CHILD; SIDE EFFECT; SPEECH DISORDER; TENSION; TREATMENT OUTCOME; TREMOR; VERTIGO; VISUAL DISORDER; VISUAL HALLUCINATION; VOMITING; WORLD HEALTH ORGANIZATION; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; DRUG COMBINATION; INFANT; ISOLATION AND PURIFICATION; MENTAL DISEASE; METHODOLOGY; NEUROLOGIC DISEASE; PHASE 4 CLINICAL TRIAL; PLASMODIUM FALCIPARUM;

AFRICA; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INFANT; MALARIA, FALCIPARUM; MALE; MEFLOQUINE; MENTAL DISORDERS; NERVOUS SYSTEM DISEASES; PLASMODIUM FALCIPARUM;

EID: 77958055444     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-9-291     Document Type: Article

References (24)

1. WHO, World health statistics 2009 Geneva, World Health Organization 2009
2. The neurological assessment in young children treated with artesunate monotherapy or artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria. MT Ambler LM Dubowitz R Arunjerdja EP Hla KL Thwai J Viladpainguen P Singhasivanon C Luxemburger F Nosten R McGready, Malar J 2009 8 207 10.1186/1475-2875-8-207 19725966
3. Mefloquine in infants and young children. C Luxemburger RN Price F Nosten FO Ter Kuile T Chongsuphajaisiddhi NJ White, Ann Trop Paediatr 1996 16 281 286 8985524
4. WHO, Facts on artemisinin based combination therapies, 2006, January update Geneva, World Health Organization 2006
5. Clinical pharmacokinetics of mefloquine. J Karbwang NJ White, Clin Pharmacokinet 1990 19 264 279 10.2165/00003088-199019040-00002 2208897
6. EMEA European Medicines Agency, ICH Topic E6 (R1) Guideline for Good Clinical Practice 2002
7. Examination of the child with minor neurological dysfunction. BCL Touwen, Mc Keith Press 2 1976
8. Hamburg-Wechsler-Intelligenztest für Kinder - HAWIK IV. F Petermann U Petermann, 2. Auflage, Hogreve-Verlag 2008
9. Assessment Battery for children by Alan S. Kaufmann, USA. AS Kaufmann NL Kaufmann, American Guidance Service Inc., Circle Press, Minnesota 1983 55014 1796
10. Safety and efficacy of a pediatric granule formulation of artesunate-mefloquine in young children from Cameroon with uncomplicated falciparum malaria. F Tietche D Chelo KM Ntoto C Hatz S Frey A Frentzel S Trapp R Zielonka E Mueller, Am J Trop Med Hyg 2010 82 1034 40 10.4269/ajtmh.2010.09- 0704 20519597
11. An open label randomized comparison of mefloquine-artesunat as separate tablets vs. a new co-formulated combination for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand. EA Ashley KM Lwin R McGready WH Simon L Phaiphun S Proux N Wangseang W Taylor K Stepniewska W Nawamaneerat KL Thwai M Barends W Leowattana P Olliaro P Singhasivanon NJ White F Nosten, Trop Med Int Health 2006 11 1653 1660 10.1111/j.1365-3156.2006.01724.x 17054744
12. Mefloquine for malaria chemoprophylaxis 1992-1998: A review. P Schlagenhauf, J Travel Med 1999 6 122 133 10.1111/j.1708-8305.1999.tb00843.x 10381965
13. CNS adverse events associated with antimalarial agents. Fact or fiction? PA Phillips-Howard F Ter Kuile, Drug Safety 1995 12 370 383 10.2165/00002018- 199512060-00003 8527012
14. Childhood mefloquine-induced mania and psychosis: a case report. R Thapa B Biswas, J Child Neurol 2009 24 1008 1009 10.1177/0883073809332700 19295181
15. A new approach for neurological evaluation of infants in resource-poor settings. L Haataja R McGready R Arunjerdja JA Simpson E Mercuri F Nosten L Dubowitz, Ann Trop Paediatr 2002 22 355 368 10.1179/027249302125002029 12530286
16. Pharmakokinetics of mefloquine alone or in combination with artesunate. J Karbwang K Na Bangchang A Thanavibul DJ Back D Bunnag T Harinasuta, Bull World Health Organ 1994 72 83 87 8131255
17. Zurich Neuromotor Assessment. RH Largo JE Fischer JA Caflisch, AWE Verlag Zurich 2002
18. Bayley scales of infant and toddler development. N Bayley, (Bayley III) San Antonio: The Psychological Corporation Third 2006
19. Antimalarial drug toxicity: A review. W Robert J Taylor NJ White, Drug Safety 2004 27 25 61 14720085
20. Serious adverse events of mefloquine in relation to blood level and gender. E Schwartz I Potasman M Rotenberg S Almog S Sadetzki, Am J Trop Med Hyg 2001 65 189 192 11561702
21. A case-control auditory evaluation of patients treated artemether-lumefantrine. SA Toovey, Am J Trop Med Hyg 2006 74 939 940 16760498
22. Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north western border of Thailand. VI Carrara AP Phyo P Nwee M Soe H Htoo J Arunkamomkiri P Singhasivanon F Nosten, Malar J 2008 7 233 10.1186/1475-2875-7- 233 18986553
23. Ototoxiticity of the artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial. R Gürkov T Eshetu IB Miranda N Berens-Riha Y Mamo T Girma E Krause M Schmidt JM Hempel T Löscher, Malar J 2008 7 179 10.1186/1475-2875-7-179 18796142
24. Tolerance and efficacy of mefloquin as first-line treatment of uncomplicated P. falciparum malaria in children. P Valeyre R Favier M Adam B Quniet E Grimprel N Parez, Pathologie Biologie 2008 56 21 28 10.1016/j.patbio.2007.09.003 18178023