Therapeutic possibilities and toxicological risk of Jatropha gossypiifolia L.: A narrative review;Possibilidades terapêuticas e risco toxicológico de Jatropha gossypiifolia L.: Uma revisão narrativa

Revista Brasileira de Plantas Medicinais

Volumn 12, Issue 3, 2010, Pages 346-357

  Mariz, S R ^a   Borges, A C R ^b   Melo Diniz, M F F ^c   Medeiros, I A ^c  

^a FEDERAL UNIVERSITY OF CAMPINA GRANDE   (Brazil)

^b FEDERAL UNIVERSITY OF MARANHÃO   (Brazil)

^c FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Euphorbiaceae; Jatropha gossypiifolia L.; Pharmacology; Toxicology

Indexed keywords

ALKALOID; EUPHORBIA EXTRACT; FLAVONOID; JATROPHA GOSSYPIIFOLIA EXTRACT; LIGNAN; TANNIN DERIVATIVE; TERPENOID; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; EUPHORBIA; EVALUATION; HYPOTENSION; INFORMATION; JATROPHA GOSSYPIIFOLIA; REVIEW; RISK BENEFIT ANALYSIS; TOXICITY TESTING;

EUPHORBIACEAE; JATROPHA GOSSYPIIFOLIA;

EID: 77958041586     PISSN: 15160572     EISSN: None     Source Type: Journal    
DOI: 10.1590/s1516-05722010000300013     Document Type: Review

References (92)

1. ABDUL, R.A. et al. Isolation and identification of mosquito larvicidal compound from Abutilon indicum (Linn.) Sweet. Parasitology Research, v.102, n.5, p.981-8, 2008.
2. ABREU, I.C. et al. Hypotensive and vasorelaxant effects of the ethanolic extract from Jatropha gossypiifolia L. in rats. Fitoterapia, v.74, n.7/8, p.650-7, 2003.
3. ADESINA, S.K. Studies on some plants used as anticonvulsants in amerindian and african tradicional medicine. Fitoterapia, v.53, p.147-62, 1982.
4. ADEWUNMI, C.O. Natural products as agents of schistosomiasis control in Nigéria: a review of progress. International Journal of Crude Drug Research, v.22, n.4, p.161-6, 1984.
5. ADEWUNMI, C.O.; ADESOGAN, E.K. Toxicology of some nigerian plants used in schistosomiasis control. 1. The effect of molluscicides on molluscan hearts. Fitoterapia, v.57, n.5, p.353-8, 1986.
6. ADEWUNMI, C.O.; MARQUIS, V.O. Molluscicidal evaluation of some Jatropha species grown in Nigeria. Quarterly Journal of Crude Drug Research, v.18, p.141-5, 1980.
7. ADEWUNMI, C.O.; MARQUIS, V.O. A rapid in vitro screening method for detecting schistosomicidal activity of some nigerian medicinal plants. International Jornal of Crude Drug Research, v.214, p.157-9, 1983.
8. ADEWUNMI, C.O.; MARQUIS, V.O. Comparative evaluation of the molluscicidal properties of aridan (Tetrapleura tetraptera), lapalapa pupa (Jatropha gossypyfolia), endod (Phytolacca dodecandra) and bayluscide. Fitoterapia, v.58, n.5, p.325-8, 1987a.
9. ADEWUNMI, C.O.; MARQUIS, V.O. Evaluation of the effects of environmental factors on molluscicidal properties of Aridan (Tetrapleura tetraptera), Lapalapa Pupa (Jatropha gossypyfolia), Endod (Phytolacca dodecandra) and Bayluscide. Phytotherapy Research, v.1, n.2, p.69-72, 1987b.
10. ADOLF, W.; OPFERKUCH, H.J.; HECKER, E. Irritant phorbol derivates from four Jatropha species. Phytochemistry, v.23, n.1, p.129-32, 1984.
11. AJOSE, F.O. Some Nigerian plants of dermatologic importance. Interntational Journal of Dermatology, v.46, p.48-55, 2007.
12. AQUINO, J.U. et al. Avaliação fitoterápica da Jatropha gossypiifolia L. na cicatrização de suturas na parede abdominal ventral de ratos. Acta Cirúrgica Brasileira, v.21, n.2, p.61-6, 2006.
13. AUVIN-GUETTE, C. et al. Cyclogossine B, a cyclic octapeptide from Jatropha gossypifolia. Journal of Natural Products, v.60, p.1155-7, 1997.
14. AWACHIE, P.I.A.; UGWU, F.O. Preliminary investigation of the antimicrobial and Brine Shrimp lethality properties of some nigerian mecidinal plants. International Journal of Pharmacognosy, v.35, n.5, p.338-43, 1997.
15. BANERJI, J. et al. Gadain, a lignan from Jatropha Gossypifolia. Phytochemistry, v.23, n.10, p.2323-7, 1984.
16. BARRETT, B. Medicinal plants of Nicaragua's atlantic coast. Economic Botany, v.48, n.1, p.8-20, 1994.
17. BEBAWI, F.F.; CAMPBELL, S.D. Effects of fire on germination and viability of bellyache bush (Jatropha gossypiifolia) seeds. Australian Journal of Experimental Agriculture, v.42, p.1063-9, 2002.
18. BHAT, R.B.; ETEJERE, E.O.; OLADIPO, V.T. Ethnobotanical studies from central Nigeria. Economic Botany, v.44, n.3, p.382-90, 1990.
19. BRASIL. Primeiro relatório nacional para a conservaçã o sobre diversidade biológica: Brasil. Ministério do Meio Ambiente, dos Recursos Hídricos e da Amazônia Legal, Brasília, 1998. 284p.
20. CAMARGO, M.T.L.A. Plantas medicinais e de rituais afrobrasileiros. II: estudo etnofarmacobotânico. São Paulo: Ícone. 1998. 232p.
21. CARBAJAL, D. et al. Pharmacological screening of plant decoctions commonly used in Cuban folk medicine. Journal of Ethnopharmacology, v.33, p.21-4, 1991.
22. CHARIANDY, C.M. et al. Screening of medicinal plants from Trinidad and Tobago for antimicrobial and isecticidal properties. Journal of Ethnopharmacology, v.64, p.265-70, 1999.
23. CHATTERJEE, A. et al. Crystal structure of a lignan from Jatropha gossypifolia. Phytochemistry, v.20, n.8, p.2047-8, 1981.
24. CHATTERJEE, A. et al. Prasanthaline: a new lignan from Jatropha gossypifolia Linn. Indian Journal of Chemistry, v.27B, p.740-1, 1988.
25. COE, F.G.; ANDERSON, G.J. Ethnobotany of the Garífuna of eastern Nicaragua. Economic Botany, v.50, n.1, p.71-107, 1996a.
26. COE, F.G.; ANDERSON, G.J. Screening of medicinal plants used by the Garífuna of eastern Nicaragua for bioactive compounds. Journal of Ethnopharmacology, v.53, p.29-50, 1996b.
27. CORRÊA, M.P. Dicionário de plantas úteis do Brasil e das exóticas cultivadas. Rio de Janeiro: Ministério da Agricultura / Instituto Brasileiro de Desenvolvimento Florestal, 1984, v.5, n.2, 485p.
28. COSTA, L.C.B. et al. Plantas medicinais mais utilizadas pelas populações rurais da região cacaueira da Bahia. Revista Brasileira de Farmácia, v.82, n.1/2, p.73-7, 2001.
29. DABUR, R. et al. Antimicrobial activity of some Indian medicinal plants. African Journal of Traditional, Complementary, and Alternative Medicines, v.4, n.3, p.313-8, 2007.
30. DAS, B.; BANERJI, J. Arylnaphthalene lignan from Jatropha gossypifolia. Phytochemistry, v.27, n.11, p.3684-6, 1988.
31. DAS, B.; DAS, R. Gossypifan, a lignan from Jatropha gossypifolia. Phytochemistry, v.40, n.3, p.931-2, 1995.
32. DAS, B.; KASHINATHAM, A. Studies on phytochemicals: Part XVII - Phenolics from the roots of Jatropha gossypifolia. Indian Journal of Chemistry, v.36B, p.1077-8, 1997.
33. DAS, B.; ANJANI, G. Gossypidien, a lignan from stems of Jatropha gossypifollia. Phytochemistry, v.51, p.115-7, 1999.
34. DAS, B.; VENKATAIAH, B. A minor coumarino-lignoid from Jatropha gossypiifolia. Biochemical Systematics and Ecology, v.29, p.213-4, 2001.
35. DAS, B.; RAO, S.P.; SRINIVAS, K.V.N.S. Jatrodien, a lignan from stems of Jatropha gossypifolia. Phytochemistry, v.41, n.3, p.985-7, 1996a.
36. DAS, B.; RAO, S.P.; SRINIVAS, K.V.N.S. Isolation of Isogadain from Jatropha gossypifolia. Planta Medica, v.62, p.90,1996b.
37. DAS, B. et al. Cleomiscosin A, a coumariono-lignoid from Jatropha gossypiifolia. Biochemical Systematics and Ecology, v.31, n.10, p.1189-91, 2003.
38. GASPERI-CAMPANI, A. et al. Seed extracts inhibiting protein synthesis in vitro. Biochemical Journal, v.186, p.439-41, 1980.
39. GBEASSOR, M. et al. Antimalarial effects of eight African medicinal plants. Journal of Ethnopharmacology, v.25, p.115-8, 1989.
40. GUIROLA, L.; GARCIA, G.; TORREALBA, A. Acute renal failure from the ingestion of toxic plants. Veterinary and Human Toxicology, v.34, n.6, p.548, 1992.
41. GUPTA, M.P.; ARIAS, T.D.; CORREA, M. Ethnopharmacognostic observations on Panamanian medicinal plants. Part I. Quarterly Journal of Crude Drug Research, v.17, n.3/4, p.115-30, 1979.
42. HECKER, E. Co-Carcinogenic diterpene esters as principal risk factors in local life style esophageal cancer in Curacao. Acta Pharmacologica et Toxicologica, v.55, p.148-53, 1984.
43. HORSTEN, S.F.A. et al. Cyclogossine A: a novel cyclic heptapeptide isolated from the latex of Jatropha gossypifolia. Planta Medica, v.62, n.1, p.46-50, 1996.
44. HOSAMANI, K.M.; KATAGI, K.S. Characterization and structure elucidation of 12-hydroxyoctadec-cis-9-enoic acid in Jatropha gossypifolia and Hevea brasiliensis seed oils: a rich source of hydroxy fatty acid. Chemistry and Physics of Lipids, v.152, n.1, p.9-12, 2008.
45. JOSHI, P. Herbal drugs used in Guinea worm disease by the tribals of southern Rajasthan (India). International Journal of Pharmacognosy, v.29, n.1, p.33-8, 1991.
46. KAVITHA, J.; RAIASEKHAR, D.; SUBBARAJU, G.V. Synthesis of tetradecyl (E)-ferulate, a metabolite of Jatropha gossypifolia. Journal of Asian Natural Products Research, v.2, n.1, p.51-4, 1999.
47. KUMAR, V.P. et al. Search for antibacterial and antifungal agents from selected indian medicinal plants. Journal of Ethnopharmacology, v.107, n.2, p.182-8, 2006.
48. KUPCHAN, S.M. et al. Structure and stereochemistry of Jatrophone, a novel macrocyclic diterpenoid tumor inhibitor. Journal of the American Chemical Society, v.98, n.8, p.2295-300, 1976.
49. LAI, M.W. et al. Annual report of the American Association of Poison Control Centers' national poisoning and exposure database. Clinical Toxicology, v.44, p.803-932, 2006.
50. LANS, C. et al. Medicinal and ethnoveterinary remedies of hunters in Trinidad. BMC Complementary and Alternative Medicine, v.1, n.10, p.1-17, 2001.
51. LEAL, C.K.A.; AGRA, M.F. Estudo farmacobotânico comparativo das folhas de Jatropha molissima (Pohl) Baill. e Jatropha ribifolia (Pohl) Baill. Acta Farmaceutica Bonaerense, v.24, n.1, p.5-13, 2005.
52. LE GRAND, A. Les phytothérapies anti-infectieuses de la Foret Savane, Sénégal (Afrique Occidentale) III: Un résume des substances phytochimiques et l'activité anti-microbienne de 43 spécies. Journal of Ethnopharmacology, v.25, p.315-38, 1989.
53. LE GRAND, A.; WONDERGEM, P.A. Les phytothérapies anti-infectieuses de la Foret Savane, Sénégal (Afrique Occidentale). I: Un Inventaire. Journal of Ethnopharmacology, v.21, p.109-25, 1987.
54. LORENZI, H.; MATOS, F.J.A. Plantas medicinais no Brasil: nativas e exóticas. Nova Odessa: Instituto Plantarium, 2002. 512p.
55. MACRAE, W.D.; HUDSON, J.B.; TOWERS, G.H.N. Studies on the pharmacological activity of amazonian Euphorbiaceae. Journal of Ethnopharmacology, v.22, p.143-72, 1988.
56. MAIA, J.M. et al. Estudo da cicatrização de suturas na bexiga urinária de ratos com e sem a utilização de extrato bruto de Jatropha gossypiifolia L. intraperitoneal. Acta Cirúrgica Brasileira, v.21, n.2, p.23-30, 2006.
57. MARIZ, S.R. Estudo toxicológico pré-clínico de Jatropha gossypiifolia L. 2007. 186p. Tese (Doutorado em produtos naturais e sintéticos bioativos - Área de concentração em Farmacologia) - Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa.
58. MARIZ, S.R. et al. Avaliação histopatológica em ratos após tratamento agudo com o extrato etanólico de partes aéreas de Jatropha gossypiifolia L. Revista Brasileira de Farmacognosia, v.18, n.2, p.213-6, 2008.
59. MARIZ, S.R. et al. Estudo toxicológico agudo do extrato etanólico de partes aéreas de Jatropha gossypiifolia L. em ratos. Revista Brasileira de Farmacognosia, v.16, n.3, p.372-8, 2006.
60. MATOS, F.J.A. Constituintes químicos ativos e propriedades biológicas de plantas medicinais brasileiras. Fortaleza: Editora UFC, 2004. 448p.
61. MEYER, B.N. et al. Brine shrimp: a convenient general bioassay for active plant constituents. Journal of Medical Plant Research, v.45, p.31-4, 1982
62. MORTON, J.F. A survey of medicinal plants of Curacao. Economic Botany, v.22, p.87-102, 1968.
63. NAIR, R.; KALARIYA, T.; CHANDA, S. Antibacterial activity of some plant extracts used in folk medicine. Journal of Herbal Pharmacotherapy, v.7, n.3-4, p.191-201, 2007
64. NORHANOMA, W.; YADAV, M. Tumour promoter activity in Malaysian Euphorbiaceae. British Journal of Cancer, v.71, n.4, p.776-9, 1995.
65. OBATOMI, D.K.; BIKOMO, E.O.; TEMPLE, V.J. Anti-diabetic properties of the African mistletoe in streptozotocin-induced diabetic rats. Journal of Ethnopharmacology, v.43, p.13-7, 1994.
66. OGBOBE, O.; AKANO, V. The physico-chemical properties of the seed and seed oil of Jatropha gossipifolia. Plant Foods for Human Nutrition, v.43, n.3, p.197-200, 1993.
67. OLIVEIRA, M.J.R.; SIMÕES, M.J.S.; SASSI, C.R.R. Fitoterapia no Sistema de Saúde Pública (SUS) no Estado de São Paulo, Brasil. Revista Brasileira de Plantas Medicinais, v.8, n.2, p.39-41, 2006.
68. OLOWOKUDEJO, J.D. Comparative epidermal morphology of West African species of Jatropha L. (Euphorbiaceae). Botanical Journal of Linnean Society, v.111, p.139-54, 1993.
69. PHOWICHIT, S.; BUATIPPAWAN, S.; BULLANGPOTI, V. Insecticidal activity of Jatropha gossypifolia L. (Euphorbiaceae) and Cleome viscosa L. (Capparidacae) on Spodoptera litura (Lepidoptera: Noctuidae). Toxicity and carboxylesterase and glutathione-S-transferase activities studies. Communications in Agricultural and Applied Biological Science, v.73, n.3, p.611-9, 2008.
70. PRASAD, Y.R.; ALANKARARAO, G.S.J.G.; BABY, P. Constituents of the seeds of Jatropha gossypifolia. Fitoterapia, v.64, n.4, p.376, 1993.
71. PURUSHOTHAMAN, K.K.; CHANDRASEKHARAN, S. Jatropholones A and B, new diterpenoids from the roots of Jatropha gossypiifolia (Euphorbiaceae) - crystal structure analysis of Jatropholone B. Tetrahedron Letters, n.11, p.979-80, 1979.
72. RAVINDRANATH, N. et al. Jatrophenone, a novel macrocyclic bioactive diterpene from Jatropha gossypifolia. Chemical & Pharmaceutical Bulletin, v.51, n.7, p.870, 2003.
73. REZENDE, E.A.; RIBEIRO, M.T.F. Conhecimento tradicional, plantas medicinais e propriedade intelectual: biopirataria ou bioprospecçã o? Revista Brasileira de Plantas Medicinais, v.7, n.3, p.37-44, 2005.
74. ROCHA, M.O. et al. Avaliação toxicológica do tratamento sub-crônico com o extrato de Cecropia adenopus Mart., Sechium edule e Jatropha gossypiifolia L. nos compostos bioquímicos do sangue. In: REUNIÃO ANUAL DA SBPC, 47., 1995, São Luís. Anais... São Luís: UFMA, p.905. 1995.
75. SAHA, J.C.; SAVINI, E.C.; KASINATHAN, S. Ecbolic properties of Indian medicinal plants. Indian Journal of Medical Research, v.49, n.1, p.130-51, 1961.
76. SANTOS, M.F. et al. Avaliação do uso do extrato bruto de Jatropha gossypiifolia L. na cicatrização de feridas cutâneas em ratos. Acta Cirúrgica Brasileira, v.21, n.3, p.2-7, 2006.
77. SCHVARTSMAN, S. Plantas venenosas e animais peçonhentos. 2.ed. São Paulo: Sarvier, 1992. 288p.
78. SERVIN, S.C. et al. Ação do extrato de Jatropha gossypiifolia L. (pião roxo) na cicatrização de anastomose colônica: estudo experimental em ratos Acta Cirúrgica Brasileira, v.21, n.3, p.89-96, 2006.
79. SIEVERS, A.F. et al. Inseticidal tests of plants from tropical America. Journal of Economic Entomology, v.42, n.3, p.549-51, 1949.
80. SILVA, I.S. Euphorbiaceae da Caatinga: distribuição de espécies e potencial oleaginoso. 1998. 132p. Tese (Doutorado - Área de concentração em Botânica) - Instituto de Biociências, Universidade de São Paulo (USP), São Paulo.
81. SINGH, A.; AGARWAL, R.A. Possibility of using latex of Euphorbiales for snail control. The Science of the Total Environement, v.77, p.231-6, 1988.
82. SINGH, D.; SINGH, A. The toxicity of four native Indian plants: effect on AChE and acid/alkaline phosphatase level in fish Channa marulius. Chemosphere, v.60, n.1, p.135-40, 2005.
83. SINITOX. SISTEMA NACINAL DE INFORMAÇÕES TÓXICO- FARMACOLÓGICAS. Tabela 10. Evolução dos casos registrados de intoxicação humana por agente tóxico, Brasil 2005. Disponível em: 〈http://www.fiocruz.br/sinitox〉. Acesso em: 05 jan. 2010.
84. SIRIARCHARUNGROJ, S. et al. Investigation of acute toxicity of Jatropha gossypifolia L. (Euphorbiaceae) and Cleome viscosa L. (Capparidacae) extract on guppies, Poecilia reticulate. Communications in Agricultural and Applied Biological Science, v.73, n.4, p.871-4, 2008.
85. SUBRAMANIAN, S.S.; NAGARAJAN, S.; SULOCHANA, N. Flavonoids of the leaves of Jatropha gossypifolia. Phytochemistry, v.10, p.1690, 1971.
86. SUKUMARAN, D.; PARASHAR, B.D.; RAO, K.M. Toxicity of Jatropha gossypiifolia and Vaccaria pyramidata against freshwater snails vectors of animal schistosomiasis. Fitoterapia, v.66, n.5, p.393-8, 1995.
87. TAYLOR, M.D. et al. New antileukemic Jatrophone derivatives from Jatropha gossypiifolia: structural and stereochemical assignment through nuclear magnetic resonance spectroscopy. Journal of the American Chemical Society, v.105, p.3177-83, 1983.
88. TAYLOR, R.S.L. et al. Antiviral activities of medicinal plants of southern Nepal. Journal of Ethnopharmacology, v.53, p.97-104, 1996.
89. TINTO, W.F.; JOHN, L.M.D. Triterpenoids of Jatropha gossypiifolia. Journal of Natural Products, v.55, n.6, p.807-9, 1992.
90. VALE, J.R. et al. Estudo comparativo da cicatrização de gastrorrafias com e sem o uso do extrato de Jatropha gossypiifolia L. (pião roxo) em ratos. Acta Cirúrgica Brasieira, v.21, n.3, p.40-8, 2006.
91. VERA, A. et al. Floristic and physiognomic characteristics of disturbed thorny xerophytic scrubland in Punta de Piedras, Miranda Municipality, Zulia State, Venezuela. Revista de Biologia Tropical, v.57, n.1-2, p.271-81, 2009.
92. WENIGER, B. et al. La medicine populaire dans le plateau central d'Haiti. 2 Inventaire ethnopharmacologique. Journal of Ethnopharmacology, v.17, p.13-30, 1986.