Depressive symptoms are associated with subclinical cerebrovascular disease among healthy older women, not men

American Journal of Geriatric Psychiatry

Volumn 18, Issue 10, 2010, Pages 940-947

  Wendell, Carrington Rice ^a   Hosey, Megan M ^a   Lefkowitz, David M ^b   Katzel, Leslie I ^c,d   Siegel, Eliot L ^b,d   Rosenberger, William F ^e   Waldstein, Shari R ^a,c,d  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b Division of Geriatric Medicine and Gerontology   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d BALTIMORE VA MEDICAL CENTER   (United States)

^e George Mason University   (United States)

Author keywords

Depression; depressive symptoms; MRI; silent infarcts; subclinical cerebrovascular disease; white matter hyperintensities

Indexed keywords

GLUCOSE;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; BECK DEPRESSION INVENTORY; BODY MASS; BRAIN ATROPHY; CEREBROVASCULAR DISEASE; COMORBIDITY; DEPRESSION; DISEASE ASSOCIATION; EDUCATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN CONSUMPTION; SEX DIFFERENCE; SYSTOLIC BLOOD PRESSURE; WHITE MATTER;

EID: 77958039225     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1097/JGP.0b013e3181d57a2b     Document Type: Article

References (34)

1. Kales HC, Maixner DF, Mellow AM: Cerebrovascular disease and late-life depression. Am J Geriatr Psychiatry 2005; 13: 88-98
2. Williams LS: Depression and stroke: cause or consequence? Se-min Neurol 2005; 25:396-409
3. Herrmann LL, Le Masurier M, Ebmeier KP: White matter hyper-intensities in late life depression: a systematic review. J Neurol Neurosurg Psychiatry 2008; 79:619-624
4. O'Brien JT, Firbank MJ, Krishnan MS, et al: White matter hyper-intensities rather than lacunar infarcts are associated with depres-sive symptoms in older people: the LADIS study. Am J Geriatr Psychiatry 2006; 14:834-841
5. Everson SA, Roberts RE, Goldberg DE, et al: Depressive symptoms and increased risk of stroke mortality over a 29-year period. Arch Intern Med 1998; 158:1133-1138
6. Soares JC, Mann JJ: The anatomy of mood disorders-review of structural neuroimaging studies. Biol Psychiatry 1997; 41:86-106
7. Beyer JL, Krishnan KR: Volumetric brain imaging findings in mood disorders. Bipolar Disord 2002; 4:89-104
8. Alexopoulos GS: The vascular depression hypothesis: 10 years later. Biol Psychiatry 2006; 60:1304-1305
9. Alexopoulos GS, Meyers BS, Young RC, et al: 'Vascular depression' hypothesis. Arch Gen Psychiatry 1997; 54:915-922
10. Baldwin RC: Is vascular depression a distinct sub-type of depressive disorder? A review of causal evidence. Int J Geriatr Psychiatry 2005; 20:1-11
11. Beyer JL: Managing depression in geriatric populations. Ann Clin Psychiatry 2007; 19:221-238
12. Lebowitz BD, Pearson JL, Schneider LS, et al: Diagnosis and treatment of depression in late life. Consensus statement update. JAMA 1997; 278:1186-1190
13. De Leeuw FE, de Groot JC, Achten E, et al: Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study. J Neu-rol Neurosurg Psychiatry 2001; 70:9-14
14. Kessler RC, McGonagle KA, Swartz M, et al: Sex and depression in the National Comorbidity Survey. I. lifetime prevalence, chro-nicity and recurrence. J Affect Disord 1993; 29:85-96
15. Grigoriadis S, Robinson GE: Gender issues in depression. Ann Clin Psychiatry 2007; 19:247-255
16. Mulsant BH, Ganguli M: Epidemiology and diagnosis of depression in late life. J Clin Psychiatry 1999; 60(suppl 20):9-15
17. Gur RC, Gunning-Dixon FM, Turetsky BI, et al: Brain region and sex differences in age association with brain volume: a quantitative MRI study of healthy young adults. Am J Geriatr Psychiatry 2002; 10:72-80
18. Coffey CE, Lucke JF, Saxton JA, et al: Sex differences in brain aging: a quantitative magnetic resonance imaging study. Arch Neurol 1998; 55:169-179
19. Paradiso S, Robinson RG: Gender differences in poststroke depression. J Neuropsychiatry Clin Neurosci 1998; 10:41-47
20. Lavretsky H, Lesser IM, Wohl M, et al: Relationship of age, age at onset, and sex to depression in older adults. Am J Geriatr Psychiatry 1998; 6:248-256
21. Faul F, Erdfelder E, Lang AG, et al: G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Beh Res Methods 2007; 39:175-191
22. Cohen J (ed.): Statistical Power Analysis for the Behavioral Sciences. Hillsdale, NJ, Lawrence Erlbaum Associates, 1988
23. Beck AT: Beck Depression Inventory: Manual. San Antonio, TX, Psychological Corporation, 1987
24. Fazekas F, Niederkorn K, Schmidt R, et al: White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and ce-rebrovascular risk factors. Stroke 1988; 19:1285-1288
25. Price TR, Manolio TA, Kronmal RA, et al: Silent brain infarction on magnetic resonance imaging and neurological abnormalities in community-dwelling older adults. The Cardiovascular Health Study CHS Collaborative Research Group. Stroke 1997; 28:1158-1164
26. Folstein MF, Folstein SE, McHugh PR: "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-198
27. Raz N, Rodrigue KM: Differential aging of the brain: patterns, cognitive correlates and modifiers. Neurosci Biobehav Rev 2006; 30:730-748
28. Nebes RD, Vora IJ, Meltzer CC, et al: Relationship of deep white matter hyperintensities and apolipoprotein E genotype to depressive symptoms in older adults without clinical depression. Am J Psychiatry 2001; 158:878-884
29. Lavretsky H, Kumar A: Clinically significant non-major depression: old concepts, new insights. Am J Geriatr Psychiatry 2002; 10:239-255
30. Lyness JM, Kim J, Tang W, et al: The clinical significance of subsyndromal depression in older primary care patients. Am J Geriatr Psychiatry 2007; 15:214-223
31. Krishnan KR, Hays JC, Blazer DG: MRI-defined vascular depression. Am J Psychiatry 1997; 154:497-501
32. Alexopoulos GS, Meyers BS, Young RC, et al: Clinically defined vascular depression. Am J Psychiatry 1997; 154:562-565
33. Lyness JM, Heo M, Datto CJ, et al: Outcomes of minor and subsyndromal depression among elderly patients in primary care settings. Ann Intern Med 2006; 144:496-504
34. Vermeer SE, Longstreth WT Jr, Koudstaal PJ: Silent brain infarcts: a systematic review. Lancet Neurol 2007; 6:611-619