Spontaneous preterm labor is associated with an increase in the proinflammatory signal transducer TLR4 receptor on maternal blood monocytes

BMC Pregnancy and Childbirth

Volumn 10, Issue , 2010, Pages

  Pawelczyk, Edyta ^a   Nowicki, Bogdan J ^b   Izban, Michael G ^b   Pratap, Siddharth ^b   Sashti, Nupur A ^c   Sanderson, Maureen ^b   Nowicki, Stella ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b MEHARRY MEDICAL COLLEGE   (United States)

^c TENNESSEE DEPARTMENT OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TOLL LIKE RECEPTOR 4; BIOLOGICAL MARKER; TLR4 PROTEIN, HUMAN;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; MATERNAL BLOOD; MONOCYTE; PREGNANCY; PREMATURE LABOR; BLOOD; CROSS-SECTIONAL STUDY; LEUKOCYTE COUNT; METABOLISM; REGRESSION ANALYSIS; SIGNAL TRANSDUCTION; UTERUS;

ADULT; BIOLOGICAL MARKERS; CROSS-SECTIONAL STUDIES; FEMALE; GENE EXPRESSION; HUMANS; LEUKOCYTE COUNT; MONOCYTES; OBSTETRIC LABOR, PREMATURE; PREGNANCY; REGRESSION ANALYSIS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; UTERUS; YOUNG ADULT;

EID: 77958038175     PISSN: None     EISSN: 14712393     Source Type: Journal    
DOI: 10.1186/1471-2393-10-66     Document Type: Article

References (30)

1. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. The Lancet 2008, 371:75-84.
2. Moore ML. Preterm Labor and Birth: What Have We Learned in the Past Two Decades?. Journal of Obstetric, Gynecologic, & Neonatal Nursing 2003, 32:638-649.
3. Nicholson WK, Frick KD, Powe NR. Economic Burden of Hospitalizations for Preterm Labor in the United States. Obstet Gynecol 2000, 96:95-101. 10.1016/S0029-7844(00)00863-2, 10862850.
4. Haas JS, Fuentes-Afflick E, Stewart AL, Jackson RA, Dean ML, Brawarsky P, Escobar GJ. Prepregnancy Health Status and the Risk of Preterm Delivery. Arch Pediatr Adolesc Med 2005, 159:58-63. 10.1001/archpedi.159.1.58, 15630059.
5. Robinson JN, Regan JA, Norwitz ER. The epidemiology of preterm labor. Seminars in Perinatology 2001, 25:204-214. 10.1053/sper.2001.27548, 11561908.
6. Mueller-Heubach E, RUubbistein DN, Schwarz SS. Histologic Chorioamnionitis and Preterm Delivery in Different Patient Populations. Obstet Gynecol 1990, 75:622-626.
7. Goldenberg RL, Hauth JC, Andrews WW. Intrauterine Infection and Preterm Delivery. N Engl J Med 2000, 342:1500-1507. 10.1056/NEJM200005183422007, 10816189.
8. DiGiulio DB, Romero R, Amogan HP, Kusanovic JP, Bik EM, Gotsch F, Kim CJ, Erez O, Edwin S, Relman DA. Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation. PLoS ONE 2008, 3:e3056. 10.1371/journal.pone.0003056, 2516597, 18725970.
9. Arntzen KJ, Kjollesdal AM, Halgunset J, Vatten L, Austgulen R. TNF, IL-1, IL-6, IL-8 and soluble TNF receptors in relation to chorioamnionitis and premature labor. J Perinat Med 1998, 26:17-26. 10.1515/jpme.1998.26.1.17, 9595363.
10. Dudley DJ. Pre-term labor: an intra-uterine inflammatory response syndrome?. Journal of Reproductive Immunology 1997, 36:93-109. 10.1016/S0165-0378(97)00065-X, 9430741.
11. Romero R, Mazor M, Sepulveda W, Avila C, Copeland D, Williams J. Tumor necrosis factor in preterm and term labor. Am J Obstet Gynecol 1992, 166:1576-1587.
12. Wang H, Hirsch E. Bacterially-Induced Preterm Labor and Regulation of Prostaglandin-Metabolizing Enzyme Expression in Mice: The Role of Toll-Like Receptor 4. Biol Reprod 2003, 69:1957-1963. 10.1095/biolreprod.103.019620, 12904319.
13. Sabroe I, Jones EC, Usher LR, Whyte MKB, Dower SK. Toll-Like Receptor (TLR)2 and TLR4 in Human Peripheral Blood Granulocytes: A Critical Role for Monocytes in Leukocyte Lipopolysaccharide Responses. J Immunol 2002, 168:4701-4710.
14. Janeway CA, Medzhitov R. Innate Immune Recognition. Annual Review of Immunology 2002, 20:197-216. 10.1146/annurev.immunol.20.083001.084359, 11861602.
15. Medzhitov R, Janeway CA. Decoding the Patterns of Self and Nonself by the Innate Immune System. Science 2002, 296:298-300. 10.1126/science.1068883, 11951031.
16. Kopp E, Medzhitov R. Recognition of microbial infection by Toll-like receptors. Current Opinion in Immunology 2003, 15:396-401. 10.1016/S0952-7915(03)00080-3, 12900270.
17. Medzhitov R, Preston-Hurlburt P, Janeway CA. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388:394-397. 10.1038/41131, 9237759.
18. Poltorak A, He X, Smirnova I, Liu MY, Huffel CV, Du X, Birdwell D, Alejos E, Silva M, Galanos C, et al. Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene. Science 1998, 282:2085-2088. 10.1126/science.282.5396.2085, 9851930.
19. Ohashi K, Burkart V, Flohe S, Kolb H. Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex. J Immunol 2000, 164:558-561.
20. Okamura Y, Watari M, Jerud ES, Young DW, Ishizaka ST, Rose J, Chow JC, Strauss JF. The Extra Domain A of Fibronectin Activates Toll-like Receptor 4. J Biol Chem 2001, 276:10229-10233. 10.1074/jbc.M100099200, 11150311.
21. Dybdahl B, Wahba A, Lien E, Flo TH, Waage A, Qureshi N, Sellevold OFM, Espevik T, Sundan A. Inflammatory Response After Open Heart Surgery: Release of Heat-Shock Protein 70 and Signaling Through Toll-Like Receptor-4. Circulation 2002, 105:685-690. 10.1161/hc0602.103617, 11839622.
22. Kumazaki K, Nakayama M, Yanagihara I, Suehara N, Wada Y. Immunohistochemical distribution of Toll-like receptor 4 in term and preterm human placentas from normal and complicated pregnancy including chorioamnionitis. Human Pathology 2004, 35:47-54. 10.1016/j.humpath.2003.08.027, 14745724.
23. Holmlund U, Cebers G, Dahlfors AR, Sandstedt B, Bremme K, Ekstrom ES, Scheynius A. Expression and regulation of the pattern recognition receptors Toll-like receptor-2 and Toll-like receptor-4 in the human placenta. Immunology 2002, 107:145-151. 10.1046/j.1365-2567.2002.01491.x, 1782774, 12225373.
24. Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007, 39:175-191.
25. Norman J, Bollapragada S, Yuan M, Nelson S. Inflammatory pathways in the mechanism of parturition. BMC Pregnancy and Childbirth 2007, 7:S7. 10.1186/1471-2393-7-S1-S7, 1892064, 17570167.
26. Sabroe I, Prince LR, Jones EC, Horsburgh MJ, Foster SJ, Vogel SN, Dower SK, Whyte MKB. Selective Roles for Toll-Like Receptor (TLR)2 and TLR4 in the Regulation of Neutrophil Activation and Life Span. J Immunol 2003, 170:5268-5275.
27. Haddad R, Tromp G, Kuivaniemi H, Chaiworapongsa T, Kim YM, Mazor M, Romero R. Human spontaneous labor without histologic chorioamnionitis is characterized by an acute inflammation gene expression signature. American Journal of Obstetrics and Gynecology 2006, 195:394. 10.1016/j.ajog.2005.08.057, 1800883, 16890549.
28. Makidono C, Mizuno M, Nasu J, Hiraoka S, Okada H, Yamamoto K, Fujita T, Shiratori Y. Increased serum concentrations and surface expression on peripheral white blood cells of decay-accelerating factor (cd55) in patients with active ulcerative colitis. Journal of Laboratory and Clinical Medicine 2004, 143:152-158. 10.1016/j.lab.2003.11.004, 15007304.
29. Nowicki S, Izban MG, Pawelczyk E, Agboto VK, Pratap S, Olson G, Nowicki B. Preterm labor: CD55 in maternal blood leukocytes. Am J Reprod Immunol 2009, 61(5):360-7. 2009, 61: 360-367, 10.1111/j.1600-0897.2009.00702.x, 19341386.
30. Yuan M, Jordan F, McInnes I, Harnett MM, Norman JE. Leukocytes are primed in peripheral blood for activation during term and preterm labour. Molecular Human Reproduction 2009, 15:713-724. 10.1093/molehr/gap054, 2762373, 19628509.