Treatment of severe borderline personality disorder with clozapine

Indian Journal of Psychiatry

Volumn 52, Issue 3, 2010, Pages 267-269

  Vohra, Adarsh Kumar ^a  

^a Consultant Psychiatrist and College Tutor Parkwood ^*  (United Kingdom)

Author keywords

borderline personality disorder; Case report; clozapine; severe

Indexed keywords

ANTIDEPRESSANT AGENT; CLOZAPINE; LORAZEPAM; NEUROLEPTIC AGENT; ZOPICLONE;

ADULT; AGGRESSION; ARTICLE; BORDERLINE STATE; CASE REPORT; CONDUCT DISORDER; DEPRESSION; DISEASE SEVERITY; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; FEMALE; FOSTER CARE; HOSPITALIZATION; HUMAN; IMPULSIVENESS; MENTAL HEALTH SERVICE; PATIENT MONITORING; SIDE EFFECT; SUBSTANCE ABUSE; TREATMENT FAILURE; TREATMENT OUTCOME; WEIGHT GAIN;

EID: 77958031687     PISSN: 00195545     EISSN: 19983794     Source Type: Journal    
DOI: 10.4103/0019-5545.70989     Document Type: Article

References (18)

1. th Ed, Washington, DC. American Psychiatric Association, 2000
2. Linehan MM. Cognitive behavioral treatment of borderline personality disorder. New York: Guilford Press; 1993
3. Binks CA, Fenton M, McCarthy L, Lee T, Adams CE, Duggan C. Pharmacological interventions for people with borderline personality disorder. Cochrane Database Syst Rev 2006;25
4. Coccaro EF, Siever LJ. The neuro-psychopharmacology of personality disorders. In: Bloom FE. Kupfer DJ, editors. Psychopharmacology: The fourth generation of Progress. New York: Raven Press; 1995. p. 1567-78
5. Kane JM, Honigfeld G, Singer J, Meltzer H. Clozapine for the treatment-resistant schizophrenic; result of a US multicentre trial. Psychopharmacology1989;99:560-3
6. Meltzer HY. Anti-psychotic and anti-cholinergic drugs. In: Gelder MG, Loppez-Ibor JJ, editors New Oxford Textbook of Psychiatry. New York: Oxford University Press; 2000
7. Buckley P, Bartell J, Donenwirth K, Lee S, Torigoe F, Schulz SC. Violence and schizophrenia: Clozapine as a specifc antiaggressive agent. Bull Am Acad Psychiatry Law 1995;23:607-11
8. Chengappa KN, Ebeling T, Levine J, Parepally H. Clozapine reduces severe self-mutilation and aggression in psychotic patients with borderline personality disorder. J Clin Psychiatry 1999;60:477-84
9. Benedetti F, Sforzini L, Colombo C, Maffei C, Sameraldi E. Low dose clozapine in acute and continuation treatment of severe borderline personality disorder. J Clin Psychiatry 1998;59:103-7
10. Steinert T, Schmidt-Michel PO, Kaschka WP. Considerable improvement in a case of obsessive-compulsive disorder in an emotionally unstable personality disorder, borderline type under treatment with clozapine. Pharmacopsychiatry 1996;29:111-4
11. Chen NC, Bedair HS, McKay B, Bowers MB Jr, Mazure C. Clozapine in the treatment of aggression in an adolescent with autistic disorder. J Clin Psychiatry 2001;62:479-80
12. Garmendia L, Sanchez JR, Azparoz A, Brain PF, Simon VM. Clozapine strong anti-aggressive effects with minimal motor impairment. Physiol Behav 1992;51:51-4
13. Walker AM, Lanza LL, Arellano F, Rothman KJ. Mortality in current and former users of clozapine. Epidemiology 1997;8:671-7
14. Frankenburge FR, Zanarini MC. Clozapine treatment of borderline patients: A preliminary study. Compr Pychiatry 1993;34:402-5
15. Swinton M. Clozapine in severe borderline personality disorder. J Forensic Psychiatry 2001;12:580-91
16. Parker G. Clozapine and borderline personality disorder. Psychiatry Service 2002;53:348-9
17. Lieberman JA, Johns CA, Kane JM, Rai K. Clozapine induced agranulositosis, non-cross-reactivity with other psychotropic drugs. J Clin Psychiatry 1988;49:271-7
18. Oberholtzer AF, Hendriksen C, Motech AU, Heierli B, Stahelin HB. Safety and effectiveness of low dose clozapine in psycho-geriatric patients a preliminary study. Int Psychogeriatr 1992;4:187-95