The growth inhibitory effects of cadmium and copper on the MDA-MB468 human breast cancer cells

Journal of Research in Medical Sciences

Volumn 15, Issue 5, 2010, Pages 1-8

  Panjehpour, Mojtaba ^a   Taher, Masih Allah ^a   Bayesteh, Mortaza ^a  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Breast neoplasms; Cadmium; Copper; Toxicity; Trace elements

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CADMIUM CHLORIDE; COPPER CHLORIDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL ASSAY; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENTIATION; HUMAN; HUMAN CELL; INCUBATION TIME;

EID: 77958016354     PISSN: 17351995     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Srisook K, Jung NH, Kim BR, Cha SH, Kim HS, Cha YN. Heme oxygenase-1-mediated partial cytoprotective effect by NO on cadmium-induced cytotoxicity in C6 rat glioma cells. Toxicol In Vitro 2005;19(1):31-9.
2. Hamada T, Tanimoto A, Sasaguri Y. Apoptosis induced by cadmium. Apoptosis 1997;2(4):359-67.
3. Limaye DA, Shaikh ZA. Cytotoxicity of cadmium and characteristics of its transport in cardiomyocytes. Toxicol Appl Pharmacol 1999;154(1):59-66.
4. Gurel Z, Ozcelik D, Dursun S. Apoptotic rate and metallothionein levels in the tissues of cadmium- and copper- exposed rats. Biol Trace Elem Res 2007;116(2):203-17.
5. Ishido M, Kunimoto M. Regulation of cell fate by cadmium and zinc. J Health Sci 2001;47(1):9-13.
6. Poliandri AH, Cabilla JP, Velardez MO, Bodo CC, Duvilanski BH. Cadmium induces apoptosis in anterior pituitary cells that can be reversed by treatment with antioxidants. Toxicol Appl Pharmacol 2003;190(1):17-24.
7. Pourahmad J, O'Brien PJ. A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+. Toxicology 2000;143(3):263-73.
8. Fotakis G, Cemeli E, Anderson D, Timbrell JA. Cadmium chloride-induced DNA and lysosomal damage in a hepa- toma cell line. Toxicol In Vitro 2005;19(4):481-9.
9. Zhukalin M, Blanksma MK, Silva TD, Suyehira SW, Harvey WA, Heggland SJ, et al. Characterization and in vitro cytotoxicity testing of ethanolamine-derived cadmium chelating agents. Biometals 2007;20(1):61-72.
10. Huff J, Lunn RM, Waalkes MP, Tomatis L, Infante PF. Cadmium-induced cancers in animals and in humans. Int J Occup Environ Health 2007;13(2):202-12.
11. Waisberg M, Joseph P, Hale B, Beyersmann D. Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 2003;192(2-3):95-117
12. Navarro Silvera SA, Rohan TE. Trace elements and cancer risk: a review of the epidemiologic evidence. Cancer Causes Control 2007;18(1):7-27.
13. Ostrakhovitch EA, Lordnejad MR, Schliess F, Sies H, Klotz LO. Copper ions strongly activate the phosphoinosi- tide-3-kinase/Akt pathway independent of the generation of reactive oxygen species. Arch Biochem Biophys 2002;397(2):232-9.
14. Letelier ME, Lepe AM, Faúndez M, Salazar J, Marín R, Aracena P, et al. Possible mechanisms underlying copper- induced damage in biological membranes leading to cellular toxicity. Chem Biol Interact 2005;151(2):71-82.
15. Klotz LO, Kröncke KD, Buchczyk DP, Sies H. Role of copper, zinc, selenium and tellurium in the cellular defense against oxidative and nitrosative stress. J Nutr 2003;133(5 Suppl 1):1448S-51S.
16. Desoize B. Cancer and metals and metal compounds: part I--carcinogenesis. Crit Rev Oncol Hematol 2002;42(1):1-3.
17. Brama M, Gnessi L, Basciani S, Cerulli N, Politi L, Spera G, et al. Cadmium induces mitogenic signaling in breast cancer cell by an ERalpha-dependent mechanism. Mol Cell Endocrinol 2007;264(1-2):102-8.
18. Stoica A, Katzenellenbogen BS, Martin MB. Activation of estrogen receptor-alpha by the heavy metal cadmium. Mol Endocrinol 2000;14(4):545-53.
19. Sinha Roy S, Mukherjee S, Mukhopadhyay S, Das SK. Differential effect of cadmium on cholinephosphotransferase activity in normal and cancerous human mammary epithelial cell lines. Mol Cancer Ther 2004;3(2):199-204.
20. Wätjen W, Beyersmann D. Cadmium-induced apoptosis in C6 glioma cells: influence of oxidative stress. Biometals 2004;17(1):65-78.
21. Chuang SM, Wang IC, Yang JL. Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhi- bition and apoptosis induced by cadmium. Carcinogenesis 2000;21(7):1423-32.
22. Fotakis G, Timbrell JA. In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol Lett 2006;160(2):171-7.
23. Schmidt CM, Cheng CN, Marino A, Konsoula R, Barile FA. Hormesis effect of trace metals on cultured normal and immortal human mammary cells. Toxicol Ind Health 2004;20(1-5):57-68.
24. Rossi A, Poverini R, Di Lullo G, Modesti A, Modica A, Scarino ML. Heavy metal toxicity following apical and basolateral exposure in the human intestinal cell line Caco-2. Toxicol In Vitro 1996;10(1):27-31.
25. Remez I, Rabkin L, Veksler H, Baumane M. Cytotoxicity of cadmium, selenium, zinc and copper to mouse mye- loma Sp2/0 cells as measured by the MTT assay. Altern Lab Anim 2000;28(3):473-6.