Oral sucrose as an analgesic drug for procedural pain in newborn infants: A randomised controlled trial

The Lancet

Volumn 376, Issue 9748, 2010, Pages 1225-1232

  Slater, Rebeccah ^a,b   Cornelissen, Laura ^b   Fabrizi, Lorenzo ^b   Patten, Debbie ^b   Yoxen, Jan ^b   Worley, Alan ^c   Boyd, Stewart ^c   Meek, Judith ^d   Fitzgerald, Maria ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^d Napolitano and Prof David)   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SUCROSE; OXYGEN; WATER;

ABSENCE OF SIDE EFFECTS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ELECTROENCEPHALOGRAM; FACIAL EXPRESSION; FEMALE; HUMAN; INVASIVE PROCEDURE; MAJOR CLINICAL STUDY; MALE; NEWBORN; NOCICEPTION; OUTCOME ASSESSMENT; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPINAL CORD; ANALGESIA; BLOOD; BLOOD SAMPLING; BRAIN; CHILD BEHAVIOR; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; EVOKED RESPONSE; HEART RATE; ORAL DRUG ADMINISTRATION; PAIN MEASUREMENT; PHYSIOLOGY; SPINE;

ADMINISTRATION, ORAL; ANALGESIA; BLOOD SPECIMEN COLLECTION; BRAIN; DOUBLE-BLIND METHOD; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; EVOKED POTENTIALS; FACIAL EXPRESSION; FEMALE; HEART RATE; HUMANS; INFANT BEHAVIOR; INFANT, NEWBORN; MALE; OXYGEN; PAIN MEASUREMENT; SPINE; SUCROSE; WATER;

EID: 77958012855     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(10)61303-7     Document Type: Article

References (36)

1. KJ Anand Consensus statement for the prevention and management of pain in the newborn Arch Pediatr Adolesc Med 155 2001 173 180
2. B Stevens, J Yamada, A Ohlsson Sucrose for analgesia in newborn infants undergoing painful procedures Cochrane Database Syst Rev 1 2010 CD001069.
3. R Carbajal, A Rousset, C Danan Epidemiology and treatment of painful procedures in neonates in intensive care units JAMA 300 2008 60 70
4. SH Simons, DM van, KS Anand, D Roofthooft, RA van Lingen, D Tibboel Do we still hurt newborn babies? A prospective study of procedural pain and analgesia in neonates Arch Pediatr Adolesc Med 157 2003 1058 1064
5. M Fitzgerald, SM Walker Infant pain management: a developmental neurobiological approach Nat Clin Pract Neurol 5 2009 35 50
6. C Hermann, J Hohmeister, S Demirakca, K Zohsel, H Flor Long-term alteration of pain sensitivity in school-aged children with early pain experiences Pain 125 2006 278 285
7. J Hohmeister, S Demirakca, K Zohsel, H Flor, C Hermann Responses to pain in school-aged children with experience in a neonatal intensive care unit: cognitive aspects and maternal influences Eur J Pain 13 2009 94 101
8. J Hohmeister, A Kroll, I Wollgarten-Hadamek Cerebral processing of pain in school-aged children with neonatal nociceptive input: an exploratory fMRI study Pain 150 2010 220 221
9. R Slater, L Fabrizi, A Worley, J Meek, S Boyd, M Fitzgerald Premature infants display increased noxious-evoked neuronal activity in the brain compared to healthy age-matched term-born infants Neuroimage 52 2010 583 589
10. M Ranger, CC Johnston, KJ Anand Current controversies regarding pain assessment in neonates Semin Perinatol 31 2007 283 288
11. SH Simons, DM van, RA van Lingen Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial JAMA 290 2003 2419 2427
12. B Stevens, C Johnston, P Petryshen, A Taddio Premature Infant Pain Profile: development and initial validation Clin J Pain 12 1996 13 22
13. A Taddio, V Shah, J Katz Reduced infant response to a routine care procedure after sucrose analgesia Pediatrics 123 2009 e425 e429
14. KJ Anand, JV Aranda, CB Berde Analgesia and anesthesia for neonates: study design and ethical issues Clin Ther 27 2005 814 843
15. M Fitzgerald When is an analgesic not an analgesic? Pain 144 2009 9
16. SM Walker Pain in children: recent advances and ongoing challenges Br J Anaesth 101 2008 101 110
17. KM Prkachin Assessing pain by facial expression: facial expression as nexus Pain Res Manag 14 2009 53 58
18. KA Puntillo, AB Morris, CL Thompson, J Stanik-Hutt, CA White, LR Wild Pain behaviors observed during six common procedures: results from Thunder Project II Crit Care Med 32 2004 421 427
19. R Slater, A Cantarella, L Franck, J Meek, M Fitzgerald How well do clinical pain assessment tools reflect pain in infants? PLoS Med 5 2008 e129
20. TF Oberlander, RE Grunau, C Fitzgerald, MF Whitfield Does parenchymal brain injury affect biobehavioral pain responses in very low birth weight infants at 32 weeks' postconceptional age? Pediatrics 110 2002 570 576
21. TF Oberlander, SW Jacobson, J Weinberg, RE Grunau, CD Molteno, JL Jacobson Prenatal alcohol exposure alters biobehavioral reactivity to pain in newborns Alcohol Clin Exp Res 34 2010 681 692
22. R Slater, A Cantarella, J Yoxen Latency to facial expression change following noxious stimulation in infants is dependent on postmenstrual age Pain 146 2009 177 182
23. R Slater, A Worley, L Fabrizi Evoked potentials generated by noxious stimulation in the human infant brain Eur J Pain 14 2010 321 326
24. K Andrews, M Fitzgerald Cutaneous flexion reflex in human neonates: a quantitative study of threshold and stimulus-response characteristics after single and repeated stimuli Dev Med Child Neurol 41 1999 696 703
25. A Truini, G Panuccio, F Galeotti Laser-evoked potentials as a tool for assessing the efficacy of antinociceptive drugs Eur J Pain 14 2010 222 225
26. GJM van Boxtel Computational and statistical methods for analyzing event-related potential data Behav Res Methods Instrum Comput 30 1998 87 102
27. DG Altman, JM Bland Measurement in medicine - the analysis of method comparison studies Statistician 32 1983 307 317
28. MC Lee, A Mouraux, GD Iannetti Characterizing the cortical activity through which pain emerges from nociception J Neurosci 29 2009 7909 7916
29. K Roberts, A Papadaki, C Goncalves Contact heat evoked potentials using simultaneous EEG and fMRI and their correlation with evoked pain BMC Anesthesiol 8 2008 8
30. G Sandrini, M Serrao, P Rossi, A Romaniello, G Cruccu, JC Willer The lower limb flexion reflex in humans Prog Neurobiol 77 2005 353 395
31. J Lorenz, H Beck, B Bromm Differential changes of laser evoked potentials, late auditory evoked potentials and P300 under morphine in chronic pain patients Electroencephalogr Clin Neurophysiol 104 1997 514 521
32. JC Willer Studies on pain. Effects of morphine on a spinal nociceptive flexion reflex and related pain sensation in man Brain Res 331 1985 105 114
33. V Anseloni, K Ren, R Dubner, M Ennis Ontogeny of analgesia elicited by non-nutritive suckling in acute and persistent neonatal rat pain models Pain 109 2004 507 513
34. VC Anseloni, K Ren, R Dubner, M Ennis A brainstem substrate for analgesia elicited by intraoral sucrose Neuroscience 133 2005 231 243
35. H Foo, P Mason Analgesia accompanying food consumption requires ingestion of hedonic foods J Neurosci 29 2009 13053 13062
36. L Holsti, RE Grunau Considerations for using sucrose to reduce procedural pain in preterm infants Pediatrics 125 2010 1042 1047