Cutaneous flexion reflex in human neonates: A quantitative study of threshold and stimulus-response characteristics after single and repeated stimuli

Developmental Medicine and Child Neurology

Volumn 41, Issue 10, 1999, Pages 696-703

  Andrews, Katharine ^b   Fitzgerald, Maria ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHILD DEVELOPMENT; CONTROLLED STUDY; ELECTROMYOGRAM; ELECTROSTIMULATION; FEMALE; FLEXOR REFLEX; FOOT; HUMAN; INFANT; LATENT PERIOD; LEG MUSCLE; MAJOR CLINICAL STUDY; MALE; MECHANICAL STIMULATION; PRIORITY JOURNAL; SOMATOSENSORY STIMULATION; SPINAL REFLEX; STIMULUS RESPONSE; TISSUE INJURY;

ELECTRIC STIMULATION; ELECTROMYOGRAPHY; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; MUSCLE, SKELETAL; PAIN; PROPRIOCEPTION; REFLEX; SENSORY THRESHOLDS; SKIN;

EID: 0032830768     PISSN: 00121622     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0012162299001425     Document Type: Article

References (36)

1. Andrews KA, Fitzgerald M. (1994) The cutaneous withdrawal reflex in human neonates: sensitization, receptive fields, and the effects of contralateral stimulation. Pain 56: 95-101.
2. Campbell IG, Carstens E, Watkins LR. (1991) Comparison of human pain sensation and flexion withdrawal evoked by noxious radiant heat. Pain 45: 259-68.
3. Chan CWY, Tsang HHY. (1985) A quantitative study of flexion reflex in man: relevance to pain research. In: Fields HC, Dubner R, Cervero F, editors. Advances in Pain Research and Therapy. Vol 9. New York: Raven. p 361-70.
4. Dimitijevic MR, Nathan PW. (1970) Studies of spasticity in man. IV: Changes in flexion reflex with repetitive cutaneous stimulation in spinal man. Brain 93: 743-68.
5. _ (1971) Studies of spasticity in man. V: Dishabituation of the flexion reflex in spinal man. Brain 94: 77-90.
6. _ Faganel J, Gregoric M, Nathan PW, Trontelj JK. (1972) Habituation: effects of regular and stochastic stimulation. Journal of Neurology, Neurosurgery, and Psychiatry 35: 234-42.
7. Ekholm J. (1967) Postnatal changes in cutaneous reflexes and in the discharge pattern of cutaneous and articular sense organs. Acta Physiologica Scandinavica 297: (Suppl.) 1-130.
8. Fitzgerald M. (1985) The postnatal development of cutaneous afferent fibre input and receptive field organization in the rat dorsal horn. Journal of Physiology 364: 1-18.
9. _ (1993) The neurobiology of fetal and neonatal pain. In: Wall PD, Melzack R, editors. A Textbook of Pain, 3rd edition. London: Churchill Livingstone. p 153-63.
10. _ (1995) Pain in infancy: some unanswered questions. Pain Reviews 2: 77-91.
11. _ Gibson S. (1984) The postnatal physiological and neurochemical development of peripheral sensory C fibres. Neuroscience 13: 933-44.
12. _ Koltzenburg M. (1986) The functional development of descending inhibitory pathways in the dorsolateral funiculus of the newborn rat spinal cord. Developmental Brain Research 24: 261-70.
13. _ Shaw A, Macintosh N. (1988) The postnatal development of the cutaneous flexor reflex: comparative study of preterm infants and newborn rat pups. Developmental Medicine & Child Neurology 30: 520-6.
14. _ Millard C, Macintosh N. (1989) Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical anaesthesia. Pain 39: 31-6.
15. _ Butcher T, Shortland P. (1994) Developmental changes in the laminar termination of A fibre cutaneous sensory afferents in the rat spinal cord dorsal horn. Journal of Comparative Neurology 348: 225-33.
16. _ Fitzgerald H, Jennings E. (1999) The postnatal development of spinal sensory processing. Proceedings of the National Academy of Sciences 96: 7719-22.
17. Hagbarth K-E. (1952) Excitatory and inhibitory skin areas for flexor and extensor motorneurons. Acta Physiologica Scandinavica. 26: (Suppl.) 3-58.
18. Handwerker HG, Kobal G. (1993) Psychophysiology of experimentally induced pain. Physiological Reviews 73: 639-71.
19. Holmberg H, Schouenborg J. (1996) Postnatal development of the nociceptive withdrawal reflexes in the rat: a behavioural and electromyographic study. Journal of Physiology 493: 239-52.
20. Hughes HE, Barr GA. (1988) Analgesic effects of intrathecally applied noradrenergic compounds in the developing rat: differences due to thermal vs mechanical nociception. Developmental Brain Research 41: 109-20.
21. Hugon M. (1973) Exteroceptive reflexes to stimulation of the sural nerve in normal man. In: Desmedt JE, editor. New Developments in Electromyography and Clinical Neurophysiology. Vol. 3. Basel: Karger. p 713-29.
22. Jennings E, Fitzgerald M. (1996) C-Fos can be induced in the neonatal rat spinal cord by both noxious and innocuous peripheral stimulation. Pain 68: 301-6.
23. _ (1998) Postnatal changes in responses of rat dorsal horn cells to afferent stimulation: a fibre induced sensitisation. Journal of Physiology 509: 859-67.
24. Jiang MC, Gebhart GF. (1998) Development of mustard oil-induced hyperalgesia in rats. Pain 77: 305-13.
25. Koltzenburg M, Wall PD, McMahon SB. (1999) Does the right side know what the left is doing? Trends in Neurosciences 22: 122-7.
26. Marsh D, Dickenson A, Hatch D, Fitzgerald M. (1999a) Epidural opioid analgesia in infant rats: mechanical and heat responses. Pain 82: 23-32.
27. _ (1999b) Epidural opioid analgesia in infant rats: responses to carrageenan and capsaicin. Pain 82: 33-8.
28. Prechtl HFR, Vlach V, Lenard HG, Kerr Grant D. (1967) Exteroceptive and tendon reflexes in various behavioural states in the newborn infant. Biologia Neonatorum 11: 159-75.
29. Rutter N. (1988) The immature skin. British Medical Bulletin 44: 957-70.
30. Schouenborg J, Holmberg H, Weng H-R. (1992) Functional organization of the nociceptive withdrawal reflexes. II. Changes of excitability and receptive fields after spinalization in the rat. Experimental Brain Research 90: 469-78.
31. Weng H-R, Schouenborg J. (1996) Cutaneous inhibitory receptive fields of withdrawal reflexes in the decerebrate spinal rat. Journal of Physiology 493: 253-66.
32. Willer J-C. (1977) Comparative study of perceived pain and nociceptive flexion reflex in man. Pain 3: 69-80.
33. _ (1985) Studies on pain: effects of morphine on a spinal nociceptive flexion reflex and related pain sensation in man. Brain Research 331: 105-14.
34. Woolf CJ. (1984) Long-term alterations in the excitability of the flexion reflex produced by peripheral tissue injury in the chronic decerebrate rat. Pain 18: 325-43.
35. _ Swett J. (1984) The cutaneous contribution to the hamstring flexor reflex in the rat. An electrophysiological and anatomical study. Brain Research 303: 299-312.
36. _ Doubell TP. (1994) The pathophysiology of chronic pain -increased sensitivity to low threshold A beta-fibre inputs. Current Opinions in Neurobiology 4: 525-34.